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P60468

- SC61B_HUMAN

UniProt

P60468 - SC61B_HUMAN

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Protein

Protein transport protein Sec61 subunit beta

Gene

SEC61B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Necessary for protein translocation in the endoplasmic reticulum.

GO - Molecular functioni

  1. epidermal growth factor binding Source: UniProtKB
  2. poly(A) RNA binding Source: UniProtKB
  3. ribosome binding Source: Ensembl

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  4. cellular protein metabolic process Source: Reactome
  5. ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
  6. gene expression Source: Reactome
  7. protein import into nucleus, translocation Source: UniProtKB
  8. retrograde protein transport, ER to cytosol Source: UniProtKB
  9. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  10. translation Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_111178. ER-Phagosome pathway.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

Protein family/group databases

TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit beta
Gene namesi
Name:SEC61B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:16993. SEC61B.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: HPA
  2. endoplasmic reticulum Sec complex Source: UniProtKB
  3. integral component of membrane Source: UniProtKB
  4. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi39 – 391C → S: Abolishes S-acylation. 1 Publication

Organism-specific databases

PharmGKBiPA134888963.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 9695Protein transport protein Sec61 subunit betaPRO_0000157254Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylproline1 Publication
Modified residuei7 – 71Phosphoserine1 Publication
Modified residuei13 – 131Phosphoserine1 Publication
Modified residuei14 – 141Phosphoserine1 Publication
Modified residuei17 – 171Phosphoserine3 Publications
Lipidationi39 – 391S-palmitoyl cysteine1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP60468.
PaxDbiP60468.
PeptideAtlasiP60468.
PRIDEiP60468.

PTM databases

PhosphoSiteiP60468.

Expressioni

Gene expression databases

BgeeiP60468.
CleanExiHS_SEC61B.
ExpressionAtlasiP60468. baseline and differential.
GenevestigatoriP60468.

Organism-specific databases

HPAiHPA049407.

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. Part of a complex composed of SEC61, SEC62 and SEC63. Interacts with SEC62.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCAP31P515727EBI-1788819,EBI-77683

Protein-protein interaction databases

BioGridi116152. 25 interactions.
DIPiDIP-40997N.
IntActiP60468. 9 interactions.
MINTiMINT-106933.
STRINGi9606.ENSP00000223641.

Structurei

3D structure databases

ProteinModelPortaliP60468.
SMRiP60468. Positions 61-96.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 7069CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei71 – 9121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC61-beta family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG248540.
GeneTreeiENSGT00390000003561.
HOGENOMiHOG000211109.
HOVERGENiHBG061281.
InParanoidiP60468.
KOiK09481.
OMAiHILAKIT.
OrthoDBiEOG77M8RR.
PhylomeDBiP60468.
TreeFamiTF313144.

Family and domain databases

InterProiIPR016482. SecG/Sec61-beta/Sbh1.
[Graphical view]
PANTHERiPTHR13509. PTHR13509. 1 hit.
PfamiPF03911. Sec61_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF006398. Sec61_beta_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60468 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGPTPSGTN VGSSGRSPSK AVAARAAGST VRQRKNASCG TRSAGRTTSA
60 70 80 90
GTGGMWRFYT EDSPGLKVGP VPVLVMSLLF IASVFMLHIW GKYTRS
Length:96
Mass (Da):9,974
Last modified:January 23, 2007 - v2
Checksum:i5FAFF4197A62FA49
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25085 mRNA. Translation: AAA19706.1.
CR456883 mRNA. Translation: CAG33164.1.
AL137067 Genomic DNA. Translation: CAC08000.1.
BC001734 mRNA. Translation: AAH01734.1.
CCDSiCCDS6741.1.
PIRiS42410.
RefSeqiNP_006799.1. NM_006808.2.
UniGeneiHs.191887.

Genome annotation databases

EnsembliENST00000223641; ENSP00000223641; ENSG00000106803.
GeneIDi10952.
KEGGihsa:10952.
UCSCiuc004azh.3. human.

Polymorphism databases

DMDMi42560366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25085 mRNA. Translation: AAA19706.1 .
CR456883 mRNA. Translation: CAG33164.1 .
AL137067 Genomic DNA. Translation: CAC08000.1 .
BC001734 mRNA. Translation: AAH01734.1 .
CCDSi CCDS6741.1.
PIRi S42410.
RefSeqi NP_006799.1. NM_006808.2.
UniGenei Hs.191887.

3D structure databases

ProteinModelPortali P60468.
SMRi P60468. Positions 61-96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116152. 25 interactions.
DIPi DIP-40997N.
IntActi P60468. 9 interactions.
MINTi MINT-106933.
STRINGi 9606.ENSP00000223641.

Protein family/group databases

TCDBi 3.A.5.9.1. the general secretory pathway (sec) family.

PTM databases

PhosphoSitei P60468.

Polymorphism databases

DMDMi 42560366.

Proteomic databases

MaxQBi P60468.
PaxDbi P60468.
PeptideAtlasi P60468.
PRIDEi P60468.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000223641 ; ENSP00000223641 ; ENSG00000106803 .
GeneIDi 10952.
KEGGi hsa:10952.
UCSCi uc004azh.3. human.

Organism-specific databases

CTDi 10952.
GeneCardsi GC09P101984.
HGNCi HGNC:16993. SEC61B.
HPAi HPA049407.
MIMi 609214. gene.
neXtProti NX_P60468.
PharmGKBi PA134888963.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG248540.
GeneTreei ENSGT00390000003561.
HOGENOMi HOG000211109.
HOVERGENi HBG061281.
InParanoidi P60468.
KOi K09481.
OMAi HILAKIT.
OrthoDBi EOG77M8RR.
PhylomeDBi P60468.
TreeFami TF313144.

Enzyme and pathway databases

Reactomei REACT_111178. ER-Phagosome pathway.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

Miscellaneous databases

GeneWikii SEC61B.
GenomeRNAii 10952.
NextBioi 41613.
PROi P60468.
SOURCEi Search...

Gene expression databases

Bgeei P60468.
CleanExi HS_SEC61B.
ExpressionAtlasi P60468. baseline and differential.
Genevestigatori P60468.

Family and domain databases

InterProi IPR016482. SecG/Sec61-beta/Sbh1.
[Graphical view ]
PANTHERi PTHR13509. PTHR13509. 1 hit.
Pfami PF03911. Sec61_beta. 1 hit.
[Graphical view ]
PIRSFi PIRSF006398. Sec61_beta_euk. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary conservation of components of the protein translocation complex."
    Hartmann E., Sommer T., Prehn S., Goerlich D., Jentsch S., Rapoport T.A.
    Nature 367:654-657(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Bienvenut W.V., Waridel P., Quadroni M.
    Submitted (MAR-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-20, CLEAVAGE OF INITIATOR METHIONINE, PHOSPHORYLATION AT SER-7, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryonic kidney.
  6. Cited for: IDENTIFICATION IN A COMPLEX WITH SEC62 AND SEC63, INTERACTION WITH SEC62.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-14 AND SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Site-specific analysis of protein S-acylation by resin-assisted capture."
    Forrester M.T., Hess D.T., Thompson J.W., Hultman R., Moseley M.A., Stamler J.S., Casey P.J.
    J. Lipid Res. 52:393-398(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF CYS-39, PALMITOYLATION AT CYS-39.
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT PRO-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSC61B_HUMAN
AccessioniPrimary (citable) accession number: P60468
Secondary accession number(s): P38390, P38391, Q6IBC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3