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Protein

Protein transport protein Sec61 subunit beta

Gene

SEC61B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for protein translocation in the endoplasmic reticulum.

GO - Molecular functioni

  • ARF guanyl-nucleotide exchange factor activity Source: GO_Central
  • epidermal growth factor binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • IRE1-mediated unfolded protein response Source: Reactome
  • posttranslational protein targeting to membrane, translocation Source: GO_Central
  • protein import into nucleus, translocation Source: UniProtKB
  • retrograde protein transport, ER to cytosol Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane, translocation Source: GO_Central
  • ubiquitin-dependent ERAD pathway Source: UniProtKB

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-381038. XBP1(S) activates chaperone genes.

Protein family/group databases

TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit beta
Gene namesi
Name:SEC61B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000106803.9.
HGNCiHGNC:16993. SEC61B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 70CytoplasmicSequence analysisAdd BLAST69
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi39C → S: Abolishes S-acylation. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000106803.
PharmGKBiPA134888963.

Polymorphism and mutation databases

BioMutaiSEC61B.
DMDMi42560366.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001572542 – 96Protein transport protein Sec61 subunit betaAdd BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylprolineCombined sources1
Modified residuei7Phosphoserine1 Publication1
Modified residuei9PhosphothreonineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Lipidationi39S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP60468.
MaxQBiP60468.
PaxDbiP60468.
PeptideAtlasiP60468.
PRIDEiP60468.
TopDownProteomicsiP60468.

PTM databases

iPTMnetiP60468.
PhosphoSitePlusiP60468.
SwissPalmiP60468.

Expressioni

Gene expression databases

BgeeiENSG00000106803.
CleanExiHS_SEC61B.
ExpressionAtlasiP60468. baseline and differential.
GenevisibleiP60468. HS.

Organism-specific databases

HPAiHPA049407.

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. Part of a complex composed of SEC61, SEC62 and SEC63. Interacts with SEC62.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • epidermal growth factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116152. 50 interactors.
CORUMiP60468.
DIPiDIP-40997N.
IntActiP60468. 51 interactors.
MINTiMINT-106933.
STRINGi9606.ENSP00000223641.

Structurei

3D structure databases

ProteinModelPortaliP60468.
SMRiP60468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC61-beta family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3457. Eukaryota.
ENOG4111UAR. LUCA.
GeneTreeiENSGT00390000003561.
HOGENOMiHOG000211109.
HOVERGENiHBG061281.
InParanoidiP60468.
KOiK09481.
OMAiNSGGMWR.
OrthoDBiEOG091G17J4.
PhylomeDBiP60468.
TreeFamiTF313144.

Family and domain databases

InterProiView protein in InterPro
IPR030671. Sec61-beta/Sbh.
IPR016482. SecG/Sec61-beta/Sbh.
PANTHERiPTHR13509. PTHR13509. 1 hit.
PfamiView protein in Pfam
PF03911. Sec61_beta. 1 hit.
PIRSFiPIRSF006398. Sec61_beta_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60468-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPTPSGTN VGSSGRSPSK AVAARAAGST VRQRKNASCG TRSAGRTTSA
60 70 80 90
GTGGMWRFYT EDSPGLKVGP VPVLVMSLLF IASVFMLHIW GKYTRS
Length:96
Mass (Da):9,974
Last modified:January 23, 2007 - v2
Checksum:i5FAFF4197A62FA49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25085 mRNA. Translation: AAA19706.1.
CR456883 mRNA. Translation: CAG33164.1.
AL137067 Genomic DNA. No translation available.
BC001734 mRNA. Translation: AAH01734.1.
CCDSiCCDS6741.1.
PIRiS42410.
RefSeqiNP_006799.1. NM_006808.2.
UniGeneiHs.191887.

Genome annotation databases

EnsembliENST00000223641; ENSP00000223641; ENSG00000106803.
GeneIDi10952.
KEGGihsa:10952.
UCSCiuc004azh.4. human.

Similar proteinsi

Entry informationi

Entry nameiSC61B_HUMAN
AccessioniPrimary (citable) accession number: P60468
Secondary accession number(s): P38390, P38391, Q6IBC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families