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Protein

Protein transport protein Sec61 subunit beta

Gene

SEC61B

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for protein translocation in the endoplasmic reticulum.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-CFA-381038 XBP1(S) activates chaperone genes

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit beta
Gene namesi
Name:SEC61B
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:49616 SEC61B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 70CytoplasmicSequence analysisAdd BLAST69
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity1 Publication
ChainiPRO_00001572532 – 96Protein transport protein Sec61 subunit betaAdd BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylprolineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei9PhosphothreonineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei17PhosphoserineBy similarity1
Lipidationi39S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP60467
PRIDEiP60467

Expressioni

Gene expression databases

BgeeiENSCAFG00000002533

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. Part of a complex composed of SEC61, SEC62 and SEC63. Interacts with SEC62 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1399311 interactor.
CORUMiP60467
IntActiP60467 1 interactor.
MINTiP60467
STRINGi9615.ENSCAFP00000003690

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WWBelectron microscopy6.48C1-96[»]
4CG5electron microscopy7.40C61-96[»]
4CG6electron microscopy7.80C1-96[»]
4CG7electron microscopy6.90C61-96[»]
5A6Uelectron microscopy9.00B61-96[»]
ProteinModelPortaliP60467
SMRiP60467
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60467

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC61-beta family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3457 Eukaryota
ENOG4111UAR LUCA
GeneTreeiENSGT00390000003561
HOGENOMiHOG000211109
HOVERGENiHBG061281
InParanoidiP60467
KOiK09481
OMAiNSGGMWR
OrthoDBiEOG091G17J4
TreeFamiTF313144

Family and domain databases

InterProiView protein in InterPro
IPR030671 Sec61-beta/Sbh
IPR016482 SecG/Sec61-beta/Sbh
PANTHERiPTHR13509 PTHR13509, 1 hit
PfamiView protein in Pfam
PF03911 Sec61_beta, 1 hit
PIRSFiPIRSF006398 Sec61_beta_euk, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPTPSGTN VGSSGRSPSK AVAARAAGST VRQRKNASCG TRSAGRTTSA
60 70 80 90
GTGGMWRFYT EDSPGLKVGP VPVLVMSLLF IASVFMLHIW GKYTRS
Length:96
Mass (Da):9,974
Last modified:January 23, 2007 - v2
Checksum:i5FAFF4197A62FA49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25052 mRNA Translation: AAA19639.1
PIRiS42409
RefSeqiNP_001003326.1, NM_001003326.1
UniGeneiCfa.3895

Genome annotation databases

EnsembliENSCAFT00000003996; ENSCAFP00000003690; ENSCAFG00000002533
GeneIDi404018
KEGGicfa:404018

Similar proteinsi

Entry informationi

Entry nameiSC61B_CANLF
AccessioniPrimary (citable) accession number: P60467
Secondary accession number(s): P38390, P38391
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome