P60413 (KR10C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin-associated protein 10-12

Alternative name(s):
High sulfur keratin-associated protein 10.12
Keratin-associated protein 10.12
Keratin-associated protein 18-12
Keratin-associated protein 18.12

Gene names

Name:	KRTAP10-12
Synonyms:	KAP10.12, KAP18-12, KRTAP10.12, KRTAP18-12, KRTAP18.12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Subunit structure	Interacts with hair keratins.
Tissue specificity	Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues. Ref.1 Ref.5
Sequence similarities	Belongs to the KRTAP type 10 family.

Ontologies

Keywords
Cellular component	Keratin
Coding sequence diversity	Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	keratin filament Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	Keratin-associated protein 10-12		PRO_0000185220
Regions
	Repeat	36 – 40	5	1
	Repeat	41 – 45	5	2
	Repeat	62 – 66	5	3
	Repeat	84 – 88	5	4
	Repeat	94 – 98	5	5
	Repeat	104 – 108	5	6
	Repeat	109 – 113	5	7
	Repeat	114 – 118	5	8
	Repeat	119 – 123	5	9
	Repeat	124 – 128	5	10
	Repeat	131 – 135	5	11
	Repeat	141 – 145	5	12
	Repeat	151 – 155	5	13
	Repeat	156 – 160	5	14
	Repeat	161 – 165	5	15
	Repeat	173 – 177	5	16
	Repeat	183 – 187	5	17
	Repeat	188 – 192	5	18
	Repeat	214 – 218	5	19
	Region	36 – 218	183	19 X 5 AA repeats of C-C-X(3)
Natural variations
	Natural variant	146	1	P → Q. Corresponds to variant rs35076450 [ dbSNP | Ensembl ].		VAR_053465
	Natural variant	226	1	G → S. Corresponds to variant rs34302939 [ dbSNP | Ensembl ].		VAR_053466

Sequences

	Sequence		Length	Mass (Da)
	P60413 [UniParc]. Last modified February 16, 2004. Version 1. Checksum: 815BC4AD4A25285E	FASTA	245	25,107
	10 20 30 40 50 60 MSVCSSDLSY GSRVCLPGSC DSCSDSWQVD DCPESCCEPP CCAPAPCLSL VCTPVSRVSS 70 80 90 100 110 120 PCCRVTCEPS PCQSGCTSSC TPSCCQQSSC QPACCTSSPC QQACCVPVCC KTVCCKPVCC 130 140 150 160 170 180 MPVCCGPSSS CCQQSSCQPA CCISSPCQQS CCVPVCCKPI CCVPVCSGAS SLCCQQSSCQ 190 200 210 220 230 240 PACCTTSCCR PSSSVSLLCR PVCRPARRVP VPSCCVPTSS CQPSCGRLAS CGSLLCRPTC SRLAC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3." Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N. Genomics 83:679-693(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Hair root.
[2]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21." Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S., Schweizer J. J. Invest. Dermatol. 122:147-158(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB076364 mRNA. Translation: BAD01551.1. AL773604 Genomic DNA. No translation available. CH471079 Genomic DNA. Translation: EAX09404.1. BC137339 mRNA. Translation: AAI37340.1. BC137341 mRNA. Translation: AAI37342.1.
IPI	IPI00394683.
RefSeq	NP_941972.1. NM_198699.1.
UniGene	Hs.297526.
3D structure databases
ProteinModelPortal	P60413.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000383216.
Polymorphism databases
DMDM	42558957.
Proteomic databases
PaxDb	P60413.
PeptideAtlas	P60413.
PRIDE	P60413.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000400365; ENSP00000383216; ENSG00000189169.
GeneID	386685.
KEGG	hsa:386685.
UCSC	uc002zfw.1. human.
Organism-specific databases
CTD	386685.
GeneCards	GC21P046117.
HGNC	HGNC:20533. KRTAP10-12.
neXtProt	NX_P60413.
PharmGKB	PA134977717.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG324830.
HOGENOM	HOG000234031.
HOVERGEN	HBG108072.
InParanoid	P60413.
OMA	ACCTSSA.
OrthoDB	EOG43BMQP.
Gene expression databases
ArrayExpress	P60413.
Bgee	P60413.
CleanEx	HS_KRTAP10-12.
Genevestigator	P60413.
Family and domain databases
InterPro	IPR002494. Keratin-assoc. [Graphical view]
PANTHER	PTHR23262. PTHR23262. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	386685.
NextBio	101020.

Entry information

Entry name

KR10C_HUMAN

Accession

Primary (citable) accession number: P60413
Secondary accession number(s): B2RPA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	February 16, 2004
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.