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Protein

Keratin-associated protein 10-11

Gene

KRTAP10-11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 10-11
Alternative name(s):
High sulfur keratin-associated protein 10.11
Keratin-associated protein 10.11
Keratin-associated protein 18-11
Keratin-associated protein 18.11
Gene namesi
Name:KRTAP10-11
Synonyms:KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:20528. KRTAP10-11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134873081.

Polymorphism and mutation databases

DMDMi296439312.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Keratin-associated protein 10-11PRO_0000185219Add
BLAST

Proteomic databases

PaxDbiP60412.
PeptideAtlasiP60412.
PRIDEiP60412.

Expressioni

Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

BgeeiP60412.
CleanExiHS_KRTAP10-11.
GenevisibleiP60412. HS.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-10217483,EBI-10173507
CAMK2BQ135543EBI-10217483,EBI-1058722
CATSPER1Q8NEC53EBI-10217483,EBI-744545
CREB5Q02930-33EBI-10217483,EBI-10192698
FAM76BQ5HYJ33EBI-10217483,EBI-751192
GLRX3O760034EBI-10217483,EBI-374781
HOXA1P496393EBI-10217483,EBI-740785
KRTAP4-2Q9BYR53EBI-10217483,EBI-10172511
KRTAP5-9P263713EBI-10217483,EBI-3958099
KRTAP9-2Q9BYQ43EBI-10217483,EBI-1044640
MEOX2A4D1273EBI-10217483,EBI-10172134
NOTCH2NLQ7Z3S93EBI-10217483,EBI-945833
OTX1P322423EBI-10217483,EBI-740446
PLSCR1O151623EBI-10217483,EBI-740019
SPRY2O435973EBI-10217483,EBI-742487

Protein-protein interaction databases

BioGridi132129. 15 interactions.
IntActiP60412. 15 interactions.
STRINGi9606.ENSP00000334197.

Structurei

3D structure databases

ProteinModelPortaliP60412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 3051
Repeati36 – 4052
Repeati57 – 6153
Repeati79 – 8354
Repeati89 – 9355
Repeati99 – 10356
Repeati104 – 10857
Repeati109 – 11358
Repeati114 – 11859
Repeati119 – 123510
Repeati126 – 130511
Repeati136 – 140512
Repeati146 – 150513
Repeati151 – 155514
Repeati156 – 160515
Repeati168 – 172516
Repeati178 – 182517
Repeati188 – 192518
Repeati193 – 197519
Repeati203 – 207520
Repeati225 – 229521
Repeati230 – 234522
Repeati249 – 253523
Repeati256 – 260524
Repeati267 – 271525

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 27124625 X 5 AA repeats of C-C-X(3)Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JNRG. Eukaryota.
ENOG41116YF. LUCA.
GeneTreeiENSGT00780000121948.
HOGENOMiHOG000234031.
HOVERGENiHBG108072.
InParanoidiP60412.
OMAiYCKPICC.
OrthoDBiEOG780RQD.
PhylomeDBiP60412.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 2 hits.
PfamiPF13885. Keratin_B2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTMSVCS SAYSDSWQVD DCPESCCEPP CSAPSCCAPA PSLSLVCTPV
60 70 80 90 100
SCVSSPCCQA ACEPSACQSG CTSSCTPSCC QQSSCQPACC TSSPCQQACC
110 120 130 140 150
VPVCCKTVCC KPVCCVPVCC GAASSCCRQS SCQPACCASS SCQPACCVPV
160 170 180 190 200
CCKPVCCVST CSEDSSSCCQ QSSCQPACCT SSSYQQACCV PVCCKTVYCK
210 220 230 240 250
PICCVPVCSR ASSSRCQQPS CQPACCTTSC CRPSSSVSLL CHPVCRSTCC
260 270 280 290
VPVSSCCAPT SSCQSSCCRP ASCVSLLCRP ASSRLACYSL CSGKKSSC
Length:298
Mass (Da):30,243
Last modified:May 18, 2010 - v3
Checksum:i11A332F802EE9222
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti213 – 2131S → Y in BAD01546 (PubMed:15028290).Curated
Sequence conflicti269 – 2691R → C in BAD01546 (PubMed:15028290).Curated
Sequence conflicti269 – 2691R → C in AAI31612 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti130 – 1301S → F.
Corresponds to variant rs4818952 [ dbSNP | Ensembl ].
VAR_060056

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076359 mRNA. Translation: BAD01546.1.
AL773602 Genomic DNA. No translation available.
BC131611 mRNA. Translation: AAI31612.1.
CCDSiCCDS42962.1.
RefSeqiNP_941965.2. NM_198692.2.
UniGeneiHs.58076.

Genome annotation databases

EnsembliENST00000334670; ENSP00000334197; ENSG00000243489.
GeneIDi386678.
KEGGihsa:386678.
UCSCiuc002zfr.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076359 mRNA. Translation: BAD01546.1.
AL773602 Genomic DNA. No translation available.
BC131611 mRNA. Translation: AAI31612.1.
CCDSiCCDS42962.1.
RefSeqiNP_941965.2. NM_198692.2.
UniGeneiHs.58076.

3D structure databases

ProteinModelPortaliP60412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132129. 15 interactions.
IntActiP60412. 15 interactions.
STRINGi9606.ENSP00000334197.

Polymorphism and mutation databases

DMDMi296439312.

Proteomic databases

PaxDbiP60412.
PeptideAtlasiP60412.
PRIDEiP60412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334670; ENSP00000334197; ENSG00000243489.
GeneIDi386678.
KEGGihsa:386678.
UCSCiuc002zfr.5. human.

Organism-specific databases

CTDi386678.
GeneCardsiKRTAP10-11.
H-InvDBHIX0040853.
HGNCiHGNC:20528. KRTAP10-11.
neXtProtiNX_P60412.
PharmGKBiPA134873081.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JNRG. Eukaryota.
ENOG41116YF. LUCA.
GeneTreeiENSGT00780000121948.
HOGENOMiHOG000234031.
HOVERGENiHBG108072.
InParanoidiP60412.
OMAiYCKPICC.
OrthoDBiEOG780RQD.
PhylomeDBiP60412.
TreeFamiTF351356.

Miscellaneous databases

GenomeRNAii386678.
PROiP60412.

Gene expression databases

BgeeiP60412.
CleanExiHS_KRTAP10-11.
GenevisibleiP60412. HS.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 2 hits.
PfamiPF13885. Keratin_B2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3."
    Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.
    Genomics 83:679-693(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Hair root.
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21."
    Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S., Schweizer J.
    J. Invest. Dermatol. 122:147-158(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiKR10B_HUMAN
AccessioniPrimary (citable) accession number: P60412
Secondary accession number(s): A2RRF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.