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Protein

Keratin-associated protein 10-9

Gene

KRTAP10-9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 10-9
Alternative name(s):
High sulfur keratin-associated protein 10.9
Keratin-associated protein 10.9
Keratin-associated protein 18-9
Keratin-associated protein 18.9
Gene namesi
Name:KRTAP10-9
Synonyms:KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:22971. KRTAP10-9.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134873081.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Keratin-associated protein 10-9PRO_0000185217Add
BLAST

Proteomic databases

PaxDbiP60411.
PeptideAtlasiP60411.
PRIDEiP60411.

PTM databases

PhosphoSiteiP60411.

Expressioni

Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

BgeeiP60411.
CleanExiHS_KRTAP10-9.
GenevestigatoriP60411.

Interactioni

Subunit structurei

Interacts with hair keratins.

Protein-protein interaction databases

BioGridi132127. 164 interactions.
132129. 15 interactions.
STRINGi9606.ENSP00000381009.

Structurei

3D structure databases

ProteinModelPortaliP60411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 3051
Repeati31 – 3552
Repeati36 – 4053
Repeati57 – 6154
Repeati79 – 8355
Repeati99 – 10356
Repeati104 – 10857
Repeati109 – 11358
Repeati114 – 11859
Repeati120 – 124510
Repeati130 – 134511
Repeati140 – 144512
Repeati145 – 149513
Repeati150 – 154514
Repeati162 – 166515
Repeati172 – 176516
Repeati182 – 186517
Repeati187 – 191518
Repeati192 – 196519
Repeati197 – 201520
Repeati209 – 213521
Repeati219 – 223522
Repeati224 – 228523
Repeati243 – 247524
Repeati250 – 254525

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 25422925 X 5 AA repeats of C-C-X(3)Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG270891.
GeneTreeiENSGT00780000121948.
HOGENOMiHOG000234031.
HOVERGENiHBG108072.
InParanoidiP60411.
OMAiEPSCCSS.
OrthoDBiEOG780RQD.
PhylomeDBiP60411.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced.

Isoform 1 (identifier: P60411-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASTMSIRS SAYSDSWQVD DCPESCCEPP CCATSCCAPA PCLTLVCTPV
60 70 80 90 100
SRVSSPCCQV TCEPSPCQSG CTSSCTPSCC QQSSCQPAYC TSSPCQQACC
110 120 130 140 150
VPVCCKPVCC VPVCCGASSC CQQSSYQPAC CASSSCQPAC CVPVCCKPVC
160 170 180 190 200
CAPTCSEDSY SCCQQSSCQP ACCTSSPCQQ SYCVPVCCKP VCCKPICCVP
210 220 230 240 250
VCSGASSLCC QQSGCQPACC TTSCCRPSSS VSLLCRPVCR PACCVPVSSC
260 270 280 290
CAPTSSRQPS YCRQASCVSL LCRPVCSRPA CYSFSSGQKS SC
Length:292
Mass (Da):30,037
Last modified:April 20, 2010 - v2
Checksum:iE61D891212803B98
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021P → PVCCKT in EAX09409. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti182 – 1821Y → C.1 Publication
Corresponds to variant rs8127342 [ dbSNP | Ensembl ].
VAR_017739
Natural varianti257 – 2571R → C.2 Publications
Corresponds to variant rs9980129 [ dbSNP | Ensembl ].
VAR_060052

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076356 mRNA. Translation: BAD01543.1.
AL773602 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09409.1.
CH471079 Genomic DNA. Translation: EAX09411.1.
BC131613 mRNA. Translation: AAI31614.1.
AJ566386 mRNA. Translation: CAD97466.1.
CCDSiCCDS42961.1. [P60411-1]
RefSeqiNP_941963.2. NM_198690.2. [P60411-1]
NP_941965.2. NM_198692.2.
UniGeneiHs.474000.
Hs.58076.

Genome annotation databases

EnsembliENST00000397911; ENSP00000381009; ENSG00000221837. [P60411-1]
GeneIDi386676.
386678.
KEGGihsa:386676.
hsa:386678.
UCSCiuc002zfp.4. human. [P60411-1]

Polymorphism databases

DMDMi294862449.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076356 mRNA. Translation: BAD01543.1.
AL773602 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09409.1.
CH471079 Genomic DNA. Translation: EAX09411.1.
BC131613 mRNA. Translation: AAI31614.1.
AJ566386 mRNA. Translation: CAD97466.1.
CCDSiCCDS42961.1. [P60411-1]
RefSeqiNP_941963.2. NM_198690.2. [P60411-1]
NP_941965.2. NM_198692.2.
UniGeneiHs.474000.
Hs.58076.

3D structure databases

ProteinModelPortaliP60411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132127. 164 interactions.
132129. 15 interactions.
STRINGi9606.ENSP00000381009.

PTM databases

PhosphoSiteiP60411.

Polymorphism databases

DMDMi294862449.

Proteomic databases

PaxDbiP60411.
PeptideAtlasiP60411.
PRIDEiP60411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397911; ENSP00000381009; ENSG00000221837. [P60411-1]
GeneIDi386676.
386678.
KEGGihsa:386676.
hsa:386678.
UCSCiuc002zfp.4. human. [P60411-1]

Organism-specific databases

CTDi386676.
386678.
GeneCardsiGC21P046047.
H-InvDBHIX0040852.
HGNCiHGNC:22971. KRTAP10-9.
neXtProtiNX_P60411.
PharmGKBiPA134873081.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG270891.
GeneTreeiENSGT00780000121948.
HOGENOMiHOG000234031.
HOVERGENiHBG108072.
InParanoidiP60411.
OMAiEPSCCSS.
OrthoDBiEOG780RQD.
PhylomeDBiP60411.
TreeFamiTF351356.

Miscellaneous databases

NextBioi100980.
PROiP60411.

Gene expression databases

BgeeiP60411.
CleanExiHS_KRTAP10-9.
GenevestigatoriP60411.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3."
    Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.
    Genomics 83:679-693(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Hair root.
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS CYS-182 AND CYS-257.
  5. "Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21."
    Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S., Schweizer J.
    J. Invest. Dermatol. 122:147-158(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-292, TISSUE SPECIFICITY, VARIANT CYS-257.
    Tissue: Scalp.

Entry informationi

Entry nameiKR109_HUMAN
AccessioniPrimary (citable) accession number: P60411
Secondary accession number(s): A2RRG1, A6NIR9, Q70LJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: April 20, 2010
Last modified: February 4, 2015
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.