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Protein

Keratin-associated protein 10-8

Gene

KRTAP10-8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 10-8
Alternative name(s):
High sulfur keratin-associated protein 10.8
Keratin-associated protein 10.8
Keratin-associated protein 18-8
Keratin-associated protein 18.8
Gene namesi
Name:KRTAP10-8
Synonyms:KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:20525. KRTAP10-8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134968895.

Polymorphism and mutation databases

BioMutaiKRTAP10-8.
DMDMi116242612.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Keratin-associated protein 10-8PRO_0000185216Add
BLAST

Proteomic databases

PaxDbiP60410.
PRIDEiP60410.

Expressioni

Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

CleanExiHS_KRTAP10-8.
GenevestigatoriP60410.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
Q5BKY63EBI-10171774,EBI-10243533
Q5XG853EBI-10171774,EBI-10248413
Q6ZVW33EBI-10171774,EBI-10255586
Q9NWL93EBI-10171774,EBI-10315054
ADAMTSL3P829873EBI-10171774,EBI-10221726
ADAMTSL4Q6UY14-33EBI-10171774,EBI-10173507
AENQ8WTP83EBI-10171774,EBI-8637627
AESQ081173EBI-10171774,EBI-717810
ALDH3B1P433533EBI-10171774,EBI-2558314
ALPIP099233EBI-10171774,EBI-1052631
APOL6B3KTP43EBI-10171774,EBI-10175904
ASPSCR1Q9BZE93EBI-10171774,EBI-1993677
ATG9AQ7Z3C63EBI-10171774,EBI-727146
BEX2Q9BXY83EBI-10171774,EBI-745073
BMP7A8K5713EBI-10171774,EBI-10174327
C11orf87Q6NUJ23EBI-10171774,EBI-6660291
C19orf66Q9NUL53EBI-10171774,EBI-10313866
C9orf9Q96E403EBI-10171774,EBI-722584
CARHSP1Q9Y2V23EBI-10171774,EBI-718719
CARKDQ8IW453EBI-10171774,EBI-8650724
CATSPER1Q8NEC55EBI-10171774,EBI-744545
CCDC26Q8TAB73EBI-10171774,EBI-10271580
CCNJLF6RF563EBI-10171774,EBI-10177725
CHIC2Q9UKJ53EBI-10171774,EBI-741528
CHRDQ9H2X03EBI-10171774,EBI-947551
CHRNGP075103EBI-10171774,EBI-9008836
CLK4Q9HAZ13EBI-10171774,EBI-633400
CNNM3Q8NE013EBI-10171774,EBI-741032
COL8A1P276583EBI-10171774,EBI-747133
CRCT1Q9UGL93EBI-10171774,EBI-713677
CREB5Q02930-35EBI-10171774,EBI-10192698
DCXO436023EBI-10171774,EBI-8646694
DDX55Q8NHQ93EBI-10171774,EBI-5459844
DDX6P261963EBI-10171774,EBI-351257
DERL2Q9GZP93EBI-10171774,EBI-7962814
DHRS1Q96LJ73EBI-10171774,EBI-746300
DHX57Q6P1583EBI-10171774,EBI-1051531
DMRT3Q9NQL93EBI-10171774,EBI-9679045
DOCK2Q926083EBI-10171774,EBI-448771
EIF4E2O605733EBI-10171774,EBI-398610
FAHP169303EBI-10171774,EBI-4397076
FAM27E3Q08E933EBI-10171774,EBI-2602739
FAM74A6Q5TZK33EBI-10171774,EBI-10247271
FAM76BQ5HYJ33EBI-10171774,EBI-751192
FBXW5Q969U63EBI-10171774,EBI-741068
FOXB1Q998533EBI-10171774,EBI-3916225
GFOD1Q9NXC23EBI-10171774,EBI-8799578
GLP1RP432203EBI-10171774,EBI-7466542
GLRX3O760035EBI-10171774,EBI-374781
GLYATQ6IB773EBI-10171774,EBI-715463
GNAI2P048993EBI-10171774,EBI-353997
GNEQ9Y2233EBI-10171774,EBI-4291090
GOLGA8DPQ0D2H93EBI-10171774,EBI-10181276
HEL-S-90nV9HWJ53EBI-10171774,EBI-10330335
HHEXQ030143EBI-10171774,EBI-747421
HOXA1P496393EBI-10171774,EBI-740785
HPCAL1P372353EBI-10171774,EBI-749311
HSD3B7Q9H2F33EBI-10171774,EBI-3918847
HSPD1P108093EBI-10171774,EBI-352528
IGSF8Q969P03EBI-10171774,EBI-8293590
ITGB5L7RT223EBI-10171774,EBI-10178729
JOSD1Q150403EBI-10171774,EBI-2510602
KLHL38Q2WGJ63EBI-10171774,EBI-6426443
KRT20P359003EBI-10171774,EBI-742094
KRT83P783853EBI-10171774,EBI-10221390
KRTAP10-7P604093EBI-10171774,EBI-10172290
KRTAP10-9P604113EBI-10171774,EBI-10172052
KRTAP12-1P599903EBI-10171774,EBI-10210845
KRTAP12-2P599913EBI-10171774,EBI-10176379
KRTAP4-11Q9BYQ63EBI-10171774,EBI-10302392
KRTAP4-12Q9BQ663EBI-10171774,EBI-739863
KRTAP4-2Q9BYR55EBI-10171774,EBI-10172511
KRTAP4-7Q9BYR03EBI-10171774,EBI-10302547
KRTAP5-6Q6L8G93EBI-10171774,EBI-10250562
KRTAP5-9P263713EBI-10171774,EBI-3958099
KRTAP9-2Q9BYQ43EBI-10171774,EBI-1044640
KRTAP9-4Q9BYQ23EBI-10171774,EBI-10185730
LCE1BQ5T7P33EBI-10171774,EBI-10245913
LCE2AQ5TA793EBI-10171774,EBI-10246607
LCE2DQ5TA823EBI-10171774,EBI-10246750
LCE3CQ5T5A83EBI-10171774,EBI-10245291
LCE3EQ5T5B03EBI-10171774,EBI-10245456
LCE4AQ5TA783EBI-10171774,EBI-10246358
LOC200261Q17RD93EBI-10171774,EBI-10239007
LRCH4O754273EBI-10171774,EBI-718707
LUZP4Q9P1273EBI-10171774,EBI-10198848
LYVE1Q9Y5Y73EBI-10171774,EBI-10329546
MAPKBP1O603363EBI-10171774,EBI-947402
MATN3O152323EBI-10171774,EBI-6262458
MEOX2A4D1273EBI-10171774,EBI-10172134
MLLT6Q6P2C63EBI-10171774,EBI-5773143
MTA1Q133303EBI-10171774,EBI-714236
MXI1P50539-33EBI-10171774,EBI-10211940
NAB2Q157423EBI-10171774,EBI-8641936
NOTCH2NLQ7Z3S93EBI-10171774,EBI-945833
NUFIP2A1L3A73EBI-10171774,EBI-10172018
OTX1P322425EBI-10171774,EBI-740446
P2RX7C6KE323EBI-10171774,EBI-10176325
PCED1AQ9H1Q73EBI-10171774,EBI-748452
PCSK5Q928243EBI-10171774,EBI-751290
PDE9AO760833EBI-10171774,EBI-742764
PIGSQ96S523EBI-10171774,EBI-2908273
PKD2Q135633EBI-10171774,EBI-7813714
PRKAB2O437413EBI-10171774,EBI-1053424
PRPF31F1T0A53EBI-10171774,EBI-10177194
PRR13Q9NZ813EBI-10171774,EBI-740924
PTGER3Q147X83EBI-10171774,EBI-10234038
PTPMT1Q8WUK03EBI-10171774,EBI-7199479
PTPRHQ9HD433EBI-10171774,EBI-1267176
PVRP151513EBI-10171774,EBI-3919694
PVRL3Q9NQS33EBI-10171774,EBI-2826725
R3HDM2Q9Y2K5-23EBI-10171774,EBI-10326419
RPS28P628573EBI-10171774,EBI-353027
RTN4RL1Q86UN23EBI-10171774,EBI-10258951
SCNM1Q9BWG63EBI-10171774,EBI-748391
SLC22A23A1A5C73EBI-10171774,EBI-10171756
SLC23A1Q9UHI73EBI-10171774,EBI-1759386
SLC25A10Q9UBX33EBI-10171774,EBI-750394
SLC6A20Q9NP913EBI-10171774,EBI-10311198
SMCPP499013EBI-10171774,EBI-750494
SMOC1Q9H4F83EBI-10171774,EBI-2801103
SPRY1O436093EBI-10171774,EBI-3866665
SPRY2O435973EBI-10171774,EBI-742487
STK16O757163EBI-10171774,EBI-749295
SUSD6Q925373EBI-10171774,EBI-2866213
TBC1D23Q9NUY83EBI-10171774,EBI-2853126
TENC1Q63HR23EBI-10171774,EBI-949753
THAP10Q9P2Z03EBI-10171774,EBI-745404
THAP7Q9BT493EBI-10171774,EBI-741350
TMEM150AQ86TG13EBI-10171774,EBI-2799342
TNIP3Q96KP63EBI-10171774,EBI-2509913
TNP2Q4VB563EBI-10171774,EBI-10241829
TRPV6Q9Y2603EBI-10171774,EBI-750052
TXNDC5Q86UY03EBI-10171774,EBI-2825190
TYMSOSQ8TAI13EBI-10171774,EBI-742060
TYRO3Q064183EBI-10171774,EBI-3951628
UTP23Q9BRU93EBI-10171774,EBI-5457544
UXTQ9UBK93EBI-10171774,EBI-357355
VPS11Q9H2703EBI-10171774,EBI-373380
WIF1Q9Y5W53EBI-10171774,EBI-3922719
WT1P195443EBI-10171774,EBI-2320534
WT1-ASQ062503EBI-10171774,EBI-10223946
YIPF3Q9GZM53EBI-10171774,EBI-743787
ZBTB24O431673EBI-10171774,EBI-744471
ZFYVE21Q9BQ243EBI-10171774,EBI-2849569
ZNF124Q159733EBI-10171774,EBI-2555767
ZNF138P52744-23EBI-10171774,EBI-10213071
ZNF20P170243EBI-10171774,EBI-717634
ZNF32P170413EBI-10171774,EBI-1965483
ZNF417Q8TAU33EBI-10171774,EBI-740727
ZNF439Q8NDP43EBI-10171774,EBI-747580
ZNF473Q8WTR73EBI-10171774,EBI-751409
ZNF572A1L4E93EBI-10171774,EBI-10172590
ZNF572Q7Z3I73EBI-10171774,EBI-10257016
ZNF578Q3MI943EBI-10171774,EBI-10241108
ZNF587Q96SQ53EBI-10171774,EBI-6427977
ZNF697Q8N5083EBI-10171774,EBI-10265733
ZSCAN21Q9Y5A63EBI-10171774,EBI-10281938

Protein-protein interaction databases

BioGridi132132. 164 interactions.
IntActiP60410. 159 interactions.

Structurei

3D structure databases

ProteinModelPortaliP60410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati50 – 5451
Repeati60 – 6452
Repeati65 – 6953
Repeati98 – 10254
Repeati108 – 11255
Repeati118 – 12256
Repeati123 – 12757
Repeati133 – 13758
Repeati145 – 14959
Repeati155 – 159510
Repeati165 – 169511
Repeati170 – 174512
Repeati175 – 179513
Repeati187 – 191514
Repeati197 – 201515
Repeati202 – 206516
Repeati221 – 225517
Repeati228 – 232518
Repeati239 – 243519

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 24321819 X 5 AA repeats of C-C-X(3)Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG113264.
GeneTreeiENSGT00780000121948.
HOGENOMiHOG000234031.
HOVERGENiHBG108072.
InParanoidiP60410.
OMAiCEPRSCA.
OrthoDBiEOG7Q5HGX.
PhylomeDBiP60410.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
IPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 2 hits.
PF05287. PMG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADACCTRTY VIAASTMSVC SSDVGHVSRV SSPSTCTGSS WQVDNCQESC
60 70 80 90 100
CEPRSCASSC CTPSCCAPAP CLALVCAPVS CEPSPCQSGC TDSCTPSCCQ
110 120 130 140 150
QSSCQPACCT SSPCQQACCV PVCCKSNCCK PVCCVSICSG ASSPCCQQSS
160 170 180 190 200
CQSACCTFSP CQQACCVPIC CKPICCVPVC SGASSLCCQK SSCQPACCTT
210 220 230 240 250
SCCRPSSSVS LLCRPVCRPA CCVPVPSCCV PASSCQPSCC HPASCLSFLC

RPACSRLAC
Length:259
Mass (Da):26,299
Last modified:October 17, 2006 - v2
Checksum:i180307276CAB4607
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261H → R.2 Publications
Corresponds to variant rs411254 [ dbSNP | Ensembl ].
VAR_028234
Natural varianti64 – 641S → N in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036560
Natural varianti159 – 1591S → F in a breast cancer sample; somatic mutation. 1 Publication
VAR_036561

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076355 mRNA. Translation: BAD01542.1.
AL773602 Genomic DNA. No translation available.
BC127016 mRNA. Translation: AAI27017.1.
CCDSiCCDS13713.1.
RefSeqiNP_941968.2. NM_198695.2.
UniGeneiHs.528021.

Genome annotation databases

EnsembliENST00000334662; ENSP00000335565; ENSG00000187766.
GeneIDi386681.
KEGGihsa:386681.
UCSCiuc002zfo.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076355 mRNA. Translation: BAD01542.1.
AL773602 Genomic DNA. No translation available.
BC127016 mRNA. Translation: AAI27017.1.
CCDSiCCDS13713.1.
RefSeqiNP_941968.2. NM_198695.2.
UniGeneiHs.528021.

3D structure databases

ProteinModelPortaliP60410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132132. 164 interactions.
IntActiP60410. 159 interactions.

Polymorphism and mutation databases

BioMutaiKRTAP10-8.
DMDMi116242612.

Proteomic databases

PaxDbiP60410.
PRIDEiP60410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334662; ENSP00000335565; ENSG00000187766.
GeneIDi386681.
KEGGihsa:386681.
UCSCiuc002zfo.1. human.

Organism-specific databases

CTDi386681.
GeneCardsiGC21P046031.
H-InvDBHIX0040851.
HGNCiHGNC:20525. KRTAP10-8.
neXtProtiNX_P60410.
PharmGKBiPA134968895.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG113264.
GeneTreeiENSGT00780000121948.
HOGENOMiHOG000234031.
HOVERGENiHBG108072.
InParanoidiP60410.
OMAiCEPRSCA.
OrthoDBiEOG7Q5HGX.
PhylomeDBiP60410.
TreeFamiTF351356.

Miscellaneous databases

GenomeRNAii386681.
NextBioi101004.
PROiP60410.

Gene expression databases

CleanExiHS_KRTAP10-8.
GenevestigatoriP60410.

Family and domain databases

InterProiIPR002494. KAP.
IPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 2 hits.
PF05287. PMG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3."
    Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.
    Genomics 83:679-693(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ARG-26.
    Tissue: Hair root.
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-26.
  4. "Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21."
    Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S., Schweizer J.
    J. Invest. Dermatol. 122:147-158(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-64 AND PHE-159.

Entry informationi

Entry nameiKR108_HUMAN
AccessioniPrimary (citable) accession number: P60410
Secondary accession number(s): A0JNW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 17, 2006
Last modified: May 27, 2015
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.