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Protein

Keratin-associated protein 10-7

Gene

KRTAP10-7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Molecular functioni

  • identical protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 10-7
Alternative name(s):
High sulfur keratin-associated protein 10.7
Keratin-associated protein 10.7
Keratin-associated protein 18-7
Keratin-associated protein 18.7
Gene namesi
Name:KRTAP10-7
Synonyms:KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:22970. KRTAP10-7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134976547.

Polymorphism and mutation databases

BioMutaiKRTAP10-7.
DMDMi116242611.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Keratin-associated protein 10-7PRO_0000185215Add
BLAST

Proteomic databases

PaxDbiP60409.
PeptideAtlasiP60409.
PRIDEiP60409.

PTM databases

iPTMnetiP60409.

Expressioni

Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

CleanExiHS_KRTAP10-7.
ExpressionAtlasiP60409. differential.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-10172290,EBI-10172290
B0FTY23EBI-10172290,EBI-10175366
Q53FW83EBI-10172290,EBI-10242473
Q5BKY63EBI-10172290,EBI-10243533
Q5XG853EBI-10172290,EBI-10248413
Q9H6F03EBI-10172290,EBI-10307481
AENQ8WTP83EBI-10172290,EBI-8637627
AESQ081173EBI-10172290,EBI-717810
ALDH3B1P433533EBI-10172290,EBI-2558314
ANKRD36BP1Q96IX93EBI-10172290,EBI-744859
AP1M1Q9BXS53EBI-10172290,EBI-541426
AQP1P299723EBI-10172290,EBI-745213
AVPI1Q5T6863EBI-10172290,EBI-8640233
B4GALT7Q9UBV73EBI-10172290,EBI-10319970
BAHD1Q8TBE03EBI-10172290,EBI-742750
BCL6BA8KA134EBI-10172290,EBI-10174813
BMP7A8K5713EBI-10172290,EBI-10174327
BUD31P412233EBI-10172290,EBI-3904603
BYSLQ138955EBI-10172290,EBI-358049
C16orf59Q7L2K03EBI-10172290,EBI-8465456
C19orf57Q0VDD73EBI-10172290,EBI-741210
C8orf33Q9H7E93EBI-10172290,EBI-715389
C9orf9Q96E403EBI-10172290,EBI-722584
CARHSP1Q9Y2V23EBI-10172290,EBI-718719
CARKDQ8IW453EBI-10172290,EBI-8650724
CATIPQ7Z7H33EBI-10172290,EBI-10258233
CBX2Q147813EBI-10172290,EBI-745934
CCDC185Q8N7153EBI-10172290,EBI-740814
CCDC26Q8TAB73EBI-10172290,EBI-10271580
CCNG1P519593EBI-10172290,EBI-3905829
CDCA7LQ96GN53EBI-10172290,EBI-5278764
CHIC2Q9UKJ53EBI-10172290,EBI-741528
CHRDQ9H2X03EBI-10172290,EBI-947551
CHRNGP075103EBI-10172290,EBI-9008836
CLK1P497593EBI-10172290,EBI-473775
CLK4Q9HAZ13EBI-10172290,EBI-633400
COL8A1P276583EBI-10172290,EBI-747133
CRCT1Q9UGL93EBI-10172290,EBI-713677
CREB5Q02930-34EBI-10172290,EBI-10192698
CSNK1G1Q9HCP03EBI-10172290,EBI-1383814
CSNK1G2P783683EBI-10172290,EBI-748380
CTNNBIP1Q9NSA33EBI-10172290,EBI-747082
CTRCQ998953EBI-10172290,EBI-10295404
DERL2Q9GZP93EBI-10172290,EBI-7962814
DHX57Q6P1583EBI-10172290,EBI-1051531
DMRT3Q9NQL93EBI-10172290,EBI-9679045
E2F6O754613EBI-10172290,EBI-749694
E4F1H3BUJ73EBI-10172290,EBI-10178160
EHHADHQ084263EBI-10172290,EBI-2339219
FAM124BQ9H5Z63EBI-10172290,EBI-741626
FAM161AQ3B8203EBI-10172290,EBI-719941
FAM27E3Q08E933EBI-10172290,EBI-2602739
FAM74A6Q5TZK33EBI-10172290,EBI-10247271
FAM76BQ5HYJ33EBI-10172290,EBI-751192
FARS2O953633EBI-10172290,EBI-2513774
GABARAPL1Q9H0R83EBI-10172290,EBI-3464833
GABARAPL2P605203EBI-10172290,EBI-720116
GEMP550403EBI-10172290,EBI-744104
GLP1RP432203EBI-10172290,EBI-7466542
GNEQ9Y2233EBI-10172290,EBI-4291090
GOLGA8DPQ0D2H93EBI-10172290,EBI-10181276
GRNP287993EBI-10172290,EBI-747754
GSTP1P092113EBI-10172290,EBI-353467
GUCD1Q96NT33EBI-10172290,EBI-8293751
HBZP020083EBI-10172290,EBI-719843
HHEXQ030143EBI-10172290,EBI-747421
HPCAL1P372353EBI-10172290,EBI-749311
HSBP1O755063EBI-10172290,EBI-748664
HSD3B7Q9H2F33EBI-10172290,EBI-3918847
IGSF8Q969P03EBI-10172290,EBI-8293590
ING5Q8WYH83EBI-10172290,EBI-488533
INPP5DQ928353EBI-10172290,EBI-1380477
IQUBQ8NA543EBI-10172290,EBI-10220600
KLHL38Q2WGJ63EBI-10172290,EBI-6426443
KRT20P359003EBI-10172290,EBI-742094
KRT83P783853EBI-10172290,EBI-10221390
KRTAP10-5P603703EBI-10172290,EBI-10172150
KRTAP10-8P604103EBI-10172290,EBI-10171774
KRTAP10-9P604113EBI-10172290,EBI-10172052
KRTAP12-1P599903EBI-10172290,EBI-10210845
KRTAP4-2Q9BYR53EBI-10172290,EBI-10172511
KRTAP5-6Q6L8G93EBI-10172290,EBI-10250562
KRTAP5-9P263715EBI-10172290,EBI-3958099
KRTAP9-2Q9BYQ43EBI-10172290,EBI-1044640
LCE1BQ5T7P33EBI-10172290,EBI-10245913
LCE2AQ5TA793EBI-10172290,EBI-10246607
LCE3EQ5T5B03EBI-10172290,EBI-10245456
LCE4AQ5TA783EBI-10172290,EBI-10246358
LIMS2Q7Z4I7-53EBI-10172290,EBI-10257651
LINC00242Q5T6M23EBI-10172290,EBI-10245897
LMNAP025453EBI-10172290,EBI-351935
LMO2P257913EBI-10172290,EBI-739696
LRCH4O754273EBI-10172290,EBI-718707
MAPKBP1O603363EBI-10172290,EBI-947402
MCM5B1AHB03EBI-10172290,EBI-10175425
MOBPQ138753EBI-10172290,EBI-10230628
MRGBPQ9NV563EBI-10172290,EBI-399076
MXD3Q9BW113EBI-10172290,EBI-741574
MXI1P50539-33EBI-10172290,EBI-10211940
NAA10P412273EBI-10172290,EBI-747693
NOL12Q9UGY13EBI-10172290,EBI-716098
NOTCH2NLQ7Z3S93EBI-10172290,EBI-945833
NPBWR2P481463EBI-10172290,EBI-10210114
NPDC1Q9NQX53EBI-10172290,EBI-748927
NUBP2Q9Y5Y23EBI-10172290,EBI-1048886
NUFIP2A1L3A73EBI-10172290,EBI-10172018
P2RY6Q150773EBI-10172290,EBI-10235794
PCED1AQ9H1Q73EBI-10172290,EBI-748452
PCSK5Q928243EBI-10172290,EBI-751290
PDIA5Q145543EBI-10172290,EBI-953879
PDLIM5Q96HC43EBI-10172290,EBI-751267
PFKLP178583EBI-10172290,EBI-487243
PIN1Q135263EBI-10172290,EBI-714158
POLLQ9UGP5-23EBI-10172290,EBI-10320765
PPARDQ03181-23EBI-10172290,EBI-10223258
PRKAB2O437413EBI-10172290,EBI-1053424
PRM2Q1LZN13EBI-10172290,EBI-10239098
PRR13Q9NZ813EBI-10172290,EBI-740924
PTGDSP412223EBI-10172290,EBI-948821
PTGER3Q147X83EBI-10172290,EBI-10234038
PTPMT1Q8WUK03EBI-10172290,EBI-7199479
PVRP151513EBI-10172290,EBI-3919694
PVRL2Q926923EBI-10172290,EBI-718419
PVRL3Q9NQS33EBI-10172290,EBI-2826725
RNF175Q8N4F73EBI-10172290,EBI-10265447
RPF1Q9H9Y23EBI-10172290,EBI-9996007
RPL11P629133EBI-10172290,EBI-354380
RPL36ALQ969Q03EBI-10172290,EBI-2877705
RPS28P628573EBI-10172290,EBI-353027
RPUSD3Q6P0873EBI-10172290,EBI-5458784
RSPO2Q6UXX93EBI-10172290,EBI-8481036
RTN4RL1Q86UN23EBI-10172290,EBI-10258951
RWDD2BP570603EBI-10172290,EBI-724442
RYDENQ9NUL53EBI-10172290,EBI-10313866
SCNM1Q9BWG63EBI-10172290,EBI-748391
SDCBPO005603EBI-10172290,EBI-727004
SLC23A1Q9UHI73EBI-10172290,EBI-1759386
SLC25A48Q6ZT893EBI-10172290,EBI-10255185
SLC6A20Q9NP913EBI-10172290,EBI-10311198
SMCO4Q9NRQ53EBI-10172290,EBI-8640191
SMCPP499013EBI-10172290,EBI-750494
SPATA8Q6RVD63EBI-10172290,EBI-8635958
SPG7Q9UQ903EBI-10172290,EBI-717201
SPRY1O436093EBI-10172290,EBI-3866665
SSX2IPQ9Y2D83EBI-10172290,EBI-2212028
STK16O757163EBI-10172290,EBI-749295
SUV39H1O434633EBI-10172290,EBI-349968
TCEA2Q155603EBI-10172290,EBI-710310
TCEANCQ8N8B73EBI-10172290,EBI-954696
THAP1Q9NVV93EBI-10172290,EBI-741515
THAP6Q8TBB03EBI-10172290,EBI-3925505
TMA16Q96EY43EBI-10172290,EBI-1045338
TMEM8AQ9HCN33EBI-10172290,EBI-10310808
TNP2Q4VB563EBI-10172290,EBI-10241829
TNS2Q63HR23EBI-10172290,EBI-949753
TOR1AO146563EBI-10172290,EBI-524257
TREX1Q9NSU23EBI-10172290,EBI-10313481
TRIM42A1L4B63EBI-10172290,EBI-10172216
TULP3O753863EBI-10172290,EBI-5357290
TXNDC5Q86UY03EBI-10172290,EBI-2825190
TYRO3Q064183EBI-10172290,EBI-3951628
UCP2P558513EBI-10172290,EBI-2842077
UXTQ9UBK93EBI-10172290,EBI-357355
VTI1BQ9UEU03EBI-10172290,EBI-723716
WDYHV1Q96HA83EBI-10172290,EBI-741158
WNT11O960143EBI-10172290,EBI-8058160
ZBTB24O431673EBI-10172290,EBI-744471
ZBTB9Q96C004EBI-10172290,EBI-395708
ZFYVE26Q96H433EBI-10172290,EBI-10286915
ZNF101Q8IZC73EBI-10172290,EBI-5278328
ZNF124Q159733EBI-10172290,EBI-2555767
ZNF133P527363EBI-10172290,EBI-2687350
ZNF155Q12901-23EBI-10172290,EBI-10227379
ZNF165Q53Z403EBI-10172290,EBI-10186058
ZNF169Q149293EBI-10172290,EBI-10234472
ZNF175Q9Y4733EBI-10172290,EBI-3438881
ZNF180Q9UJW83EBI-10172290,EBI-10322527
ZNF2Q9BSG1-23EBI-10172290,EBI-10297542
ZNF20P170243EBI-10172290,EBI-717634
ZNF223Q9UK113EBI-10172290,EBI-10322867
ZNF250P15622-33EBI-10172290,EBI-10177272
ZNF26P170313EBI-10172290,EBI-2841331
ZNF266Q145845EBI-10172290,EBI-7115319
ZNF32P170413EBI-10172290,EBI-1965483
ZNF320A2RRD83EBI-10172290,EBI-10173019
ZNF329Q86UD43EBI-10172290,EBI-7233259
ZNF337Q9Y3M93EBI-10172290,EBI-714987
ZNF41P518143EBI-10172290,EBI-2681830
ZNF417Q8TAU33EBI-10172290,EBI-740727
ZNF418Q8TF453EBI-10172290,EBI-3446851
ZNF419Q96HQ03EBI-10172290,EBI-10288482
ZNF425Q6IV723EBI-10172290,EBI-10250516
ZNF433Q8N7K03EBI-10172290,EBI-10267553
ZNF439Q8NDP43EBI-10172290,EBI-747580
ZNF490Q9ULM23EBI-10172290,EBI-1105370
ZNF543Q08ER83EBI-10172290,EBI-10226133
ZNF555Q8NEP93EBI-10172290,EBI-10270752
ZNF564Q8TBZ83EBI-10172290,EBI-10273713
ZNF572Q7Z3I73EBI-10172290,EBI-10257016
ZNF578Q3MI943EBI-10172290,EBI-10241108
ZNF581Q9P0T43EBI-10172290,EBI-745520
ZNF587Q96SQ53EBI-10172290,EBI-6427977
ZNF625Q96I273EBI-10172290,EBI-4395587
ZNF670Q9BS343EBI-10172290,EBI-745276
ZNF697Q8N5083EBI-10172290,EBI-10265733
ZNF707Q96C283EBI-10172290,EBI-748111
ZNF778Q96MU63EBI-10172290,EBI-10291463
ZNF792Q3KQV33EBI-10172290,EBI-10240849
ZNF846Q147U13EBI-10172290,EBI-10234020
ZNHIT1O432573EBI-10172290,EBI-347522
ZSCAN26Q166703EBI-10172290,EBI-3920053

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi132126. 217 interactions.
IntActiP60409. 211 interactions.
STRINGi9606.ENSP00000369445.

Structurei

3D structure databases

ProteinModelPortaliP60409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati41 – 4551
Repeati46 – 5052
Repeati72 – 7653
Repeati94 – 9854
Repeati104 – 10855
Repeati114 – 11856
Repeati119 – 12357
Repeati124 – 12858
Repeati140 – 14459
Repeati150 – 154510
Repeati160 – 164511
Repeati165 – 169512
Repeati177 – 181513
Repeati191 – 195514
Repeati213 – 217515
Repeati223 – 227516
Repeati233 – 237517
Repeati238 – 242518
Repeati243 – 247519
Repeati255 – 259520
Repeati260 – 264521
Repeati270 – 274522
Repeati275 – 279523
Repeati280 – 284524
Repeati292 – 296525
Repeati302 – 306526
Repeati307 – 311527
Repeati326 – 330528
Repeati344 – 348529
Repeati364 – 368530

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 36832830 X 5 AA repeats of C-C-X(3)Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JBCF. Eukaryota.
ENOG4111398. LUCA.
HOGENOMiHOG000234031.
HOVERGENiHBG052270.
InParanoidiP60409.
OrthoDBiEOG780RQD.
PhylomeDBiP60409.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 4 hits.
PfamiPF13885. Keratin_B2_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P60409-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASTMSVCS SDLSYGSRVC LPGSCDSCSD SWQVDDCPES CCEPPCCAPS
60 70 80 90 100
CCAPAPCLSL VCTPVSRVSS PCCPVTCEPS PCQSGCTSSC TPSCCQQSSC
110 120 130 140 150
QLACCASSPC QQACCMPVCC KTVCCKPVYC VPVCSGDSSC CQQSSCQSAC
160 170 180 190 200
CTSSPCQQAC CVPICCKPVC SGISSSCCQQ SSCVSCVSSP CCQAVCEPSP
210 220 230 240 250
CQSGCISSCT PSCCQQSSCQ PACCTSSPCQ QACCVPVCCK PVCCVPTCSD
260 270 280 290 300
DSGSCCQPAC CTSSQSQQGC CVPVCCKPVC CVPVCSGASS SCCQQSSCQP
310 320 330 340 350
ACCTTSCCRP SSSVSLLCRP VCRPTCCVPV PSCCAPTSSC QASCCRPASC
360 370
VSLLCRPACS RPACCGPTST QKSSC
Length:375
Mass (Da):37,816
Last modified:October 17, 2006 - v2
Checksum:i4E01FF3E14F10B5B
GO
Isoform 2 (identifier: P60409-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     50-54: Missing.

Show »
Length:370
Mass (Da):37,354
Checksum:i7B965870FCB5E97A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671R → Y in BAD01541 (PubMed:15028290).Curated
Sequence conflicti67 – 671R → Y in EAX09413 (Ref. 3) Curated
Sequence conflicti67 – 671R → Y in AAI19644 (PubMed:15489334).Curated
Sequence conflicti74 – 741P → R in BAD01541 (PubMed:15028290).Curated
Sequence conflicti74 – 741P → R in EAX09413 (Ref. 3) Curated
Sequence conflicti74 – 741P → R in AAI19644 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti116 – 1161M → V.3 Publications
Corresponds to variant rs944419 [ dbSNP | Ensembl ].
VAR_047852
Natural varianti129 – 1291Y → C.
Corresponds to variant rs233308 [ dbSNP | Ensembl ].
VAR_060051
Natural varianti220 – 2201Q → K.3 Publications
Corresponds to variant rs363877 [ dbSNP | Ensembl ].
VAR_047853
Natural varianti290 – 2901S → T.3 Publications
Corresponds to variant rs446817 [ dbSNP | Ensembl ].
VAR_047854
Natural varianti325 – 3251T → A.4 Publications
Corresponds to variant rs369720 [ dbSNP | Ensembl ].
VAR_047855

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei50 – 545Missing in isoform 2. 2 PublicationsVSP_021023

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076354 mRNA. Translation: BAD01541.1.
AL773602 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09413.1.
BC119643 mRNA. Translation: AAI19644.1.
AJ566385 mRNA. Translation: CAD97465.1.
CCDSiCCDS74803.1. [P60409-2]
RefSeqiNP_941962.1. NM_198689.2.
UniGeneiHs.473999.

Genome annotation databases

EnsembliENST00000609664; ENSP00000476821; ENSG00000272804.
GeneIDi386675.
KEGGihsa:386675.
UCSCiuc032qbr.1. human. [P60409-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076354 mRNA. Translation: BAD01541.1.
AL773602 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09413.1.
BC119643 mRNA. Translation: AAI19644.1.
AJ566385 mRNA. Translation: CAD97465.1.
CCDSiCCDS74803.1. [P60409-2]
RefSeqiNP_941962.1. NM_198689.2.
UniGeneiHs.473999.

3D structure databases

ProteinModelPortaliP60409.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132126. 217 interactions.
IntActiP60409. 211 interactions.
STRINGi9606.ENSP00000369445.

PTM databases

iPTMnetiP60409.

Polymorphism and mutation databases

BioMutaiKRTAP10-7.
DMDMi116242611.

Proteomic databases

PaxDbiP60409.
PeptideAtlasiP60409.
PRIDEiP60409.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000609664; ENSP00000476821; ENSG00000272804.
GeneIDi386675.
KEGGihsa:386675.
UCSCiuc032qbr.1. human. [P60409-1]

Organism-specific databases

CTDi386675.
GeneCardsiKRTAP10-7.
HGNCiHGNC:22970. KRTAP10-7.
neXtProtiNX_P60409.
PharmGKBiPA134976547.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JBCF. Eukaryota.
ENOG4111398. LUCA.
HOGENOMiHOG000234031.
HOVERGENiHBG052270.
InParanoidiP60409.
OrthoDBiEOG780RQD.
PhylomeDBiP60409.

Miscellaneous databases

GenomeRNAii386675.
PROiP60409.

Gene expression databases

CleanExiHS_KRTAP10-7.
ExpressionAtlasiP60409. differential.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 4 hits.
PfamiPF13885. Keratin_B2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3."
    Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.
    Genomics 83:679-693(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, VARIANTS VAL-116; LYS-220; THR-290 AND ALA-325.
    Tissue: Hair root.
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS VAL-116; LYS-220; THR-290 AND ALA-325.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS VAL-116; LYS-220; THR-290 AND ALA-325.
  5. "Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21."
    Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S., Schweizer J.
    J. Invest. Dermatol. 122:147-158(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 323-375, TISSUE SPECIFICITY, VARIANT ALA-325.
    Tissue: Scalp.

Entry informationi

Entry nameiKR107_HUMAN
AccessioniPrimary (citable) accession number: P60409
Secondary accession number(s): Q0VDJ8, Q70LJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 17, 2006
Last modified: July 6, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.