Reviewed,
UniProtKB/Swiss-Prot P60381 (SPX_STRP1)
Last modified
June 16, 2009.
Version 42.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Regulatory protein spx | ||||
| Gene names |
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| Organism | Streptococcus pyogenes serotype M1 [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 301447 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus |
Protein attributes
| Sequence length | 134 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress By similarity. |
| Subcellular location | Cytoplasm Probable. |
| Sequence similarities | Belongs to the arsC family. Spx subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Cytoplasm |
| Domain | Redox-active center |
| PTM | Disulfide bond |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | transcription regulator activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 134 | 134 | Regulatory protein spx HAMAP MF_01132 | PRO_0000162577 | |||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 10 ↔ 13 | Redox-active Potential | |||||||||
Sequences
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References
| [1] | "Complete genome sequence of an M1 strain of Streptococcus pyogenes." Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. McLaughlin R.E.Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed: 11296296] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700294 / SF370 / Serotype M1. |
| [2] | "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events." Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M. J. Infect. Dis. 192:771-782(2005) [PubMed: 16088826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-947 / MGAS5005 / Serotype M1. |
Cross-references
Sequence databases | |
|---|---|
| AE004092 Genomic DNA. Translation: AAK34104.1. CP000017 Genomic DNA. Translation: AAZ51577.1. | |
| RefSeq | NP_269383.1. YP_282322.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3571934. 901349. |
| GenomeReviews | Gene locus SPy_1249 in contig AE004092_GR. Gene locus M5005_Spy0959 in contig CP000017_GR. |
| KEGG | spy:SPy_1249. spz:M5005_Spy_0959. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P60381. |
| OMA | P60381. FTERNIF. |
Enzyme and pathway databases | |
| BioCyc | SPYO160490:SPY1249-MON. SPYO293653:M5005_SPY0959-MON. |
Family and domain databases | |
| HAMAP | MF_01132. [Tree] |
| InterPro | IPR006660. Arsenate_reductase-like. IPR006504. CHP1617_ArsC_rel. IPR012335. Thioredoxin_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit. |
| Pfam | PF03960. ArsC. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01617. arsC_related. 1 hit. |
| PROSITE | PS51353. ARSC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SPX_STRP1 | ||||||||
| Accession | Primary (citable) accession number: P60381 Secondary accession number(s): Q48YJ5, Q99ZF7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

Clusters with


