P60381 (SPX_STRP1) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 64.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Regulatory protein spx | ||||
| Gene names |
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| Organism | Streptococcus pyogenes serotype M1 [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 301447 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus |
Protein attributes
| Sequence length | 134 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress By similarity. HAMAP MF_01132 |
| Subcellular location | Cytoplasm Probable HAMAP MF_01132. |
| Sequence similarities | Belongs to the ArsC family. Spx subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Cytoplasm |
| Domain | Redox-active center |
| PTM | Disulfide bond |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 134 | 134 | Regulatory protein spx HAMAP MF_01132 | PRO_0000162577 | |||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 10 ↔ 13 | Redox-active Potential | |||||||||
Sequences
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References
| [1] | "Complete genome sequence of an M1 strain of Streptococcus pyogenes." Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. McLaughlin R.E.Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed: 11296296] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700294 / SF370 / Serotype M1. |
| [2] | "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events." Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M. J. Infect. Dis. 192:771-782(2005) [PubMed: 16088826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-947 / MGAS5005 / Serotype M1. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE004092 Genomic DNA. Translation: AAK34104.1. CP000017 Genomic DNA. Translation: AAZ51577.1. |
| RefSeq | NP_269383.1. NC_002737.1. YP_282322.1. NC_007297.1. |
3D structure databases | |
| ProteinModelPortal | P60381. |
| SMR | P60381. Positions 1-116. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBSTRT00000000985; EBSTRP00000000985; EBSTRG00000000985. EBSTRT00000028578; EBSTRP00000027596; EBSTRG00000028578. |
| GeneID | 3571934. 901349. |
| GenomeReviews | Gene locus SPy_1249 in contig AE004092_GR. Gene locus M5005_Spy0959 in contig CP000017_GR. |
| KEGG | spy:SPy_1249. spz:M5005_Spy_0959. |
| PATRIC | 19716055. VBIStrPyo79812_1092. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000027616. |
| HOGENOM | HBG734370. |
| OMA | FTERNIF. |
| ProtClustDB | PRK01655. |
Enzyme and pathway databases | |
| BioCyc | SPYO160490:SPY1249-MONOMER. SPYO293653:M5005_SPY0959-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01132. SpxA. [Tree] |
| InterPro | IPR006660. Arsenate_reductase-like. IPR012336. Thioredoxin-like_fold. IPR023731. Tscrpt_reg_Spx. IPR006504. Tscrpt_reg_Spx/MgsR. [Graphical view] |
| Gene3D | G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit. |
| KO | K00537. |
| Pfam | PF03960. ArsC. 1 hit. [Graphical view] |
| SUPFAM | SSF52833. Thiordxn-like_fd. 1 hit. |
| TIGRFAMs | TIGR01617. ArsC_related. 1 hit. |
| PROSITE | PS51353. ARSC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SPX_STRP1 | ||||||||
| Accession | Primary (citable) accession number: P60381 Secondary accession number(s): Q48YJ5, Q99ZF7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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