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Protein

Keratin-associated protein 10-4

Gene

KRTAP10-4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Enzyme and pathway databases

BioCyciZFISH:G66-32112-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 10-4
Alternative name(s):
High sulfur keratin-associated protein 10.4
Keratin-associated protein 10.4
Keratin-associated protein 18-4
Keratin-associated protein 18.4
Gene namesi
Name:KRTAP10-4
Synonyms:KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:20521. KRTAP10-4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134942730.

Polymorphism and mutation databases

BioMutaiKRTAP10-4.
DMDMi42558952.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001852121 – 401Keratin-associated protein 10-4Add BLAST401

Proteomic databases

PaxDbiP60372.
PeptideAtlasiP60372.
PRIDEiP60372.

PTM databases

PhosphoSitePlusiP60372.

Expressioni

Tissue specificityi

Restricted to hair root, not detected in any other tissues.

Gene expression databases

CleanExiHS_KRTAP10-4.
GenevisibleiP60372. HS.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
E4F1H3BUJ73EBI-10178153,EBI-10178160
IGSF8Q969P03EBI-10178153,EBI-8293590
JOSD1Q150403EBI-10178153,EBI-2510602
RSPO2Q6UXX93EBI-10178153,EBI-8481036
ZNF32P170413EBI-10178153,EBI-1965483
ZNF625Q96I273EBI-10178153,EBI-4395587
ZSCAN26Q166703EBI-10178153,EBI-3920053

Protein-protein interaction databases

IntActiP60372. 9 interactors.
STRINGi9606.ENSP00000383225.

Structurei

3D structure databases

ProteinModelPortaliP60372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 4015
Repeati41 – 4525
Repeati46 – 5035
Repeati67 – 7145
Repeati89 – 9355
Repeati99 – 10365
Repeati109 – 11375
Repeati114 – 11885
Repeati119 – 12395
Repeati124 – 128105
Repeati129 – 133115
Repeati135 – 139125
Repeati145 – 149135
Repeati155 – 159145
Repeati160 – 164155
Repeati172 – 176165
Repeati186 – 190175
Repeati208 – 212185
Repeati218 – 222195
Repeati228 – 232205
Repeati233 – 237215
Repeati238 – 242225
Repeati250 – 254235
Repeati270 – 274245
Repeati275 – 279255
Repeati280 – 284265
Repeati297 – 301275
Repeati307 – 311285
Repeati317 – 321295
Repeati322 – 326305
Repeati339 – 343315
Repeati349 – 353335
Repeati354 – 358345
Repeati373 – 377355
Repeati391 – 395365

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni36 – 39536 X 5 AA repeats of C-C-X(3)Add BLAST360

Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J9PE. Eukaryota.
ENOG4111BE4. LUCA.
HOGENOMiHOG000234031.
HOVERGENiHBG052270.
InParanoidiP60372.
OrthoDBiEOG091G17RC.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 3 hits.
PfamiPF13885. Keratin_B2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60372-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVCSSDLSY SSRVCLPGSC DSCSDSWQVD DCPESCCEPP CCAPSCCAPA
60 70 80 90 100
PCLSLVCTPV SRVSSPCCPV TCEPSPCQSG CTSSCTPSCC QQSSCQLACC
110 120 130 140 150
ASSPCQQACC VPVCCKTVCC KPVCCVPVCC GDSSCCQQSS CQSACCTSSP
160 170 180 190 200
CQQACCVPIC CKPVCSGISS SCCQQSSCVS CVSSPCCQAV CEPSPCQSGC
210 220 230 240 250
ISSCTPSCCQ QSSCQPACCT SSSCQQACCV PVCCKTVCCK PVCSEDSSSC
260 270 280 290 300
CQQSSCQPAC CTSSPCQQAC CVPVCCKPVC CKPVGSVPIC SGASSLCCQQ
310 320 330 340 350
SSCQPACCTS SQSQQGCCVP VCCKPVSCVP VCSGASSSCC QQSSCQPACC
360 370 380 390 400
TTSCCRPSSS VSLLCRPVCR PACCVPVPSC CAPTSSCQPS CCRPASCVSL

L
Length:401
Mass (Da):40,429
Last modified:February 16, 2004 - v1
Checksum:i0B3649E610CE78E7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01769462R → C.2 PublicationsCorresponds to variant rs233285dbSNPEnsembl.1
Natural variantiVAR_017695159I → V.1 Publication1
Natural variantiVAR_062112285G → C.Corresponds to variant rs396912dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076351 mRNA. Translation: BAD01538.1.
AL773602 Genomic DNA. No translation available.
BC125048 mRNA. Translation: AAI25049.1.
BC125049 mRNA. Translation: AAI25050.1.
CCDSiCCDS42957.1.
UniGeneiHs.567901.

Genome annotation databases

EnsembliENST00000400374; ENSP00000383225; ENSG00000215454.
UCSCiuc002zfk.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076351 mRNA. Translation: BAD01538.1.
AL773602 Genomic DNA. No translation available.
BC125048 mRNA. Translation: AAI25049.1.
BC125049 mRNA. Translation: AAI25050.1.
CCDSiCCDS42957.1.
UniGeneiHs.567901.

3D structure databases

ProteinModelPortaliP60372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP60372. 9 interactors.
STRINGi9606.ENSP00000383225.

PTM databases

PhosphoSitePlusiP60372.

Polymorphism and mutation databases

BioMutaiKRTAP10-4.
DMDMi42558952.

Proteomic databases

PaxDbiP60372.
PeptideAtlasiP60372.
PRIDEiP60372.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400374; ENSP00000383225; ENSG00000215454.
UCSCiuc002zfk.2. human.

Organism-specific databases

GeneCardsiKRTAP10-4.
HGNCiHGNC:20521. KRTAP10-4.
neXtProtiNX_P60372.
PharmGKBiPA134942730.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9PE. Eukaryota.
ENOG4111BE4. LUCA.
HOGENOMiHOG000234031.
HOVERGENiHBG052270.
InParanoidiP60372.
OrthoDBiEOG091G17RC.
TreeFamiTF351356.

Enzyme and pathway databases

BioCyciZFISH:G66-32112-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.

Miscellaneous databases

PROiP60372.

Gene expression databases

CleanExiHS_KRTAP10-4.
GenevisibleiP60372. HS.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 3 hits.
PfamiPF13885. Keratin_B2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKR104_HUMAN
AccessioniPrimary (citable) accession number: P60372
Secondary accession number(s): Q08AS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.