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P60370 (KR105_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Keratin-associated protein 10-5
Alternative name(s):
High sulfur keratin-associated protein 10.5
Keratin-associated protein 10.5
Keratin-associated protein 18-5
Keratin-associated protein 18.5
Gene names
Name:KRTAP10-5
Synonyms:KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Subunit structure

Interacts with hair keratins.

Tissue specificity

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues. Ref.1 Ref.4

Sequence similarities

Belongs to the KRTAP type 10 family.

Ontologies

Keywords
   Cellular componentKeratin
   Coding sequence diversityPolymorphism
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentkeratin filament

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Keratin-associated protein 10-5
PRO_0000185213

Regions

Repeat26 – 3051
Repeat51 – 5552
Repeat73 – 7753
Repeat78 – 8254
Repeat88 – 9255
Repeat93 – 9756
Repeat98 – 10257
Repeat110 – 11458
Repeat120 – 12459
Repeat130 – 134510
Repeat135 – 139511
Repeat140 – 144512
Repeat152 – 156513
Repeat162 – 166514
Repeat177 – 181515
Repeat187 – 191516
Repeat199 – 203517
Repeat209 – 213518
Repeat214 – 218519
Repeat233 – 237520
Repeat240 – 244521
Repeat251 – 255522
Region26 – 25523022 X 5 AA repeats of C-C-X(3)

Natural variations

Natural variant41C → S.
Corresponds to variant rs5017208 [ dbSNP | Ensembl ].
VAR_062113
Natural variant201D → N. Ref.3
Corresponds to variant rs2020221 [ dbSNP | Ensembl ].
VAR_017696
Natural variant1831F → C.
Corresponds to variant rs380585 [ dbSNP | Ensembl ].
VAR_047505
Natural variant2351V → L. Ref.1
Corresponds to variant rs464424 [ dbSNP | Ensembl ].
VAR_017697
Natural variant2471Y → C.
Corresponds to variant rs7509970 [ dbSNP | Ensembl ].
VAR_047506
Natural variant2681R → P. Ref.1
Corresponds to variant rs464391 [ dbSNP | Ensembl ].
VAR_047507

Sequences

Sequence LengthMass (Da)Tools
P60370 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 20E32DB102D523ED

FASTA27127,626
        10         20         30         40         50         60 
MAACTMSVCS SACSDSWRVD DCPESCCEPP CGTAPCLTLV CTPVSCVSSP CCQAACEPSP 

        70         80         90        100        110        120 
CQSGCTSSCT PSCCQPACCA SSPCQQACCV PVCCKPVCCL PTCSKDSSSC CQQSSCQPTC 

       130        140        150        160        170        180 
CASSSCQQSC CVPVCCKPVC CVPTCSEDSS SCCQHSSCQP TCCTSSPCQQ SCYVPVCCKP 

       190        200        210        220        230        240 
VCFKPICCVP VCSGASTSCC QQSSCQPACC TTSCCRPSSS VSLLCRPICR PACCVPISSC 

       250        260        270 
CAPASSYQAS CCRPASCVSL LCRPACSRLA C 

« Hide

References

« Hide 'large scale' references
[1]"A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3."
Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.
Genomics 83:679-693(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS LEU-235 AND PRO-268.
Tissue: Hair root.
[2]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-20.
[4]"Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21."
Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S., Schweizer J.
J. Invest. Dermatol. 122:147-158(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 261-271, TISSUE SPECIFICITY.
Tissue: Scalp.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB076352 mRNA. Translation: BAD01539.1.
AL773602 Genomic DNA. No translation available.
BC120949 mRNA. Translation: AAI20950.1.
BC120950 mRNA. Translation: AAI20951.1.
AJ566384 mRNA. Translation: CAD97464.1.
UniGeneHs.688629.

3D structure databases

ProteinModelPortalP60370.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000383223.

Polymorphism databases

DMDM215274018.

Proteomic databases

PaxDbP60370.
PRIDEP60370.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000400372; ENSP00000383223; ENSG00000241123.
KEGGhsa:386680.
UCSCuc002zfl.1. human.

Organism-specific databases

CTD386680.
GeneCardsGC21M045999.
HGNCHGNC:22969. KRTAP10-5.
neXtProtNX_P60370.
PharmGKBPA134950015.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG304457.
HOGENOMHOG000234031.
InParanoidP60370.
OMAICRPACC.
OrthoDBEOG780RQD.
PhylomeDBP60370.
TreeFamTF351356.

Gene expression databases

CleanExHS_KRTAP10-5.
GenevestigatorP60370.

Family and domain databases

InterProIPR002494. KAP.
[Graphical view]
PANTHERPTHR23262. PTHR23262. 1 hit.
PfamPF13885. Keratin_B2_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi386680.
NextBio101000.
PROP60370.

Entry information

Entry nameKR105_HUMAN
AccessionPrimary (citable) accession number: P60370
Secondary accession number(s): Q0VAR7, Q0VAR8, Q70LJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM