P60370 (KR105_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin-associated protein 10-5

Alternative name(s):
High sulfur keratin-associated protein 10.5
Keratin-associated protein 10.5
Keratin-associated protein 18-5
Keratin-associated protein 18.5

Gene names

Name:	KRTAP10-5
Synonyms:	KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Subunit structure	Interacts with hair keratins.
Tissue specificity	Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues. Ref.1 Ref.4
Sequence similarities	Belongs to the KRTAP type 10 family.

Ontologies

Keywords
Cellular component	Keratin
Coding sequence diversity	Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	keratin filament Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Keratin-associated protein 10-5		PRO_0000185213
Regions
	Repeat	26 – 30	5	1
	Repeat	51 – 55	5	2
	Repeat	73 – 77	5	3
	Repeat	78 – 82	5	4
	Repeat	88 – 92	5	5
	Repeat	93 – 97	5	6
	Repeat	98 – 102	5	7
	Repeat	110 – 114	5	8
	Repeat	120 – 124	5	9
	Repeat	130 – 134	5	10
	Repeat	135 – 139	5	11
	Repeat	140 – 144	5	12
	Repeat	152 – 156	5	13
	Repeat	162 – 166	5	14
	Repeat	177 – 181	5	15
	Repeat	187 – 191	5	16
	Repeat	199 – 203	5	17
	Repeat	209 – 213	5	18
	Repeat	214 – 218	5	19
	Repeat	233 – 237	5	20
	Repeat	240 – 244	5	21
	Repeat	251 – 255	5	22
	Region	26 – 255	230	22 X 5 AA repeats of C-C-X(3)
Natural variations
	Natural variant	4	1	C → S. Corresponds to variant rs5017208 [ dbSNP | Ensembl ].		VAR_062113
	Natural variant	20	1	D → N. Ref.3 Corresponds to variant rs2020221 [ dbSNP | Ensembl ].		VAR_017696
	Natural variant	183	1	F → C. Corresponds to variant rs380585 [ dbSNP | Ensembl ].		VAR_047505
	Natural variant	235	1	V → L. Ref.1 Corresponds to variant rs464424 [ dbSNP | Ensembl ].		VAR_017697
	Natural variant	247	1	Y → C. Corresponds to variant rs7509970 [ dbSNP | Ensembl ].		VAR_047506
	Natural variant	268	1	R → P. Ref.1 Corresponds to variant rs464391 [ dbSNP | Ensembl ].		VAR_047507

Sequences

	Sequence		Length	Mass (Da)
	P60370 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 20E32DB102D523ED	FASTA	271	27,626
	10 20 30 40 50 60 MAACTMSVCS SACSDSWRVD DCPESCCEPP CGTAPCLTLV CTPVSCVSSP CCQAACEPSP 70 80 90 100 110 120 CQSGCTSSCT PSCCQPACCA SSPCQQACCV PVCCKPVCCL PTCSKDSSSC CQQSSCQPTC 130 140 150 160 170 180 CASSSCQQSC CVPVCCKPVC CVPTCSEDSS SCCQHSSCQP TCCTSSPCQQ SCYVPVCCKP 190 200 210 220 230 240 VCFKPICCVP VCSGASTSCC QQSSCQPACC TTSCCRPSSS VSLLCRPICR PACCVPISSC 250 260 270 CAPASSYQAS CCRPASCVSL LCRPACSRLA C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3." Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N. Genomics 83:679-693(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS LEU-235 AND PRO-268. Tissue: Hair root.
[2]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-20.
[4]	"Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21." Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S., Schweizer J. J. Invest. Dermatol. 122:147-158(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 261-271, TISSUE SPECIFICITY. Tissue: Scalp.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB076352 mRNA. Translation: BAD01539.1. AL773602 Genomic DNA. No translation available. BC120949 mRNA. Translation: AAI20950.1. BC120950 mRNA. Translation: AAI20951.1. AJ566384 mRNA. Translation: CAD97464.1.
IPI	IPI00394675.
RefSeq	NP_941967.2. NM_198694.2.
UniGene	Hs.688629.
3D structure databases
ProteinModelPortal	P60370.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000383223.
Polymorphism databases
DMDM	215274018.
Proteomic databases
PaxDb	P60370.
PRIDE	P60370.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000400372; ENSP00000383223; ENSG00000241123.
GeneID	386680.
KEGG	hsa:386680.
UCSC	uc002zfl.1. human.
Organism-specific databases
CTD	386680.
GeneCards	GC21M045999.
HGNC	HGNC:22969. KRTAP10-5.
neXtProt	NX_P60370.
PharmGKB	PA134950015.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG304457.
HOGENOM	HOG000234031.
InParanoid	P60370.
OMA	CCRPASY.
OrthoDB	EOG41C6XX.
Gene expression databases
CleanEx	HS_KRTAP10-5.
Genevestigator	P60370.
Family and domain databases
InterPro	IPR002494. Keratin-assoc. [Graphical view]
PANTHER	PTHR23262. PTHR23262. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	386680.
NextBio	101000.

Entry information

Entry name

KR105_HUMAN

Accession

Primary (citable) accession number: P60370
Secondary accession number(s): Q0VAR7, Q0VAR8, Q70LJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	November 25, 2008
Last modified:	April 3, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.