Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin-associated protein 10-5

Gene

KRTAP10-5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Molecular functioni

  1. identical protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 10-5
Alternative name(s):
High sulfur keratin-associated protein 10.5
Keratin-associated protein 10.5
Keratin-associated protein 18-5
Keratin-associated protein 18.5
Gene namesi
Name:KRTAP10-5
Synonyms:KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:22969. KRTAP10-5.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950015.

Polymorphism and mutation databases

BioMutaiKRTAP10-5.
DMDMi215274018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Keratin-associated protein 10-5PRO_0000185213Add
BLAST

Proteomic databases

PaxDbiP60370.
PRIDEiP60370.

Expressioni

Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

CleanExiHS_KRTAP10-5.
GenevestigatoriP60370.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-10172150,EBI-10172150
Q5BKY63EBI-10172150,EBI-10243533
Q5XG853EBI-10172150,EBI-10248413
Q9NWL93EBI-10172150,EBI-10315054
ADAMTSL4Q6UY14-33EBI-10172150,EBI-10173507
AENQ8WTP83EBI-10172150,EBI-8637627
ALDH3B1P433533EBI-10172150,EBI-2558314
AMOTL2Q9Y2J4-43EBI-10172150,EBI-10187270
BCL6BA8KA133EBI-10172150,EBI-10174813
BMP7A8K5713EBI-10172150,EBI-10174327
BYSLQ138955EBI-10172150,EBI-358049
C11orf87Q6NUJ23EBI-10172150,EBI-6660291
C19orf66Q9NUL53EBI-10172150,EBI-10313866
C9orf9Q96E403EBI-10172150,EBI-722584
CARD9Q9H2573EBI-10172150,EBI-751319
CHRDQ9H2X03EBI-10172150,EBI-947551
CNNM3Q8NE013EBI-10172150,EBI-741032
CREB5Q02930-33EBI-10172150,EBI-10192698
DHX57Q6P1583EBI-10172150,EBI-1051531
ECE1P428923EBI-10172150,EBI-2859983
EIF4E2O605733EBI-10172150,EBI-398610
ENKD1Q9H0I23EBI-10172150,EBI-744099
FAM74A6Q5TZK33EBI-10172150,EBI-10247271
FAM76BQ5HYJ35EBI-10172150,EBI-751192
FARS2O953633EBI-10172150,EBI-2513774
GATA1P159763EBI-10172150,EBI-3909284
GLRX3O760033EBI-10172150,EBI-374781
GNEQ9Y2233EBI-10172150,EBI-4291090
GOLGA8DPQ0D2H93EBI-10172150,EBI-10181276
HHEXQ030143EBI-10172150,EBI-747421
HOXA1P496393EBI-10172150,EBI-740785
HPCAL1P372353EBI-10172150,EBI-749311
KRTAP10-7P604093EBI-10172150,EBI-10172290
KRTAP12-1P599903EBI-10172150,EBI-10210845
KRTAP12-2P599913EBI-10172150,EBI-10176379
KRTAP2-3P0C7H83EBI-10172150,EBI-10196781
KRTAP26-1Q6PEX33EBI-10172150,EBI-3957672
KRTAP3-2Q9BYR73EBI-10172150,EBI-751260
KRTAP4-12Q9BQ663EBI-10172150,EBI-739863
KRTAP4-2Q9BYR55EBI-10172150,EBI-10172511
KRTAP5-6Q6L8G93EBI-10172150,EBI-10250562
KRTAP5-9P263715EBI-10172150,EBI-3958099
KRTAP9-2Q9BYQ45EBI-10172150,EBI-1044640
KRTAP9-4Q9BYQ25EBI-10172150,EBI-10185730
LCE1BQ5T7P33EBI-10172150,EBI-10245913
LCE2AQ5TA793EBI-10172150,EBI-10246607
LCE2DQ5TA823EBI-10172150,EBI-10246750
LCE3CQ5T5A84EBI-10172150,EBI-10245291
LCE3EQ5T5B03EBI-10172150,EBI-10245456
LCE4AQ5TA783EBI-10172150,EBI-10246358
LIMS2Q7Z4I7-53EBI-10172150,EBI-10257651
LUZP4Q9P1273EBI-10172150,EBI-10198848
MEOX2A4D1273EBI-10172150,EBI-10172134
MOBPQ138753EBI-10172150,EBI-10230628
MT1DPA1L3X43EBI-10172150,EBI-10172129
MXI1P50539-33EBI-10172150,EBI-10211940
NAA10P412273EBI-10172150,EBI-747693
NOTCH2NLQ7Z3S93EBI-10172150,EBI-945833
NPDC1Q9NQX53EBI-10172150,EBI-748927
NR4A1P227363EBI-10172150,EBI-721550
NUFIP2A1L3A73EBI-10172150,EBI-10172018
OTX1P322423EBI-10172150,EBI-740446
PRKAB2O437413EBI-10172150,EBI-1053424
PRR13Q9NZ813EBI-10172150,EBI-740924
PVRL2Q926923EBI-10172150,EBI-718419
SCNM1Q9BWG63EBI-10172150,EBI-748391
SLC23A1Q9UHI73EBI-10172150,EBI-1759386
SLC6A20Q9NP913EBI-10172150,EBI-10311198
SMCPP499013EBI-10172150,EBI-750494
SPRY1O436093EBI-10172150,EBI-3866665
SPRY2O435973EBI-10172150,EBI-742487
STK16O757163EBI-10172150,EBI-749295
TENC1Q63HR23EBI-10172150,EBI-949753
THAP10Q9P2Z03EBI-10172150,EBI-745404
TNP2Q4VB563EBI-10172150,EBI-10241829
TRPV6Q9Y2603EBI-10172150,EBI-750052
TULP3O753863EBI-10172150,EBI-5357290
TXNDC5Q86UY03EBI-10172150,EBI-2825190
TYMSOSQ8TAI13EBI-10172150,EBI-742060
UTP23Q9BRU93EBI-10172150,EBI-5457544
WDYHV1Q96HA83EBI-10172150,EBI-741158
WT1-ASQ062503EBI-10172150,EBI-10223946
ZBTB24O431673EBI-10172150,EBI-744471
ZBTB48P100743EBI-10172150,EBI-744864
ZFYVE21Q9BQ243EBI-10172150,EBI-2849569
ZNF20P170243EBI-10172150,EBI-717634
ZNF264Q14C613EBI-10172150,EBI-2826570
ZNF273Q145933EBI-10172150,EBI-3922471
ZNF286AQ9HBT8-23EBI-10172150,EBI-10310244
ZNF32P170413EBI-10172150,EBI-1965483
ZNF320A2RRD83EBI-10172150,EBI-10173019
ZNF329Q86UD43EBI-10172150,EBI-7233259
ZNF34Q8IZ263EBI-10172150,EBI-10264496
ZNF417Q8TAU35EBI-10172150,EBI-740727
ZNF433Q8N7K03EBI-10172150,EBI-10267553
ZNF439Q8NDP43EBI-10172150,EBI-747580
ZNF559Q9BR843EBI-10172150,EBI-746605
ZNF572Q7Z3I73EBI-10172150,EBI-10257016
ZNF587Q96SQ53EBI-10172150,EBI-6427977
ZNF670Q9BS343EBI-10172150,EBI-745276
ZNF679Q8IYX03EBI-10172150,EBI-745567
ZNF697Q8N5083EBI-10172150,EBI-10265733
ZNF707Q96C283EBI-10172150,EBI-748111
ZNF785A8K8V03EBI-10172150,EBI-3925400
ZNF792Q3KQV33EBI-10172150,EBI-10240849
ZSCAN21Q9Y5A63EBI-10172150,EBI-10281938
ZSCAN26Q166703EBI-10172150,EBI-3920053

Protein-protein interaction databases

BioGridi132131. 109 interactions.
IntActiP60370. 106 interactions.
STRINGi9606.ENSP00000383223.

Structurei

3D structure databases

ProteinModelPortaliP60370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 3051
Repeati51 – 5552
Repeati73 – 7753
Repeati78 – 8254
Repeati88 – 9255
Repeati93 – 9756
Repeati98 – 10257
Repeati110 – 11458
Repeati120 – 12459
Repeati130 – 134510
Repeati135 – 139511
Repeati140 – 144512
Repeati152 – 156513
Repeati162 – 166514
Repeati177 – 181515
Repeati187 – 191516
Repeati199 – 203517
Repeati209 – 213518
Repeati214 – 218519
Repeati233 – 237520
Repeati240 – 244521
Repeati251 – 255522

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 25523022 X 5 AA repeats of C-C-X(3)Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG304457.
HOGENOMiHOG000234031.
InParanoidiP60370.
OMAiCESSSCC.
OrthoDBiEOG780RQD.
PhylomeDBiP60370.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAACTMSVCS SACSDSWRVD DCPESCCEPP CGTAPCLTLV CTPVSCVSSP
60 70 80 90 100
CCQAACEPSP CQSGCTSSCT PSCCQPACCA SSPCQQACCV PVCCKPVCCL
110 120 130 140 150
PTCSKDSSSC CQQSSCQPTC CASSSCQQSC CVPVCCKPVC CVPTCSEDSS
160 170 180 190 200
SCCQHSSCQP TCCTSSPCQQ SCYVPVCCKP VCFKPICCVP VCSGASTSCC
210 220 230 240 250
QQSSCQPACC TTSCCRPSSS VSLLCRPICR PACCVPISSC CAPASSYQAS
260 270
CCRPASCVSL LCRPACSRLA C
Length:271
Mass (Da):27,626
Last modified:November 25, 2008 - v2
Checksum:i20E32DB102D523ED
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41C → S.
Corresponds to variant rs5017208 [ dbSNP | Ensembl ].
VAR_062113
Natural varianti20 – 201D → N.1 Publication
Corresponds to variant rs2020221 [ dbSNP | Ensembl ].
VAR_017696
Natural varianti183 – 1831F → C.
Corresponds to variant rs380585 [ dbSNP | Ensembl ].
VAR_047505
Natural varianti235 – 2351V → L.1 Publication
Corresponds to variant rs464424 [ dbSNP | Ensembl ].
VAR_017697
Natural varianti247 – 2471Y → C.
Corresponds to variant rs7509970 [ dbSNP | Ensembl ].
VAR_047506
Natural varianti268 – 2681R → P.1 Publication
Corresponds to variant rs464391 [ dbSNP | Ensembl ].
VAR_047507

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076352 mRNA. Translation: BAD01539.1.
AL773602 Genomic DNA. No translation available.
BC120949 mRNA. Translation: AAI20950.1.
BC120950 mRNA. Translation: AAI20951.1.
AJ566384 mRNA. Translation: CAD97464.1.
CCDSiCCDS42958.1.
UniGeneiHs.688629.

Genome annotation databases

EnsembliENST00000400372; ENSP00000383223; ENSG00000241123.
UCSCiuc002zfl.1. human.

Polymorphism and mutation databases

BioMutaiKRTAP10-5.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076352 mRNA. Translation: BAD01539.1.
AL773602 Genomic DNA. No translation available.
BC120949 mRNA. Translation: AAI20950.1.
BC120950 mRNA. Translation: AAI20951.1.
AJ566384 mRNA. Translation: CAD97464.1.
CCDSiCCDS42958.1.
UniGeneiHs.688629.

3D structure databases

ProteinModelPortaliP60370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132131. 109 interactions.
IntActiP60370. 106 interactions.
STRINGi9606.ENSP00000383223.

Polymorphism and mutation databases

BioMutaiKRTAP10-5.
DMDMi215274018.

Proteomic databases

PaxDbiP60370.
PRIDEiP60370.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400372; ENSP00000383223; ENSG00000241123.
UCSCiuc002zfl.1. human.

Organism-specific databases

GeneCardsiGC21M045999.
HGNCiHGNC:22969. KRTAP10-5.
neXtProtiNX_P60370.
PharmGKBiPA134950015.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG304457.
HOGENOMiHOG000234031.
InParanoidiP60370.
OMAiCESSSCC.
OrthoDBiEOG780RQD.
PhylomeDBiP60370.
TreeFamiTF351356.

Miscellaneous databases

GenomeRNAii386680.
NextBioi101000.
PROiP60370.

Gene expression databases

CleanExiHS_KRTAP10-5.
GenevestigatoriP60370.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3."
    Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.
    Genomics 83:679-693(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS LEU-235 AND PRO-268.
    Tissue: Hair root.
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-20.
  4. "Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21."
    Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S., Schweizer J.
    J. Invest. Dermatol. 122:147-158(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 261-271, TISSUE SPECIFICITY.
    Tissue: Scalp.

Entry informationi

Entry nameiKR105_HUMAN
AccessioniPrimary (citable) accession number: P60370
Secondary accession number(s): Q0VAR7, Q0VAR8, Q70LJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 25, 2008
Last modified: April 29, 2015
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.