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P60370

- KR105_HUMAN

UniProt

P60370 - KR105_HUMAN

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Protein
Keratin-associated protein 10-5
Gene
KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 10-5
Alternative name(s):
High sulfur keratin-associated protein 10.5
Keratin-associated protein 10.5
Keratin-associated protein 18-5
Keratin-associated protein 18.5
Gene namesi
Synonyms:KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:22969. KRTAP10-5.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Keratin-associated protein 10-5
PRO_0000185213Add
BLAST

Proteomic databases

PaxDbiP60370.
PRIDEiP60370.

Expressioni

Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

CleanExiHS_KRTAP10-5.
GenevestigatoriP60370.

Interactioni

Subunit structurei

Interacts with hair keratins.

Protein-protein interaction databases

STRINGi9606.ENSP00000383223.

Structurei

3D structure databases

ProteinModelPortaliP60370.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 3051
Repeati51 – 5552
Repeati73 – 7753
Repeati78 – 8254
Repeati88 – 9255
Repeati93 – 9756
Repeati98 – 10257
Repeati110 – 11458
Repeati120 – 12459
Repeati130 – 134510
Repeati135 – 139511
Repeati140 – 144512
Repeati152 – 156513
Repeati162 – 166514
Repeati177 – 181515
Repeati187 – 191516
Repeati199 – 203517
Repeati209 – 213518
Repeati214 – 218519
Repeati233 – 237520
Repeati240 – 244521
Repeati251 – 255522

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 25523022 X 5 AA repeats of C-C-X(3)
Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 10 family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG304457.
HOGENOMiHOG000234031.
InParanoidiP60370.
OMAiICRPACC.
OrthoDBiEOG780RQD.
PhylomeDBiP60370.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60370-1 [UniParc]FASTAAdd to Basket

« Hide

MAACTMSVCS SACSDSWRVD DCPESCCEPP CGTAPCLTLV CTPVSCVSSP    50
CCQAACEPSP CQSGCTSSCT PSCCQPACCA SSPCQQACCV PVCCKPVCCL 100
PTCSKDSSSC CQQSSCQPTC CASSSCQQSC CVPVCCKPVC CVPTCSEDSS 150
SCCQHSSCQP TCCTSSPCQQ SCYVPVCCKP VCFKPICCVP VCSGASTSCC 200
QQSSCQPACC TTSCCRPSSS VSLLCRPICR PACCVPISSC CAPASSYQAS 250
CCRPASCVSL LCRPACSRLA C 271
Length:271
Mass (Da):27,626
Last modified:November 25, 2008 - v2
Checksum:i20E32DB102D523ED
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41C → S.
Corresponds to variant rs5017208 [ dbSNP | Ensembl ].
VAR_062113
Natural varianti20 – 201D → N.1 Publication
Corresponds to variant rs2020221 [ dbSNP | Ensembl ].
VAR_017696
Natural varianti183 – 1831F → C.
Corresponds to variant rs380585 [ dbSNP | Ensembl ].
VAR_047505
Natural varianti235 – 2351V → L.1 Publication
Corresponds to variant rs464424 [ dbSNP | Ensembl ].
VAR_017697
Natural varianti247 – 2471Y → C.
Corresponds to variant rs7509970 [ dbSNP | Ensembl ].
VAR_047506
Natural varianti268 – 2681R → P.1 Publication
Corresponds to variant rs464391 [ dbSNP | Ensembl ].
VAR_047507

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB076352 mRNA. Translation: BAD01539.1.
AL773602 Genomic DNA. No translation available.
BC120949 mRNA. Translation: AAI20950.1.
BC120950 mRNA. Translation: AAI20951.1.
AJ566384 mRNA. Translation: CAD97464.1.
CCDSiCCDS42958.1.
UniGeneiHs.688629.

Genome annotation databases

EnsembliENST00000400372; ENSP00000383223; ENSG00000241123.
KEGGihsa:386680.
UCSCiuc002zfl.1. human.

Polymorphism databases

DMDMi215274018.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB076352 mRNA. Translation: BAD01539.1 .
AL773602 Genomic DNA. No translation available.
BC120949 mRNA. Translation: AAI20950.1 .
BC120950 mRNA. Translation: AAI20951.1 .
AJ566384 mRNA. Translation: CAD97464.1 .
CCDSi CCDS42958.1.
UniGenei Hs.688629.

3D structure databases

ProteinModelPortali P60370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000383223.

Polymorphism databases

DMDMi 215274018.

Proteomic databases

PaxDbi P60370.
PRIDEi P60370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000400372 ; ENSP00000383223 ; ENSG00000241123 .
KEGGi hsa:386680.
UCSCi uc002zfl.1. human.

Organism-specific databases

CTDi 386680.
GeneCardsi GC21M045999.
HGNCi HGNC:22969. KRTAP10-5.
neXtProti NX_P60370.
PharmGKBi PA134950015.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG304457.
HOGENOMi HOG000234031.
InParanoidi P60370.
OMAi ICRPACC.
OrthoDBi EOG780RQD.
PhylomeDBi P60370.
TreeFami TF351356.

Miscellaneous databases

GenomeRNAii 386680.
NextBioi 101000.
PROi P60370.

Gene expression databases

CleanExi HS_KRTAP10-5.
Genevestigatori P60370.

Family and domain databases

InterProi IPR002494. KAP.
[Graphical view ]
PANTHERi PTHR23262. PTHR23262. 1 hit.
Pfami PF13885. Keratin_B2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3."
    Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.
    Genomics 83:679-693(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS LEU-235 AND PRO-268.
    Tissue: Hair root.
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-20.
  4. "Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21."
    Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S., Schweizer J.
    J. Invest. Dermatol. 122:147-158(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 261-271, TISSUE SPECIFICITY.
    Tissue: Scalp.

Entry informationi

Entry nameiKR105_HUMAN
AccessioniPrimary (citable) accession number: P60370
Secondary accession number(s): Q0VAR7, Q0VAR8, Q70LJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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