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P60370

- KR105_HUMAN

UniProt

P60370 - KR105_HUMAN

Protein

Keratin-associated protein 10-5

Gene

KRTAP10-5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin-associated protein 10-5
    Alternative name(s):
    High sulfur keratin-associated protein 10.5
    Keratin-associated protein 10.5
    Keratin-associated protein 18-5
    Keratin-associated protein 18.5
    Gene namesi
    Name:KRTAP10-5
    Synonyms:KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:22969. KRTAP10-5.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: InterPro

    Keywords - Cellular componenti

    Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134950015.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Keratin-associated protein 10-5PRO_0000185213Add
    BLAST

    Proteomic databases

    PaxDbiP60370.
    PRIDEiP60370.

    Expressioni

    Tissue specificityi

    Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

    Gene expression databases

    CleanExiHS_KRTAP10-5.
    GenevestigatoriP60370.

    Interactioni

    Subunit structurei

    Interacts with hair keratins.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000383223.

    Structurei

    3D structure databases

    ProteinModelPortaliP60370.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati26 – 3051
    Repeati51 – 5552
    Repeati73 – 7753
    Repeati78 – 8254
    Repeati88 – 9255
    Repeati93 – 9756
    Repeati98 – 10257
    Repeati110 – 11458
    Repeati120 – 12459
    Repeati130 – 134510
    Repeati135 – 139511
    Repeati140 – 144512
    Repeati152 – 156513
    Repeati162 – 166514
    Repeati177 – 181515
    Repeati187 – 191516
    Repeati199 – 203517
    Repeati209 – 213518
    Repeati214 – 218519
    Repeati233 – 237520
    Repeati240 – 244521
    Repeati251 – 255522

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni26 – 25523022 X 5 AA repeats of C-C-X(3)Add
    BLAST

    Sequence similaritiesi

    Belongs to the KRTAP type 10 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG304457.
    HOGENOMiHOG000234031.
    InParanoidiP60370.
    OMAiICRPACC.
    OrthoDBiEOG780RQD.
    PhylomeDBiP60370.
    TreeFamiTF351356.

    Family and domain databases

    InterProiIPR002494. KAP.
    [Graphical view]
    PANTHERiPTHR23262. PTHR23262. 1 hit.
    PfamiPF13885. Keratin_B2_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60370-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAACTMSVCS SACSDSWRVD DCPESCCEPP CGTAPCLTLV CTPVSCVSSP    50
    CCQAACEPSP CQSGCTSSCT PSCCQPACCA SSPCQQACCV PVCCKPVCCL 100
    PTCSKDSSSC CQQSSCQPTC CASSSCQQSC CVPVCCKPVC CVPTCSEDSS 150
    SCCQHSSCQP TCCTSSPCQQ SCYVPVCCKP VCFKPICCVP VCSGASTSCC 200
    QQSSCQPACC TTSCCRPSSS VSLLCRPICR PACCVPISSC CAPASSYQAS 250
    CCRPASCVSL LCRPACSRLA C 271
    Length:271
    Mass (Da):27,626
    Last modified:November 25, 2008 - v2
    Checksum:i20E32DB102D523ED
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41C → S.
    Corresponds to variant rs5017208 [ dbSNP | Ensembl ].
    VAR_062113
    Natural varianti20 – 201D → N.1 Publication
    Corresponds to variant rs2020221 [ dbSNP | Ensembl ].
    VAR_017696
    Natural varianti183 – 1831F → C.
    Corresponds to variant rs380585 [ dbSNP | Ensembl ].
    VAR_047505
    Natural varianti235 – 2351V → L.1 Publication
    Corresponds to variant rs464424 [ dbSNP | Ensembl ].
    VAR_017697
    Natural varianti247 – 2471Y → C.
    Corresponds to variant rs7509970 [ dbSNP | Ensembl ].
    VAR_047506
    Natural varianti268 – 2681R → P.1 Publication
    Corresponds to variant rs464391 [ dbSNP | Ensembl ].
    VAR_047507

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB076352 mRNA. Translation: BAD01539.1.
    AL773602 Genomic DNA. No translation available.
    BC120949 mRNA. Translation: AAI20950.1.
    BC120950 mRNA. Translation: AAI20951.1.
    AJ566384 mRNA. Translation: CAD97464.1.
    CCDSiCCDS42958.1.
    UniGeneiHs.688629.

    Genome annotation databases

    EnsembliENST00000400372; ENSP00000383223; ENSG00000241123.
    KEGGihsa:386680.
    UCSCiuc002zfl.1. human.

    Polymorphism databases

    DMDMi215274018.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB076352 mRNA. Translation: BAD01539.1 .
    AL773602 Genomic DNA. No translation available.
    BC120949 mRNA. Translation: AAI20950.1 .
    BC120950 mRNA. Translation: AAI20951.1 .
    AJ566384 mRNA. Translation: CAD97464.1 .
    CCDSi CCDS42958.1.
    UniGenei Hs.688629.

    3D structure databases

    ProteinModelPortali P60370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000383223.

    Polymorphism databases

    DMDMi 215274018.

    Proteomic databases

    PaxDbi P60370.
    PRIDEi P60370.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000400372 ; ENSP00000383223 ; ENSG00000241123 .
    KEGGi hsa:386680.
    UCSCi uc002zfl.1. human.

    Organism-specific databases

    CTDi 386680.
    GeneCardsi GC21M045999.
    HGNCi HGNC:22969. KRTAP10-5.
    neXtProti NX_P60370.
    PharmGKBi PA134950015.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG304457.
    HOGENOMi HOG000234031.
    InParanoidi P60370.
    OMAi ICRPACC.
    OrthoDBi EOG780RQD.
    PhylomeDBi P60370.
    TreeFami TF351356.

    Miscellaneous databases

    GenomeRNAii 386680.
    NextBioi 101000.
    PROi P60370.

    Gene expression databases

    CleanExi HS_KRTAP10-5.
    Genevestigatori P60370.

    Family and domain databases

    InterProi IPR002494. KAP.
    [Graphical view ]
    PANTHERi PTHR23262. PTHR23262. 1 hit.
    Pfami PF13885. Keratin_B2_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3."
      Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.
      Genomics 83:679-693(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS LEU-235 AND PRO-268.
      Tissue: Hair root.
    2. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-20.
    4. "Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21."
      Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S., Schweizer J.
      J. Invest. Dermatol. 122:147-158(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 261-271, TISSUE SPECIFICITY.
      Tissue: Scalp.

    Entry informationi

    Entry nameiKR105_HUMAN
    AccessioniPrimary (citable) accession number: P60370
    Secondary accession number(s): Q0VAR7, Q0VAR8, Q70LJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3