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Protein

Keratin-associated protein 10-5

Gene

KRTAP10-5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 10-5
Alternative name(s):
High sulfur keratin-associated protein 10.5
Keratin-associated protein 10.5
Keratin-associated protein 18-5
Keratin-associated protein 18.5
Gene namesi
Name:KRTAP10-5
Synonyms:KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:22969. KRTAP10-5.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Keratin-associated protein 10-5PRO_0000185213Add
BLAST

Proteomic databases

PaxDbiP60370.
PRIDEiP60370.

Expressioni

Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

CleanExiHS_KRTAP10-5.
GenevestigatoriP60370.

Interactioni

Subunit structurei

Interacts with hair keratins.

Protein-protein interaction databases

BioGridi132131. 109 interactions.
STRINGi9606.ENSP00000383223.

Structurei

3D structure databases

ProteinModelPortaliP60370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 3051
Repeati51 – 5552
Repeati73 – 7753
Repeati78 – 8254
Repeati88 – 9255
Repeati93 – 9756
Repeati98 – 10257
Repeati110 – 11458
Repeati120 – 12459
Repeati130 – 134510
Repeati135 – 139511
Repeati140 – 144512
Repeati152 – 156513
Repeati162 – 166514
Repeati177 – 181515
Repeati187 – 191516
Repeati199 – 203517
Repeati209 – 213518
Repeati214 – 218519
Repeati233 – 237520
Repeati240 – 244521
Repeati251 – 255522

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 25523022 X 5 AA repeats of C-C-X(3)Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG304457.
HOGENOMiHOG000234031.
InParanoidiP60370.
OMAiCESSSCC.
OrthoDBiEOG780RQD.
PhylomeDBiP60370.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60370-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAACTMSVCS SACSDSWRVD DCPESCCEPP CGTAPCLTLV CTPVSCVSSP
60 70 80 90 100
CCQAACEPSP CQSGCTSSCT PSCCQPACCA SSPCQQACCV PVCCKPVCCL
110 120 130 140 150
PTCSKDSSSC CQQSSCQPTC CASSSCQQSC CVPVCCKPVC CVPTCSEDSS
160 170 180 190 200
SCCQHSSCQP TCCTSSPCQQ SCYVPVCCKP VCFKPICCVP VCSGASTSCC
210 220 230 240 250
QQSSCQPACC TTSCCRPSSS VSLLCRPICR PACCVPISSC CAPASSYQAS
260 270
CCRPASCVSL LCRPACSRLA C
Length:271
Mass (Da):27,626
Last modified:November 25, 2008 - v2
Checksum:i20E32DB102D523ED
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41C → S.
Corresponds to variant rs5017208 [ dbSNP | Ensembl ].
VAR_062113
Natural varianti20 – 201D → N.1 Publication
Corresponds to variant rs2020221 [ dbSNP | Ensembl ].
VAR_017696
Natural varianti183 – 1831F → C.
Corresponds to variant rs380585 [ dbSNP | Ensembl ].
VAR_047505
Natural varianti235 – 2351V → L.1 Publication
Corresponds to variant rs464424 [ dbSNP | Ensembl ].
VAR_017697
Natural varianti247 – 2471Y → C.
Corresponds to variant rs7509970 [ dbSNP | Ensembl ].
VAR_047506
Natural varianti268 – 2681R → P.1 Publication
Corresponds to variant rs464391 [ dbSNP | Ensembl ].
VAR_047507

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076352 mRNA. Translation: BAD01539.1.
AL773602 Genomic DNA. No translation available.
BC120949 mRNA. Translation: AAI20950.1.
BC120950 mRNA. Translation: AAI20951.1.
AJ566384 mRNA. Translation: CAD97464.1.
CCDSiCCDS42958.1.
UniGeneiHs.688629.

Genome annotation databases

EnsembliENST00000400372; ENSP00000383223; ENSG00000241123.
UCSCiuc002zfl.1. human.

Polymorphism databases

DMDMi215274018.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076352 mRNA. Translation: BAD01539.1.
AL773602 Genomic DNA. No translation available.
BC120949 mRNA. Translation: AAI20950.1.
BC120950 mRNA. Translation: AAI20951.1.
AJ566384 mRNA. Translation: CAD97464.1.
CCDSiCCDS42958.1.
UniGeneiHs.688629.

3D structure databases

ProteinModelPortaliP60370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132131. 109 interactions.
STRINGi9606.ENSP00000383223.

Polymorphism databases

DMDMi215274018.

Proteomic databases

PaxDbiP60370.
PRIDEiP60370.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400372; ENSP00000383223; ENSG00000241123.
UCSCiuc002zfl.1. human.

Organism-specific databases

GeneCardsiGC21M045999.
HGNCiHGNC:22969. KRTAP10-5.
neXtProtiNX_P60370.
PharmGKBiPA134950015.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG304457.
HOGENOMiHOG000234031.
InParanoidiP60370.
OMAiCESSSCC.
OrthoDBiEOG780RQD.
PhylomeDBiP60370.
TreeFamiTF351356.

Miscellaneous databases

GenomeRNAii386680.
NextBioi101000.
PROiP60370.

Gene expression databases

CleanExiHS_KRTAP10-5.
GenevestigatoriP60370.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3."
    Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.
    Genomics 83:679-693(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS LEU-235 AND PRO-268.
    Tissue: Hair root.
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-20.
  4. "Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21."
    Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S., Schweizer J.
    J. Invest. Dermatol. 122:147-158(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 261-271, TISSUE SPECIFICITY.
    Tissue: Scalp.

Entry informationi

Entry nameiKR105_HUMAN
AccessioniPrimary (citable) accession number: P60370
Secondary accession number(s): Q0VAR7, Q0VAR8, Q70LJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 25, 2008
Last modified: February 4, 2015
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.