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Protein

Keratin-associated protein 10-3

Gene

KRTAP10-3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Enzyme and pathway databases

BioCyciZFISH:G66-31901-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 10-3
Alternative name(s):
High sulfur keratin-associated protein 10.3
Keratin-associated protein 10.3
Keratin-associated protein 18-3
Keratin-associated protein 18.3
Gene namesi
Name:KRTAP10-3
Synonyms:KAP10.3, KAP18-3, KRTAP10.3, KRTAP18-3, KRTAP18.3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:22968. KRTAP10-3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000212935.
PharmGKBiPA134941853.

Polymorphism and mutation databases

BioMutaiKRTAP10-3.
DMDMi218511664.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001852111 – 221Keratin-associated protein 10-3Add BLAST221

Proteomic databases

PaxDbiP60369.
PeptideAtlasiP60369.
PRIDEiP60369.

Expressioni

Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

CleanExiHS_KRTAP10-3.

Organism-specific databases

HPAiCAB016204.

Interactioni

Subunit structurei

Interacts with hair keratins.

Protein-protein interaction databases

BioGridi132133. 289 interactors.
STRINGi9606.ENSP00000375478.

Structurei

3D structure databases

ProteinModelPortaliP60369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 3015
Repeati31 – 3525
Repeati36 – 4035
Repeati57 – 6145
Repeati79 – 8355
Repeati89 – 9365
Repeati99 – 10375
Repeati104 – 10885
Repeati109 – 11395
Repeati114 – 118105
Repeati119 – 123115
Repeati124 – 128125
Repeati136 – 140135
Repeati146 – 150145
Repeati151 – 155155
Repeati177 – 181165
Repeati188 – 192175
Repeati210 – 214185

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 21418 X 5 AA repeats of C-C-X(3)Add BLAST189

Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JNRG. Eukaryota.
ENOG41116YF. LUCA.
GeneTreeiENSGT00850000132280.
HOGENOMiHOG000234031.
HOVERGENiHBG108072.
InParanoidiP60369.
OMAiNSECTSH.
OrthoDBiEOG091G17RC.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSTMSVCS SAYSDSWQVD ACPESCCEPP CCATSCCAPA PCLTLVCTPV
60 70 80 90 100
SCVSSPCCQA ACEPSPCQSG CTSSCTPSCC QQSSCQPACC TSSPCQQACC
110 120 130 140 150
VPVCCKPVCC VPVCCKPVCC KPICCVPVCS GASSSCCQQS SRQPACCTTS
160 170 180 190 200
CCRPSSSVSL LCRPVCRSTC CVPIPSCCAP ASTCQPSCCR PASCVSLLCR
210 220
PTCSRLSSAC CGLSSGQKSS C
Length:221
Mass (Da):22,348
Last modified:December 16, 2008 - v2
Checksum:iE4045CE97F41B3B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34T → P in BAD01537 (PubMed:15028290).Curated1
Sequence conflicti34T → P in AAI33678 (PubMed:15489334).Curated1
Sequence conflicti39P → L in AAI33678 (PubMed:15489334).Curated1
Sequence conflicti165 – 191Missing in AAI33678 (PubMed:15489334).CuratedAdd BLAST27

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0478503T → A.1 PublicationCorresponds to variant rs452472dbSNPEnsembl.1
Natural variantiVAR_047851170C → Y.2 PublicationsCorresponds to variant rs233252dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076350 mRNA. Translation: BAD01537.1.
AP001067 Genomic DNA. No translation available.
BC133677 mRNA. Translation: AAI33678.1.
AJ566383 mRNA. Translation: CAD97463.1.
CCDSiCCDS42956.1.
RefSeqiNP_941969.2. NM_198696.2.
UniGeneiHs.688630.

Genome annotation databases

EnsembliENST00000391620; ENSP00000375478; ENSG00000212935.
GeneIDi386682.
KEGGihsa:386682.
UCSCiuc002zfj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076350 mRNA. Translation: BAD01537.1.
AP001067 Genomic DNA. No translation available.
BC133677 mRNA. Translation: AAI33678.1.
AJ566383 mRNA. Translation: CAD97463.1.
CCDSiCCDS42956.1.
RefSeqiNP_941969.2. NM_198696.2.
UniGeneiHs.688630.

3D structure databases

ProteinModelPortaliP60369.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132133. 289 interactors.
STRINGi9606.ENSP00000375478.

Polymorphism and mutation databases

BioMutaiKRTAP10-3.
DMDMi218511664.

Proteomic databases

PaxDbiP60369.
PeptideAtlasiP60369.
PRIDEiP60369.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391620; ENSP00000375478; ENSG00000212935.
GeneIDi386682.
KEGGihsa:386682.
UCSCiuc002zfj.2. human.

Organism-specific databases

CTDi386682.
GeneCardsiKRTAP10-3.
H-InvDBHIX0060037.
HGNCiHGNC:22968. KRTAP10-3.
HPAiCAB016204.
neXtProtiNX_P60369.
OpenTargetsiENSG00000212935.
PharmGKBiPA134941853.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JNRG. Eukaryota.
ENOG41116YF. LUCA.
GeneTreeiENSGT00850000132280.
HOGENOMiHOG000234031.
HOVERGENiHBG108072.
InParanoidiP60369.
OMAiNSECTSH.
OrthoDBiEOG091G17RC.
TreeFamiTF351356.

Enzyme and pathway databases

BioCyciZFISH:G66-31901-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.

Miscellaneous databases

GenomeRNAii386682.
PROiP60369.

Gene expression databases

CleanExiHS_KRTAP10-3.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKR103_HUMAN
AccessioniPrimary (citable) accession number: P60369
Secondary accession number(s): A3KN67, Q70LJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 16, 2008
Last modified: November 30, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.