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Protein

Keratin-associated protein 10-3

Gene

KRTAP10-3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 10-3
Alternative name(s):
High sulfur keratin-associated protein 10.3
Keratin-associated protein 10.3
Keratin-associated protein 18-3
Keratin-associated protein 18.3
Gene namesi
Name:KRTAP10-3
Synonyms:KAP10.3, KAP18-3, KRTAP10.3, KRTAP18-3, KRTAP18.3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:22968. KRTAP10-3.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941853.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Keratin-associated protein 10-3PRO_0000185211Add
BLAST

Proteomic databases

PaxDbiP60369.
PeptideAtlasiP60369.
PRIDEiP60369.

Expressioni

Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

CleanExiHS_KRTAP10-3.
GenevestigatoriP60369.

Interactioni

Subunit structurei

Interacts with hair keratins.

Protein-protein interaction databases

BioGridi132133. 289 interactions.
STRINGi9606.ENSP00000375478.

Structurei

3D structure databases

ProteinModelPortaliP60369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 3051
Repeati31 – 3552
Repeati36 – 4053
Repeati57 – 6154
Repeati79 – 8355
Repeati89 – 9356
Repeati99 – 10357
Repeati104 – 10858
Repeati109 – 11359
Repeati114 – 118510
Repeati119 – 123511
Repeati124 – 128512
Repeati136 – 140513
Repeati146 – 150514
Repeati151 – 155515
Repeati177 – 181516
Repeati188 – 192517
Repeati210 – 214518

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 21418918 X 5 AA repeats of C-C-X(3)Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG258336.
GeneTreeiENSGT00780000121948.
HOGENOMiHOG000234031.
HOVERGENiHBG108072.
InParanoidiP60369.
OMAiCAPVAPC.
OrthoDBiEOG780RQD.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60369-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATSTMSVCS SAYSDSWQVD ACPESCCEPP CCATSCCAPA PCLTLVCTPV
60 70 80 90 100
SCVSSPCCQA ACEPSPCQSG CTSSCTPSCC QQSSCQPACC TSSPCQQACC
110 120 130 140 150
VPVCCKPVCC VPVCCKPVCC KPICCVPVCS GASSSCCQQS SRQPACCTTS
160 170 180 190 200
CCRPSSSVSL LCRPVCRSTC CVPIPSCCAP ASTCQPSCCR PASCVSLLCR
210 220
PTCSRLSSAC CGLSSGQKSS C
Length:221
Mass (Da):22,348
Last modified:December 16, 2008 - v2
Checksum:iE4045CE97F41B3B9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341T → P in BAD01537. (PubMed:15028290)Curated
Sequence conflicti34 – 341T → P in AAI33678. (PubMed:15489334)Curated
Sequence conflicti39 – 391P → L in AAI33678. (PubMed:15489334)Curated
Sequence conflicti165 – 19127Missing in AAI33678. (PubMed:15489334)CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31T → A.1 Publication
Corresponds to variant rs452472 [ dbSNP | Ensembl ].
VAR_047850
Natural varianti170 – 1701C → Y.2 Publications
Corresponds to variant rs233252 [ dbSNP | Ensembl ].
VAR_047851

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076350 mRNA. Translation: BAD01537.1.
AP001067 Genomic DNA. No translation available.
BC133677 mRNA. Translation: AAI33678.1.
AJ566383 mRNA. Translation: CAD97463.1.
CCDSiCCDS42956.1.
RefSeqiNP_941969.2. NM_198696.2.
UniGeneiHs.688630.

Genome annotation databases

EnsembliENST00000391620; ENSP00000375478; ENSG00000212935.
GeneIDi386682.
KEGGihsa:386682.
UCSCiuc002zfj.1. human.

Polymorphism databases

DMDMi218511664.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076350 mRNA. Translation: BAD01537.1.
AP001067 Genomic DNA. No translation available.
BC133677 mRNA. Translation: AAI33678.1.
AJ566383 mRNA. Translation: CAD97463.1.
CCDSiCCDS42956.1.
RefSeqiNP_941969.2. NM_198696.2.
UniGeneiHs.688630.

3D structure databases

ProteinModelPortaliP60369.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132133. 289 interactions.
STRINGi9606.ENSP00000375478.

Polymorphism databases

DMDMi218511664.

Proteomic databases

PaxDbiP60369.
PeptideAtlasiP60369.
PRIDEiP60369.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391620; ENSP00000375478; ENSG00000212935.
GeneIDi386682.
KEGGihsa:386682.
UCSCiuc002zfj.1. human.

Organism-specific databases

CTDi386682.
GeneCardsiGC21M045977.
H-InvDBHIX0060037.
HGNCiHGNC:22968. KRTAP10-3.
neXtProtiNX_P60369.
PharmGKBiPA134941853.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG258336.
GeneTreeiENSGT00780000121948.
HOGENOMiHOG000234031.
HOVERGENiHBG108072.
InParanoidiP60369.
OMAiCAPVAPC.
OrthoDBiEOG780RQD.
TreeFamiTF351356.

Miscellaneous databases

NextBioi101008.
PROiP60369.

Gene expression databases

CleanExiHS_KRTAP10-3.
GenevestigatoriP60369.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3."
    Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.
    Genomics 83:679-693(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT TYR-170.
    Tissue: Hair root.
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-3.
  4. "Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21."
    Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S., Schweizer J.
    J. Invest. Dermatol. 122:147-158(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 167-221, TISSUE SPECIFICITY, VARIANT TYR-170.
    Tissue: Scalp.

Entry informationi

Entry nameiKR103_HUMAN
AccessioniPrimary (citable) accession number: P60369
Secondary accession number(s): A3KN67, Q70LJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 16, 2008
Last modified: February 4, 2015
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.