P60369 (KR103_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin-associated protein 10-3

Alternative name(s):
High sulfur keratin-associated protein 10.3
Keratin-associated protein 10.3
Keratin-associated protein 18-3
Keratin-associated protein 18.3

Gene names

Name:	KRTAP10-3
Synonyms:	KAP10.3, KAP18-3, KRTAP10.3, KRTAP18-3, KRTAP18.3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Subunit structure	Interacts with hair keratins.
Tissue specificity	Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues. Ref.1 Ref.4
Sequence similarities	Belongs to the KRTAP type 10 family.

Ontologies

Keywords
Cellular component	Keratin
Coding sequence diversity	Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	keratin filament Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Keratin-associated protein 10-3		PRO_0000185211
Regions
	Repeat	26 – 30	5	1
	Repeat	31 – 35	5	2
	Repeat	36 – 40	5	3
	Repeat	57 – 61	5	4
	Repeat	79 – 83	5	5
	Repeat	89 – 93	5	6
	Repeat	99 – 103	5	7
	Repeat	104 – 108	5	8
	Repeat	109 – 113	5	9
	Repeat	114 – 118	5	10
	Repeat	119 – 123	5	11
	Repeat	124 – 128	5	12
	Repeat	136 – 140	5	13
	Repeat	146 – 150	5	14
	Repeat	151 – 155	5	15
	Repeat	177 – 181	5	16
	Repeat	188 – 192	5	17
	Repeat	210 – 214	5	18
	Region	26 – 214	189	18 X 5 AA repeats of C-C-X(3)
Natural variations
	Natural variant	3	1	T → A. Ref.3 Corresponds to variant rs452472 [ dbSNP | Ensembl ].		VAR_047850
	Natural variant	170	1	C → Y. Ref.1 Ref.4 Corresponds to variant rs233252 [ dbSNP | Ensembl ].		VAR_047851
Experimental info
	Sequence conflict	34	1	T → P in BAD01537. Ref.1
	Sequence conflict	34	1	T → P in AAI33678. Ref.3
	Sequence conflict	39	1	P → L in AAI33678. Ref.3
	Sequence conflict	165 – 191	27	Missing in AAI33678. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P60369 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: E4045CE97F41B3B9	FASTA	221	22,348
	10 20 30 40 50 60 MATSTMSVCS SAYSDSWQVD ACPESCCEPP CCATSCCAPA PCLTLVCTPV SCVSSPCCQA 70 80 90 100 110 120 ACEPSPCQSG CTSSCTPSCC QQSSCQPACC TSSPCQQACC VPVCCKPVCC VPVCCKPVCC 130 140 150 160 170 180 KPICCVPVCS GASSSCCQQS SRQPACCTTS CCRPSSSVSL LCRPVCRSTC CVPIPSCCAP 190 200 210 220 ASTCQPSCCR PASCVSLLCR PTCSRLSSAC CGLSSGQKSS C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3." Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N. Genomics 83:679-693(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT TYR-170. Tissue: Hair root.
[2]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-3.
[4]	"Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21." Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S., Schweizer J. J. Invest. Dermatol. 122:147-158(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 167-221, TISSUE SPECIFICITY, VARIANT TYR-170. Tissue: Scalp.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB076350 mRNA. Translation: BAD01537.1. AP001067 Genomic DNA. No translation available. BC133677 mRNA. Translation: AAI33678.1. AJ566383 mRNA. Translation: CAD97463.1.
IPI	IPI00394678.
RefSeq	NP_941969.2. NM_198696.2.
UniGene	Hs.688630.
3D structure databases
ProteinModelPortal	P60369.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000375478.
Polymorphism databases
DMDM	218511664.
Proteomic databases
PaxDb	P60369.
PeptideAtlas	P60369.
PRIDE	P60369.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000391620; ENSP00000375478; ENSG00000212935.
GeneID	386682.
KEGG	hsa:386682.
UCSC	uc002zfj.1. human.
Organism-specific databases
CTD	386682.
GeneCards	GC21M045977.
H-InvDB	HIX0060037.
HGNC	HGNC:22968. KRTAP10-3.
neXtProt	NX_P60369.
PharmGKB	PA134941853.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG258336.
HOGENOM	HOG000234031.
HOVERGEN	HBG108072.
InParanoid	P60369.
OMA	KCAARCT.
OrthoDB	EOG41C6XX.
Gene expression databases
CleanEx	HS_KRTAP10-3.
Genevestigator	P60369.
Family and domain databases
InterPro	IPR002494. Keratin-assoc. [Graphical view]
PANTHER	PTHR23262. PTHR23262. 1 hit.
ProtoNet	Search...
Other
NextBio	101008.

Entry information

Entry name

KR103_HUMAN

Accession

Primary (citable) accession number: P60369
Secondary accession number(s): A3KN67, Q70LJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	December 16, 2008
Last modified:	April 3, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.