Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P60369

- KR103_HUMAN

UniProt

P60369 - KR103_HUMAN

Protein

Keratin-associated protein 10-3

Gene

KRTAP10-3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin-associated protein 10-3
    Alternative name(s):
    High sulfur keratin-associated protein 10.3
    Keratin-associated protein 10.3
    Keratin-associated protein 18-3
    Keratin-associated protein 18.3
    Gene namesi
    Name:KRTAP10-3
    Synonyms:KAP10.3, KAP18-3, KRTAP10.3, KRTAP18-3, KRTAP18.3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:22968. KRTAP10-3.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: InterPro

    Keywords - Cellular componenti

    Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134941853.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 221221Keratin-associated protein 10-3PRO_0000185211Add
    BLAST

    Proteomic databases

    PaxDbiP60369.
    PeptideAtlasiP60369.
    PRIDEiP60369.

    Expressioni

    Tissue specificityi

    Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

    Gene expression databases

    CleanExiHS_KRTAP10-3.
    GenevestigatoriP60369.

    Interactioni

    Subunit structurei

    Interacts with hair keratins.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000375478.

    Structurei

    3D structure databases

    ProteinModelPortaliP60369.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati26 – 3051
    Repeati31 – 3552
    Repeati36 – 4053
    Repeati57 – 6154
    Repeati79 – 8355
    Repeati89 – 9356
    Repeati99 – 10357
    Repeati104 – 10858
    Repeati109 – 11359
    Repeati114 – 118510
    Repeati119 – 123511
    Repeati124 – 128512
    Repeati136 – 140513
    Repeati146 – 150514
    Repeati151 – 155515
    Repeati177 – 181516
    Repeati188 – 192517
    Repeati210 – 214518

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni26 – 21418918 X 5 AA repeats of C-C-X(3)Add
    BLAST

    Sequence similaritiesi

    Belongs to the KRTAP type 10 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG258336.
    HOGENOMiHOG000234031.
    HOVERGENiHBG108072.
    InParanoidiP60369.
    OMAiCKPECCK.
    OrthoDBiEOG780RQD.
    TreeFamiTF351356.

    Family and domain databases

    InterProiIPR002494. KAP.
    [Graphical view]
    PANTHERiPTHR23262. PTHR23262. 1 hit.
    PfamiPF13885. Keratin_B2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60369-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATSTMSVCS SAYSDSWQVD ACPESCCEPP CCATSCCAPA PCLTLVCTPV    50
    SCVSSPCCQA ACEPSPCQSG CTSSCTPSCC QQSSCQPACC TSSPCQQACC 100
    VPVCCKPVCC VPVCCKPVCC KPICCVPVCS GASSSCCQQS SRQPACCTTS 150
    CCRPSSSVSL LCRPVCRSTC CVPIPSCCAP ASTCQPSCCR PASCVSLLCR 200
    PTCSRLSSAC CGLSSGQKSS C 221
    Length:221
    Mass (Da):22,348
    Last modified:December 16, 2008 - v2
    Checksum:iE4045CE97F41B3B9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti34 – 341T → P in BAD01537. (PubMed:15028290)Curated
    Sequence conflicti34 – 341T → P in AAI33678. (PubMed:15489334)Curated
    Sequence conflicti39 – 391P → L in AAI33678. (PubMed:15489334)Curated
    Sequence conflicti165 – 19127Missing in AAI33678. (PubMed:15489334)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31T → A.1 Publication
    Corresponds to variant rs452472 [ dbSNP | Ensembl ].
    VAR_047850
    Natural varianti170 – 1701C → Y.2 Publications
    Corresponds to variant rs233252 [ dbSNP | Ensembl ].
    VAR_047851

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB076350 mRNA. Translation: BAD01537.1.
    AP001067 Genomic DNA. No translation available.
    BC133677 mRNA. Translation: AAI33678.1.
    AJ566383 mRNA. Translation: CAD97463.1.
    CCDSiCCDS42956.1.
    RefSeqiNP_941969.2. NM_198696.2.
    UniGeneiHs.688630.

    Genome annotation databases

    EnsembliENST00000391620; ENSP00000375478; ENSG00000212935.
    GeneIDi386682.
    KEGGihsa:386682.
    UCSCiuc002zfj.1. human.

    Polymorphism databases

    DMDMi218511664.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB076350 mRNA. Translation: BAD01537.1 .
    AP001067 Genomic DNA. No translation available.
    BC133677 mRNA. Translation: AAI33678.1 .
    AJ566383 mRNA. Translation: CAD97463.1 .
    CCDSi CCDS42956.1.
    RefSeqi NP_941969.2. NM_198696.2.
    UniGenei Hs.688630.

    3D structure databases

    ProteinModelPortali P60369.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000375478.

    Polymorphism databases

    DMDMi 218511664.

    Proteomic databases

    PaxDbi P60369.
    PeptideAtlasi P60369.
    PRIDEi P60369.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000391620 ; ENSP00000375478 ; ENSG00000212935 .
    GeneIDi 386682.
    KEGGi hsa:386682.
    UCSCi uc002zfj.1. human.

    Organism-specific databases

    CTDi 386682.
    GeneCardsi GC21M045977.
    H-InvDB HIX0060037.
    HGNCi HGNC:22968. KRTAP10-3.
    neXtProti NX_P60369.
    PharmGKBi PA134941853.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG258336.
    HOGENOMi HOG000234031.
    HOVERGENi HBG108072.
    InParanoidi P60369.
    OMAi CKPECCK.
    OrthoDBi EOG780RQD.
    TreeFami TF351356.

    Miscellaneous databases

    NextBioi 101008.
    PROi P60369.

    Gene expression databases

    CleanExi HS_KRTAP10-3.
    Genevestigatori P60369.

    Family and domain databases

    InterProi IPR002494. KAP.
    [Graphical view ]
    PANTHERi PTHR23262. PTHR23262. 1 hit.
    Pfami PF13885. Keratin_B2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3."
      Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.
      Genomics 83:679-693(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT TYR-170.
      Tissue: Hair root.
    2. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-3.
    4. "Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21."
      Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S., Schweizer J.
      J. Invest. Dermatol. 122:147-158(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 167-221, TISSUE SPECIFICITY, VARIANT TYR-170.
      Tissue: Scalp.

    Entry informationi

    Entry nameiKR103_HUMAN
    AccessioniPrimary (citable) accession number: P60369
    Secondary accession number(s): A3KN67, Q70LJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3