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Protein

Keratin-associated protein 10-2

Gene

KRTAP10-2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 10-2
Alternative name(s):
High sulfur keratin-associated protein 10.2
Keratin-associated protein 10.2
Keratin-associated protein 18-2
Keratin-associated protein 18.2
Gene namesi
Name:KRTAP10-2
Synonyms:KAP10.2, KAP18-2, KRTAP10.2, KRTAP18-2, KRTAP18.2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:22967. KRTAP10-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134989110.

Polymorphism and mutation databases

BioMutaiKRTAP10-2.
DMDMi42558948.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Keratin-associated protein 10-2PRO_0000185210Add
BLAST

Proteomic databases

PaxDbiP60368.
PeptideAtlasiP60368.
PRIDEiP60368.

Expressioni

Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

CleanExiHS_KRTAP10-2.

Interactioni

Subunit structurei

Interacts with hair keratins.

Protein-protein interaction databases

STRINGi9606.ENSP00000375479.

Structurei

3D structure databases

ProteinModelPortaliP60368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 3051
Repeati36 – 4052
Repeati57 – 6153
Repeati79 – 8354
Repeati89 – 9355
Repeati99 – 10356
Repeati104 – 10857
Repeati109 – 11358
Repeati114 – 11859
Repeati120 – 124510
Repeati130 – 134511
Repeati145 – 149512
Repeati150 – 154513
Repeati162 – 166514
Repeati172 – 176515
Repeati182 – 186516
Repeati187 – 191517
Repeati192 – 196518
Repeati197 – 201519
Repeati209 – 213520
Repeati219 – 223521
Repeati224 – 228522

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 22820322 X 5 AA repeats of C-C-X(3)Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi156 – 1616Poly-Ser

Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JH3R. Eukaryota.
ENOG4111BSI. LUCA.
GeneTreeiENSGT00780000121948.
HOGENOMiHOG000234031.
HOVERGENiHBG108072.
InParanoidiP60368.
OMAiQSCCVSV.
OrthoDBiEOG091G17RC.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced.
Isoform 1 (identifier: P60368-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASTMSICS SACTNSWQVD DCPESCCELP CGTPSCCAPA PCLTLVCTPV
60 70 80 90 100
SCVSSPCCQA ACEPSACQSG CTSSCTPSCC QQSSCQPACC TSSPCQQACC
110 120 130 140 150
VPVCCKPVCC VPVCCGASSC CQQSSCQPAC CASSSCQQSC RVPVCCKAVC
160 170 180 190 200
CVPTCSESSS SCCQQSSCQP ACCTSSPCQQ SCCVSVCCKP VCCKSICCVP
210 220 230 240 250
VCSGASSPCC QQSSCQPACC TSSCCRPSSS VSLLCRPVCS RPASCSFSSG

QKSSC
Length:255
Mass (Da):25,616
Last modified:February 16, 2004 - v1
Checksum:i13CCCC3B85126110
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151N → D.1 Publication
Corresponds to variant rs233240 [ dbSNP | Ensembl ].
VAR_017690
Natural varianti107 – 1071P → T.1 Publication
Corresponds to variant rs478967 [ dbSNP | Ensembl ].
VAR_017691
Natural varianti117 – 1171A → P.1 Publication
Corresponds to variant rs233239 [ dbSNP | Ensembl ].
VAR_017692
Natural varianti177 – 1771P → L.
Corresponds to variant rs2329834 [ dbSNP | Ensembl ].
VAR_053462
Natural varianti241 – 2411R → G.1 Publication
Corresponds to variant rs146792277 [ dbSNP | Ensembl ].
VAR_017693

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076348 mRNA. Translation: BAD01535.1.
AP001067 Genomic DNA. No translation available.
AJ566381 mRNA. Translation: CAD97462.1.
CCDSiCCDS42955.1. [P60368-1]
RefSeqiNP_941966.1. NM_198693.3. [P60368-1]
UniGeneiHs.664660.
Hs.689667.

Genome annotation databases

EnsembliENST00000391621; ENSP00000375479; ENSG00000205445. [P60368-1]
GeneIDi386679.
KEGGihsa:386679.
UCSCiuc002zfi.2. human. [P60368-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076348 mRNA. Translation: BAD01535.1.
AP001067 Genomic DNA. No translation available.
AJ566381 mRNA. Translation: CAD97462.1.
CCDSiCCDS42955.1. [P60368-1]
RefSeqiNP_941966.1. NM_198693.3. [P60368-1]
UniGeneiHs.664660.
Hs.689667.

3D structure databases

ProteinModelPortaliP60368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000375479.

Polymorphism and mutation databases

BioMutaiKRTAP10-2.
DMDMi42558948.

Proteomic databases

PaxDbiP60368.
PeptideAtlasiP60368.
PRIDEiP60368.

Protocols and materials databases

DNASUi386679.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391621; ENSP00000375479; ENSG00000205445. [P60368-1]
GeneIDi386679.
KEGGihsa:386679.
UCSCiuc002zfi.2. human. [P60368-1]

Organism-specific databases

CTDi386679.
GeneCardsiKRTAP10-2.
HGNCiHGNC:22967. KRTAP10-2.
neXtProtiNX_P60368.
PharmGKBiPA134989110.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JH3R. Eukaryota.
ENOG4111BSI. LUCA.
GeneTreeiENSGT00780000121948.
HOGENOMiHOG000234031.
HOVERGENiHBG108072.
InParanoidiP60368.
OMAiQSCCVSV.
OrthoDBiEOG091G17RC.
TreeFamiTF351356.

Miscellaneous databases

GenomeRNAii386679.
PROiP60368.

Gene expression databases

CleanExiHS_KRTAP10-2.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKR102_HUMAN
AccessioniPrimary (citable) accession number: P60368
Secondary accession number(s): Q70LJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.