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Protein

Manganese catalase

Gene
N/A
Organism
Lactobacillus plantarum
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 H2O2 = O2 + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Ca2+Note: Binds 1 Ca2+ ion per subunit.
  • Mn2+Note: Binds 2 manganese ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi35Manganese 11
Metal bindingi57Calcium1
Metal bindingi61Calcium1
Metal bindingi66Manganese 11
Metal bindingi66Manganese 21
Metal bindingi69Manganese 11
Metal bindingi148Manganese 21
Metal bindingi181Manganese 21
Metal bindingi218Calcium1
Metal bindingi220Calcium; via carbonyl oxygen1
Metal bindingi222Calcium; via carbonyl oxygen1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Ligandi

Calcium, Manganese, Metal-binding

Protein family/group databases

PeroxiBasei3978. LplMnCat01.

Names & Taxonomyi

Protein namesi
Recommended name:
Manganese catalase (EC:1.11.1.6)
Alternative name(s):
Pseudocatalase
OrganismiLactobacillus plantarum
Taxonomic identifieri1590 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi42Y → F: Loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000961551 – 266Manganese catalaseAdd BLAST266

Interactioni

Subunit structurei

Homohexamer.1 Publication

Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 4Combined sources3
Helixi19 – 30Combined sources12
Helixi35 – 48Combined sources14
Helixi53 – 80Combined sources28
Turni81 – 83Combined sources3
Helixi88 – 93Combined sources6
Helixi97 – 103Combined sources7
Helixi106 – 110Combined sources5
Beta strandi113 – 115Combined sources3
Helixi128 – 130Combined sources3
Helixi137 – 159Combined sources23
Helixi165 – 196Combined sources32
Beta strandi198 – 201Combined sources4
Turni205 – 207Combined sources3
Helixi210 – 212Combined sources3
Beta strandi215 – 217Combined sources3
Helixi224 – 228Combined sources5
Beta strandi240 – 244Combined sources5
Helixi259 – 261Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JKUX-ray1.84A/B/C/D/E/F1-266[»]
1JKVX-ray1.39A/B/C/D/E/F1-266[»]
1O9IX-ray1.33A/B/C/D/E/F1-266[»]
ProteinModelPortaliP60355.
SMRiP60355.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60355.

Family & Domainsi

Sequence similaritiesi

Belongs to the manganese catalase family.Curated

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
3.30.1530.10. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR007760. Mn_catalase.
IPR027407. Mn_catalase_dom2.
[Graphical view]
PfamiPF05067. Mn_catalase. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

P60355-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKHTRKLQY NAKPDRSDPI MARRLQESLG GQWGETTGMM SYLSQGWAST
60 70 80 90 100
GAEKYKDLLL DTGTEEMAHV EMISTMIGYL LEDAPFGPED LKRDPSLATT
110 120 130 140 150
MAGMDPEHSL VHGLNASLNN PNGAAWNAGY VTSSGNLVAD MRFNVVRESE
160 170 180 190 200
ARLQVSRLYS MTEDEGVRDM LKFLLARETQ HQLQFMKAQE ELEEKYGIIV
210 220 230 240 250
PGDMKEIEHS EFSHVLMNFS DGDGSKAFEG QVAKDGEKFT YQENPEAMGG
260
IPHIKPGDPR LHNHQG
Length:266
Mass (Da):29,743
Last modified:February 16, 2004 - v1
Checksum:i2943A15DD7A60CB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87070 Genomic DNA. Translation: BAA13239.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87070 Genomic DNA. Translation: BAA13239.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JKUX-ray1.84A/B/C/D/E/F1-266[»]
1JKVX-ray1.39A/B/C/D/E/F1-266[»]
1O9IX-ray1.33A/B/C/D/E/F1-266[»]
ProteinModelPortaliP60355.
SMRiP60355.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei3978. LplMnCat01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP60355.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
3.30.1530.10. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR007760. Mn_catalase.
IPR027407. Mn_catalase_dom2.
[Graphical view]
PfamiPF05067. Mn_catalase. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMCAT_LACPN
AccessioniPrimary (citable) accession number: P60355
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.