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P60337

- BETA_STAAN

UniProt

P60337 - BETA_STAAN

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei475 – 4751UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 3830FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-2568-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:SA2405
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000751: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Oxygen-dependent choline dehydrogenasePRO_0000205597Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi158879.SA2405.

Structurei

3D structure databases

ProteinModelPortaliP60337.
SMRiP60337. Positions 5-540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60337-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNKNKSYDY VIIGGGSAGS VLGNRLSEDK DKEVLVLEAG RSDYFWDLFI
60 70 80 90 100
QMPAALMFPS GNKFYDWIYS TDEEPHMGGR KVAHARGKVL GGSSSINGMI
110 120 130 140 150
YQRGNPMDYE GWAEPEGMET WDFAHCLPYF KKLEKTYGAA PYDKFRGHDG
160 170 180 190 200
PIKLKRGPAT NPLFQSFFDA GVEAGYHKTP DVNGFRQEGF GPFDSQVHRG
210 220 230 240 250
RRMSASRAYL HPAMKRKNLT VETRAFVTEI HYEGRRATGV TYKKNGKLHT
260 270 280 290 300
IDANEVILSG GAFNTPQLLQ LSGIGDSEFL KSKGIEPRVH LPGVGENFED
310 320 330 340 350
HLEVYIQHKC KEPVSLQPSL DIKRMPFIGL QWIFTRTGAA ASNHFEGGGF
360 370 380 390 400
VRSNNEVDYP NLMFHFLPIA VRYDGQKAAV AHGYQVHVGP MYSNSRGSLK
410 420 430 440 450
IKSKDPFEKP SIRFNYLSTE EDKKEWVEAI RVARNILSQK AMDPFNGGEI
460 470 480 490 500
SPGPEVQTDE EILDWVRRDG ETALHPSCSA KMGPASDPMA VVDPLTMKVH
510 520 530 540 550
GMENLRVVDA SAMPRTTNGN IHAPVLMLAE KAADIIRGRK PLEPQYIDYY
560
KHGVHDENEG AIEVKPYAK
Length:569
Mass (Da):63,610
Last modified:February 16, 2004 - v1
Checksum:iA6E35293AADDDFA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB43710.1.
PIRiD90068.
RefSeqiNP_375731.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB43710; BAB43710; BAB43710.
GeneIDi1125334.
KEGGisau:SA2405.
PATRICi19577376. VBIStaAur116463_2606.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB43710.1 .
PIRi D90068.
RefSeqi NP_375731.1. NC_002745.2.

3D structure databases

ProteinModelPortali P60337.
SMRi P60337. Positions 5-540.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158879.SA2405.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB43710 ; BAB43710 ; BAB43710 .
GeneIDi 1125334.
KEGGi sau:SA2405.
PATRICi 19577376. VBIStaAur116463_2606.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci SAUR158879:GJCB-2568-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.
  2. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
    Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
    Submitted (OCT-2007) to UniProtKB
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: N315.

Entry informationi

Entry nameiBETA_STAAN
AccessioniPrimary (citable) accession number: P60337
Secondary accession number(s): Q99R25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: October 1, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3