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P60336

- BETA_STAAM

UniProt

P60336 - BETA_STAAM

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Protein

Oxygen-dependent choline dehydrogenase

Gene
betA, SAV2612
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei475 – 4751 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 3830FAD By similarityAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2680-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:SAV2612
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002481: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Oxygen-dependent choline dehydrogenaseUniRule annotationPRO_0000205596Add
BLAST

2D gel databases

World-2DPAGE0002:P60336.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2612.

Structurei

3D structure databases

ProteinModelPortaliP60336.
SMRiP60336. Positions 5-540.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.
PhylomeDBiP60336.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60336-1 [UniParc]FASTAAdd to Basket

« Hide

MSNKNKSYDY VIIGGGSAGS VLGNRLSEDK DKEVLVLEAG RSDYFWDLFI    50
QMPAALMFPS GNKFYDWIYS TDEEPHMGGR KVAHARGKVL GGSSSINGMI 100
YQRGNPMDYE GWAEPEGMET WDFAHCLPYF KKLEKTYGAA PYDKFRGHDG 150
PIKLKRGPAT NPLFQSFFDA GVEAGYHKTP DVNGFRQEGF GPFDSQVHRG 200
RRMSASRAYL HPAMKRKNLT VETRAFVTEI HYEGRRATGV TYKKNGKLHT 250
IDANEVILSG GAFNTPQLLQ LSGIGDSEFL KSKGIEPRVH LPGVGENFED 300
HLEVYIQHKC KEPVSLQPSL DIKRMPFIGL QWIFTRTGAA ASNHFEGGGF 350
VRSNNEVDYP NLMFHFLPIA VRYDGQKAAV AHGYQVHVGP MYSNSRGSLK 400
IKSKDPFEKP SIRFNYLSTE EDKKEWVEAI RVARNILSQK AMDPFNGGEI 450
SPGPEVQTDE EILDWVRRDG ETALHPSCSA KMGPASDPMA VVDPLTMKVH 500
GMENLRVVDA SAMPRTTNGN IHAPVLMLAE KAADIIRGRK PLEPQYIDYY 550
KHGVHDENEG AIEVKPYAK 569
Length:569
Mass (Da):63,610
Last modified:February 16, 2004 - v1
Checksum:iA6E35293AADDDFA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB58774.1.
RefSeqiNP_373136.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58774; BAB58774; SAV2612.
GeneIDi1122637.
KEGGisav:SAV2612.
PATRICi19566160. VBIStaAur52173_2706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB58774.1 .
RefSeqi NP_373136.1. NC_002758.2.

3D structure databases

ProteinModelPortali P60336.
SMRi P60336. Positions 5-540.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158878.SAV2612.

2D gel databases

World-2DPAGE 0002:P60336.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB58774 ; BAB58774 ; SAV2612 .
GeneIDi 1122637.
KEGGi sav:SAV2612.
PATRICi 19566160. VBIStaAur52173_2706.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.
PhylomeDBi P60336.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci SAUR158878:GJJ5-2680-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiBETA_STAAM
AccessioniPrimary (citable) accession number: P60336
Secondary accession number(s): Q99R25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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