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Protein

Poly(rC)-binding protein 1

Gene

Pcbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.By similarity

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: MGI
  • mRNA 3'-UTR binding Source: UniProtKB
  • mRNA binding Source: MGI
  • poly(A) RNA binding Source: MGI
  • RNA binding Source: MGI
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: MGI
  • sequence-specific single stranded DNA binding Source: MGI
  • single-stranded DNA binding Source: MGI
  • translation activator activity Source: MGI

GO - Biological processi

  • mRNA processing Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • viral RNA genome replication Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

DNA-binding, RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72203. Processing of Capped Intron-Containing Pre-mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(rC)-binding protein 1
Alternative name(s):
Alpha-CP1
Heterogeneous nuclear ribonucleoprotein E1
Short name:
hnRNP E1
Gene namesi
Name:Pcbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1345635. Pcbp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000500881 – 356Poly(rC)-binding protein 1Add BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei173PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Modified residuei246PhosphoserineBy similarity1
Modified residuei264PhosphoserineBy similarity1
Modified residuei273PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP60335.
MaxQBiP60335.
PaxDbiP60335.
PeptideAtlasiP60335.
PRIDEiP60335.

2D gel databases

REPRODUCTION-2DPAGEIPI00128904.
P60335.

PTM databases

iPTMnetiP60335.
PhosphoSitePlusiP60335.

Expressioni

Gene expression databases

BgeeiENSMUSG00000051695.
CleanExiMM_PCBP1.
GenevisibleiP60335. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Hdac9Q99N136EBI-309059,EBI-645361

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204835. 9 interactors.
IntActiP60335. 13 interactors.
MINTiMINT-1850326.
STRINGi10090.ENSMUSP00000054863.

Structurei

3D structure databases

ProteinModelPortaliP60335.
SMRiP60335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 75KH 1PROSITE-ProRule annotationAdd BLAST63
Domaini97 – 162KH 2PROSITE-ProRule annotationAdd BLAST66
Domaini279 – 343KH 3PROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Contains 3 KH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2190. Eukaryota.
ENOG410XNN8. LUCA.
GeneTreeiENSGT00760000119144.
HOGENOMiHOG000182823.
HOVERGENiHBG053520.
InParanoidiP60335.
KOiK12889.
OMAiTIAGMPQ.
OrthoDBiEOG091G0DHI.
PhylomeDBiP60335.
TreeFamiTF318292.

Family and domain databases

Gene3Di3.30.1370.10. 3 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF00013. KH_1. 3 hits.
[Graphical view]
SMARTiSM00322. KH. 3 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 3 hits.
PROSITEiPS50084. KH_TYPE_1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAGVTESGL NVTLTIRLLM HGKEVGSIIG KKGESVKRIR EESGARINIS
60 70 80 90 100
EGNCPERIIT LTGPTNAIFK AFAMIIDKLE EDINSSMTNS TAASRPPVTL
110 120 130 140 150
RLVVPATQCG SLIGKGGCKI KEIRESTGAQ VQVAGDMLPN STERAITIAG
160 170 180 190 200
VPQSVTECVK QICLVMLETL SQSPQGRVMT IPYQPMPASS PVICAGGQDR
210 220 230 240 250
CSDAAGYPHA THDLEGPPLD AYSIQGQHTI SPLDLAKLNQ VARQQSHFAM
260 270 280 290 300
MHGGTGFAGI DSSSPEVKGY WASLDASTQT THELTIPNNL IGCIIGRQGA
310 320 330 340 350
NINEIRQMSG AQIKIANPVE GSSGRQVTIT GSAASISLAQ YLINARLSSE

KGMGCS
Length:356
Mass (Da):37,498
Last modified:February 16, 2004 - v1
Checksum:i6D1A261276CA206D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139894 mRNA. Translation: AAD51920.1.
AF139895 Genomic DNA. Translation: AAD51921.1.
BC069915 mRNA. Translation: AAH69915.1.
BC004793 mRNA. Translation: AAH04793.1.
CCDSiCCDS20314.1.
RefSeqiNP_035995.1. NM_011865.3.
UniGeneiMm.274146.

Genome annotation databases

EnsembliENSMUST00000053015; ENSMUSP00000054863; ENSMUSG00000051695.
GeneIDi23983.
KEGGimmu:23983.
UCSCiuc009csc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139894 mRNA. Translation: AAD51920.1.
AF139895 Genomic DNA. Translation: AAD51921.1.
BC069915 mRNA. Translation: AAH69915.1.
BC004793 mRNA. Translation: AAH04793.1.
CCDSiCCDS20314.1.
RefSeqiNP_035995.1. NM_011865.3.
UniGeneiMm.274146.

3D structure databases

ProteinModelPortaliP60335.
SMRiP60335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204835. 9 interactors.
IntActiP60335. 13 interactors.
MINTiMINT-1850326.
STRINGi10090.ENSMUSP00000054863.

PTM databases

iPTMnetiP60335.
PhosphoSitePlusiP60335.

2D gel databases

REPRODUCTION-2DPAGEIPI00128904.
P60335.

Proteomic databases

EPDiP60335.
MaxQBiP60335.
PaxDbiP60335.
PeptideAtlasiP60335.
PRIDEiP60335.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053015; ENSMUSP00000054863; ENSMUSG00000051695.
GeneIDi23983.
KEGGimmu:23983.
UCSCiuc009csc.1. mouse.

Organism-specific databases

CTDi5093.
MGIiMGI:1345635. Pcbp1.

Phylogenomic databases

eggNOGiKOG2190. Eukaryota.
ENOG410XNN8. LUCA.
GeneTreeiENSGT00760000119144.
HOGENOMiHOG000182823.
HOVERGENiHBG053520.
InParanoidiP60335.
KOiK12889.
OMAiTIAGMPQ.
OrthoDBiEOG091G0DHI.
PhylomeDBiP60335.
TreeFamiTF318292.

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72203. Processing of Capped Intron-Containing Pre-mRNA.

Miscellaneous databases

ChiTaRSiPcbp1. mouse.
PROiP60335.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051695.
CleanExiMM_PCBP1.
GenevisibleiP60335. MM.

Family and domain databases

Gene3Di3.30.1370.10. 3 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF00013. KH_1. 3 hits.
[Graphical view]
SMARTiSM00322. KH. 3 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 3 hits.
PROSITEiPS50084. KH_TYPE_1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCBP1_MOUSE
AccessioniPrimary (citable) accession number: P60335
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.