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P60334

- CDO1_MOUSE

UniProt

P60334 - CDO1_MOUSE

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Protein

Cysteine dioxygenase type 1

Gene

Cdo1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-cysteine + O2 = 3-sulfinoalanine.

Cofactori

Fe2+, Ni2+, Zn2+Note: Binds 1 Fe(2+) cation per subunit. Ni(2+) and Zn(2+) can be used to a lesser extent.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Iron; catalytic
Metal bindingi88 – 881Iron; catalytic
Metal bindingi140 – 1401Iron; catalytic

GO - Molecular functioni

  1. cysteine dioxygenase activity Source: MGI
  2. ferrous iron binding Source: Ensembl

GO - Biological processi

  1. lactation Source: Ensembl
  2. L-cysteine catabolic process to taurine Source: MGI
  3. response to amino acid Source: Ensembl
  4. response to cAMP Source: Ensembl
  5. response to ethanol Source: Ensembl
  6. response to glucagon Source: Ensembl
  7. response to glucocorticoid Source: Ensembl
  8. taurine biosynthetic process Source: UniProtKB-UniPathway
  9. taurine metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_198964. Degradation of cysteine and homocysteine.
REACT_258600. CDO in myogenesis.
UniPathwayiUPA00012; UER00537.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine dioxygenase type 1 (EC:1.13.11.20)
Alternative name(s):
Cysteine dioxygenase type I
Short name:
CDO
Short name:
CDO-I
Gene namesi
Name:Cdo1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:105925. Cdo1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. plasma membrane Source: Reactome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Cysteine dioxygenase type 1PRO_0000206607Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki93 ↔ 1573'-(S-cysteinyl)-tyrosine (Cys-Tyr)

Post-translational modificationi

The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.

Keywords - PTMi

Thioether bond

Proteomic databases

MaxQBiP60334.
PaxDbiP60334.
PRIDEiP60334.

2D gel databases

REPRODUCTION-2DPAGEP60334.

PTM databases

PhosphoSiteiP60334.

Expressioni

Tissue specificityi

Highest expression in liver. Also expressed in kidney, lung, brain and small intestine.1 Publication

Gene expression databases

BgeeiP60334.
CleanExiMM_CDO1.
GenevestigatoriP60334.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046517.

Structurei

Secondary structure

1
200
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi12 – 2211Combined sources
Beta strandi24 – 274Combined sources
Helixi30 – 3910Combined sources
Helixi44 – 474Combined sources
Helixi48 – 503Combined sources
Beta strandi55 – 573Combined sources
Beta strandi59 – 646Combined sources
Helixi66 – 683Combined sources
Beta strandi71 – 777Combined sources
Beta strandi92 – 1009Combined sources
Beta strandi102 – 1076Combined sources
Beta strandi112 – 1143Combined sources
Beta strandi121 – 1255Combined sources
Beta strandi130 – 1334Combined sources
Turni135 – 1373Combined sources
Beta strandi139 – 1435Combined sources
Beta strandi151 – 1599Combined sources
Beta strandi162 – 1676Combined sources
Turni169 – 1713Combined sources
Beta strandi174 – 1785Combined sources
Beta strandi182 – 1843Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ATFX-ray1.75A2-200[»]
2Q4SX-ray1.75A2-200[»]
ProteinModelPortaliP60334.
SMRiP60334. Positions 5-190.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60334.

Family & Domainsi

Sequence similaritiesi

Belongs to the cysteine dioxygenase family.Curated

Phylogenomic databases

eggNOGiNOG126313.
GeneTreeiENSGT00390000018226.
HOGENOMiHOG000177818.
HOVERGENiHBG004469.
InParanoidiP60334.
KOiK00456.
OMAiKMTFWSK.
OrthoDBiEOG77M8PK.
PhylomeDBiP60334.
TreeFamiTF105636.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

P60334-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERTELLKPR TLADLIRILH ELFAGDEVNV EEVQAVLEAY ESNPAEWALY
60 70 80 90 100
AKFDQYRYTR NLVDQGNGKF NLMILCWGEG HGSSIHDHTD SHCFLKLLQG
110 120 130 140 150
NLKETLFDWP DKKSNEMIKK SERTLRENQC AYINDSIGLH RVENVSHTEP
160 170 180 190 200
AVSLHLYSPP FDTCHAFDQR TGHKNKVTMT FHSKFGIRTP FTTSGSLENN
Length:200
Mass (Da):23,026
Last modified:February 16, 2004 - v1
Checksum:i118F1A3326B340F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF355472
, AF355469, AF355470, AF355471 Genomic DNA. Translation: AAK53364.1.
AK004249 mRNA. Translation: BAB23236.1.
AK149582 mRNA. Translation: BAE28973.1.
BC013638 mRNA. Translation: AAH13638.1.
CCDSiCCDS29234.1.
RefSeqiNP_149026.1. NM_033037.3.
UniGeneiMm.241056.

Genome annotation databases

EnsembliENSMUST00000035804; ENSMUSP00000046517; ENSMUSG00000033022.
GeneIDi12583.
KEGGimmu:12583.
UCSCiuc008evt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF355472
, AF355469 , AF355470 , AF355471 Genomic DNA. Translation: AAK53364.1 .
AK004249 mRNA. Translation: BAB23236.1 .
AK149582 mRNA. Translation: BAE28973.1 .
BC013638 mRNA. Translation: AAH13638.1 .
CCDSi CCDS29234.1.
RefSeqi NP_149026.1. NM_033037.3.
UniGenei Mm.241056.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ATF X-ray 1.75 A 2-200 [» ]
2Q4S X-ray 1.75 A 2-200 [» ]
ProteinModelPortali P60334.
SMRi P60334. Positions 5-190.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000046517.

PTM databases

PhosphoSitei P60334.

2D gel databases

REPRODUCTION-2DPAGE P60334.

Proteomic databases

MaxQBi P60334.
PaxDbi P60334.
PRIDEi P60334.

Protocols and materials databases

DNASUi 12583.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035804 ; ENSMUSP00000046517 ; ENSMUSG00000033022 .
GeneIDi 12583.
KEGGi mmu:12583.
UCSCi uc008evt.1. mouse.

Organism-specific databases

CTDi 1036.
MGIi MGI:105925. Cdo1.

Phylogenomic databases

eggNOGi NOG126313.
GeneTreei ENSGT00390000018226.
HOGENOMi HOG000177818.
HOVERGENi HBG004469.
InParanoidi P60334.
KOi K00456.
OMAi KMTFWSK.
OrthoDBi EOG77M8PK.
PhylomeDBi P60334.
TreeFami TF105636.

Enzyme and pathway databases

UniPathwayi UPA00012 ; UER00537 .
Reactomei REACT_198964. Degradation of cysteine and homocysteine.
REACT_258600. CDO in myogenesis.

Miscellaneous databases

EvolutionaryTracei P60334.
NextBioi 281718.
PROi P60334.
SOURCEi Search...

Gene expression databases

Bgeei P60334.
CleanExi MM_CDO1.
Genevestigatori P60334.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF05995. CDO_I. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine cysteine dioxygenase gene: structural organization, tissue-specific expression and promoter identification."
    Hirschberger L.L., Daval S., Stover P.J., Stipanuk M.H.
    Gene 277:153-161(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  4. Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH NICKEL IONS, CROSS-LINK, SUBUNIT.

Entry informationi

Entry nameiCDO1_MOUSE
AccessioniPrimary (citable) accession number: P60334
Secondary accession number(s): Q3UED8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3