Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P60334

- CDO1_MOUSE

UniProt

P60334 - CDO1_MOUSE

Protein

Cysteine dioxygenase type 1

Gene

Cdo1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (16 Feb 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    L-cysteine + O2 = 3-sulfinoalanine.

    Cofactori

    Binds 1 iron ion per subunit. Nickel and zinc to a lesser extent.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi86 – 861Iron; catalytic
    Metal bindingi88 – 881Iron; catalytic
    Metal bindingi140 – 1401Iron; catalytic

    GO - Molecular functioni

    1. cysteine dioxygenase activity Source: MGI
    2. ferrous iron binding Source: Ensembl

    GO - Biological processi

    1. lactation Source: Ensembl
    2. L-cysteine catabolic process to taurine Source: MGI
    3. response to amino acid Source: Ensembl
    4. response to cAMP Source: Ensembl
    5. response to ethanol Source: Ensembl
    6. response to glucagon Source: Ensembl
    7. response to glucocorticoid Source: Ensembl
    8. taurine biosynthetic process Source: UniProtKB-UniPathway
    9. taurine metabolic process Source: MGI

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_198964. Degradation of cysteine and homocysteine.
    UniPathwayiUPA00012; UER00537.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine dioxygenase type 1 (EC:1.13.11.20)
    Alternative name(s):
    Cysteine dioxygenase type I
    Short name:
    CDO
    Short name:
    CDO-I
    Gene namesi
    Name:Cdo1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:105925. Cdo1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: MGI
    2. plasma membrane Source: Reactome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 200200Cysteine dioxygenase type 1PRO_0000206607Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki93 ↔ 1573'-(S-cysteinyl)-tyrosine (Cys-Tyr)

    Post-translational modificationi

    The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.

    Keywords - PTMi

    Thioether bond

    Proteomic databases

    MaxQBiP60334.
    PaxDbiP60334.
    PRIDEiP60334.

    2D gel databases

    REPRODUCTION-2DPAGEP60334.

    PTM databases

    PhosphoSiteiP60334.

    Expressioni

    Tissue specificityi

    Highest expression in liver. Also expressed in kidney, lung, brain and small intestine.1 Publication

    Gene expression databases

    BgeeiP60334.
    CleanExiMM_CDO1.
    GenevestigatoriP60334.

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000046517.

    Structurei

    Secondary structure

    1
    200
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi12 – 2211
    Beta strandi24 – 274
    Helixi30 – 3910
    Helixi44 – 474
    Helixi48 – 503
    Beta strandi55 – 573
    Beta strandi59 – 646
    Helixi66 – 683
    Beta strandi71 – 777
    Beta strandi92 – 1009
    Beta strandi102 – 1076
    Beta strandi112 – 1143
    Beta strandi121 – 1255
    Beta strandi130 – 1334
    Turni135 – 1373
    Beta strandi139 – 1435
    Beta strandi151 – 1599
    Beta strandi162 – 1676
    Turni169 – 1713
    Beta strandi174 – 1785
    Beta strandi182 – 1843

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ATFX-ray1.75A2-200[»]
    2Q4SX-ray1.75A2-200[»]
    ProteinModelPortaliP60334.
    SMRiP60334. Positions 5-190.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP60334.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cysteine dioxygenase family.Curated

    Phylogenomic databases

    eggNOGiNOG126313.
    GeneTreeiENSGT00390000018226.
    HOGENOMiHOG000177818.
    HOVERGENiHBG004469.
    InParanoidiP60334.
    KOiK00456.
    OMAiKMTFWSK.
    OrthoDBiEOG77M8PK.
    PhylomeDBiP60334.
    TreeFamiTF105636.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR010300. Cys_dOase_I.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF05995. CDO_I. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P60334-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERTELLKPR TLADLIRILH ELFAGDEVNV EEVQAVLEAY ESNPAEWALY    50
    AKFDQYRYTR NLVDQGNGKF NLMILCWGEG HGSSIHDHTD SHCFLKLLQG 100
    NLKETLFDWP DKKSNEMIKK SERTLRENQC AYINDSIGLH RVENVSHTEP 150
    AVSLHLYSPP FDTCHAFDQR TGHKNKVTMT FHSKFGIRTP FTTSGSLENN 200
    Length:200
    Mass (Da):23,026
    Last modified:February 16, 2004 - v1
    Checksum:i118F1A3326B340F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF355472
    , AF355469, AF355470, AF355471 Genomic DNA. Translation: AAK53364.1.
    AK004249 mRNA. Translation: BAB23236.1.
    AK149582 mRNA. Translation: BAE28973.1.
    BC013638 mRNA. Translation: AAH13638.1.
    CCDSiCCDS29234.1.
    RefSeqiNP_149026.1. NM_033037.3.
    UniGeneiMm.241056.

    Genome annotation databases

    EnsembliENSMUST00000035804; ENSMUSP00000046517; ENSMUSG00000033022.
    GeneIDi12583.
    KEGGimmu:12583.
    UCSCiuc008evt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF355472
    , AF355469 , AF355470 , AF355471 Genomic DNA. Translation: AAK53364.1 .
    AK004249 mRNA. Translation: BAB23236.1 .
    AK149582 mRNA. Translation: BAE28973.1 .
    BC013638 mRNA. Translation: AAH13638.1 .
    CCDSi CCDS29234.1.
    RefSeqi NP_149026.1. NM_033037.3.
    UniGenei Mm.241056.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ATF X-ray 1.75 A 2-200 [» ]
    2Q4S X-ray 1.75 A 2-200 [» ]
    ProteinModelPortali P60334.
    SMRi P60334. Positions 5-190.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000046517.

    PTM databases

    PhosphoSitei P60334.

    2D gel databases

    REPRODUCTION-2DPAGE P60334.

    Proteomic databases

    MaxQBi P60334.
    PaxDbi P60334.
    PRIDEi P60334.

    Protocols and materials databases

    DNASUi 12583.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035804 ; ENSMUSP00000046517 ; ENSMUSG00000033022 .
    GeneIDi 12583.
    KEGGi mmu:12583.
    UCSCi uc008evt.1. mouse.

    Organism-specific databases

    CTDi 1036.
    MGIi MGI:105925. Cdo1.

    Phylogenomic databases

    eggNOGi NOG126313.
    GeneTreei ENSGT00390000018226.
    HOGENOMi HOG000177818.
    HOVERGENi HBG004469.
    InParanoidi P60334.
    KOi K00456.
    OMAi KMTFWSK.
    OrthoDBi EOG77M8PK.
    PhylomeDBi P60334.
    TreeFami TF105636.

    Enzyme and pathway databases

    UniPathwayi UPA00012 ; UER00537 .
    Reactomei REACT_198964. Degradation of cysteine and homocysteine.

    Miscellaneous databases

    EvolutionaryTracei P60334.
    NextBioi 281718.
    PROi P60334.
    SOURCEi Search...

    Gene expression databases

    Bgeei P60334.
    CleanExi MM_CDO1.
    Genevestigatori P60334.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR010300. Cys_dOase_I.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF05995. CDO_I. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Murine cysteine dioxygenase gene: structural organization, tissue-specific expression and promoter identification."
      Hirschberger L.L., Daval S., Stover P.J., Stipanuk M.H.
      Gene 277:153-161(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    4. Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH NICKEL IONS, CROSS-LINK, SUBUNIT.

    Entry informationi

    Entry nameiCDO1_MOUSE
    AccessioniPrimary (citable) accession number: P60334
    Secondary accession number(s): Q3UED8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: February 16, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3