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Protein

Keratin-associated protein 12-4

Gene

KRTAP12-4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Enzyme and pathway databases

BioCyciZFISH:G66-30804-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 12-4
Alternative name(s):
High sulfur keratin-associated protein 12.4
Keratin-associated protein 12.4
Gene namesi
Name:KRTAP12-4
Synonyms:KAP12.4, KRTAP12.4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:20532. KRTAP12-4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000212933.
PharmGKBiPA134932676.

Polymorphism and mutation databases

BioMutaiKRTAP12-4.
DMDMi41688566.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001851991 – 112Keratin-associated protein 12-4Add BLAST112

Proteomic databases

PaxDbiP60329.
PRIDEiP60329.

Expressioni

Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

CleanExiHS_KRTAP12-4.

Organism-specific databases

HPAiCAB016204.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
ARID5AC9J1Q03EBI-10176396,EBI-10176351
HMGB4Q8WW323EBI-10176396,EBI-10277297
HOXA1P496397EBI-10176396,EBI-740785
IQUBQ8NA545EBI-10176396,EBI-10220600
MEOX2A4D1275EBI-10176396,EBI-10172134
NOTCH2NLQ7Z3S95EBI-10176396,EBI-945833
OTX1P322427EBI-10176396,EBI-740446
PIH1D2Q8WWB55EBI-10176396,EBI-10232538
VENTXO952313EBI-10176396,EBI-10191303

Protein-protein interaction databases

BioGridi132135. 9 interactors.
IntActiP60329. 18 interactors.
STRINGi9606.ENSP00000375476.

Structurei

3D structure databases

ProteinModelPortaliP60329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 1415
Repeati20 – 2425
Repeati25 – 2935
Repeati35 – 3945
Repeati41 – 4555
Repeati46 – 5065
Repeati56 – 6075
Repeati61 – 6585
Repeati66 – 7095
Repeati71 – 75105
Repeati76 – 80115
Repeati81 – 85125
Repeati86 – 90135
Repeati91 – 95145
Repeati96 – 100155

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 10015 X 5 AA approximate repeatsAdd BLAST91

Sequence similaritiesi

Belongs to the KRTAP type 12 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4726. Eukaryota.
ENOG410XY8D. LUCA.
GeneTreeiENSGT00720000108835.
HOGENOMiHOG000234031.
HOVERGENiHBG095457.
InParanoidiP60329.
OMAiPSTCYPP.
OrthoDBiEOG091G0SMR.
PhylomeDBiP60329.
TreeFamiTF339135.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.

Sequencei

Sequence statusi: Complete.

P60329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHTSHSSGC PMACPGSPCC VPSTCYPPEG YGTSCCCSAP CVALLCRPLC
60 70 80 90 100
GVSTCCQPAC CVPSPCQVAC CVPVSCKPVL CVASFCPTSG CCQPFCPTLV
110
YRPVTWSTPT GC
Length:112
Mass (Da):11,433
Last modified:February 2, 2004 - v1
Checksum:i05DC36FA889EB98A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076360 mRNA. Translation: BAD01547.1.
AL773602 Genomic DNA. No translation available.
BC125198 mRNA. Translation: AAI25199.1.
CCDSiCCDS42963.1.
RefSeqiNP_941971.1. NM_198698.1.
UniGeneiHs.689664.

Genome annotation databases

EnsembliENST00000391618; ENSP00000375476; ENSG00000212933.
GeneIDi386684.
KEGGihsa:386684.
UCSCiuc002zfs.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076360 mRNA. Translation: BAD01547.1.
AL773602 Genomic DNA. No translation available.
BC125198 mRNA. Translation: AAI25199.1.
CCDSiCCDS42963.1.
RefSeqiNP_941971.1. NM_198698.1.
UniGeneiHs.689664.

3D structure databases

ProteinModelPortaliP60329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132135. 9 interactors.
IntActiP60329. 18 interactors.
STRINGi9606.ENSP00000375476.

Polymorphism and mutation databases

BioMutaiKRTAP12-4.
DMDMi41688566.

Proteomic databases

PaxDbiP60329.
PRIDEiP60329.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391618; ENSP00000375476; ENSG00000212933.
GeneIDi386684.
KEGGihsa:386684.
UCSCiuc002zfs.1. human.

Organism-specific databases

CTDi386684.
GeneCardsiKRTAP12-4.
HGNCiHGNC:20532. KRTAP12-4.
HPAiCAB016204.
neXtProtiNX_P60329.
OpenTargetsiENSG00000212933.
PharmGKBiPA134932676.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4726. Eukaryota.
ENOG410XY8D. LUCA.
GeneTreeiENSGT00720000108835.
HOGENOMiHOG000234031.
HOVERGENiHBG095457.
InParanoidiP60329.
OMAiPSTCYPP.
OrthoDBiEOG091G0SMR.
PhylomeDBiP60329.
TreeFamiTF339135.

Enzyme and pathway databases

BioCyciZFISH:G66-30804-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.

Miscellaneous databases

GenomeRNAii386684.
PROiP60329.

Gene expression databases

CleanExiHS_KRTAP12-4.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKR124_HUMAN
AccessioniPrimary (citable) accession number: P60329
Secondary accession number(s): Q08AF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 2, 2004
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.