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Protein

Nanos homolog 3

Gene

NANOS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 111Nanos-typePROSITE-ProRule annotationAdd BLAST55

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processDifferentiation, Oogenesis, Spermatogenesis, Translation regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nanos homolog 3
Short name:
NOS-3
Gene namesi
Name:NANOS3
Synonyms:NOS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000187556.7.
HGNCiHGNC:22048. NANOS3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi342977.
OpenTargetsiENSG00000187556.
PharmGKBiPA134867615.

Polymorphism and mutation databases

BioMutaiNANOS3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076891 – 173Nanos homolog 3Add BLAST173

Proteomic databases

PeptideAtlasiP60323.
PRIDEiP60323.

PTM databases

iPTMnetiP60323.
PhosphoSitePlusiP60323.
SwissPalmiP60323.

Expressioni

Tissue specificityi

Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids.1 Publication

Developmental stagei

Fetal ovary and fetal testis (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000187556.
CleanExiHS_NANOS3.
HS_NOS3.
GenevisibleiP60323. HS.

Organism-specific databases

HPAiHPA062989.

Interactioni

Subunit structurei

Binds mRNA from germ cells. Interacts with PUM2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi131219. 4 interactors.
ELMiP60323.

Structurei

3D structure databases

ProteinModelPortaliP60323.
SMRiP60323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi58 – 85C2HC 1Add BLAST28
Motifi93 – 109C2HC 2Add BLAST17

Domaini

The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.PROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the nanos family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 111Nanos-typePROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00640000091383.
HOGENOMiHOG000082528.
HOVERGENiHBG052575.
InParanoidiP60323.
KOiK18761.
OMAiFDLWTDY.
OrthoDBiEOG091G0JUB.
PhylomeDBiP60323.
TreeFamiTF326882.

Family and domain databases

InterProiView protein in InterPro
IPR008705. Nanos/Xcar2.
IPR024161. Znf_nanos-typ.
PANTHERiPTHR12887. PTHR12887. 1 hit.
PfamiView protein in Pfam
PF05741. zf-nanos. 1 hit.
PROSITEiView protein in PROSITE
PS51522. ZF_NANOS. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P60323-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTFDLWTDY LGLAHLVRAL SGKEGPETRL SPQPEPEPML EPDQKRSLES
60 70 80 90 100
SPAPERLCSF CKHNGESRAI YQSHVLKDEA GRVLCPILRD YVCPQCGATR
110 120 130 140 150
ERAHTRRFCP LTGQGYTSVY SHTTRNSAGK KLVRPDKAKT QDTGHRRGGG
160 170
GGAGFRGAGK SEPSPSCSPS MST
Length:173
Mass (Da):18,844
Last modified:February 2, 2004 - v1
Checksum:i14C18866070795D9
GO
Isoform 2 (identifier: P60323-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-42: P → PVSALEPMPAPESVPVPGPK

Show »
Length:192
Mass (Da):20,728
Checksum:i9702678D89D57EAF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03869542P → PVSALEPMPAPESVPVPGPK in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020916 Genomic DNA. No translation available.
BC101209 mRNA. Translation: AAI01210.1.
BC101210 mRNA. Translation: AAI01211.1.
BM702754 mRNA. No translation available.
CCDSiCCDS42511.1. [P60323-2]
RefSeqiNP_001092092.1. NM_001098622.2. [P60323-2]
UniGeneiHs.127982.

Genome annotation databases

EnsembliENST00000339133; ENSP00000341992; ENSG00000187556. [P60323-2]
ENST00000397555; ENSP00000380687; ENSG00000187556. [P60323-1]
GeneIDi342977.
KEGGihsa:342977.
UCSCiuc002mxj.5. human. [P60323-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNANO3_HUMAN
AccessioniPrimary (citable) accession number: P60323
Secondary accession number(s): Q495E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 2, 2004
Last modified: September 27, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families