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P60321

- NANO2_HUMAN

UniProt

P60321 - NANO2_HUMAN

Protein

Nanos homolog 2

Gene

NANOS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri62 – 11655Nanos-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. germ-line stem cell maintenance Source: UniProtKB
    2. mRNA catabolic process Source: UniProtKB
    3. multicellular organismal development Source: UniProtKB-KW
    4. negative regulation of meiosis Source: UniProtKB
    5. regulation of translation Source: UniProtKB-KW
    6. spermatogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis, Translation regulation

    Keywords - Ligandi

    Metal-binding, RNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nanos homolog 2
    Short name:
    NOS-2
    Gene namesi
    Name:NANOS2
    Synonyms:NOS2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:23292. NANOS2.

    Subcellular locationi

    Cytoplasm 1 Publication. CytoplasmP-body By similarity. Cytoplasmperinuclear region 1 Publication
    Note: Localizes at P-bodies during gonocyte development By similarity. More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytoplasmic mRNA processing body Source: UniProtKB
    3. nucleus Source: UniProtKB
    4. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134909776.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 138138Nanos homolog 2PRO_0000207687Add
    BLAST

    Proteomic databases

    PaxDbiP60321.
    PRIDEiP60321.

    Expressioni

    Tissue specificityi

    Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level).2 Publications

    Developmental stagei

    Fetal ovary and fetal testis. Present in all germ cells of seminiferous tubules of the 24-week fetus (at protein level).2 Publications

    Gene expression databases

    BgeeiP60321.
    CleanExiHS_NANOS2.
    HS_NOS2.
    GenevestigatoriP60321.

    Organism-specific databases

    HPAiHPA014190.

    Interactioni

    Subunit structurei

    Interacts with CNOT1, CNOT3, CNOT6L, CNOT7 and CNOT9.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000341021.

    Structurei

    3D structure databases

    ProteinModelPortaliP60321.
    SMRiP60321. Positions 62-115.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi63 – 9028C2HC 1Add
    BLAST
    Motifi98 – 11417C2HC 2Add
    BLAST

    Domaini

    The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.PROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the nanos family.PROSITE-ProRule annotation
    Contains 1 nanos-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri62 – 11655Nanos-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG254777.
    HOGENOMiHOG000082528.
    HOVERGENiHBG052575.
    InParanoidiP60321.
    OMAiALCNFCK.
    OrthoDBiEOG7PGDT1.
    PhylomeDBiP60321.
    TreeFamiTF326882.

    Family and domain databases

    InterProiIPR008705. Nanos/Xcar2.
    IPR024161. Znf_nanos-typ.
    [Graphical view]
    PANTHERiPTHR12887. PTHR12887. 1 hit.
    PfamiPF05741. zf-nanos. 1 hit.
    [Graphical view]
    PROSITEiPS51522. ZF_NANOS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60321-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLPPFDMWK DYFNLSQVVW ALIASRGQRL ETQEIEEPSP GPPLGQDQGL    50
    GAPGANGGLG TLCNFCKHNG ESRHVYSSHQ LKTPDGVVVC PILRHYVCPV 100
    CGATGDQAHT LKYCPLNGGQ QSLYRRSGRN SAGRRVKR 138
    Length:138
    Mass (Da):15,132
    Last modified:February 2, 2004 - v1
    Checksum:i98469E0F1AA6BC11
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti68 – 681H → Q.1 Publication
    VAR_065246

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC042883 mRNA. Translation: AAH42883.1.
    BC117484 mRNA. Translation: AAI17485.1.
    BC117486 mRNA. Translation: AAI17487.1.
    CCDSiCCDS33056.1.
    RefSeqiNP_001025032.1. NM_001029861.2.
    UniGeneiHs.434218.

    Genome annotation databases

    EnsembliENST00000341294; ENSP00000341021; ENSG00000188425.
    GeneIDi339345.
    KEGGihsa:339345.
    UCSCiuc002pdu.3. human.

    Polymorphism databases

    DMDMi41688561.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC042883 mRNA. Translation: AAH42883.1 .
    BC117484 mRNA. Translation: AAI17485.1 .
    BC117486 mRNA. Translation: AAI17487.1 .
    CCDSi CCDS33056.1.
    RefSeqi NP_001025032.1. NM_001029861.2.
    UniGenei Hs.434218.

    3D structure databases

    ProteinModelPortali P60321.
    SMRi P60321. Positions 62-115.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000341021.

    Polymorphism databases

    DMDMi 41688561.

    Proteomic databases

    PaxDbi P60321.
    PRIDEi P60321.

    Protocols and materials databases

    DNASUi 339345.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341294 ; ENSP00000341021 ; ENSG00000188425 .
    GeneIDi 339345.
    KEGGi hsa:339345.
    UCSCi uc002pdu.3. human.

    Organism-specific databases

    CTDi 339345.
    GeneCardsi GC19M046416.
    HGNCi HGNC:23292. NANOS2.
    HPAi HPA014190.
    MIMi 608228. gene.
    neXtProti NX_P60321.
    PharmGKBi PA134909776.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG254777.
    HOGENOMi HOG000082528.
    HOVERGENi HBG052575.
    InParanoidi P60321.
    OMAi ALCNFCK.
    OrthoDBi EOG7PGDT1.
    PhylomeDBi P60321.
    TreeFami TF326882.

    Miscellaneous databases

    GenomeRNAii 339345.
    NextBioi 97363.
    PROi P60321.
    SOURCEi Search...

    Gene expression databases

    Bgeei P60321.
    CleanExi HS_NANOS2.
    HS_NOS2.
    Genevestigatori P60321.

    Family and domain databases

    InterProi IPR008705. Nanos/Xcar2.
    IPR024161. Znf_nanos-typ.
    [Graphical view ]
    PANTHERi PTHR12887. PTHR12887. 1 hit.
    Pfami PF05741. zf-nanos. 1 hit.
    [Graphical view ]
    PROSITEi PS51522. ZF_NANOS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction."
      Kusz K.M., Tomczyk L., Sajek M., Spik A., Latos-Bielenska A., Jedrzejczak P., Pawelczyk L., Jaruzelska J.
      Mol. Hum. Reprod. 15:165-171(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT GLN-68.
    3. "NANOS3 function in human germ cell development."
      Julaton V.T., Reijo Pera R.A.
      Hum. Mol. Genet. 20:2238-2250(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiNANO2_HUMAN
    AccessioniPrimary (citable) accession number: P60321
    Secondary accession number(s): Q17R30, Q4G0P8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: February 2, 2004
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3