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P60321

- NANO2_HUMAN

UniProt

P60321 - NANO2_HUMAN

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Protein
Nanos homolog 2
Gene
NANOS2, NOS2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri62 – 11655Nanos-type
Add
BLAST

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. mRNA catabolic process Source: UniProtKB
  3. multicellular organismal development Source: UniProtKB-KW
  4. negative regulation of meiosis Source: UniProtKB
  5. regulation of translation Source: UniProtKB-KW
  6. spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis, Translation regulation

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nanos homolog 2
Short name:
NOS-2
Gene namesi
Name:NANOS2
Synonyms:NOS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:23292. NANOS2.

Subcellular locationi

Cytoplasm. CytoplasmP-body By similarity. Cytoplasmperinuclear region
Note: Localizes at P-bodies during gonocyte development By similarity. More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoplasmic mRNA processing body Source: UniProtKB
  3. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909776.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Nanos homolog 2
PRO_0000207687Add
BLAST

Proteomic databases

PaxDbiP60321.
PRIDEiP60321.

Expressioni

Tissue specificityi

Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level).2 Publications

Developmental stagei

Fetal ovary and fetal testis. Present in all germ cells of seminiferous tubules of the 24-week fetus (at protein level).2 Publications

Gene expression databases

BgeeiP60321.
CleanExiHS_NANOS2.
HS_NOS2.
GenevestigatoriP60321.

Organism-specific databases

HPAiHPA014190.

Interactioni

Subunit structurei

Interacts with CNOT1, CNOT3, CNOT6L, CNOT7 and CNOT9 By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000341021.

Structurei

3D structure databases

ProteinModelPortaliP60321.
SMRiP60321. Positions 62-115.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi63 – 9028C2HC 1
Add
BLAST
Motifi98 – 11417C2HC 2
Add
BLAST

Domaini

The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein By similarity.

Sequence similaritiesi

Belongs to the nanos family.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG254777.
HOGENOMiHOG000082528.
HOVERGENiHBG052575.
InParanoidiP60321.
OMAiALCNFCK.
OrthoDBiEOG7PGDT1.
PhylomeDBiP60321.
TreeFamiTF326882.

Family and domain databases

InterProiIPR008705. Nanos/Xcar2.
IPR024161. Znf_nanos-typ.
[Graphical view]
PANTHERiPTHR12887. PTHR12887. 1 hit.
PfamiPF05741. zf-nanos. 1 hit.
[Graphical view]
PROSITEiPS51522. ZF_NANOS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60321-1 [UniParc]FASTAAdd to Basket

« Hide

MQLPPFDMWK DYFNLSQVVW ALIASRGQRL ETQEIEEPSP GPPLGQDQGL    50
GAPGANGGLG TLCNFCKHNG ESRHVYSSHQ LKTPDGVVVC PILRHYVCPV 100
CGATGDQAHT LKYCPLNGGQ QSLYRRSGRN SAGRRVKR 138
Length:138
Mass (Da):15,132
Last modified:February 2, 2004 - v1
Checksum:i98469E0F1AA6BC11
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681H → Q.1 Publication
VAR_065246

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC042883 mRNA. Translation: AAH42883.1.
BC117484 mRNA. Translation: AAI17485.1.
BC117486 mRNA. Translation: AAI17487.1.
CCDSiCCDS33056.1.
RefSeqiNP_001025032.1. NM_001029861.2.
UniGeneiHs.434218.

Genome annotation databases

EnsembliENST00000341294; ENSP00000341021; ENSG00000188425.
GeneIDi339345.
KEGGihsa:339345.
UCSCiuc002pdu.3. human.

Polymorphism databases

DMDMi41688561.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC042883 mRNA. Translation: AAH42883.1 .
BC117484 mRNA. Translation: AAI17485.1 .
BC117486 mRNA. Translation: AAI17487.1 .
CCDSi CCDS33056.1.
RefSeqi NP_001025032.1. NM_001029861.2.
UniGenei Hs.434218.

3D structure databases

ProteinModelPortali P60321.
SMRi P60321. Positions 62-115.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000341021.

Polymorphism databases

DMDMi 41688561.

Proteomic databases

PaxDbi P60321.
PRIDEi P60321.

Protocols and materials databases

DNASUi 339345.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341294 ; ENSP00000341021 ; ENSG00000188425 .
GeneIDi 339345.
KEGGi hsa:339345.
UCSCi uc002pdu.3. human.

Organism-specific databases

CTDi 339345.
GeneCardsi GC19M046416.
HGNCi HGNC:23292. NANOS2.
HPAi HPA014190.
MIMi 608228. gene.
neXtProti NX_P60321.
PharmGKBi PA134909776.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG254777.
HOGENOMi HOG000082528.
HOVERGENi HBG052575.
InParanoidi P60321.
OMAi ALCNFCK.
OrthoDBi EOG7PGDT1.
PhylomeDBi P60321.
TreeFami TF326882.

Miscellaneous databases

GenomeRNAii 339345.
NextBioi 97363.
PROi P60321.
SOURCEi Search...

Gene expression databases

Bgeei P60321.
CleanExi HS_NANOS2.
HS_NOS2.
Genevestigatori P60321.

Family and domain databases

InterProi IPR008705. Nanos/Xcar2.
IPR024161. Znf_nanos-typ.
[Graphical view ]
PANTHERi PTHR12887. PTHR12887. 1 hit.
Pfami PF05741. zf-nanos. 1 hit.
[Graphical view ]
PROSITEi PS51522. ZF_NANOS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction."
    Kusz K.M., Tomczyk L., Sajek M., Spik A., Latos-Bielenska A., Jedrzejczak P., Pawelczyk L., Jaruzelska J.
    Mol. Hum. Reprod. 15:165-171(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT GLN-68.
  3. "NANOS3 function in human germ cell development."
    Julaton V.T., Reijo Pera R.A.
    Hum. Mol. Genet. 20:2238-2250(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiNANO2_HUMAN
AccessioniPrimary (citable) accession number: P60321
Secondary accession number(s): Q17R30, Q4G0P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 2, 2004
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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