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Protein

Nanos homolog 2

Gene

NANOS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri62 – 11655Nanos-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis, Translation regulation

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nanos homolog 2
Short name:
NOS-2
Gene namesi
Name:NANOS2
Synonyms:NOS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23292. NANOS2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoplasmic mRNA processing body Source: UniProtKB
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909776.

Polymorphism and mutation databases

BioMutaiNANOS2.
DMDMi41688561.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Nanos homolog 2PRO_0000207687Add
BLAST

Proteomic databases

PaxDbiP60321.
PRIDEiP60321.

Expressioni

Tissue specificityi

Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level).2 Publications

Developmental stagei

Fetal ovary and fetal testis. Present in all germ cells of seminiferous tubules of the 24-week fetus (at protein level).2 Publications

Gene expression databases

BgeeiP60321.
CleanExiHS_NANOS2.
HS_NOS2.
GenevisibleiP60321. HS.

Organism-specific databases

HPAiHPA014190.

Interactioni

Subunit structurei

Interacts with CNOT1, CNOT3, CNOT6L, CNOT7 and CNOT9.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-10216569,EBI-748961
MAGEA12Q6FHH83EBI-10216569,EBI-10178394

Protein-protein interaction databases

BioGridi130871. 4 interactions.
IntActiP60321. 2 interactions.
STRINGi9606.ENSP00000341021.

Structurei

3D structure databases

ProteinModelPortaliP60321.
SMRiP60321. Positions 62-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi63 – 9028C2HC 1Add
BLAST
Motifi98 – 11417C2HC 2Add
BLAST

Domaini

The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.PROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the nanos family.PROSITE-ProRule annotation
Contains 1 nanos-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri62 – 11655Nanos-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG254777.
GeneTreeiENSGT00640000091383.
HOGENOMiHOG000082528.
HOVERGENiHBG052575.
InParanoidiP60321.
KOiK18760.
OMAiALCNFCK.
OrthoDBiEOG7PGDT1.
PhylomeDBiP60321.
TreeFamiTF326882.

Family and domain databases

InterProiIPR008705. Nanos/Xcar2.
IPR024161. Znf_nanos-typ.
[Graphical view]
PANTHERiPTHR12887. PTHR12887. 1 hit.
PfamiPF05741. zf-nanos. 1 hit.
[Graphical view]
PROSITEiPS51522. ZF_NANOS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLPPFDMWK DYFNLSQVVW ALIASRGQRL ETQEIEEPSP GPPLGQDQGL
60 70 80 90 100
GAPGANGGLG TLCNFCKHNG ESRHVYSSHQ LKTPDGVVVC PILRHYVCPV
110 120 130
CGATGDQAHT LKYCPLNGGQ QSLYRRSGRN SAGRRVKR
Length:138
Mass (Da):15,132
Last modified:February 2, 2004 - v1
Checksum:i98469E0F1AA6BC11
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681H → Q.1 Publication
VAR_065246

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC042883 mRNA. Translation: AAH42883.1.
BC117484 mRNA. Translation: AAI17485.1.
BC117486 mRNA. Translation: AAI17487.1.
CCDSiCCDS33056.1.
RefSeqiNP_001025032.1. NM_001029861.2.
UniGeneiHs.434218.

Genome annotation databases

EnsembliENST00000341294; ENSP00000341021; ENSG00000188425.
GeneIDi339345.
KEGGihsa:339345.
UCSCiuc002pdu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC042883 mRNA. Translation: AAH42883.1.
BC117484 mRNA. Translation: AAI17485.1.
BC117486 mRNA. Translation: AAI17487.1.
CCDSiCCDS33056.1.
RefSeqiNP_001025032.1. NM_001029861.2.
UniGeneiHs.434218.

3D structure databases

ProteinModelPortaliP60321.
SMRiP60321. Positions 62-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130871. 4 interactions.
IntActiP60321. 2 interactions.
STRINGi9606.ENSP00000341021.

Polymorphism and mutation databases

BioMutaiNANOS2.
DMDMi41688561.

Proteomic databases

PaxDbiP60321.
PRIDEiP60321.

Protocols and materials databases

DNASUi339345.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341294; ENSP00000341021; ENSG00000188425.
GeneIDi339345.
KEGGihsa:339345.
UCSCiuc002pdu.3. human.

Organism-specific databases

CTDi339345.
GeneCardsiGC19M046416.
HGNCiHGNC:23292. NANOS2.
HPAiHPA014190.
MIMi608228. gene.
neXtProtiNX_P60321.
PharmGKBiPA134909776.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG254777.
GeneTreeiENSGT00640000091383.
HOGENOMiHOG000082528.
HOVERGENiHBG052575.
InParanoidiP60321.
KOiK18760.
OMAiALCNFCK.
OrthoDBiEOG7PGDT1.
PhylomeDBiP60321.
TreeFamiTF326882.

Miscellaneous databases

GenomeRNAii339345.
NextBioi97363.
PROiP60321.
SOURCEiSearch...

Gene expression databases

BgeeiP60321.
CleanExiHS_NANOS2.
HS_NOS2.
GenevisibleiP60321. HS.

Family and domain databases

InterProiIPR008705. Nanos/Xcar2.
IPR024161. Znf_nanos-typ.
[Graphical view]
PANTHERiPTHR12887. PTHR12887. 1 hit.
PfamiPF05741. zf-nanos. 1 hit.
[Graphical view]
PROSITEiPS51522. ZF_NANOS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction."
    Kusz K.M., Tomczyk L., Sajek M., Spik A., Latos-Bielenska A., Jedrzejczak P., Pawelczyk L., Jaruzelska J.
    Mol. Hum. Reprod. 15:165-171(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT GLN-68.
  3. "NANOS3 function in human germ cell development."
    Julaton V.T., Reijo Pera R.A.
    Hum. Mol. Genet. 20:2238-2250(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiNANO2_HUMAN
AccessioniPrimary (citable) accession number: P60321
Secondary accession number(s): Q17R30, Q4G0P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 2, 2004
Last modified: June 24, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.