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P60321 (NANO2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nanos homolog 2

Short name=NOS-2
Gene names
Name:NANOS2
Synonyms:NOS2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length138 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state By similarity.

Subunit structure

Interacts with CNOT1, CNOT3, CNOT6L, CNOT7 and CNOT9 By similarity.

Subcellular location

Cytoplasm. CytoplasmP-body By similarity. Cytoplasmperinuclear region. Note: Localizes at P-bodies during gonocyte development By similarity. More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis. Ref.2

Tissue specificity

Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level). Ref.2 Ref.3

Developmental stage

Fetal ovary and fetal testis. Present in all germ cells of seminiferous tubules of the 24-week fetus (at protein level). Ref.2 Ref.3

Domain

The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein By similarity.

Sequence similarities

Belongs to the nanos family.

Contains 1 nanos-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 138138Nanos homolog 2
PRO_0000207687

Regions

Zinc finger62 – 11655Nanos-type
Motif63 – 9028C2HC 1
Motif98 – 11417C2HC 2

Natural variations

Natural variant681H → Q. Ref.2
VAR_065246

Sequences

Sequence LengthMass (Da)Tools
P60321 [UniParc].

Last modified February 2, 2004. Version 1.
Checksum: 98469E0F1AA6BC11

FASTA13815,132
        10         20         30         40         50         60 
MQLPPFDMWK DYFNLSQVVW ALIASRGQRL ETQEIEEPSP GPPLGQDQGL GAPGANGGLG 

        70         80         90        100        110        120 
TLCNFCKHNG ESRHVYSSHQ LKTPDGVVVC PILRHYVCPV CGATGDQAHT LKYCPLNGGQ 

       130 
QSLYRRSGRN SAGRRVKR 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]"The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction."
Kusz K.M., Tomczyk L., Sajek M., Spik A., Latos-Bielenska A., Jedrzejczak P., Pawelczyk L., Jaruzelska J.
Mol. Hum. Reprod. 15:165-171(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT GLN-68.
[3]"NANOS3 function in human germ cell development."
Julaton V.T., Reijo Pera R.A.
Hum. Mol. Genet. 20:2238-2250(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC042883 mRNA. Translation: AAH42883.1.
BC117484 mRNA. Translation: AAI17485.1.
BC117486 mRNA. Translation: AAI17487.1.
RefSeqNP_001025032.1. NM_001029861.2.
UniGeneHs.434218.

3D structure databases

ProteinModelPortalP60321.
SMRP60321. Positions 62-115.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000341021.

Polymorphism databases

DMDM41688561.

Proteomic databases

PaxDbP60321.
PRIDEP60321.

Protocols and materials databases

DNASU339345.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341294; ENSP00000341021; ENSG00000188425.
GeneID339345.
KEGGhsa:339345.
UCSCuc002pdu.3. human.

Organism-specific databases

CTD339345.
GeneCardsGC19M046416.
HGNCHGNC:23292. NANOS2.
HPAHPA014190.
MIM608228. gene.
neXtProtNX_P60321.
PharmGKBPA134909776.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG254777.
HOGENOMHOG000082528.
HOVERGENHBG052575.
InParanoidP60321.
OMAALCNFCK.
OrthoDBEOG7PGDT1.
PhylomeDBP60321.
TreeFamTF326882.

Gene expression databases

BgeeP60321.
CleanExHS_NANOS2.
HS_NOS2.
GenevestigatorP60321.

Family and domain databases

InterProIPR008705. Nanos/Xcar2.
IPR024161. Znf_nanos-typ.
[Graphical view]
PANTHERPTHR12887. PTHR12887. 1 hit.
PfamPF05741. zf-nanos. 1 hit.
[Graphical view]
PROSITEPS51522. ZF_NANOS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi339345.
NextBio97363.
PROP60321.
SOURCESearch...

Entry information

Entry nameNANO2_HUMAN
AccessionPrimary (citable) accession number: P60321
Secondary accession number(s): Q17R30, Q4G0P8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 2, 2004
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM