Reviewed, UniProtKB/Swiss-Prot P60295 (OAT1_STAAM)

Names and origin

Protein names

Recommended name:
    Ornithine aminotransferase 1
      Short name=OAT 1
    EC=2.6.1.13
Alternative name(s):
    Ornithine--oxo-acid aminotransferase 1

Gene names

Name:	rocD1
Ordered Locus Names:	SAV0185

Organism

Staphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]

Taxonomic identifier

158878 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the interconversion of ornithine to glutamate semialdehyde By similarity.
Catalytic activity	L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ornithine-oxo-acid transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Ornithine aminotransferase 1		PRO_0000112782
Amino acid modifications
	Modified residue	252	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P60295-1 [UniParc]. Last modified January 16, 2004. Version 1. Checksum: D74BFF1F623D9396	FASTA	394	43,057
	10 20 30 40 50 60 MNSIIELTDY YSSNNYAPLK LVISKGKGVK VWDTDGKQYI DCISGFSVAN QGHCHPTIVK 70 80 90 100 110 120 AMTEQASKLS IISRVLYSDN LGKWEEKICH LAKKDKVLSL NSGTEAVEAA IKIARKWGSE 130 140 150 160 170 180 VKGITDGQVE IIAMNNNFHG RTLGSLSLSN HDAYKAGFHP LLQGTTTVDF GDIEQLTQAI 190 200 210 220 230 240 SPNTAAIILE PIQGEGGVNI PPKGYIQAVR QLCDKHQILM IADEIQVGLG RTGKWFAMEW 250 260 270 280 290 300 EQVVPDIYIL GKALGGGLYP VSAVLANNDV MRVLTPGTHG STFGGNPLAI AISTAALDVL 310 320 330 340 350 360 KDEQLVERSE RLGSFLLKAL LQLKHPSIKE IRGRGLFIGI ELNTDAAPFV DQLIQRGILC 370 380 390 KDTHRTIIRL SPPLVIDKEE IHQIVAAFQD VFKN

References

[1]

"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000017 Genomic DNA. Translation: BAB56347.1.
RefSeq	NP_370709.1.
3D structure databases
HSSP	HSSP built from PDB template 2OAT based on UniProtKB P04181.
ModBase	Search...
Genome annotation databases
GeneID	1120144.
GenomeReviews	Gene locus SAV0185 in contig BA000017_GR.
KEGG	sav:SAV0185.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P60295.
OMA	P60295. TICAANG.
Enzyme and pathway databases
BioCyc	SAUR158878:SAV0185-MON.
Family and domain databases
HAMAP	MF_01689. [Tree]
InterPro	IPR005814. Aminotrans_3. IPR010164. Orn_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11986. Aminotrans_3. 1 hit. PTHR11986:SF18. Orn_aminotrans. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR01885. Orn_aminotrans. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OAT1_STAAM

Accession

Primary (citable) accession number: P60295
Secondary accession number(s): Q99X36

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	January 16, 2004
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)