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Protein

Kappa-theraphotoxin-Gr2a

Gene
N/A
Organism
Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Blocks mammalian Kv4.2/KCND2 and Kv4.3/KCND3 (By similarity). Blocks mechanosensitive ion channels in rat astrocytes, without having effect on whole-cell voltage-sensitive currents.By similarity

Miscellaneous

The primary structure of this mature peptide is identical to that of kappa-theraphotoxin-Ps1b (Phrixotoxin-2) from Paraphysa scrofa (AC P61231).

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-theraphotoxin-Gr2a
Short name:
Kappa-TRTX-Gr2a
Alternative name(s):
Toxin GsMTx-2
Short name:
MTx2
OrganismiGrammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Taxonomic identifieri432528 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeTheraphosidaeGrammostola

Organism-specific databases

ArachnoServeriAS000067. kappa-theraphotoxin-Gr2a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000450141 – 31Kappa-theraphotoxin-Gr2aAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 161 Publication
Disulfide bondi9 ↔ 211 Publication
Disulfide bondi15 ↔ 251 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

131
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 6Combined sources3
Beta strandi17 – 20Combined sources4
Beta strandi22 – 24Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LUPNMR-A1-31[»]
ProteinModelPortaliP60273.
SMRiP60273.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60273.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Belongs to the phrixotoxin family.Curated

Keywords - Domaini

Knottin

Sequencei

Sequence statusi: Complete.

P60273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
YCQKWMWTCD EERKCCEGLV CRLWCKRIIN M
Length:31
Mass (Da):3,929
Last modified:January 16, 2004 - v1
Checksum:iAAECBB87A92AAC1B
GO

Similar proteinsi

Entry informationi

Entry nameiMTX2_GRARO
AccessioniPrimary (citable) accession number: P60273
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: November 2, 2016
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families