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Protein

U2-hexatoxin-Hi1a

Gene
N/A
Organism
Hadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits sodium channels (Nav) of insects.By similarity

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
U2-hexatoxin-Hi1a
Short name:
U2-HXTX-Hi1a
Alternative name(s):
Toxin AcTx-Hi:OB42191 Publication
OrganismiHadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)
Taxonomic identifieri153481 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeHexathelidaeHadronyche

Organism-specific databases

ArachnoServeriAS000390. U2-hexatoxin-Hi1a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449661 – 38U2-hexatoxin-Hi1aAdd BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 18
Disulfide bondi9 ↔ 23
Disulfide bondi17 ↔ 33
Disulfide bondi25 ↔ 31

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

138
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 9Combined sources3
Beta strandi11 – 14Combined sources4
Beta strandi22 – 24Combined sources3
Beta strandi27 – 34Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KQHNMR-A1-38[»]
1KQINMR-A1-38[»]
ProteinModelPortaliP60272.
SMRiP60272.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60272.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Belongs to the beta/delta-agatoxin family.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR009243. Mu-agatoxin.
PROSITEiView protein in PROSITE
PS60015. MU_AGATOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P60272-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
KCLAEAADCS PWSGDSCCKP YLCSCIFFYP CSCRPKGW
Length:38
Mass (Da):4,227
Last modified:January 16, 2004 - v1
Checksum:i44E8E46D067B9320
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KQHNMR-A1-38[»]
1KQINMR-A1-38[»]
ProteinModelPortaliP60272.
SMRiP60272.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS000390. U2-hexatoxin-Hi1a.

Miscellaneous databases

EvolutionaryTraceiP60272.

Family and domain databases

InterProiView protein in InterPro
IPR009243. Mu-agatoxin.
PROSITEiView protein in PROSITE
PS60015. MU_AGATOXIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTXMO_HADIN
AccessioniPrimary (citable) accession number: P60272
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: November 2, 2016
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

Exists in two forms, due to cis-trans isomerization at Pro-30.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.