P60271 (SCX1_PARSC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Toxin PBITx1 Alternative name(s): sITx10
Organism	Parabuthus schlechteri (Scorpion)
Taxonomic identifier	190110 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Parabuthus

Protein attributes

Sequence length	25 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable chloride channel ligand, which blocks small-conductance chloride channels By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Chloride channel inhibitor family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Chloride channel inhibitor Ion channel impairing toxin Neurotoxin Toxin
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	chloride channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 25	25	Toxin PBITx1		PRO_0000044944

Sequences

	Sequence		Length	Mass (Da)
	P60271 [UniParc]. Last modified January 16, 2004. Version 1. Checksum: 4C3F25A32A0456E4	FASTA	25	2,739
	10 20 RCKPCFTTDP QMSKKCADXC GGXKX

References

[1]

"Purification and partial characterization of a 'short' insectotoxin-like peptide from the venom of the scorpion Parabuthus schlechteri." Tytgat J., Debont T., Rostoll K., Mueller G.J., Verdonck F., Daenens P., van der Walt J.J., Possani L.D. FEBS Lett. 441:387-391(1998) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR003614. Scorpion_toxin-like. IPR007958. Scorpion_toxinS_Cl_inh. [Graphical view]
Pfam	PF05294. Toxin_5. 1 hit. [Graphical view]
SUPFAM	SSF57095. SSF57095. 1 hit.
PROSITE	PS51200. SHORT_SCORPION_CHLORIDE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SCX1_PARSC

Accession

Primary (citable) accession number: P60271

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	January 16, 2004
Last modified:	May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program