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Protein

Maurocalcin

Gene
N/A
Organism
Scorpio palmatus (Israeli golden scorpion) (Scorpio maurus palmatus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potently and reversibly modifies channel gating behavior of the type 1 ryanodine receptor (RYR1) by inducing prominent subconductance behavior. Binds a different site as ryanodine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Ryanodine-sensitive calcium-release channel impairing toxin, Toxin

Protein family/group databases

TCDBi8.B.16.1.1. the maurocalcine family.

Names & Taxonomyi

Protein namesi
Recommended name:
Maurocalcin
Short name:
MCa
Alternative name(s):
Maurocalcine
OrganismiScorpio palmatus (Israeli golden scorpion) (Scorpio maurus palmatus)
Taxonomic identifieri1662106 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeScorpio

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 1 mg/kg mice by intracerebroventricular injection into mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449501 – 33MaurocalcinAdd BLAST33

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 171 Publication
Disulfide bondi10 ↔ 211 Publication
Disulfide bondi16 ↔ 321 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

133
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 12Combined sources4
Helixi13 – 15Combined sources3
Beta strandi20 – 22Combined sources3
Beta strandi25 – 28Combined sources4
Beta strandi30 – 33Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C6WNMR-A1-33[»]
ProteinModelPortaliP60254.
SMRiP60254.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60254.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Belongs to the scorpion calcine family.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR012632. Scorpion_calcine.
PfamiView protein in Pfam
PF08099. Toxin_27. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD874489. Scorpion_calcine. 1 hit.
PROSITEiView protein in PROSITE
PS60028. SCORPION_CALCINE. 1 hit.

Sequencei

Sequence statusi: Complete.

P60254-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
GDCLPHLKLC KENKDCCSKK CKRRGTNIEK RCR
Length:33
Mass (Da):3,865
Last modified:January 16, 2004 - v1
Checksum:iA5FE70F945FEC8E6
GO

Mass spectrometryi

Molecular mass is 3858.2 Da from positions 1 - 33. Determined by MALDI. 1 Publication

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSCXC_SCOPA
AccessioniPrimary (citable) accession number: P60254
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: March 15, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families