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P60211

- KA181_TITOB

UniProt

P60211 - KA181_TITOB

Protein

Potassium channel toxin alpha-KTx 18.1

Gene
N/A
Organism
Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Reversible blocker of both Kv1.3/KCNA3 potassium channels of human T-lymphocytes (high affinity) and Shaker B potassium channels (very low affinity).1 Publication

    GO - Molecular functioni

    1. potassium channel inhibitor activity Source: UniProtKB

    GO - Biological processi

    1. pathogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin alpha-KTx 18.1
    Alternative name(s):
    Toxin Tc32
    Toxin To32
    OrganismiTityus obscurus (Amazonian scorpion) (Tityus cambridgei)
    Taxonomic identifieri184226 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 3535Potassium channel toxin alpha-KTx 18.1PRO_0000044921Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi7 ↔ 26
    Disulfide bondi12 ↔ 31
    Disulfide bondi16 ↔ 33

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.1 Publication

    Structurei

    Secondary structure

    35
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1 – 33
    Helixi10 – 1910
    Beta strandi21 – 244
    Beta strandi26 – 294
    Beta strandi32 – 343

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2JP6NMR-A1-35[»]
    ProteinModelPortaliP60211.
    SMRiP60211. Positions 1-35.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP60211.

    Family & Domainsi

    Domaini

    Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).

    Sequence similaritiesi

    Sequencei

    Sequence statusi: Complete.

    P60211-1 [UniParc]FASTAAdd to Basket

    « Hide

    TGPQTTCQAA MCEAGCKGLG KSMESCQGDT CKCKA                   35
    Length:35
    Mass (Da):3,528
    Last modified:January 16, 2004 - v1
    Checksum:iB8BB8B54DC016D33
    GO

    Mass spectrometryi

    Molecular mass is 3521.5 Da from positions 1 - 35. Determined by ESI. 2 Publications

    Cross-referencesi

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2JP6 NMR - A 1-35 [» ]
    ProteinModelPortali P60211.
    SMRi P60211. Positions 1-35.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P60211.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K(+)-channels with distinctly different affinities."
      Batista C.V.F., Gomez-Lagunas F., Rodriguez de la Vega R.C., Hajdu P., Panyi G., Gaspar R., Possani L.D.
      Biochim. Biophys. Acta 1601:123-131(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, 3D-STRUCTURE MODELING.
      Tissue: Venom.
    2. "Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins."
      Batista C.V.F., del Pozo L., Zamudio F.Z., Contreras S., Becerril B., Wanke E., Possani L.D.
      J. Chromatogr. B 803:55-66(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-10, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY.
      Tissue: Venom.
    3. "Structural and functional characterization of the recombinant form of the kv1.3 channel blocker tc32."
      Stehling E.G., Sforca M.L., Zanchin N.I., Pignatelli A., Belluzzi O., Spisni A., Pertinhez T.A.
      Submitted (APR-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiKA181_TITOB
    AccessioniPrimary (citable) accession number: P60211
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: January 16, 2004
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3