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Protein

Potassium channel toxin alpha-KTx 18.1

Gene
N/A
Organism
Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Reversible blocker of both Kv1.3/KCNA3 potassium channels (high affinity) and Shaker B (mammalian Kv1.1 analog) potassium channels (very low affinity).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei34Penetrates into Kv pores (more deeply into Kv1.3 than into Kv1.1)1 Publication1

GO - Molecular functioni

  • potassium channel inhibitor activity Source: UniProtKB

GO - Biological processi

  • pathogenesis Source: UniProtKB

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 18.1
Alternative name(s):
Toxin Tc321 Publication
Toxin To32Curated
OrganismiTityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Taxonomic identifieri1221240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449211 – 35Potassium channel toxin alpha-KTx 18.11 PublicationAdd BLAST35

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 261 Publication
Disulfide bondi12 ↔ 311 Publication
Disulfide bondi16 ↔ 331 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

Secondary structure

135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 3Combined sources3
Helixi10 – 19Combined sources10
Beta strandi21 – 24Combined sources4
Beta strandi26 – 29Combined sources4
Beta strandi32 – 34Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JP6NMR-A1-35[»]
ProteinModelPortaliP60211.
SMRiP60211.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60211.

Family & Domainsi

Domaini

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).1 Publication

Sequence similaritiesi

Sequencei

Sequence statusi: Complete.

P60211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
TGPQTTCQAA MCEAGCKGLG KSMESCQGDT CKCKA
Length:35
Mass (Da):3,528
Last modified:January 16, 2004 - v1
Checksum:iB8BB8B54DC016D33
GO

Mass spectrometryi

Molecular mass is 3521.5 Da from positions 1 - 35. Determined by ESI. 2 Publications

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKA181_TITOB
AccessioniPrimary (citable) accession number: P60211
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: November 2, 2016
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Caution

Lacks the dyad motif characteristic of alpha-KTx and generally associated with channel blockage.Curated

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families