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P60210 (KAX44_TITOB) Reviewed, UniProtKB/Swiss-Prot

Last modified September 18, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 4.4
Alternative name(s):
Toxin Tc30
Toxin To30
OrganismTityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Taxonomic identifier184226 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Protein attributes

Sequence length37 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Reversible blocker of both Shaker B potassium channels (high affinity), and Kv1.3/KCNA3 potassium channels of human T lymphocytes (low affinity). Ref.1

Subcellular location

Secreted Ref.2.

Tissue specificity

Expressed by the venom gland. Ref.2

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 4 subfamily.

Mass spectrometry

Molecular mass is 3871.8 Da from positions 1 - 37. Determined by ESI. Ref.1 Ref.2

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3737Potassium channel toxin alpha-KTx 4.4
PRO_0000044920

Regions

Region26 – 338Interaction with Ca(2+)-activated K(+) channels Potential

Sites

Site271Basic residue of the functional dyad By similarity
Site361Aromatic residue of the functional dyad By similarity

Amino acid modifications

Disulfide bond7 ↔ 28 By similarity
Disulfide bond13 ↔ 33 By similarity
Disulfide bond17 ↔ 35 By similarity

Sequences

Sequence LengthMass (Da)Tools
P60210 [UniParc].

Last modified January 16, 2004. Version 1.
Checksum: 6B17BB651C3E3449

FASTA373,878
        10         20         30 
VFINVKCRGS KECLPACKAA VGKAAGKCMN GKCKCYP 

« Hide

References

[1]"Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K(+)-channels with distinctly different affinities."
Batista C.V.F., Gomez-Lagunas F., Rodriguez de la Vega R.C., Hajdu P., Panyi G., Gaspar R., Possani L.D.
Biochim. Biophys. Acta 1601:123-131(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY.
Tissue: Venom.
[2]"Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins."
Batista C.V.F., del Pozo L., Zamudio F.Z., Contreras S., Becerril B., Wanke E., Possani L.D.
J. Chromatogr. B 803:55-66(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-10, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY.
Tissue: Venom.

Cross-references

3D structure databases

ProteinModelPortalP60210.
SMRP60210. Positions 1-37.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.30.10. 1 hit.
InterProIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
PRINTSPR00286. CHARYBDTOXIN.
SUPFAMSSF57095. SSF57095. 1 hit.
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKAX44_TITOB
AccessionPrimary (citable) accession number: P60210
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: September 18, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries