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P60210

- KAX44_TITOB

UniProt

P60210 - KAX44_TITOB

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Protein

Potassium channel toxin alpha-KTx 4.4

Gene
N/A
Organism
Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Reversible blocker of both Shaker B potassium channels (high affinity), and Kv1.3/KCNA3 potassium channels of human T lymphocytes (low affinity).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei27 – 271Basic residue of the functional dyadBy similarity
Sitei36 – 361Aromatic residue of the functional dyadBy similarity

GO - Molecular functioni

  1. potassium channel inhibitor activity Source: UniProtKB

GO - Biological processi

  1. defense response Source: InterPro
  2. pathogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 4.4
Alternative name(s):
Toxin Tc30
Toxin To30
OrganismiTityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Taxonomic identifieri184226 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3737Potassium channel toxin alpha-KTx 4.4PRO_0000044920Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi7 ↔ 28By similarity
Disulfide bondi13 ↔ 33By similarity
Disulfide bondi17 ↔ 35By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP60210.
SMRiP60210. Positions 1-37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 338Interaction with Ca(2+)-activated K(+) channelsSequence Analysis

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamiPF00451. Toxin_2. 1 hit.
[Graphical view]
PRINTSiPR00286. CHARYBDTOXIN.
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60210-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30 
VFINVKCRGS KECLPACKAA VGKAAGKCMN GKCKCYP
Length:37
Mass (Da):3,878
Last modified:January 16, 2004 - v1
Checksum:i6B17BB651C3E3449
GO

Mass spectrometryi

Molecular mass is 3871.8 Da from positions 1 - 37. Determined by ESI. 2 Publications

Cross-referencesi

3D structure databases

ProteinModelPortali P60210.
SMRi P60210. Positions 1-37.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.30.10. 1 hit.
InterProi IPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view ]
Pfami PF00451. Toxin_2. 1 hit.
[Graphical view ]
PRINTSi PR00286. CHARYBDTOXIN.
SUPFAMi SSF57095. SSF57095. 1 hit.
PROSITEi PS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K(+)-channels with distinctly different affinities."
    Batista C.V.F., Gomez-Lagunas F., Rodriguez de la Vega R.C., Hajdu P., Panyi G., Gaspar R., Possani L.D.
    Biochim. Biophys. Acta 1601:123-131(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY.
    Tissue: Venom.
  2. "Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins."
    Batista C.V.F., del Pozo L., Zamudio F.Z., Contreras S., Becerril B., Wanke E., Possani L.D.
    J. Chromatogr. B 803:55-66(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-10, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY.
    Tissue: Venom.

Entry informationi

Entry nameiKAX44_TITOB
AccessioniPrimary (citable) accession number: P60210
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: October 1, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3