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Protein

Potassium channel toxin alpha-KTx 4.4

Gene
N/A
Organism
Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Reversible blocker of both Shaker B potassium channels (high affinity), and Kv1.3/KCNA3 potassium channels of human T lymphocytes (low affinity).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei27Basic residue of the functional dyadBy similarity1
Sitei36Aromatic residue of the functional dyadBy similarity1

GO - Molecular functioni

  • potassium channel inhibitor activity Source: UniProtKB

GO - Biological processi

  • defense response Source: InterPro
  • pathogenesis Source: UniProtKB

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 4.4
Alternative name(s):
Toxin Tc30
Toxin To30
OrganismiTityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Taxonomic identifieri1221240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449201 – 37Potassium channel toxin alpha-KTx 4.4Add BLAST37

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 28By similarity
Disulfide bondi13 ↔ 33By similarity
Disulfide bondi17 ↔ 35By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP60210.
SMRiP60210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 33Interaction with Ca(2+)-activated K(+) channelsSequence analysis8

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiView protein in InterPro
IPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
PfamiView protein in Pfam
PF00451. Toxin_2. 1 hit.
PRINTSiPR00286. CHARYBDTOXIN.
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiView protein in PROSITE
PS01138. SCORP_SHORT_TOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P60210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
VFINVKCRGS KECLPACKAA VGKAAGKCMN GKCKCYP
Length:37
Mass (Da):3,878
Last modified:January 16, 2004 - v1
Checksum:i6B17BB651C3E3449
GO

Mass spectrometryi

Molecular mass is 3871.8 Da from positions 1 - 37. Determined by ESI. 2 Publications

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKAX44_TITOB
AccessioniPrimary (citable) accession number: P60210
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: May 10, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families