Reviewed, UniProtKB/Swiss-Prot P60209 (KAX94_MESTA)

Names and origin

Protein names	Recommended name:     Potassium channel toxin alpha-KTx 9.4 Alternative name(s):     Bt BTK-2     Toxin BTK-2
Organism	Mesobuthus tamulus (Eastern Indian scorpion) (Buthus tamulus)
Taxonomic identifier	34647 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Mesobuthus

Protein attributes

Sequence length	32 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Blocker of human potassium channel Kv1.1.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 9 subfamily.
Mass spectrometry	Molecular mass is 3452 Da from positions 1 - 32. Determined by ESI. Ref.1

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Ionic channel inhibitor Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 32	32	Potassium channel toxin alpha-KTx 9.4		PRO_0000044948
Amino acid modifications
	Disulfide bond	3 ↔ 19		By similarity
	Disulfide bond	6 ↔ 24		By similarity
	Disulfide bond	10 ↔ 26		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P60209-1 [UniParc]. Last modified January 16, 2004. Version 1. Checksum: D472FEEB98E7E97F	FASTA	32	3,456
	10 20 30 VGCAECPMHC KGKMAKPTCE NEVCKCNIGK KD

References

[1]	"BTK-2, a new inhibitor of the Kv1.1 potassium channel purified from Indian scorpion Buthus tamulus." Dhawan R., Varshney A., Mathew M.K., Lala A.K. FEBS Lett. 539:7-13(2003) [PubMed: 12650917] [Abstract] Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY, 3D-STRUCTURE MODELING. Tissue: Venom.

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR008911. Toxin_6. [Graphical view]
Pfam	PF05453. Toxin_6. 1 hit. [Graphical view]
PROSITE	PS01138. SCORP_SHORT_TOXIN. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAX94_MESTA

Accession

Primary (citable) accession number: P60209

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	January 16, 2004
Last modified:	November 24, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Tox-Prot (Toxin Annotation Project)