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P60203 (MYPR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myelin proteolipid protein

Short name=PLP
Alternative name(s):
Lipophilin
Gene names
Name:Plp1
Synonyms:Plp
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Involvement in disease

Defects in Plp1 are the causee of the dysmyelinating disease MD.

Sequence similarities

Belongs to the myelin proteolipid protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 277276Myelin proteolipid protein
PRO_0000159008

Regions

Topological domain2 – 98Cytoplasmic Probable
Transmembrane10 – 3627Helical; Name=1; Probable
Topological domain37 – 6327Extracellular Probable
Transmembrane64 – 8825Helical; Name=2; Probable
Topological domain89 – 15163Cytoplasmic Probable
Transmembrane152 – 17726Helical; Name=3; Probable
Topological domain178 – 23356Extracellular Probable
Transmembrane234 – 26027Helical; Name=4; Probable
Topological domain261 – 27717Cytoplasmic Probable

Amino acid modifications

Lipidation61S-palmitoyl cysteine By similarity
Lipidation71S-palmitoyl cysteine By similarity
Lipidation101S-palmitoyl cysteine By similarity
Lipidation1091S-palmitoyl cysteine By similarity
Lipidation1391S-palmitoyl cysteine By similarity
Lipidation1411S-palmitoyl cysteine By similarity
Lipidation1991O-palmitoyl serine Probable
Disulfide bond184 ↔ 228 By similarity
Disulfide bond201 ↔ 220 By similarity

Natural variations

Natural variant751T → P in MD. Ref.5 Ref.6 Ref.7

Sequences

Sequence LengthMass (Da)Tools
P60203 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 3C2BC973C3061C38

FASTA27730,077
        10         20         30         40         50         60 
MGLLECCARC LVGAPFASLV ATGLCFFGVA LFCGCGHEAL TGTEKLIETY FSKNYQDYEY 

        70         80         90        100        110        120 
LINVIHAFQY VIYGTASFFF LYGALLLAEG FYTTGAVRQI FGDYKTTICG KGLSATVTGG 

       130        140        150        160        170        180 
QKGRGSRGQH QAHSLERVCH CLGKWLGHPD KFVGITYALT VVWLLVFACS AVPVYIYFNT 

       190        200        210        220        230        240 
WTTCQSIAFP SKTSASIGSL CADARMYGVL PWNAFPGKVC GSNLLSICKT AEFQMTFHLF 

       250        260        270 
IAAFVGAAAT LVSLLTFMIA ATYNFAVLKL MGRGTKF 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and nucleotide sequence of a cDNA clone coding for rat brain myelin proteolipid."
Dautigny A., Alliel P.M., D'Auriol L., Pham Dinh D., Nussbaum J.-L., Galibert F., Jolles P.
FEBS Lett. 188:33-36(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein."
Milner R.J., Lai C., Nave K.-A., Lenoir D., Ogata J., Sutcliffe J.G.
Cell 42:931-939(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]Lubec G., Kang S.U.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-9; 46-53; 99-105; 112-122; 145-151 AND 193-229, PALMITOYLATION AT SER-199, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain.
[5]"Myelin-deficient rat: a point mutation in exon III (A-->C, Thr75-->Pro) of the myelin proteolipid protein causes dysmyelination and oligodendrocyte death."
Boison D., Stoffel W.
EMBO J. 8:3295-3302(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT MD PRO-75.
[6]"Single base substitution in codon 74 of the MD rat myelin proteolipid protein gene."
Simons R., Riordan J.R.
Ann. N. Y. Acad. Sci. 605:146-154(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT MD PRO-75.
[7]"The myelin-deficient rat has a single base substitution in the third exon of the myelin proteolipid protein gene."
Simons R., Riordan J.R.
J. Neurochem. 54:1079-1081(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT MD PRO-75.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X02809 mRNA. Translation: CAA26577.1.
M11185 mRNA. Translation: AAA41898.1.
BC093596 mRNA. Translation: AAH93596.1.
PIRMPRTPL. I52775.
RefSeqNP_112252.1. NM_030990.2.
UniGeneRn.4550.

3D structure databases

ProteinModelPortalP60203.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid247046. 1 interaction.
MINTMINT-245388.

PTM databases

PhosphoSiteP60203.

Proteomic databases

PaxDbP60203.
PRIDEP60203.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000003283; ENSRNOP00000003283; ENSRNOG00000002419.
GeneID24943.
KEGGrno:24943.
UCSCRGD:3354. rat.

Organism-specific databases

CTD5354.
RGD3354. Plp1.

Phylogenomic databases

eggNOGNOG311658.
GeneTreeENSGT00390000006915.
HOGENOMHOG000231338.
HOVERGENHBG000096.
InParanoidP60203.
KOK17271.
OMAIGTLCAD.
OrthoDBEOG7X3QRG.
PhylomeDBP60203.
TreeFamTF315162.

Gene expression databases

ArrayExpressP60203.
GenevestigatorP60203.

Family and domain databases

InterProIPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view]
PANTHERPTHR11683. PTHR11683. 1 hit.
PfamPF01275. Myelin_PLP. 1 hit.
[Graphical view]
PRINTSPR00214. MYELINPLP.
SMARTSM00002. PLP. 1 hit.
[Graphical view]
PROSITEPS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio604939.
PROP60203.

Entry information

Entry nameMYPR_RAT
AccessionPrimary (citable) accession number: P60203
Secondary accession number(s): P04400, P06905, Q561K5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families