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P60203

- MYPR_RAT

UniProt

P60203 - MYPR_RAT

Protein

Myelin proteolipid protein

Gene

Plp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

    GO - Molecular functioni

    1. structural constituent of myelin sheath Source: RGD
    2. structural molecule activity Source: RGD

    GO - Biological processi

    1. axon ensheathment Source: RGD
    2. cell maturation Source: Ensembl
    3. central nervous system myelination Source: Ensembl
    4. glial cell differentiation Source: RGD
    5. integrin-mediated signaling pathway Source: RGD
    6. long-chain fatty acid biosynthetic process Source: Ensembl
    7. myelination Source: RGD
    8. positive regulation of gene expression Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myelin proteolipid protein
    Short name:
    PLP
    Alternative name(s):
    Lipophilin
    Gene namesi
    Name:Plp1
    Synonyms:Plp
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi3354. Plp1.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Myelin membrane By similarity
    Note: Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: RGD
    2. myelin sheath Source: Ensembl
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Plp1 are the causee of the dysmyelinating disease MD.

    Keywords - Diseasei

    Disease mutation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 277276Myelin proteolipid proteinPRO_0000159008Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi6 – 61S-palmitoyl cysteineBy similarity
    Lipidationi7 – 71S-palmitoyl cysteineBy similarity
    Lipidationi10 – 101S-palmitoyl cysteineBy similarity
    Lipidationi109 – 1091S-palmitoyl cysteineBy similarity
    Lipidationi139 – 1391S-palmitoyl cysteineBy similarity
    Lipidationi141 – 1411S-palmitoyl cysteineBy similarity
    Disulfide bondi184 ↔ 228By similarity
    Lipidationi199 – 1991O-palmitoyl serine1 Publication
    Disulfide bondi201 ↔ 220By similarity

    Keywords - PTMi

    Disulfide bond, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP60203.
    PRIDEiP60203.

    PTM databases

    PhosphoSiteiP60203.

    Expressioni

    Gene expression databases

    ArrayExpressiP60203.
    GenevestigatoriP60203.

    Interactioni

    Protein-protein interaction databases

    BioGridi247046. 1 interaction.
    IntActiP60203. 1 interaction.
    MINTiMINT-245388.

    Structurei

    3D structure databases

    ProteinModelPortaliP60203.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 98CytoplasmicCurated
    Topological domaini37 – 6327ExtracellularCuratedAdd
    BLAST
    Topological domaini89 – 15163CytoplasmicCuratedAdd
    BLAST
    Topological domaini178 – 23356ExtracellularCuratedAdd
    BLAST
    Topological domaini261 – 27717CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3627Helical; Name=1CuratedAdd
    BLAST
    Transmembranei64 – 8825Helical; Name=2CuratedAdd
    BLAST
    Transmembranei152 – 17726Helical; Name=3CuratedAdd
    BLAST
    Transmembranei234 – 26027Helical; Name=4CuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the myelin proteolipid protein family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG311658.
    GeneTreeiENSGT00390000006915.
    HOGENOMiHOG000231338.
    HOVERGENiHBG000096.
    InParanoidiP60203.
    KOiK17271.
    OMAiYTVSTTY.
    OrthoDBiEOG7X3QRG.
    PhylomeDBiP60203.
    TreeFamiTF315162.

    Family and domain databases

    InterProiIPR001614. Myelin_PLP.
    IPR018237. Myelin_PLP_CS.
    [Graphical view]
    PANTHERiPTHR11683. PTHR11683. 1 hit.
    PfamiPF01275. Myelin_PLP. 1 hit.
    [Graphical view]
    PRINTSiPR00214. MYELINPLP.
    SMARTiSM00002. PLP. 1 hit.
    [Graphical view]
    PROSITEiPS00575. MYELIN_PLP_1. 1 hit.
    PS01004. MYELIN_PLP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P60203-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLLECCARC LVGAPFASLV ATGLCFFGVA LFCGCGHEAL TGTEKLIETY    50
    FSKNYQDYEY LINVIHAFQY VIYGTASFFF LYGALLLAEG FYTTGAVRQI 100
    FGDYKTTICG KGLSATVTGG QKGRGSRGQH QAHSLERVCH CLGKWLGHPD 150
    KFVGITYALT VVWLLVFACS AVPVYIYFNT WTTCQSIAFP SKTSASIGSL 200
    CADARMYGVL PWNAFPGKVC GSNLLSICKT AEFQMTFHLF IAAFVGAAAT 250
    LVSLLTFMIA ATYNFAVLKL MGRGTKF 277
    Length:277
    Mass (Da):30,077
    Last modified:January 23, 2007 - v2
    Checksum:i3C2BC973C3061C38
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti75 – 751T → P in MD. 3 Publications

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02809 mRNA. Translation: CAA26577.1.
    M11185 mRNA. Translation: AAA41898.1.
    BC093596 mRNA. Translation: AAH93596.1.
    PIRiI52775. MPRTPL.
    RefSeqiNP_112252.1. NM_030990.2.
    UniGeneiRn.4550.

    Genome annotation databases

    EnsembliENSRNOT00000003283; ENSRNOP00000003283; ENSRNOG00000002419.
    GeneIDi24943.
    KEGGirno:24943.
    UCSCiRGD:3354. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02809 mRNA. Translation: CAA26577.1 .
    M11185 mRNA. Translation: AAA41898.1 .
    BC093596 mRNA. Translation: AAH93596.1 .
    PIRi I52775. MPRTPL.
    RefSeqi NP_112252.1. NM_030990.2.
    UniGenei Rn.4550.

    3D structure databases

    ProteinModelPortali P60203.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 247046. 1 interaction.
    IntActi P60203. 1 interaction.
    MINTi MINT-245388.

    PTM databases

    PhosphoSitei P60203.

    Proteomic databases

    PaxDbi P60203.
    PRIDEi P60203.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000003283 ; ENSRNOP00000003283 ; ENSRNOG00000002419 .
    GeneIDi 24943.
    KEGGi rno:24943.
    UCSCi RGD:3354. rat.

    Organism-specific databases

    CTDi 5354.
    RGDi 3354. Plp1.

    Phylogenomic databases

    eggNOGi NOG311658.
    GeneTreei ENSGT00390000006915.
    HOGENOMi HOG000231338.
    HOVERGENi HBG000096.
    InParanoidi P60203.
    KOi K17271.
    OMAi YTVSTTY.
    OrthoDBi EOG7X3QRG.
    PhylomeDBi P60203.
    TreeFami TF315162.

    Miscellaneous databases

    NextBioi 604939.
    PROi P60203.

    Gene expression databases

    ArrayExpressi P60203.
    Genevestigatori P60203.

    Family and domain databases

    InterProi IPR001614. Myelin_PLP.
    IPR018237. Myelin_PLP_CS.
    [Graphical view ]
    PANTHERi PTHR11683. PTHR11683. 1 hit.
    Pfami PF01275. Myelin_PLP. 1 hit.
    [Graphical view ]
    PRINTSi PR00214. MYELINPLP.
    SMARTi SM00002. PLP. 1 hit.
    [Graphical view ]
    PROSITEi PS00575. MYELIN_PLP_1. 1 hit.
    PS01004. MYELIN_PLP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and nucleotide sequence of a cDNA clone coding for rat brain myelin proteolipid."
      Dautigny A., Alliel P.M., D'Auriol L., Pham Dinh D., Nussbaum J.-L., Galibert F., Jolles P.
      FEBS Lett. 188:33-36(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein."
      Milner R.J., Lai C., Nave K.-A., Lenoir D., Ogata J., Sutcliffe J.G.
      Cell 42:931-939(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Lubec G., Kang S.U.
      Submitted (JUL-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-9; 46-53; 99-105; 112-122; 145-151 AND 193-229, PALMITOYLATION AT SER-199, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    5. "Myelin-deficient rat: a point mutation in exon III (A-->C, Thr75-->Pro) of the myelin proteolipid protein causes dysmyelination and oligodendrocyte death."
      Boison D., Stoffel W.
      EMBO J. 8:3295-3302(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT MD PRO-75.
    6. "Single base substitution in codon 74 of the MD rat myelin proteolipid protein gene."
      Simons R., Riordan J.R.
      Ann. N. Y. Acad. Sci. 605:146-154(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT MD PRO-75.
    7. "The myelin-deficient rat has a single base substitution in the third exon of the myelin proteolipid protein gene."
      Simons R., Riordan J.R.
      J. Neurochem. 54:1079-1081(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT MD PRO-75.

    Entry informationi

    Entry nameiMYPR_RAT
    AccessioniPrimary (citable) accession number: P60203
    Secondary accession number(s): P04400, P06905, Q561K5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3