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Protein

Myelin proteolipid protein

Gene

Plp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

GO - Molecular functioni

  • structural constituent of myelin sheath Source: RGD
  • structural molecule activity Source: RGD

GO - Biological processi

  • astrocyte development Source: Ensembl
  • axon development Source: Ensembl
  • axon ensheathment Source: RGD
  • cell maturation Source: Ensembl
  • central nervous system myelination Source: Ensembl
  • glial cell differentiation Source: RGD
  • inflammatory response Source: Ensembl
  • integrin-mediated signaling pathway Source: RGD
  • long-chain fatty acid biosynthetic process Source: Ensembl
  • myelination Source: RGD
  • positive regulation of gene expression Source: Ensembl
  • substantia nigra development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin proteolipid protein
Short name:
PLP
Alternative name(s):
Lipophilin
Gene namesi
Name:Plp1
Synonyms:Plp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi3354. Plp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 98CytoplasmicCurated
Transmembranei10 – 3627Helical; Name=1CuratedAdd
BLAST
Topological domaini37 – 6327ExtracellularCuratedAdd
BLAST
Transmembranei64 – 8825Helical; Name=2CuratedAdd
BLAST
Topological domaini89 – 15163CytoplasmicCuratedAdd
BLAST
Transmembranei152 – 17726Helical; Name=3CuratedAdd
BLAST
Topological domaini178 – 23356ExtracellularCuratedAdd
BLAST
Transmembranei234 – 26027Helical; Name=4CuratedAdd
BLAST
Topological domaini261 – 27717CytoplasmicCuratedAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: RGD
  • myelin sheath Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Plp1 are the causee of the dysmyelinating disease MD.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 277276Myelin proteolipid proteinPRO_0000159008Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi6 – 61S-palmitoyl cysteineBy similarity
Lipidationi7 – 71S-palmitoyl cysteineBy similarity
Lipidationi10 – 101S-palmitoyl cysteineBy similarity
Lipidationi109 – 1091S-palmitoyl cysteineBy similarity
Lipidationi139 – 1391S-palmitoyl cysteineBy similarity
Lipidationi141 – 1411S-palmitoyl cysteineBy similarity
Disulfide bondi184 ↔ 228By similarity
Lipidationi199 – 1991O-palmitoyl serine1 Publication
Disulfide bondi201 ↔ 220By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP60203.
PRIDEiP60203.

PTM databases

PhosphoSiteiP60203.

Expressioni

Gene expression databases

ExpressionAtlasiP60203. baseline and differential.
GenevisibleiP60203. RN.

Interactioni

Protein-protein interaction databases

BioGridi247046. 1 interaction.
IntActiP60203. 1 interaction.
MINTiMINT-245388.
STRINGi10116.ENSRNOP00000003283.

Structurei

3D structure databases

ProteinModelPortaliP60203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the myelin proteolipid protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311658.
GeneTreeiENSGT00390000006915.
HOGENOMiHOG000231338.
HOVERGENiHBG000096.
InParanoidiP60203.
KOiK17271.
OMAiYCIVLLA.
OrthoDBiEOG7X3QRG.
PhylomeDBiP60203.
TreeFamiTF315162.

Family and domain databases

InterProiIPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view]
PANTHERiPTHR11683. PTHR11683. 1 hit.
PfamiPF01275. Myelin_PLP. 1 hit.
[Graphical view]
PRINTSiPR00214. MYELINPLP.
SMARTiSM00002. PLP. 1 hit.
[Graphical view]
PROSITEiPS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLECCARC LVGAPFASLV ATGLCFFGVA LFCGCGHEAL TGTEKLIETY
60 70 80 90 100
FSKNYQDYEY LINVIHAFQY VIYGTASFFF LYGALLLAEG FYTTGAVRQI
110 120 130 140 150
FGDYKTTICG KGLSATVTGG QKGRGSRGQH QAHSLERVCH CLGKWLGHPD
160 170 180 190 200
KFVGITYALT VVWLLVFACS AVPVYIYFNT WTTCQSIAFP SKTSASIGSL
210 220 230 240 250
CADARMYGVL PWNAFPGKVC GSNLLSICKT AEFQMTFHLF IAAFVGAAAT
260 270
LVSLLTFMIA ATYNFAVLKL MGRGTKF
Length:277
Mass (Da):30,077
Last modified:January 23, 2007 - v2
Checksum:i3C2BC973C3061C38
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751T → P in MD. 3 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02809 mRNA. Translation: CAA26577.1.
M11185 mRNA. Translation: AAA41898.1.
BC093596 mRNA. Translation: AAH93596.1.
PIRiI52775. MPRTPL.
RefSeqiNP_112252.1. NM_030990.2.
XP_008771623.1. XM_008773401.1.
UniGeneiRn.4550.

Genome annotation databases

EnsembliENSRNOT00000003283; ENSRNOP00000003283; ENSRNOG00000002419.
GeneIDi24943.
KEGGirno:24943.
UCSCiRGD:3354. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02809 mRNA. Translation: CAA26577.1.
M11185 mRNA. Translation: AAA41898.1.
BC093596 mRNA. Translation: AAH93596.1.
PIRiI52775. MPRTPL.
RefSeqiNP_112252.1. NM_030990.2.
XP_008771623.1. XM_008773401.1.
UniGeneiRn.4550.

3D structure databases

ProteinModelPortaliP60203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247046. 1 interaction.
IntActiP60203. 1 interaction.
MINTiMINT-245388.
STRINGi10116.ENSRNOP00000003283.

PTM databases

PhosphoSiteiP60203.

Proteomic databases

PaxDbiP60203.
PRIDEiP60203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003283; ENSRNOP00000003283; ENSRNOG00000002419.
GeneIDi24943.
KEGGirno:24943.
UCSCiRGD:3354. rat.

Organism-specific databases

CTDi5354.
RGDi3354. Plp1.

Phylogenomic databases

eggNOGiNOG311658.
GeneTreeiENSGT00390000006915.
HOGENOMiHOG000231338.
HOVERGENiHBG000096.
InParanoidiP60203.
KOiK17271.
OMAiYCIVLLA.
OrthoDBiEOG7X3QRG.
PhylomeDBiP60203.
TreeFamiTF315162.

Miscellaneous databases

NextBioi604939.
PROiP60203.

Gene expression databases

ExpressionAtlasiP60203. baseline and differential.
GenevisibleiP60203. RN.

Family and domain databases

InterProiIPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view]
PANTHERiPTHR11683. PTHR11683. 1 hit.
PfamiPF01275. Myelin_PLP. 1 hit.
[Graphical view]
PRINTSiPR00214. MYELINPLP.
SMARTiSM00002. PLP. 1 hit.
[Graphical view]
PROSITEiPS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and nucleotide sequence of a cDNA clone coding for rat brain myelin proteolipid."
    Dautigny A., Alliel P.M., D'Auriol L., Pham Dinh D., Nussbaum J.-L., Galibert F., Jolles P.
    FEBS Lett. 188:33-36(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein."
    Milner R.J., Lai C., Nave K.-A., Lenoir D., Ogata J., Sutcliffe J.G.
    Cell 42:931-939(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-9; 46-53; 99-105; 112-122; 145-151 AND 193-229, PALMITOYLATION AT SER-199, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  5. "Myelin-deficient rat: a point mutation in exon III (A-->C, Thr75-->Pro) of the myelin proteolipid protein causes dysmyelination and oligodendrocyte death."
    Boison D., Stoffel W.
    EMBO J. 8:3295-3302(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT MD PRO-75.
  6. "Single base substitution in codon 74 of the MD rat myelin proteolipid protein gene."
    Simons R., Riordan J.R.
    Ann. N. Y. Acad. Sci. 605:146-154(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT MD PRO-75.
  7. "The myelin-deficient rat has a single base substitution in the third exon of the myelin proteolipid protein gene."
    Simons R., Riordan J.R.
    J. Neurochem. 54:1079-1081(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT MD PRO-75.

Entry informationi

Entry nameiMYPR_RAT
AccessioniPrimary (citable) accession number: P60203
Secondary accession number(s): P04400, P06905, Q561K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.