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P60202

- MYPR_MOUSE

UniProt

P60202 - MYPR_MOUSE

Protein

Myelin proteolipid protein

Gene

Plp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. structural constituent of myelin sheath Source: Ensembl

    GO - Biological processi

    1. astrocyte development Source: MGI
    2. axon development Source: MGI
    3. axon ensheathment Source: MGI
    4. cell maturation Source: MGI
    5. central nervous system myelination Source: MGI
    6. inflammatory response Source: MGI
    7. integrin-mediated signaling pathway Source: Ensembl
    8. long-chain fatty acid biosynthetic process Source: MGI
    9. myelination Source: MGI
    10. positive regulation of gene expression Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myelin proteolipid protein
    Short name:
    PLP
    Alternative name(s):
    Lipophilin
    Gene namesi
    Name:Plp1
    Synonyms:Plp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:97623. Plp1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Myelin membrane 1 Publication
    Note: Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. myelin sheath Source: MGI
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Plp1 are the cause of the dysmyelinating diseases Jimpy and Rumpshaker (rsh).

    Keywords - Diseasei

    Disease mutation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 277276Myelin proteolipid proteinPRO_0000159007Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi6 – 61S-palmitoyl cysteineBy similarity
    Lipidationi7 – 71S-palmitoyl cysteineBy similarity
    Lipidationi10 – 101S-palmitoyl cysteineBy similarity
    Lipidationi109 – 1091S-palmitoyl cysteineBy similarity
    Lipidationi139 – 1391S-palmitoyl cysteineBy similarity
    Lipidationi141 – 1411S-palmitoyl cysteineBy similarity
    Disulfide bondi184 ↔ 228By similarity
    Lipidationi199 – 1991O-palmitoyl serineBy similarity
    Disulfide bondi201 ↔ 220By similarity

    Keywords - PTMi

    Disulfide bond, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiP60202.
    PaxDbiP60202.
    PRIDEiP60202.

    PTM databases

    PhosphoSiteiP60202.

    Expressioni

    Gene expression databases

    ArrayExpressiP60202.
    BgeeiP60202.
    CleanExiMM_PLP1.
    GenevestigatoriP60202.

    Interactioni

    Protein-protein interaction databases

    BioGridi202254. 4 interactions.
    IntActiP60202. 3 interactions.
    MINTiMINT-4102954.

    Structurei

    3D structure databases

    ProteinModelPortaliP60202.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 98CytoplasmicCurated
    Topological domaini37 – 6327ExtracellularCuratedAdd
    BLAST
    Topological domaini89 – 15163CytoplasmicCuratedAdd
    BLAST
    Topological domaini178 – 23356ExtracellularCuratedAdd
    BLAST
    Topological domaini261 – 27717CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3627Helical; Name=1CuratedAdd
    BLAST
    Transmembranei64 – 8825Helical; Name=2CuratedAdd
    BLAST
    Transmembranei152 – 17726Helical; Name=3CuratedAdd
    BLAST
    Transmembranei234 – 26027Helical; Name=4CuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the myelin proteolipid protein family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG311658.
    GeneTreeiENSGT00390000006915.
    HOGENOMiHOG000231338.
    HOVERGENiHBG000096.
    InParanoidiP60202.
    KOiK17271.
    OMAiYTVSTTY.
    OrthoDBiEOG7X3QRG.
    PhylomeDBiP60202.
    TreeFamiTF315162.

    Family and domain databases

    InterProiIPR001614. Myelin_PLP.
    IPR018237. Myelin_PLP_CS.
    [Graphical view]
    PANTHERiPTHR11683. PTHR11683. 1 hit.
    PfamiPF01275. Myelin_PLP. 1 hit.
    [Graphical view]
    PRINTSiPR00214. MYELINPLP.
    SMARTiSM00002. PLP. 1 hit.
    [Graphical view]
    PROSITEiPS00575. MYELIN_PLP_1. 1 hit.
    PS01004. MYELIN_PLP_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P60202-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLLECCARC LVGAPFASLV ATGLCFFGVA LFCGCGHEAL TGTEKLIETY    50
    FSKNYQDYEY LINVIHAFQY VIYGTASFFF LYGALLLAEG FYTTGAVRQI 100
    FGDYKTTICG KGLSATVTGG QKGRGSRGQH QAHSLERVCH CLGKWLGHPD 150
    KFVGITYALT VVWLLVFACS AVPVYIYFNT WTTCQSIAFP SKTSASIGSL 200
    CADARMYGVL PWNAFPGKVC GSNLLSICKT AEFQMTFHLF IAAFVGAAAT 250
    LVSLLTFMIA ATYNFAVLKL MGRGTKF 277
    Length:277
    Mass (Da):30,077
    Last modified:January 23, 2007 - v2
    Checksum:i3C2BC973C3061C38
    GO
    Isoform DM-20 (identifier: P60202-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         117-151: Missing.

    Show »
    Length:242
    Mass (Da):26,274
    Checksum:i90DEFE60148DC659
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti70 – 701Y → C(PubMed:3466187)Curated
    Sequence conflicti70 – 701Y → C(PubMed:2441390)Curated
    Sequence conflicti126 – 1261S → Y in AAA39955. (PubMed:3466187)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti187 – 1871I → T in Rumpshaker. 1 Publication
    Natural varianti243 – 2431A → V in Jimpy MSD. 1 Publication

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei117 – 15135Missing in isoform DM-20. 2 PublicationsVSP_009194Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15442 mRNA. Translation: AAA39951.1.
    M15442 mRNA. Translation: AAA39952.1. Sequence problems.
    M15442 mRNA. Translation: AAA39953.1.
    X07215
    , X07216, X07217, X07218, X07219, X07220, X07221 Genomic DNA. Translation: CAA30184.1.
    M37335
    , M37329, M37330, M37331, M37332, M37333, M37334 Genomic DNA. Translation: AAA39954.1.
    M14674 mRNA. Translation: AAA39955.1.
    M16472 mRNA. Translation: AAA39950.1.
    BC027010 mRNA. Translation: AAH27010.1.
    X06375 Genomic DNA. Translation: CAB40821.1.
    CCDSiCCDS30424.1. [P60202-1]
    CCDS72436.1. [P60202-2]
    PIRiS34792.
    RefSeqiNP_001277490.1. NM_001290561.1. [P60202-2]
    NP_001277491.1. NM_001290562.1.
    NP_035253.1. NM_011123.3. [P60202-1]
    UniGeneiMm.1268.

    Genome annotation databases

    EnsembliENSMUST00000033800; ENSMUSP00000033800; ENSMUSG00000031425. [P60202-1]
    ENSMUST00000113085; ENSMUSP00000108708; ENSMUSG00000031425. [P60202-2]
    GeneIDi18823.
    KEGGimmu:18823.
    UCSCiuc009ujc.1. mouse. [P60202-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15442 mRNA. Translation: AAA39951.1 .
    M15442 mRNA. Translation: AAA39952.1 . Sequence problems.
    M15442 mRNA. Translation: AAA39953.1 .
    X07215
    , X07216 , X07217 , X07218 , X07219 , X07220 , X07221 Genomic DNA. Translation: CAA30184.1 .
    M37335
    , M37329 , M37330 , M37331 , M37332 , M37333 , M37334 Genomic DNA. Translation: AAA39954.1 .
    M14674 mRNA. Translation: AAA39955.1 .
    M16472 mRNA. Translation: AAA39950.1 .
    BC027010 mRNA. Translation: AAH27010.1 .
    X06375 Genomic DNA. Translation: CAB40821.1 .
    CCDSi CCDS30424.1. [P60202-1 ]
    CCDS72436.1. [P60202-2 ]
    PIRi S34792.
    RefSeqi NP_001277490.1. NM_001290561.1. [P60202-2 ]
    NP_001277491.1. NM_001290562.1.
    NP_035253.1. NM_011123.3. [P60202-1 ]
    UniGenei Mm.1268.

    3D structure databases

    ProteinModelPortali P60202.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202254. 4 interactions.
    IntActi P60202. 3 interactions.
    MINTi MINT-4102954.

    PTM databases

    PhosphoSitei P60202.

    Proteomic databases

    MaxQBi P60202.
    PaxDbi P60202.
    PRIDEi P60202.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033800 ; ENSMUSP00000033800 ; ENSMUSG00000031425 . [P60202-1 ]
    ENSMUST00000113085 ; ENSMUSP00000108708 ; ENSMUSG00000031425 . [P60202-2 ]
    GeneIDi 18823.
    KEGGi mmu:18823.
    UCSCi uc009ujc.1. mouse. [P60202-1 ]

    Organism-specific databases

    CTDi 5354.
    MGIi MGI:97623. Plp1.

    Phylogenomic databases

    eggNOGi NOG311658.
    GeneTreei ENSGT00390000006915.
    HOGENOMi HOG000231338.
    HOVERGENi HBG000096.
    InParanoidi P60202.
    KOi K17271.
    OMAi YTVSTTY.
    OrthoDBi EOG7X3QRG.
    PhylomeDBi P60202.
    TreeFami TF315162.

    Miscellaneous databases

    ChiTaRSi PLP1. mouse.
    NextBioi 295188.
    PROi P60202.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P60202.
    Bgeei P60202.
    CleanExi MM_PLP1.
    Genevestigatori P60202.

    Family and domain databases

    InterProi IPR001614. Myelin_PLP.
    IPR018237. Myelin_PLP_CS.
    [Graphical view ]
    PANTHERi PTHR11683. PTHR11683. 1 hit.
    Pfami PF01275. Myelin_PLP. 1 hit.
    [Graphical view ]
    PRINTSi PR00214. MYELINPLP.
    SMARTi SM00002. PLP. 1 hit.
    [Graphical view ]
    PROSITEi PS00575. MYELIN_PLP_1. 1 hit.
    PS01004. MYELIN_PLP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouse."
      Hudson L.D., Berndt J.A., Puckett C., Kozak C.A., Lazzarini R.A.
      Proc. Natl. Acad. Sci. U.S.A. 84:1454-1458(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND DM-20).
    2. "Myelin proteolipid protein gene structure and its regulation of expression in normal and jimpy mutant mice."
      Ikenaka K., Furuichi T., Iwasaki Y., Moriguchi A., Okano H., Mikoshiba K.
      J. Mol. Biol. 199:587-596(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    3. "Structure and expression of the mouse myelin proteolipid protein gene."
      Macklin W.B., Campagnoni C.W., Deininger P.L., Gardinier M.V.
      J. Neurosci. Res. 18:383-394(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
      Strain: BALB/cByJ.
    4. "Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing."
      Nave K.-A., Lai C., Bloom F.E., Milner R.J.
      Proc. Natl. Acad. Sci. U.S.A. 83:9264-9268(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin."
      Nave K.-A., Lai C., Bloom F.E., Milner R.J.
      Proc. Natl. Acad. Sci. U.S.A. 84:5665-5669(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DM-20).
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Retina.
    7. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-9; 46-53; 99-122; 145-151 AND 193-229, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    8. "Developmental expression of the myelin proteolipid protein and basic protein mRNAs in normal and dysmyelinating mutant mice."
      Sorg B.A., Smith M.M., Campagnoni A.T.
      J. Neurochem. 49:1146-1154(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 50-277.
    9. "Characterization of myelin proteolipid mRNAs in normal and jimpy mice."
      Gardinier M.V., Macklin W.B., Diniak A.J., Deininger P.L.
      Mol. Cell. Biol. 6:3755-3762(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 176-270.
    10. "An AG to a GG transition at a splice site in the myelin proteolipid protein gene in jimpy mice results in the removal of an exon."
      Macklin W.B., Gardinier M.V., King K.D., Kampf K.
      FEBS Lett. 223:417-421(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 209-232, ALTERNATIVE SPLICING.
    11. Cited for: SUBCELLULAR LOCATION.
    12. "Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice."
      Gencic S., Hudson L.D.
      J. Neurosci. 10:117-124(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT JIMPY MSD VAL-243.
    13. "Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene."
      Schneider A., Montague P., Griffiths I., Fanarraga M., Kennedy P., Brophy P., Nave K.-A.
      Nature 358:758-761(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT RUMPSHAKER THR-187.

    Entry informationi

    Entry nameiMYPR_MOUSE
    AccessioniPrimary (citable) accession number: P60202
    Secondary accession number(s): P04400, P06905, Q9WUS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3