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Protein

Myelin proteolipid protein

Gene

Plp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

GO - Molecular functioni

GO - Biological processi

  • astrocyte development Source: MGI
  • axon development Source: MGI
  • axon ensheathment Source: MGI
  • cell maturation Source: MGI
  • central nervous system myelination Source: MGI
  • inflammatory response Source: MGI
  • integrin-mediated signaling pathway Source: Ensembl
  • long-chain fatty acid biosynthetic process Source: MGI
  • myelination Source: MGI
  • positive regulation of gene expression Source: UniProtKB
  • substantia nigra development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin proteolipid protein
Short name:
PLP
Alternative name(s):
Lipophilin
Gene namesi
Name:Plp1
Synonyms:Plp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:97623. Plp1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 9CytoplasmicCurated8
Transmembranei10 – 36Helical; Name=1CuratedAdd BLAST27
Topological domaini37 – 63ExtracellularCuratedAdd BLAST27
Transmembranei64 – 88Helical; Name=2CuratedAdd BLAST25
Topological domaini89 – 151CytoplasmicCuratedAdd BLAST63
Transmembranei152 – 177Helical; Name=3CuratedAdd BLAST26
Topological domaini178 – 233ExtracellularCuratedAdd BLAST56
Transmembranei234 – 260Helical; Name=4CuratedAdd BLAST27
Topological domaini261 – 277CytoplasmicCuratedAdd BLAST17

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • myelin sheath Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Plp1 are the cause of the dysmyelinating diseases Jimpy and Rumpshaker (rsh).

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001590072 – 277Myelin proteolipid proteinAdd BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi6S-palmitoyl cysteineBy similarity1
Lipidationi7S-palmitoyl cysteineBy similarity1
Lipidationi10S-palmitoyl cysteineBy similarity1
Lipidationi109S-palmitoyl cysteineBy similarity1
Modified residuei114PhosphoserineBy similarity1
Modified residuei116PhosphothreonineBy similarity1
Modified residuei118PhosphothreonineBy similarity1
Lipidationi139S-palmitoyl cysteineBy similarity1
Lipidationi141S-palmitoyl cysteineBy similarity1
Disulfide bondi184 ↔ 228By similarity
Lipidationi199O-palmitoyl serineBy similarity1
Disulfide bondi201 ↔ 220By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP60202.
PeptideAtlasiP60202.
PRIDEiP60202.

PTM databases

iPTMnetiP60202.
PhosphoSitePlusiP60202.
SwissPalmiP60202.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031425.
CleanExiMM_PLP1.
ExpressionAtlasiP60202. baseline and differential.
GenevisibleiP60202. MM.

Interactioni

Protein-protein interaction databases

BioGridi202254. 4 interactors.
IntActiP60202. 3 interactors.
MINTiMINT-4102954.
STRINGi10090.ENSMUSP00000033800.

Structurei

3D structure databases

ProteinModelPortaliP60202.
SMRiP60202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the myelin proteolipid protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4800. Eukaryota.
ENOG4110EPW. LUCA.
GeneTreeiENSGT00390000006915.
HOGENOMiHOG000231338.
HOVERGENiHBG000096.
InParanoidiP60202.
KOiK17271.
OMAiYCIVLLA.
OrthoDBiEOG091G0IM5.
PhylomeDBiP60202.
TreeFamiTF315162.

Family and domain databases

InterProiIPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view]
PANTHERiPTHR11683. PTHR11683. 2 hits.
PfamiPF01275. Myelin_PLP. 1 hit.
[Graphical view]
PRINTSiPR00214. MYELINPLP.
SMARTiSM00002. PLP. 1 hit.
[Graphical view]
PROSITEiPS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P60202-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLLECCARC LVGAPFASLV ATGLCFFGVA LFCGCGHEAL TGTEKLIETY
60 70 80 90 100
FSKNYQDYEY LINVIHAFQY VIYGTASFFF LYGALLLAEG FYTTGAVRQI
110 120 130 140 150
FGDYKTTICG KGLSATVTGG QKGRGSRGQH QAHSLERVCH CLGKWLGHPD
160 170 180 190 200
KFVGITYALT VVWLLVFACS AVPVYIYFNT WTTCQSIAFP SKTSASIGSL
210 220 230 240 250
CADARMYGVL PWNAFPGKVC GSNLLSICKT AEFQMTFHLF IAAFVGAAAT
260 270
LVSLLTFMIA ATYNFAVLKL MGRGTKF
Length:277
Mass (Da):30,077
Last modified:January 23, 2007 - v2
Checksum:i3C2BC973C3061C38
GO
Isoform DM-20 (identifier: P60202-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-151: Missing.

Show »
Length:242
Mass (Da):26,274
Checksum:i90DEFE60148DC659
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70Y → C (PubMed:3466187).Curated1
Sequence conflicti70Y → C (PubMed:2441390).Curated1
Sequence conflicti126S → Y in AAA39955 (PubMed:3466187).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti187I → T in Rumpshaker. 1 Publication1
Natural varianti243A → V in Jimpy MSD. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009194117 – 151Missing in isoform DM-20. 2 PublicationsAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15442 mRNA. Translation: AAA39951.1.
M15442 mRNA. Translation: AAA39952.1. Sequence problems.
M15442 mRNA. Translation: AAA39953.1.
X07215
, X07216, X07217, X07218, X07219, X07220, X07221 Genomic DNA. Translation: CAA30184.1.
M37335
, M37329, M37330, M37331, M37332, M37333, M37334 Genomic DNA. Translation: AAA39954.1.
M14674 mRNA. Translation: AAA39955.1.
M16472 mRNA. Translation: AAA39950.1.
BC027010 mRNA. Translation: AAH27010.1.
X06375 Genomic DNA. Translation: CAB40821.1.
CCDSiCCDS30424.1. [P60202-1]
CCDS72436.1. [P60202-2]
PIRiS34792.
RefSeqiNP_001277490.1. NM_001290561.1. [P60202-2]
NP_001277491.1. NM_001290562.1.
NP_035253.1. NM_011123.3. [P60202-1]
XP_017173919.1. XM_017318430.1. [P60202-1]
XP_017173920.1. XM_017318431.1. [P60202-1]
XP_017173921.1. XM_017318432.1. [P60202-2]
UniGeneiMm.1268.

Genome annotation databases

EnsembliENSMUST00000033800; ENSMUSP00000033800; ENSMUSG00000031425. [P60202-1]
ENSMUST00000113085; ENSMUSP00000108708; ENSMUSG00000031425. [P60202-2]
GeneIDi18823.
KEGGimmu:18823.
UCSCiuc009ujc.2. mouse. [P60202-1]
uc009ujd.2. mouse. [P60202-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15442 mRNA. Translation: AAA39951.1.
M15442 mRNA. Translation: AAA39952.1. Sequence problems.
M15442 mRNA. Translation: AAA39953.1.
X07215
, X07216, X07217, X07218, X07219, X07220, X07221 Genomic DNA. Translation: CAA30184.1.
M37335
, M37329, M37330, M37331, M37332, M37333, M37334 Genomic DNA. Translation: AAA39954.1.
M14674 mRNA. Translation: AAA39955.1.
M16472 mRNA. Translation: AAA39950.1.
BC027010 mRNA. Translation: AAH27010.1.
X06375 Genomic DNA. Translation: CAB40821.1.
CCDSiCCDS30424.1. [P60202-1]
CCDS72436.1. [P60202-2]
PIRiS34792.
RefSeqiNP_001277490.1. NM_001290561.1. [P60202-2]
NP_001277491.1. NM_001290562.1.
NP_035253.1. NM_011123.3. [P60202-1]
XP_017173919.1. XM_017318430.1. [P60202-1]
XP_017173920.1. XM_017318431.1. [P60202-1]
XP_017173921.1. XM_017318432.1. [P60202-2]
UniGeneiMm.1268.

3D structure databases

ProteinModelPortaliP60202.
SMRiP60202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202254. 4 interactors.
IntActiP60202. 3 interactors.
MINTiMINT-4102954.
STRINGi10090.ENSMUSP00000033800.

PTM databases

iPTMnetiP60202.
PhosphoSitePlusiP60202.
SwissPalmiP60202.

Proteomic databases

PaxDbiP60202.
PeptideAtlasiP60202.
PRIDEiP60202.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033800; ENSMUSP00000033800; ENSMUSG00000031425. [P60202-1]
ENSMUST00000113085; ENSMUSP00000108708; ENSMUSG00000031425. [P60202-2]
GeneIDi18823.
KEGGimmu:18823.
UCSCiuc009ujc.2. mouse. [P60202-1]
uc009ujd.2. mouse. [P60202-2]

Organism-specific databases

CTDi5354.
MGIiMGI:97623. Plp1.

Phylogenomic databases

eggNOGiKOG4800. Eukaryota.
ENOG4110EPW. LUCA.
GeneTreeiENSGT00390000006915.
HOGENOMiHOG000231338.
HOVERGENiHBG000096.
InParanoidiP60202.
KOiK17271.
OMAiYCIVLLA.
OrthoDBiEOG091G0IM5.
PhylomeDBiP60202.
TreeFamiTF315162.

Miscellaneous databases

ChiTaRSiPlp1. mouse.
PROiP60202.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031425.
CleanExiMM_PLP1.
ExpressionAtlasiP60202. baseline and differential.
GenevisibleiP60202. MM.

Family and domain databases

InterProiIPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view]
PANTHERiPTHR11683. PTHR11683. 2 hits.
PfamiPF01275. Myelin_PLP. 1 hit.
[Graphical view]
PRINTSiPR00214. MYELINPLP.
SMARTiSM00002. PLP. 1 hit.
[Graphical view]
PROSITEiPS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYPR_MOUSE
AccessioniPrimary (citable) accession number: P60202
Secondary accession number(s): P04400, P06905, Q9WUS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.