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P60202

- MYPR_MOUSE

UniProt

P60202 - MYPR_MOUSE

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Protein

Myelin proteolipid protein

Gene

Plp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

GO - Molecular functioni

  1. structural constituent of myelin sheath Source: Ensembl

GO - Biological processi

  1. astrocyte development Source: MGI
  2. axon development Source: MGI
  3. axon ensheathment Source: MGI
  4. cell maturation Source: MGI
  5. central nervous system myelination Source: MGI
  6. inflammatory response Source: MGI
  7. integrin-mediated signaling pathway Source: Ensembl
  8. long-chain fatty acid biosynthetic process Source: MGI
  9. myelination Source: MGI
  10. positive regulation of gene expression Source: MGI
  11. substantia nigra development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin proteolipid protein
Short name:
PLP
Alternative name(s):
Lipophilin
Gene namesi
Name:Plp1
Synonyms:Plp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:97623. Plp1.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Myelin membrane 1 Publication
Note: Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 98CytoplasmicCurated
Transmembranei10 – 3627Helical; Name=1CuratedAdd
BLAST
Topological domaini37 – 6327ExtracellularCuratedAdd
BLAST
Transmembranei64 – 8825Helical; Name=2CuratedAdd
BLAST
Topological domaini89 – 15163CytoplasmicCuratedAdd
BLAST
Transmembranei152 – 17726Helical; Name=3CuratedAdd
BLAST
Topological domaini178 – 23356ExtracellularCuratedAdd
BLAST
Transmembranei234 – 26027Helical; Name=4CuratedAdd
BLAST
Topological domaini261 – 27717CytoplasmicCuratedAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. myelin sheath Source: MGI
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Plp1 are the cause of the dysmyelinating diseases Jimpy and Rumpshaker (rsh).

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 277276Myelin proteolipid proteinPRO_0000159007Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi6 – 61S-palmitoyl cysteineBy similarity
Lipidationi7 – 71S-palmitoyl cysteineBy similarity
Lipidationi10 – 101S-palmitoyl cysteineBy similarity
Lipidationi109 – 1091S-palmitoyl cysteineBy similarity
Lipidationi139 – 1391S-palmitoyl cysteineBy similarity
Lipidationi141 – 1411S-palmitoyl cysteineBy similarity
Disulfide bondi184 ↔ 228By similarity
Lipidationi199 – 1991O-palmitoyl serineBy similarity
Disulfide bondi201 ↔ 220By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP60202.
PaxDbiP60202.
PRIDEiP60202.

PTM databases

PhosphoSiteiP60202.

Expressioni

Gene expression databases

BgeeiP60202.
CleanExiMM_PLP1.
ExpressionAtlasiP60202. baseline and differential.
GenevestigatoriP60202.

Interactioni

Protein-protein interaction databases

BioGridi202254. 4 interactions.
IntActiP60202. 3 interactions.
MINTiMINT-4102954.

Structurei

3D structure databases

ProteinModelPortaliP60202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the myelin proteolipid protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311658.
GeneTreeiENSGT00390000006915.
HOGENOMiHOG000231338.
HOVERGENiHBG000096.
InParanoidiP60202.
KOiK17271.
OMAiYTVSTTY.
OrthoDBiEOG7X3QRG.
PhylomeDBiP60202.
TreeFamiTF315162.

Family and domain databases

InterProiIPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view]
PANTHERiPTHR11683. PTHR11683. 1 hit.
PfamiPF01275. Myelin_PLP. 1 hit.
[Graphical view]
PRINTSiPR00214. MYELINPLP.
SMARTiSM00002. PLP. 1 hit.
[Graphical view]
PROSITEiPS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P60202-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLLECCARC LVGAPFASLV ATGLCFFGVA LFCGCGHEAL TGTEKLIETY
60 70 80 90 100
FSKNYQDYEY LINVIHAFQY VIYGTASFFF LYGALLLAEG FYTTGAVRQI
110 120 130 140 150
FGDYKTTICG KGLSATVTGG QKGRGSRGQH QAHSLERVCH CLGKWLGHPD
160 170 180 190 200
KFVGITYALT VVWLLVFACS AVPVYIYFNT WTTCQSIAFP SKTSASIGSL
210 220 230 240 250
CADARMYGVL PWNAFPGKVC GSNLLSICKT AEFQMTFHLF IAAFVGAAAT
260 270
LVSLLTFMIA ATYNFAVLKL MGRGTKF
Length:277
Mass (Da):30,077
Last modified:January 23, 2007 - v2
Checksum:i3C2BC973C3061C38
GO
Isoform DM-20 (identifier: P60202-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-151: Missing.

Show »
Length:242
Mass (Da):26,274
Checksum:i90DEFE60148DC659
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701Y → C(PubMed:3466187)Curated
Sequence conflicti70 – 701Y → C(PubMed:2441390)Curated
Sequence conflicti126 – 1261S → Y in AAA39955. (PubMed:3466187)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti187 – 1871I → T in Rumpshaker. 1 Publication
Natural varianti243 – 2431A → V in Jimpy MSD. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei117 – 15135Missing in isoform DM-20. 2 PublicationsVSP_009194Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15442 mRNA. Translation: AAA39951.1.
M15442 mRNA. Translation: AAA39952.1. Sequence problems.
M15442 mRNA. Translation: AAA39953.1.
X07215
, X07216, X07217, X07218, X07219, X07220, X07221 Genomic DNA. Translation: CAA30184.1.
M37335
, M37329, M37330, M37331, M37332, M37333, M37334 Genomic DNA. Translation: AAA39954.1.
M14674 mRNA. Translation: AAA39955.1.
M16472 mRNA. Translation: AAA39950.1.
BC027010 mRNA. Translation: AAH27010.1.
X06375 Genomic DNA. Translation: CAB40821.1.
CCDSiCCDS30424.1. [P60202-1]
CCDS72436.1. [P60202-2]
PIRiS34792.
RefSeqiNP_001277490.1. NM_001290561.1. [P60202-2]
NP_001277491.1. NM_001290562.1.
NP_035253.1. NM_011123.3. [P60202-1]
UniGeneiMm.1268.

Genome annotation databases

EnsembliENSMUST00000033800; ENSMUSP00000033800; ENSMUSG00000031425. [P60202-1]
ENSMUST00000113085; ENSMUSP00000108708; ENSMUSG00000031425. [P60202-2]
GeneIDi18823.
KEGGimmu:18823.
UCSCiuc009ujc.1. mouse. [P60202-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15442 mRNA. Translation: AAA39951.1 .
M15442 mRNA. Translation: AAA39952.1 . Sequence problems.
M15442 mRNA. Translation: AAA39953.1 .
X07215
, X07216 , X07217 , X07218 , X07219 , X07220 , X07221 Genomic DNA. Translation: CAA30184.1 .
M37335
, M37329 , M37330 , M37331 , M37332 , M37333 , M37334 Genomic DNA. Translation: AAA39954.1 .
M14674 mRNA. Translation: AAA39955.1 .
M16472 mRNA. Translation: AAA39950.1 .
BC027010 mRNA. Translation: AAH27010.1 .
X06375 Genomic DNA. Translation: CAB40821.1 .
CCDSi CCDS30424.1. [P60202-1 ]
CCDS72436.1. [P60202-2 ]
PIRi S34792.
RefSeqi NP_001277490.1. NM_001290561.1. [P60202-2 ]
NP_001277491.1. NM_001290562.1.
NP_035253.1. NM_011123.3. [P60202-1 ]
UniGenei Mm.1268.

3D structure databases

ProteinModelPortali P60202.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202254. 4 interactions.
IntActi P60202. 3 interactions.
MINTi MINT-4102954.

PTM databases

PhosphoSitei P60202.

Proteomic databases

MaxQBi P60202.
PaxDbi P60202.
PRIDEi P60202.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033800 ; ENSMUSP00000033800 ; ENSMUSG00000031425 . [P60202-1 ]
ENSMUST00000113085 ; ENSMUSP00000108708 ; ENSMUSG00000031425 . [P60202-2 ]
GeneIDi 18823.
KEGGi mmu:18823.
UCSCi uc009ujc.1. mouse. [P60202-1 ]

Organism-specific databases

CTDi 5354.
MGIi MGI:97623. Plp1.

Phylogenomic databases

eggNOGi NOG311658.
GeneTreei ENSGT00390000006915.
HOGENOMi HOG000231338.
HOVERGENi HBG000096.
InParanoidi P60202.
KOi K17271.
OMAi YTVSTTY.
OrthoDBi EOG7X3QRG.
PhylomeDBi P60202.
TreeFami TF315162.

Miscellaneous databases

ChiTaRSi Plp1. mouse.
NextBioi 295188.
PROi P60202.
SOURCEi Search...

Gene expression databases

Bgeei P60202.
CleanExi MM_PLP1.
ExpressionAtlasi P60202. baseline and differential.
Genevestigatori P60202.

Family and domain databases

InterProi IPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view ]
PANTHERi PTHR11683. PTHR11683. 1 hit.
Pfami PF01275. Myelin_PLP. 1 hit.
[Graphical view ]
PRINTSi PR00214. MYELINPLP.
SMARTi SM00002. PLP. 1 hit.
[Graphical view ]
PROSITEi PS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouse."
    Hudson L.D., Berndt J.A., Puckett C., Kozak C.A., Lazzarini R.A.
    Proc. Natl. Acad. Sci. U.S.A. 84:1454-1458(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND DM-20).
  2. "Myelin proteolipid protein gene structure and its regulation of expression in normal and jimpy mutant mice."
    Ikenaka K., Furuichi T., Iwasaki Y., Moriguchi A., Okano H., Mikoshiba K.
    J. Mol. Biol. 199:587-596(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  3. "Structure and expression of the mouse myelin proteolipid protein gene."
    Macklin W.B., Campagnoni C.W., Deininger P.L., Gardinier M.V.
    J. Neurosci. Res. 18:383-394(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
    Strain: BALB/cByJ.
  4. "Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing."
    Nave K.-A., Lai C., Bloom F.E., Milner R.J.
    Proc. Natl. Acad. Sci. U.S.A. 83:9264-9268(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin."
    Nave K.-A., Lai C., Bloom F.E., Milner R.J.
    Proc. Natl. Acad. Sci. U.S.A. 84:5665-5669(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DM-20).
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Retina.
  7. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-9; 46-53; 99-122; 145-151 AND 193-229, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  8. "Developmental expression of the myelin proteolipid protein and basic protein mRNAs in normal and dysmyelinating mutant mice."
    Sorg B.A., Smith M.M., Campagnoni A.T.
    J. Neurochem. 49:1146-1154(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 50-277.
  9. "Characterization of myelin proteolipid mRNAs in normal and jimpy mice."
    Gardinier M.V., Macklin W.B., Diniak A.J., Deininger P.L.
    Mol. Cell. Biol. 6:3755-3762(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 176-270.
  10. "An AG to a GG transition at a splice site in the myelin proteolipid protein gene in jimpy mice results in the removal of an exon."
    Macklin W.B., Gardinier M.V., King K.D., Kampf K.
    FEBS Lett. 223:417-421(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 209-232, ALTERNATIVE SPLICING.
  11. Cited for: SUBCELLULAR LOCATION.
  12. "Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice."
    Gencic S., Hudson L.D.
    J. Neurosci. 10:117-124(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT JIMPY MSD VAL-243.
  13. "Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene."
    Schneider A., Montague P., Griffiths I., Fanarraga M., Kennedy P., Brophy P., Nave K.-A.
    Nature 358:758-761(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT RUMPSHAKER THR-187.

Entry informationi

Entry nameiMYPR_MOUSE
AccessioniPrimary (citable) accession number: P60202
Secondary accession number(s): P04400, P06905, Q9WUS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3