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P60202 (MYPR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myelin proteolipid protein

Short name=PLP
Alternative name(s):
Lipophilin
Gene names
Name:Plp1
Synonyms:Plp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Involvement in disease

Defects in Plp1 are the cause of the dysmyelinating diseases Jimpy and Rumpshaker (rsh).

Sequence similarities

Belongs to the myelin proteolipid protein family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P60202-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform DM-20 (identifier: P60202-2)

The sequence of this isoform differs from the canonical sequence as follows:
     117-151: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 277276Myelin proteolipid protein
PRO_0000159007

Regions

Topological domain2 – 98Cytoplasmic Probable
Transmembrane10 – 3627Helical; Name=1; Probable
Topological domain37 – 6327Extracellular Probable
Transmembrane64 – 8825Helical; Name=2; Probable
Topological domain89 – 15163Cytoplasmic Probable
Transmembrane152 – 17726Helical; Name=3; Probable
Topological domain178 – 23356Extracellular Probable
Transmembrane234 – 26027Helical; Name=4; Probable
Topological domain261 – 27717Cytoplasmic Probable

Amino acid modifications

Lipidation61S-palmitoyl cysteine By similarity
Lipidation71S-palmitoyl cysteine By similarity
Lipidation101S-palmitoyl cysteine By similarity
Lipidation1091S-palmitoyl cysteine By similarity
Lipidation1391S-palmitoyl cysteine By similarity
Lipidation1411S-palmitoyl cysteine By similarity
Lipidation1991O-palmitoyl serine By similarity
Disulfide bond184 ↔ 228 By similarity
Disulfide bond201 ↔ 220 By similarity

Natural variations

Alternative sequence117 – 15135Missing in isoform DM-20.
VSP_009194
Natural variant1871I → T in Rumpshaker. Ref.12
Natural variant2431A → V in Jimpy MSD. Ref.11

Experimental info

Sequence conflict701Y → C Ref.4
Sequence conflict701Y → C Ref.5
Sequence conflict1261S → Y in AAA39955. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 3C2BC973C3061C38

FASTA27730,077
        10         20         30         40         50         60 
MGLLECCARC LVGAPFASLV ATGLCFFGVA LFCGCGHEAL TGTEKLIETY FSKNYQDYEY 

        70         80         90        100        110        120 
LINVIHAFQY VIYGTASFFF LYGALLLAEG FYTTGAVRQI FGDYKTTICG KGLSATVTGG 

       130        140        150        160        170        180 
QKGRGSRGQH QAHSLERVCH CLGKWLGHPD KFVGITYALT VVWLLVFACS AVPVYIYFNT 

       190        200        210        220        230        240 
WTTCQSIAFP SKTSASIGSL CADARMYGVL PWNAFPGKVC GSNLLSICKT AEFQMTFHLF 

       250        260        270 
IAAFVGAAAT LVSLLTFMIA ATYNFAVLKL MGRGTKF 

« Hide

Isoform DM-20 [UniParc].

Checksum: 90DEFE60148DC659
Show »

FASTA24226,274

References

« Hide 'large scale' references
[1]"Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouse."
Hudson L.D., Berndt J.A., Puckett C., Kozak C.A., Lazzarini R.A.
Proc. Natl. Acad. Sci. U.S.A. 84:1454-1458(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND DM-20).
[2]"Myelin proteolipid protein gene structure and its regulation of expression in normal and jimpy mutant mice."
Ikenaka K., Furuichi T., Iwasaki Y., Moriguchi A., Okano H., Mikoshiba K.
J. Mol. Biol. 199:587-596(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[3]"Structure and expression of the mouse myelin proteolipid protein gene."
Macklin W.B., Campagnoni C.W., Deininger P.L., Gardinier M.V.
J. Neurosci. Res. 18:383-394(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
Strain: BALB/cByJ.
[4]"Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing."
Nave K.-A., Lai C., Bloom F.E., Milner R.J.
Proc. Natl. Acad. Sci. U.S.A. 83:9264-9268(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]"Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin."
Nave K.-A., Lai C., Bloom F.E., Milner R.J.
Proc. Natl. Acad. Sci. U.S.A. 84:5665-5669(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DM-20).
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Retina.
[7]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-9; 46-53; 99-122; 145-151 AND 193-229, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
[8]"Developmental expression of the myelin proteolipid protein and basic protein mRNAs in normal and dysmyelinating mutant mice."
Sorg B.A., Smith M.M., Campagnoni A.T.
J. Neurochem. 49:1146-1154(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 50-277.
[9]"Characterization of myelin proteolipid mRNAs in normal and jimpy mice."
Gardinier M.V., Macklin W.B., Diniak A.J., Deininger P.L.
Mol. Cell. Biol. 6:3755-3762(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 176-270.
[10]"An AG to a GG transition at a splice site in the myelin proteolipid protein gene in jimpy mice results in the removal of an exon."
Macklin W.B., Gardinier M.V., King K.D., Kampf K.
FEBS Lett. 223:417-421(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 209-232, ALTERNATIVE SPLICING.
[11]"Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice."
Gencic S., Hudson L.D.
J. Neurosci. 10:117-124(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT JIMPY MSD VAL-243.
[12]"Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene."
Schneider A., Montague P., Griffiths I., Fanarraga M., Kennedy P., Brophy P., Nave K.-A.
Nature 358:758-761(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT RUMPSHAKER THR-187.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M15442 mRNA. Translation: AAA39951.1.
M15442 mRNA. Translation: AAA39952.1. Sequence problems.
M15442 mRNA. Translation: AAA39953.1.
X07215 expand/collapse EMBL AC list , X07216, X07217, X07218, X07219, X07220, X07221 Genomic DNA. Translation: CAA30184.1.
M37335 expand/collapse EMBL AC list , M37329, M37330, M37331, M37332, M37333, M37334 Genomic DNA. Translation: AAA39954.1.
M14674 mRNA. Translation: AAA39955.1.
M16472 mRNA. Translation: AAA39950.1.
BC027010 mRNA. Translation: AAH27010.1.
X06375 Genomic DNA. Translation: CAB40821.1.
PIRS34792.
RefSeqNP_035253.1. NM_011123.2.
XP_006528576.1. XM_006528513.1.
UniGeneMm.1268.

3D structure databases

ProteinModelPortalP60202.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202254. 4 interactions.
IntActP60202. 3 interactions.
MINTMINT-4102954.

PTM databases

PhosphoSiteP60202.

Proteomic databases

PaxDbP60202.
PRIDEP60202.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033800; ENSMUSP00000033800; ENSMUSG00000031425. [P60202-1]
ENSMUST00000113085; ENSMUSP00000108708; ENSMUSG00000031425. [P60202-2]
GeneID18823.
KEGGmmu:18823.
UCSCuc009ujc.1. mouse. [P60202-1]

Organism-specific databases

CTD5354.
MGIMGI:97623. Plp1.

Phylogenomic databases

eggNOGNOG311658.
GeneTreeENSGT00390000006915.
HOGENOMHOG000231338.
HOVERGENHBG000096.
InParanoidP60202.
KOK17271.
OMAIGTLCAD.
OrthoDBEOG7X3QRG.
PhylomeDBP60202.
TreeFamTF315162.

Gene expression databases

ArrayExpressP60202.
BgeeP60202.
CleanExMM_PLP1.
GenevestigatorP60202.

Family and domain databases

InterProIPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view]
PANTHERPTHR11683. PTHR11683. 1 hit.
PfamPF01275. Myelin_PLP. 1 hit.
[Graphical view]
PRINTSPR00214. MYELINPLP.
SMARTSM00002. PLP. 1 hit.
[Graphical view]
PROSITEPS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPLP1. mouse.
NextBio295188.
PROP60202.
SOURCESearch...

Entry information

Entry nameMYPR_MOUSE
AccessionPrimary (citable) accession number: P60202
Secondary accession number(s): P04400, P06905, Q9WUS9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot