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Protein

Ribonuclease Z

Gene

rnz

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi63 – 631Zinc 1; catalyticUniRule annotation
Metal bindingi65 – 651Zinc 1; catalyticUniRule annotation
Active sitei67 – 671Proton acceptorUniRule annotation
Metal bindingi67 – 671Zinc 2; catalyticUniRule annotation
Metal bindingi68 – 681Zinc 2; catalyticUniRule annotation
Metal bindingi141 – 1411Zinc 1; catalyticUniRule annotation
Metal bindingi211 – 2111Zinc 1; catalyticUniRule annotation
Metal bindingi211 – 2111Zinc 2; catalyticUniRule annotation
Metal bindingi269 – 2691Zinc 2; catalyticUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-1404-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:SA1335
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Ribonuclease ZPRO_0000155895Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP60197.
SMRiP60197. Positions 1-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000272419.
OMAiIFFTHYH.
OrthoDBiEOG61P6TK.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

P60197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVTFFGTSA GLPTKERNTQ AIALNLEPYS NSIWLFDVGE GTQHQILHHA
60 70 80 90 100
IKLGKVTHIF ITHMHGDHIF GLPGLLSSRS FQGGEQKPLT LVGPKGIKAY
110 120 130 140 150
VEMSMNLSES HLNYPITYIE IDDHLTYHHD GFTVEAHLLN HGIPSYGYRV
160 170 180 190 200
MAPETTGTIN VEALKNIGLE PGPKYQEVKS HDTFEHNGQV YQSKDFRGES
210 220 230 240 250
KQGPVVAIFG DTKPCSNERV ISRDADVMVH EATYIDGEKH LANNYHHSHI
260 270 280 290 300
EDVFALIKEA NVKRTLITHL SNRYNTEDIN EIYQILIQNE DTPNFNFVKD

FDSFKV
Length:306
Mass (Da):34,583
Last modified:January 16, 2004 - v1
Checksum:i5B0F75A23CD0F15F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB42597.1.
PIRiH89929.
RefSeqiWP_000454063.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB42597; BAB42597; BAB42597.
PATRICi19574936. VBIStaAur116463_1437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB42597.1.
PIRiH89929.
RefSeqiWP_000454063.1. NC_002745.2.

3D structure databases

ProteinModelPortaliP60197.
SMRiP60197. Positions 1-274.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB42597; BAB42597; BAB42597.
PATRICi19574936. VBIStaAur116463_1437.

Phylogenomic databases

HOGENOMiHOG000272419.
OMAiIFFTHYH.
OrthoDBiEOG61P6TK.

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-1404-MONOMER.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.

Entry informationi

Entry nameiRNZ_STAAN
AccessioniPrimary (citable) accession number: P60197
Secondary accession number(s): Q99TY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: May 11, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.