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Protein

Regulating synaptic membrane exocytosis protein 4

Gene

Rims4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates synaptic membrane exocytosis.By similarity

GO - Molecular functioni

  • ion channel binding Source: MGI

GO - Biological processi

Keywordsi

Biological processExocytosis, Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Regulating synaptic membrane exocytosis protein 4
Alternative name(s):
RIM4 gamma
Rab3-interacting molecule 4
Short name:
RIM 4
Gene namesi
Name:Rims4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2674366 Rims4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001902081 – 269Regulating synaptic membrane exocytosis protein 4Add BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei254PhosphoserineCombined sources1
Modified residuei257PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP60191
PaxDbiP60191
PRIDEiP60191

PTM databases

iPTMnetiP60191
PhosphoSitePlusiP60191

Expressioni

Gene expression databases

BgeeiENSMUSG00000035226
CleanExiMM_RIMS4
GenevisibleiP60191 MM

Interactioni

Subunit structurei

Binds PPFIA3 (By similarity). Does not bind RAB3.By similarity

GO - Molecular functioni

  • ion channel binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045637

Structurei

3D structure databases

ProteinModelPortaliP60191
SMRiP60191
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 217C2PROSITE-ProRule annotationAdd BLAST103

Phylogenomic databases

eggNOGiKOG2060 Eukaryota
ENOG410ZNB1 LUCA
GeneTreeiENSGT00550000074588
HOGENOMiHOG000231017
HOVERGENiHBG056381
InParanoidiP60191
KOiK15299
OMAiSTVGPCC
OrthoDBiEOG091G0IYY
PhylomeDBiP60191

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
PfamiView protein in Pfam
PF00168 C2, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

Sequencei

Sequence statusi: Complete.

P60191-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERSQSRLSL SASFEALAIY FPCMNSFDDE DAADSRRLKG AIQRSTETGL
60 70 80 90 100
AVEMPSRTLR QASHESIEDS MNSYGSEGNL NYGGVCLASD AQFSDFLGSM
110 120 130 140 150
GPAQFVGRQT LATTPMGDVE IGLQERNGQL EVDIIQARGL TAKPGSKTLP
160 170 180 190 200
AAYIKAYLLE NGVCIAKKKT KVARKSLDPL YNQVLLFPES PQGKVLQVIV
210 220 230 240 250
WGNYGRMERK QFMGVARVLL EELDLTTLAV GWYKLFPTSS MVDPATGPLL
260
RQASQLSLES TVGPCGERS
Length:269
Mass (Da):29,329
Last modified:January 16, 2004 - v1
Checksum:i5CB33B573A9CECAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY326955 mRNA Translation: AAQ01682.1
CCDSiCCDS17018.1
RefSeqiNP_898844.1, NM_183023.1
UniGeneiMm.330760
Mm.459039

Genome annotation databases

EnsembliENSMUST00000044734; ENSMUSP00000045637; ENSMUSG00000035226
GeneIDi241770
KEGGimmu:241770
UCSCiuc008nto.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRIMS4_MOUSE
AccessioniPrimary (citable) accession number: P60191
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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