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Protein

Regulating synaptic membrane exocytosis protein 4

Gene

Rims4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates synaptic membrane exocytosis.By similarity

GO - Molecular functioni

  • ion channel binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Regulating synaptic membrane exocytosis protein 4
Alternative name(s):
RIM4 gamma
Rab3-interacting molecule 4
Short name:
RIM 4
Gene namesi
Name:Rims4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2674366. Rims4.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • synaptic membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Regulating synaptic membrane exocytosis protein 4PRO_0000190208Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei254 – 2541PhosphoserineCombined sources
Modified residuei257 – 2571PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP60191.
PaxDbiP60191.
PRIDEiP60191.

PTM databases

iPTMnetiP60191.
PhosphoSiteiP60191.

Expressioni

Gene expression databases

BgeeiP60191.
CleanExiMM_RIMS4.
GenevisibleiP60191. MM.

Interactioni

Subunit structurei

Binds PPFIA3 (By similarity). Does not bind RAB3.By similarity

GO - Molecular functioni

  • ion channel binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045637.

Structurei

3D structure databases

ProteinModelPortaliP60191.
SMRiP60191. Positions 99-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 217103C2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2060. Eukaryota.
ENOG410ZNB1. LUCA.
GeneTreeiENSGT00550000074588.
HOGENOMiHOG000231017.
HOVERGENiHBG056381.
InParanoidiP60191.
KOiK15299.
OMAiSTVGPCC.
OrthoDBiEOG7BGHJV.
PhylomeDBiP60191.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60191-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERSQSRLSL SASFEALAIY FPCMNSFDDE DAADSRRLKG AIQRSTETGL
60 70 80 90 100
AVEMPSRTLR QASHESIEDS MNSYGSEGNL NYGGVCLASD AQFSDFLGSM
110 120 130 140 150
GPAQFVGRQT LATTPMGDVE IGLQERNGQL EVDIIQARGL TAKPGSKTLP
160 170 180 190 200
AAYIKAYLLE NGVCIAKKKT KVARKSLDPL YNQVLLFPES PQGKVLQVIV
210 220 230 240 250
WGNYGRMERK QFMGVARVLL EELDLTTLAV GWYKLFPTSS MVDPATGPLL
260
RQASQLSLES TVGPCGERS
Length:269
Mass (Da):29,329
Last modified:January 16, 2004 - v1
Checksum:i5CB33B573A9CECAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY326955 mRNA. Translation: AAQ01682.1.
CCDSiCCDS17018.1.
RefSeqiNP_898844.1. NM_183023.1.
UniGeneiMm.330760.
Mm.459039.

Genome annotation databases

EnsembliENSMUST00000044734; ENSMUSP00000045637; ENSMUSG00000035226.
GeneIDi241770.
KEGGimmu:241770.
UCSCiuc008nto.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY326955 mRNA. Translation: AAQ01682.1.
CCDSiCCDS17018.1.
RefSeqiNP_898844.1. NM_183023.1.
UniGeneiMm.330760.
Mm.459039.

3D structure databases

ProteinModelPortaliP60191.
SMRiP60191. Positions 99-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045637.

PTM databases

iPTMnetiP60191.
PhosphoSiteiP60191.

Proteomic databases

MaxQBiP60191.
PaxDbiP60191.
PRIDEiP60191.

Protocols and materials databases

DNASUi241770.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044734; ENSMUSP00000045637; ENSMUSG00000035226.
GeneIDi241770.
KEGGimmu:241770.
UCSCiuc008nto.1. mouse.

Organism-specific databases

CTDi140730.
MGIiMGI:2674366. Rims4.

Phylogenomic databases

eggNOGiKOG2060. Eukaryota.
ENOG410ZNB1. LUCA.
GeneTreeiENSGT00550000074588.
HOGENOMiHOG000231017.
HOVERGENiHBG056381.
InParanoidiP60191.
KOiK15299.
OMAiSTVGPCC.
OrthoDBiEOG7BGHJV.
PhylomeDBiP60191.

Miscellaneous databases

PROiP60191.
SOURCEiSearch...

Gene expression databases

BgeeiP60191.
CleanExiMM_RIMS4.
GenevisibleiP60191. MM.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins."
    Wang Y., Suedhof T.C.
    Genomics 81:126-137(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254 AND SER-257, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiRIMS4_MOUSE
AccessioniPrimary (citable) accession number: P60191
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.