Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Delta-conotoxin Am2766

Gene
N/A
Organism
Conus amadis (Amadis cone)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-conotoxin Am2766
OrganismiConus amadis (Amadis cone)
Taxonomic identifieri198732 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1630. Am2766.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000444741 – 26Delta-conotoxin Am2766Add BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1 ↔ 161 Publication
Disulfide bondi8 ↔ 201 Publication
Disulfide bondi15 ↔ 241 Publication
Modified residuei26Glutamic acid 1-amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

Secondary structure

126
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 12Combined sources3
Beta strandi21 – 23Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YZ2NMR-A1-26[»]
ProteinModelPortaliP60179.
SMRiP60179.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60179.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin O1 superfamily.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR012322. Conotoxin_d-typ_CS.
PROSITEiView protein in PROSITE
PS60005. DELTA_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P60179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
CKQAGESCDI FSQNCCVGTC AFICIE
Length:26
Mass (Da):2,773
Last modified:December 15, 2003 - v1
Checksum:iADF678066CF6D615
GO

Mass spectrometryi

Molecular mass is 2766 Da from positions 1 - 26. Determined by ESI. 1 Publication
Molecular mass is 2766 Da from positions 1 - 26. Determined by MALDI. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiCO66_CONAA
AccessioniPrimary (citable) accession number: P60179
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: January 18, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families