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P60178 (TXMG3_AGEAP) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mu-agatoxin-Aa1c

Short name=Mu-AGTX-Aa1c
Alternative name(s):
Mu-agatoxin III
Mu-agatoxin-3
OrganismAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifier6908 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Protein attributes

Sequence length38 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons. Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Domain

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.

Toxic dose

Lethal dose is 28 +-12 mg/kg into third stadium larvae of M.sexta. Ref.1

Sequence similarities

Belongs to the beta/delta-agatoxin family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3838Mu-agatoxin-Aa1c
PRO_0000044955

Amino acid modifications

Modified residue381Serine amide
Disulfide bond3 ↔ 19 By similarity
Disulfide bond10 ↔ 24 By similarity
Disulfide bond18 ↔ 34 By similarity
Disulfide bond26 ↔ 32 By similarity

Sequences

Sequence LengthMass (Da)Tools
P60178 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 6031DFF4DB386AD0

FASTA384,197
        10         20         30 
ADCVGDGQRC ADWAGPYCCS GYYCSCRSMP YCRCRSDS 

« Hide

References

[1]"Purification and characterization of two classes of neurotoxins from the funnel web spider, Agelenopsis aperta."
Skinner W.S., Adams M.E., Quistad G.B., Kataoka H., Cesarin B.J., Enderlin F.E., Schooley D.A.
J. Biol. Chem. 264:2150-2155(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, LETHAL DOSE.
Tissue: Venom.
[2]"Agatoxins: ion channel specific toxins from the American funnel web spider, Agelenopsis aperta."
Adams M.E.
Toxicon 43:509-525(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

PIRC32038.

3D structure databases

ProteinModelPortalP60178.
SMRP60178. Positions 3-38.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ArachnoServerAS000379. mu-agatoxin-Aa1c.

Family and domain databases

InterProIPR016328. Curtatoxin.
IPR009243. Toxin_7.
[Graphical view]
PIRSFPIRSF001882. Curtatoxin. 1 hit.
PROSITEPS60015. MU_AGATOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTXMG3_AGEAP
AccessionPrimary (citable) accession number: P60178
Secondary accession number(s): P11059
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: October 16, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families