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P60178

- TXMG3_AGEAP

UniProt

P60178 - TXMG3_AGEAP

Protein

Mu-agatoxin-Aa1c

Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons.1 Publication

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mu-agatoxin-Aa1c
    Short name:
    Mu-AGTX-Aa1c
    Alternative name(s):
    Mu-agatoxin III
    Mu-agatoxin-3
    OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
    Taxonomic identifieri6908 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

    Organism-specific databases

    ArachnoServeriAS000379. mu-agatoxin-Aa1c.

    Subcellular locationi

    GO - Cellular componenti

    1. other organism presynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Toxic dosei

    Lethal dose is 28 +-12 mg/kg into third stadium larvae of M.sexta.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 3838Mu-agatoxin-Aa1cPRO_0000044955Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi3 ↔ 19By similarity
    Disulfide bondi10 ↔ 24By similarity
    Disulfide bondi18 ↔ 34By similarity
    Disulfide bondi26 ↔ 32By similarity
    Modified residuei38 – 381Serine amide

    Keywords - PTMi

    Amidation, Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    3D structure databases

    ProteinModelPortaliP60178.
    SMRiP60178. Positions 3-38.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

    Sequence similaritiesi

    Belongs to the beta/delta-agatoxin family.Curated

    Keywords - Domaini

    Knottin

    Family and domain databases

    InterProiIPR016328. Curtatoxin.
    IPR009243. Toxin_7.
    [Graphical view]
    PIRSFiPIRSF001882. Curtatoxin. 1 hit.
    PROSITEiPS60015. MU_AGATOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60178-1 [UniParc]FASTAAdd to Basket

    « Hide

    ADCVGDGQRC ADWAGPYCCS GYYCSCRSMP YCRCRSDS                38
    Length:38
    Mass (Da):4,197
    Last modified:December 15, 2003 - v1
    Checksum:i6031DFF4DB386AD0
    GO

    Sequence databases

    PIRiC32038.

    Cross-referencesi

    Sequence databases

    PIRi C32038.

    3D structure databases

    ProteinModelPortali P60178.
    SMRi P60178. Positions 3-38.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ArachnoServeri AS000379. mu-agatoxin-Aa1c.

    Family and domain databases

    InterProi IPR016328. Curtatoxin.
    IPR009243. Toxin_7.
    [Graphical view ]
    PIRSFi PIRSF001882. Curtatoxin. 1 hit.
    PROSITEi PS60015. MU_AGATOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Purification and characterization of two classes of neurotoxins from the funnel web spider, Agelenopsis aperta."
      Skinner W.S., Adams M.E., Quistad G.B., Kataoka H., Cesarin B.J., Enderlin F.E., Schooley D.A.
      J. Biol. Chem. 264:2150-2155(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, LETHAL DOSE.
      Tissue: Venom.
    2. "Agatoxins: ion channel specific toxins from the American funnel web spider, Agelenopsis aperta."
      Adams M.E.
      Toxicon 43:509-525(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiTXMG3_AGEAP
    AccessioniPrimary (citable) accession number: P60178
    Secondary accession number(s): P11059
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3