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Protein

Mu-agatoxin-Hc1b

Gene
N/A
Organism
Hololena curta (Funnel-web spider) (Agelena curta)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Insecticidal neurotoxin that induces irreversible neuromuscular blockade in the cricket A.domestica. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Mu-agatoxin-Hc1b
Short name:
Mu-AGTX-Hc1b
Alternative name(s):
Curtatoxin-21 Publication
Short name:
CT-II1 Publication
OrganismiHololena curta (Funnel-web spider) (Agelena curta)
Taxonomic identifieri6910 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeHololena

Organism-specific databases

ArachnoServeriAS000295. mu-agatoxin-Hc1b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

Lethal dose is 4 mg/kg into the thoracic cavity of crickets (A.domestica).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449561 – 38Mu-agatoxin-Hc1bAdd BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 19By similarity
Disulfide bondi10 ↔ 24By similarity
Disulfide bondi18 ↔ 34By similarity
Disulfide bondi26 ↔ 32By similarity
Modified residuei38Serine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP60177.
SMRiP60177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR016328. Beta/delta-agatoxin_fam.
PIRSFiPIRSF001882. Curtatoxin. 1 hit.
PROSITEiView protein in PROSITE
PS60015. MU_AGATOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P60177-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
ADCVGDGQRC ADWAGPYCCS GYYCSCRSMP YCRCRSDS
Length:38
Mass (Da):4,197
Last modified:December 15, 2003 - v1
Checksum:i6031DFF4DB386AD0
GO

Sequence databases

PIRiB35030.

Similar proteinsi

Entry informationi

Entry nameiT3C2_HOLCU
AccessioniPrimary (citable) accession number: P60177
Secondary accession number(s): P11059
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: November 22, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families