Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P60165

- KA112_PARVI

UniProt

P60165 - KA112_PARVI

Protein

Potassium channel toxin alpha-KTx 11.2

Gene
N/A
Organism
Parabuthus villosus (Scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds and inhibits voltage-sensitive potassium channels. Inhibits the vertebrate potassium channel Kv1.1/KCNA1 with low affinity.1 Publication

    GO - Molecular functioni

    1. potassium channel inhibitor activity Source: UniProtKB

    GO - Biological processi

    1. pathogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin alpha-KTx 11.2
    Alternative name(s):
    Parabutoxin-2
    Short name:
    PBTx2
    OrganismiParabuthus villosus (Scorpion)
    Taxonomic identifieri252780 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeParabuthus

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 3737Potassium channel toxin alpha-KTx 11.2PRO_0000044916Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi8 ↔ 27By similarity
    Disulfide bondi13 ↔ 33By similarity
    Disulfide bondi17 ↔ 35By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR012635. Parabutoxin.
    [Graphical view]
    PfamiPF08119. Toxin_31. 1 hit.
    [Graphical view]
    ProDomiPD926031. Parabutoxin. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P60165-1 [UniParc]FASTAAdd to Basket

    « Hide

    DEEPKETCSD EMCVIYCKGE EYSTGVCDGP QKCKCSD                 37
    Length:37
    Mass (Da):4,111
    Last modified:December 15, 2003 - v1
    Checksum:i24D4CB1ADF1D56A2
    GO

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR012635. Parabutoxin.
    [Graphical view ]
    Pfami PF08119. Toxin_31. 1 hit.
    [Graphical view ]
    ProDomi PD926031. Parabutoxin. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies."
      Tytgat J., Chandy K.G., Garcia M.L., Gutman G.A., Martin-Eauclaire M.-F., van der Walt J.J., Possani L.D.
      Trends Pharmacol. Sci. 20:444-447(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, REVIEW.
      Tissue: Venom.
    2. Cited for: FUNCTION.

    Entry informationi

    Entry nameiKA112_PARVI
    AccessioniPrimary (citable) accession number: P60165
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3