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Protein

Potassium channel toxin alpha-KTx 11.2

Gene
N/A
Organism
Parabuthus villosus (Scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds and inhibits voltage-sensitive potassium channels. Inhibits the vertebrate potassium channel Kv1.1/KCNA1 with low affinity.1 Publication

GO - Molecular functioni

  1. potassium channel inhibitor activity Source: UniProtKB

GO - Biological processi

  1. pathogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 11.2
Alternative name(s):
Parabutoxin-2
Short name:
PBTx2
OrganismiParabuthus villosus (Scorpion)
Taxonomic identifieri252780 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeParabuthus

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3737Potassium channel toxin alpha-KTx 11.2PRO_0000044916Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi8 ↔ 27By similarity
Disulfide bondi13 ↔ 33By similarity
Disulfide bondi17 ↔ 35By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR012635. Parabutoxin.
[Graphical view]
PfamiPF08119. Toxin_31. 1 hit.
[Graphical view]
ProDomiPD926031. Parabutoxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P60165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
DEEPKETCSD EMCVIYCKGE EYSTGVCDGP QKCKCSD
Length:37
Mass (Da):4,111
Last modified:December 14, 2003 - v1
Checksum:i24D4CB1ADF1D56A2
GO

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR012635. Parabutoxin.
[Graphical view]
PfamiPF08119. Toxin_31. 1 hit.
[Graphical view]
ProDomiPD926031. Parabutoxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies."
    Tytgat J., Chandy K.G., Garcia M.L., Gutman G.A., Martin-Eauclaire M.-F., van der Walt J.J., Possani L.D.
    Trends Pharmacol. Sci. 20:444-447(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, REVIEW.
    Tissue: Venom.
  2. Cited for: FUNCTION.

Entry informationi

Entry nameiKA112_PARVI
AccessioniPrimary (citable) accession number: P60165
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2003
Last sequence update: December 14, 2003
Last modified: September 30, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.