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P60165

- KA112_PARVI

UniProt

P60165 - KA112_PARVI

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Protein

Potassium channel toxin alpha-KTx 11.2

Gene
N/A
Organism
Parabuthus villosus (Scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Binds and inhibits voltage-sensitive potassium channels. Inhibits the vertebrate potassium channel Kv1.1/KCNA1 with low affinity.1 Publication

GO - Molecular functioni

  1. potassium channel inhibitor activity Source: UniProtKB

GO - Biological processi

  1. pathogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 11.2
Alternative name(s):
Parabutoxin-2
Short name:
PBTx2
OrganismiParabuthus villosus (Scorpion)
Taxonomic identifieri252780 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeParabuthus

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3737Potassium channel toxin alpha-KTx 11.2PRO_0000044916Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi8 ↔ 27By similarity
Disulfide bondi13 ↔ 33By similarity
Disulfide bondi17 ↔ 35By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR012635. Parabutoxin.
[Graphical view]
PfamiPF08119. Toxin_31. 1 hit.
[Graphical view]
ProDomiPD926031. Parabutoxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P60165-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30 
DEEPKETCSD EMCVIYCKGE EYSTGVCDGP QKCKCSD
Length:37
Mass (Da):4,111
Last modified:December 15, 2003 - v1
Checksum:i24D4CB1ADF1D56A2
GO

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR012635. Parabutoxin.
[Graphical view ]
Pfami PF08119. Toxin_31. 1 hit.
[Graphical view ]
ProDomi PD926031. Parabutoxin. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies."
    Tytgat J., Chandy K.G., Garcia M.L., Gutman G.A., Martin-Eauclaire M.-F., van der Walt J.J., Possani L.D.
    Trends Pharmacol. Sci. 20:444-447(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, REVIEW.
    Tissue: Venom.
  2. Cited for: FUNCTION.

Entry informationi

Entry nameiKA112_PARVI
AccessioniPrimary (citable) accession number: P60165
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: October 1, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3