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P60165 (KA112_PARVI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 11.2
Alternative name(s):
Parabutoxin-2
Short name=PBTx2
OrganismParabuthus villosus (Scorpion)
Taxonomic identifier252780 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeParabuthus

Protein attributes

Sequence length37 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds and inhibits voltage-sensitive potassium channels. Inhibits the vertebrate potassium channel Kv1.1/KCNA1 with low affinity. Ref.2

Subcellular location

Secreted Ref.1.

Tissue specificity

Expressed by the venom gland. Ref.1

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 11 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3737Potassium channel toxin alpha-KTx 11.2
PRO_0000044916

Amino acid modifications

Disulfide bond8 ↔ 27 By similarity
Disulfide bond13 ↔ 33 By similarity
Disulfide bond17 ↔ 35 By similarity

Sequences

Sequence LengthMass (Da)Tools
P60165 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 24D4CB1ADF1D56A2

FASTA374,111
        10         20         30 
DEEPKETCSD EMCVIYCKGE EYSTGVCDGP QKCKCSD 

« Hide

References

[1]"A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies."
Tytgat J., Chandy K.G., Garcia M.L., Gutman G.A., Martin-Eauclaire M.-F., van der Walt J.J., Possani L.D.
Trends Pharmacol. Sci. 20:444-447(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, REVIEW.
Tissue: Venom.
[2]"A subfamily of acidic alpha-K(+) toxins."
Huys I., Olamendi-Portugal T., Garcia-Gomez B.I., Vandenberghe I., Van Beeumen J., Dyason K., Clynen E., Zhu S., van der Walt J., Possani L.D., Tytgat J.
J. Biol. Chem. 279:2781-2789(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR012635. Parabutoxin.
[Graphical view]
PfamPF08119. Toxin_31. 1 hit.
[Graphical view]
ProDomPD926031. Parabutoxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameKA112_PARVI
AccessionPrimary (citable) accession number: P60165
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: February 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries