P60165 (KA112_PARVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Potassium channel toxin alpha-KTx 11.2 Alternative name(s): Parabutoxin-2 Short name=PBTx2
Organism	Parabuthus villosus (Scorpion)
Taxonomic identifier	252780 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Parabuthus

Protein attributes

Sequence length	37 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds and inhibits voltage-sensitive potassium channels. Inhibits the vertebrate potassium channel Kv1.1/KCNA1 with low affinity. Ref.2
Subcellular location	Secreted Ref.1.
Tissue specificity	Expressed by the venom gland. Ref.1
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 11 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Ion channel impairing toxin Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from direct assay Ref.2. Source: UniProtKB
Cellular_component	extracellular region Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	potassium channel inhibitor activity Inferred from direct assay Ref.2. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 37	37	Potassium channel toxin alpha-KTx 11.2		PRO_0000044916
Amino acid modifications
	Disulfide bond	8 ↔ 27		By similarity
	Disulfide bond	13 ↔ 33		By similarity
	Disulfide bond	17 ↔ 35		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P60165 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 24D4CB1ADF1D56A2	FASTA	37	4,111
	10 20 30 DEEPKETCSD EMCVIYCKGE EYSTGVCDGP QKCKCSD

References

[1]	"A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies." Tytgat J., Chandy K.G., Garcia M.L., Gutman G.A., Martin-Eauclaire M.-F., van der Walt J.J., Possani L.D. Trends Pharmacol. Sci. 20:444-447(1999) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, REVIEW. Tissue: Venom.
[2]	"A subfamily of acidic alpha-K(+) toxins." Huys I., Olamendi-Portugal T., Garcia-Gomez B.I., Vandenberghe I., Van Beeumen J., Dyason K., Clynen E., Zhu S., van der Walt J., Possani L.D., Tytgat J. J. Biol. Chem. 279:2781-2789(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR012635. Parabutoxin. [Graphical view]
Pfam	PF08119. Toxin_31. 1 hit. [Graphical view]
ProDom	PD926031. Parabutoxin. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01138. SCORP_SHORT_TOXIN. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KA112_PARVI

Accession

Primary (citable) accession number: P60165

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	December 15, 2003
Last modified:	March 6, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program