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P60164 (KA111_PARVI) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 11.1
Alternative name(s):
Parabutoxin-1
Short name=PBTx1
OrganismParabuthus villosus (Scorpion)
Taxonomic identifier252780 [NCBI]
Taxonomic lineageEukaryotaMetazoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeParabuthus

Protein attributes

Sequence length37 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds and inhibits voltage-sensitive potassium channels. Inhibits the vertebrate potassium channels Kv1.1/KCNA1, Kv1.2/KCNA2 and Kv1.3/KCNA3 with low affinity. Ref.2

Subcellular location

Secreted Ref.1.

Tissue specificity

Expressed by the venom gland. Ref.1

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 11 subfamily.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionIonic channel inhibitor
Neurotoxin
Potassium channel inhibitor
Toxin
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processpathogenesis

Inferred from direct assay Ref.2. Source: UniProtKB

   Cellular componentextracellular region

Inferred from direct assay Ref.1. Source: UniProtKB

   Molecular functionpotassium channel inhibitor activity

Inferred from direct assay Ref.2. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3737Potassium channel toxin alpha-KTx 11.1
PRO_0000044915

Amino acid modifications

Disulfide bond8 ↔ 27 By similarity
Disulfide bond13 ↔ 33 By similarity
Disulfide bond17 ↔ 35 By similarity

Experimental info

Mutagenesis241T → F: Increased affinity towards Kv1.1, Kv1.2 and Kv1.3 channels. Ref.2
Mutagenesis261V → K: Increased affinity towards Kv1.1, Kv1.2 and Kv1.3 channels. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P60164 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 61C4CB1ADF1D51D2

FASTA374,096
        10         20         30 
DEEPKESCSD EMCVIYCKGE EYSTGVCDGP QKCKCSD 

« Hide

References

[1]"A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies."
Tytgat J., Chandy K.G., Garcia M.L., Gutman G.A., Martin-Eauclaire M.-F., van der Walt J.J., Possani L.D.
Trends Pharmacol. Sci. 20:444-447(1999) [PubMed: 10542442] [Abstract]
Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, REVIEW.
Tissue: Venom.
[2]"A subfamily of acidic alpha-K(+) toxins."
Huys I., Olamendi-Portugal T., Garcia-Gomez B.I., Vandenberghe I., Van Beeumen J., Dyason K., Clynen E., Zhu S., van der Walt J., Possani L.D., Tytgat J.
J. Biol. Chem. 279:2781-2789(2004) [PubMed: 14561751] [Abstract]
Cited for: FUNCTION, MUTAGENESIS OF THR-24 AND VAL-26.

Cross-references

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR012635. Parabutoxin.
[Graphical view]
PfamPF08119. Toxin_31. 1 hit.
[Graphical view]
ProDomPD926031. Parabutoxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS01138. SCORP_SHORT_TOXIN. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKA111_PARVI
AccessionPrimary (citable) accession number: P60164
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: September 21, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries

SIMILARITY comments

Index of protein domains and families