ID   RNAS9_MOUSE             Reviewed;         184 AA.
AC   P60154;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2003, sequence version 1.
DT   24-JAN-2024, entry version 127.
DE   RecName: Full=Inactive ribonuclease-like protein 9;
DE   Flags: Precursor;
GN   Name=Rnase9;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=FVB/N; TISSUE=Epididymis;
RX   PubMed=12920233; DOI=10.1210/me.2003-0008;
RA   Penttinen J., Pujianto D.A., Sipilae P., Huhtaniemi I., Poutanen M.;
RT   "Discovery in silico and characterization in vitro of novel genes
RT   exclusively expressed in the mouse epididymis.";
RL   Mol. Endocrinol. 17:2138-2151(2003).
CC   -!- FUNCTION: Does not exhibit any ribonuclease activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC       {ECO:0000305}.
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DR   EMBL; AY226989; AAP43946.1; -; mRNA.
DR   CCDS; CCDS36909.1; -.
DR   RefSeq; NP_898853.2; NM_183032.2.
DR   RefSeq; XP_006519205.1; XM_006519142.3.
DR   AlphaFoldDB; P60154; -.
DR   SMR; P60154; -.
DR   STRING; 10090.ENSMUSP00000066637; -.
DR   GlyCosmos; P60154; 2 sites, No reported glycans.
DR   GlyGen; P60154; 2 sites.
DR   iPTMnet; P60154; -.
DR   PhosphoSitePlus; P60154; -.
DR   PaxDb; 10090-ENSMUSP00000066637; -.
DR   ProteomicsDB; 299924; -.
DR   Antibodypedia; 175; 128 antibodies from 18 providers.
DR   Ensembl; ENSMUST00000064214.4; ENSMUSP00000066637.4; ENSMUSG00000052382.6.
DR   GeneID; 328401; -.
DR   KEGG; mmu:328401; -.
DR   UCSC; uc007tmh.1; mouse.
DR   AGR; MGI:3057273; -.
DR   CTD; 390443; -.
DR   MGI; MGI:3057273; Rnase9.
DR   VEuPathDB; HostDB:ENSMUSG00000052382; -.
DR   eggNOG; ENOG502TDU6; Eukaryota.
DR   GeneTree; ENSGT00390000013952; -.
DR   HOGENOM; CLU_1464451_0_0_1; -.
DR   InParanoid; P60154; -.
DR   OMA; LITCRWQ; -.
DR   OrthoDB; 5264213at2759; -.
DR   PhylomeDB; P60154; -.
DR   TreeFam; TF338401; -.
DR   BioGRID-ORCS; 328401; 2 hits in 75 CRISPR screens.
DR   PRO; PR:P60154; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; P60154; Protein.
DR   Bgee; ENSMUSG00000052382; Expressed in mesodermal cell in embryo and 1 other cell type or tissue.
DR   ExpressionAtlas; P60154; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0060474; P:positive regulation of flagellated sperm motility involved in capacitation; IMP:MGI.
DR   CDD; cd00163; RNase_A; 1.
DR   Gene3D; 3.10.130.10; Ribonuclease A-like domain; 1.
DR   InterPro; IPR001427; RNaseA.
DR   InterPro; IPR036816; RNaseA-like_dom_sf.
DR   InterPro; IPR023412; RNaseA_domain.
DR   PANTHER; PTHR11437:SF14; INACTIVE RIBONUCLEASE-LIKE PROTEIN 9; 1.
DR   PANTHER; PTHR11437; RIBONUCLEASE; 1.
DR   Pfam; PF00074; RnaseA; 1.
DR   SUPFAM; SSF54076; RNase A-like; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..184
FT                   /note="Inactive ribonuclease-like protein 9"
FT                   /id="PRO_0000030956"
FT   CARBOHYD        147
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        179
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        93..148
FT                   /evidence="ECO:0000250"
FT   DISULFID        111..163
FT                   /evidence="ECO:0000250"
FT   DISULFID        118..125
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   184 AA;  21378 MW;  89B3A112C06066C3 CRC64;
     MKPLVIKFAW PLPLLLLLLL PPKLQGNYWD FGEYELNPEV RDFIREYEST GPTKPPTVKR
     IIEMITIGDQ PFNDYDYCNT ELRTKQIHYK GRCYPEHYIA GVPYGELVKA CDGEEVQCKN
     GVKSCRRSMN LIEGVRCVLE TGQQMTNCTY KTILMIGYPV VSCQWDEETK IFIPDHIYNM
     SLPK
//