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P60153

- RNAS9_HUMAN

UniProt

P60153 - RNAS9_HUMAN

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Protein
Inactive ribonuclease-like protein 9
Gene
RNASE9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Does not exhibit any ribonuclease activity.2 Publications

GO - Molecular functioni

  1. endoribonuclease activity, producing 3'-phosphomonoesters Source: InterPro
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive ribonuclease-like protein 9
Gene namesi
Name:RNASE9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20673. RNASE9.

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887351.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 Publication
Add
BLAST
Chaini27 – 205179Inactive ribonuclease-like protein 9
PRO_0000030951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi116 ↔ 168 By similarity
Disulfide bondi123 ↔ 130 By similarity
Glycosylationi131 – 1311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi143 – 1431N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP60153.
PRIDEiP60153.

Expressioni

Tissue specificityi

At the mRNA level, widely expressed (1 Publication). At protein level, restricted to epididymis (1 Publication). Expressed in spermatozoa (sperm head and neck), with higher levels on ejaculated and epididymal sperm than on testicular sperm (at protein level). Expressed in the epithelial cells of the epididymal tubule (at protein level). Not detected in muscle.2 Publications

Gene expression databases

BgeeiP60153.
CleanExiHS_RNASE9.
GenevestigatoriP60153.

Organism-specific databases

HPAiHPA003391.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340162.

Structurei

3D structure databases

ProteinModelPortaliP60153.
SMRiP60153. Positions 80-186.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46399.
HOGENOMiHOG000236243.
HOVERGENiHBG056874.
InParanoidiP60153.
OMAiKNGIRKC.
OrthoDBiEOG7XDBHR.
PhylomeDBiP60153.
TreeFamiTF338401.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54076. SSF54076. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P60153-1) [UniParc]FASTAAdd to Basket

Also known as: alpha1, alpha2, alpha12, beta2, beta12

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMRTLITTHP LPLLLLPQQL LQLVQFQEVD TDFDFPEEDK KEEFEECLEK    50
FFSTGPARPP TKEKVKRRVL IEPGMPLNHI EYCNHEIMGK NVYYKHRWVA 100
EHYFLLMQYD ELQKICYNRF VPCKNGIRKC NRSKGLVEGV YCNLTEAFEI 150
PACKYESLYR KGYVLITCSW QNEMQKRIPH TINDLVEPPE HRSFLSEDGV 200
FVISP 205
Length:205
Mass (Da):24,307
Last modified:November 28, 2003 - v1
Checksum:iEDE63F0727282BF6
GO
Isoform 2 (identifier: P60153-2) [UniParc]FASTAAdd to Basket

Also known as: alpha23, alpha123

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSAGKM

Show »
Length:210
Mass (Da):24,782
Checksum:iFCF929B3261222E6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti148 – 1481F → S.3 Publications
Corresponds to variant rs12590446 [ dbSNP | Ensembl ].
VAR_052197
Natural varianti204 – 2041S → P.3 Publications
Corresponds to variant rs1243647 [ dbSNP | Ensembl ].
VAR_034473

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MSAGKM in isoform 2.
VSP_041856

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY665804 mRNA. Translation: AAV87182.1.
EU414264 mRNA. Translation: ACA49544.1.
AF382949 mRNA. Translation: AAQ02792.1.
AY907670 mRNA. Translation: AAX86045.1.
EF061296 mRNA. Translation: ABP97451.1.
EF061297 mRNA. Translation: ABP97452.1.
EF061298 mRNA. Translation: ABP97453.1.
EF061299 mRNA. Translation: ABP97454.1.
EF061300 mRNA. Translation: ABP97455.1.
EF061301 mRNA. Translation: ABP97456.1.
EF061302 mRNA. Translation: ABP97457.1.
EF061303 mRNA. Translation: ABP97458.1.
EF061304 mRNA. Translation: ABP97459.1.
AL163195 Genomic DNA. No translation available.
BC130311 mRNA. Translation: AAI30312.1.
BC130313 mRNA. Translation: AAI30314.1.
CCDSiCCDS32036.1. [P60153-1]
CCDS53883.1. [P60153-2]
CCDS55904.1. [P60153-2]
RefSeqiNP_001001673.2. NM_001001673.3. [P60153-1]
NP_001103826.1. NM_001110356.1. [P60153-1]
NP_001103827.1. NM_001110357.1. [P60153-1]
NP_001103828.1. NM_001110358.1. [P60153-2]
NP_001103829.1. NM_001110359.1. [P60153-2]
NP_001103830.1. NM_001110360.1. [P60153-2]
NP_001103831.1. NM_001110361.1. [P60153-2]
NP_001276039.1. NM_001289110.1. [P60153-1]
XP_006720205.1. XM_006720142.1. [P60153-1]
UniGeneiHs.533972.

Genome annotation databases

EnsembliENST00000338904; ENSP00000340162; ENSG00000188655. [P60153-1]
ENST00000404716; ENSP00000384683; ENSG00000188655. [P60153-2]
ENST00000429244; ENSP00000409504; ENSG00000188655. [P60153-1]
ENST00000553541; ENSP00000451285; ENSG00000188655. [P60153-1]
ENST00000553706; ENSP00000450570; ENSG00000188655. [P60153-2]
ENST00000554964; ENSP00000450599; ENSG00000188655. [P60153-1]
ENST00000555230; ENSP00000450800; ENSG00000188655. [P60153-1]
ENST00000556208; ENSP00000451160; ENSG00000188655. [P60153-2]
ENST00000557068; ENSP00000451565; ENSG00000188655. [P60153-1]
ENST00000557209; ENSP00000450987; ENSG00000188655. [P60153-2]
GeneIDi390443.
KEGGihsa:390443.
UCSCiuc001vxq.4. human. [P60153-2]
uc010aho.3. human. [P60153-1]

Polymorphism databases

DMDMi38605140.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY665804 mRNA. Translation: AAV87182.1 .
EU414264 mRNA. Translation: ACA49544.1 .
AF382949 mRNA. Translation: AAQ02792.1 .
AY907670 mRNA. Translation: AAX86045.1 .
EF061296 mRNA. Translation: ABP97451.1 .
EF061297 mRNA. Translation: ABP97452.1 .
EF061298 mRNA. Translation: ABP97453.1 .
EF061299 mRNA. Translation: ABP97454.1 .
EF061300 mRNA. Translation: ABP97455.1 .
EF061301 mRNA. Translation: ABP97456.1 .
EF061302 mRNA. Translation: ABP97457.1 .
EF061303 mRNA. Translation: ABP97458.1 .
EF061304 mRNA. Translation: ABP97459.1 .
AL163195 Genomic DNA. No translation available.
BC130311 mRNA. Translation: AAI30312.1 .
BC130313 mRNA. Translation: AAI30314.1 .
CCDSi CCDS32036.1. [P60153-1 ]
CCDS53883.1. [P60153-2 ]
CCDS55904.1. [P60153-2 ]
RefSeqi NP_001001673.2. NM_001001673.3. [P60153-1 ]
NP_001103826.1. NM_001110356.1. [P60153-1 ]
NP_001103827.1. NM_001110357.1. [P60153-1 ]
NP_001103828.1. NM_001110358.1. [P60153-2 ]
NP_001103829.1. NM_001110359.1. [P60153-2 ]
NP_001103830.1. NM_001110360.1. [P60153-2 ]
NP_001103831.1. NM_001110361.1. [P60153-2 ]
NP_001276039.1. NM_001289110.1. [P60153-1 ]
XP_006720205.1. XM_006720142.1. [P60153-1 ]
UniGenei Hs.533972.

3D structure databases

ProteinModelPortali P60153.
SMRi P60153. Positions 80-186.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000340162.

Polymorphism databases

DMDMi 38605140.

Proteomic databases

PaxDbi P60153.
PRIDEi P60153.

Protocols and materials databases

DNASUi 390443.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338904 ; ENSP00000340162 ; ENSG00000188655 . [P60153-1 ]
ENST00000404716 ; ENSP00000384683 ; ENSG00000188655 . [P60153-2 ]
ENST00000429244 ; ENSP00000409504 ; ENSG00000188655 . [P60153-1 ]
ENST00000553541 ; ENSP00000451285 ; ENSG00000188655 . [P60153-1 ]
ENST00000553706 ; ENSP00000450570 ; ENSG00000188655 . [P60153-2 ]
ENST00000554964 ; ENSP00000450599 ; ENSG00000188655 . [P60153-1 ]
ENST00000555230 ; ENSP00000450800 ; ENSG00000188655 . [P60153-1 ]
ENST00000556208 ; ENSP00000451160 ; ENSG00000188655 . [P60153-2 ]
ENST00000557068 ; ENSP00000451565 ; ENSG00000188655 . [P60153-1 ]
ENST00000557209 ; ENSP00000450987 ; ENSG00000188655 . [P60153-2 ]
GeneIDi 390443.
KEGGi hsa:390443.
UCSCi uc001vxq.4. human. [P60153-2 ]
uc010aho.3. human. [P60153-1 ]

Organism-specific databases

CTDi 390443.
GeneCardsi GC14M021024.
HGNCi HGNC:20673. RNASE9.
HPAi HPA003391.
MIMi 614014. gene.
neXtProti NX_P60153.
PharmGKBi PA134887351.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46399.
HOGENOMi HOG000236243.
HOVERGENi HBG056874.
InParanoidi P60153.
OMAi KNGIRKC.
OrthoDBi EOG7XDBHR.
PhylomeDBi P60153.
TreeFami TF338401.

Miscellaneous databases

GenomeRNAii 390443.
NextBioi 103822.
PROi P60153.
SOURCEi Search...

Gene expression databases

Bgeei P60153.
CleanExi HS_RNASE9.
Genevestigatori P60153.

Family and domain databases

Gene3Di 3.10.130.10. 1 hit.
InterProi IPR001427. RNaseA.
IPR023412. RNaseA_domain.
[Graphical view ]
PANTHERi PTHR11437. PTHR11437. 1 hit.
Pfami PF00074. RnaseA. 1 hit.
[Graphical view ]
ProDomi PD000535. RNaseA. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF54076. SSF54076. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories."
    Cho S., Beintema J.J., Zhang J.
    Genomics 85:208-220(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning, expression and location of RNase9 in human epididymis."
    Liu J., Li J., Wang H., Zhang C., Li N., Lin Y., Liu J., Wang W.
    BMC Res. Notes 1:111-111(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS SER-148 AND PRO-204, FUNCTION, TISSUE SPECIFICITY.
    Tissue: Epididymis.
  3. "Human RNASE9 transcript variants."
    Liu Q., Hamil K.G., Gao B., French F.S., Hall S.H., Zhang Y.-L.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS SER-148 AND PRO-204.
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-148 AND PRO-204.
  6. "Human ribonuclease 9, a member of ribonuclease A superfamily, specifically expressed in epididymis, is a novel sperm-binding protein."
    Cheng G.Z., Li J.Y., Li F., Wang H.Y., Shi G.X.
    Asian J. Androl. 11:240-251(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-36, FUNCTION, TISSUE SPECIFICITY, SIGNAL SEQUENCE CLEAVAGE SITE.

Entry informationi

Entry nameiRNAS9_HUMAN
AccessioniPrimary (citable) accession number: P60153
Secondary accession number(s): A2RQR8
, A8QJS1, Q5GAN7, Q6KG53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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