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P60153

- RNAS9_HUMAN

UniProt

P60153 - RNAS9_HUMAN

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Protein
Inactive ribonuclease-like protein 9
Gene
RNASE9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Does not exhibit any ribonuclease activity.2 Publications

GO - Molecular functioni

  1. endoribonuclease activity, producing 3'-phosphomonoesters Source: InterPro
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive ribonuclease-like protein 9
    Gene namesi
    Name:RNASE9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20673. RNASE9.

    Subcellular locationi

    Secreted Inferred

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134887351.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 26261 Publication
    Add
    BLAST
    Chaini27 – 205179Inactive ribonuclease-like protein 9
    PRO_0000030951Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi116 ↔ 168 By similarity
    Disulfide bondi123 ↔ 130 By similarity
    Glycosylationi131 – 1311N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi143 – 1431N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP60153.
    PRIDEiP60153.

    Expressioni

    Tissue specificityi

    At the mRNA level, widely expressed (1 Publication). At protein level, restricted to epididymis (1 Publication). Expressed in spermatozoa (sperm head and neck), with higher levels on ejaculated and epididymal sperm than on testicular sperm (at protein level). Expressed in the epithelial cells of the epididymal tubule (at protein level). Not detected in muscle.2 Publications

    Gene expression databases

    BgeeiP60153.
    CleanExiHS_RNASE9.
    GenevestigatoriP60153.

    Organism-specific databases

    HPAiHPA003391.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000340162.

    Structurei

    3D structure databases

    ProteinModelPortaliP60153.
    SMRiP60153. Positions 80-186.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46399.
    HOGENOMiHOG000236243.
    HOVERGENiHBG056874.
    InParanoidiP60153.
    OMAiKNGIRKC.
    OrthoDBiEOG7XDBHR.
    PhylomeDBiP60153.
    TreeFamiTF338401.

    Family and domain databases

    Gene3Di3.10.130.10. 1 hit.
    InterProiIPR001427. RNaseA.
    IPR023412. RNaseA_domain.
    [Graphical view]
    PANTHERiPTHR11437. PTHR11437. 1 hit.
    PfamiPF00074. RnaseA. 1 hit.
    [Graphical view]
    ProDomiPD000535. RNaseA. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF54076. SSF54076. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P60153-1) [UniParc]FASTAAdd to Basket

    Also known as: alpha1, alpha2, alpha12, beta2, beta12

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMRTLITTHP LPLLLLPQQL LQLVQFQEVD TDFDFPEEDK KEEFEECLEK    50
    FFSTGPARPP TKEKVKRRVL IEPGMPLNHI EYCNHEIMGK NVYYKHRWVA 100
    EHYFLLMQYD ELQKICYNRF VPCKNGIRKC NRSKGLVEGV YCNLTEAFEI 150
    PACKYESLYR KGYVLITCSW QNEMQKRIPH TINDLVEPPE HRSFLSEDGV 200
    FVISP 205
    Length:205
    Mass (Da):24,307
    Last modified:November 28, 2003 - v1
    Checksum:iEDE63F0727282BF6
    GO
    Isoform 2 (identifier: P60153-2) [UniParc]FASTAAdd to Basket

    Also known as: alpha23, alpha123

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MSAGKM

    Show »
    Length:210
    Mass (Da):24,782
    Checksum:iFCF929B3261222E6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti148 – 1481F → S.3 Publications
    Corresponds to variant rs12590446 [ dbSNP | Ensembl ].
    VAR_052197
    Natural varianti204 – 2041S → P.3 Publications
    Corresponds to variant rs1243647 [ dbSNP | Ensembl ].
    VAR_034473

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MSAGKM in isoform 2.
    VSP_041856

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY665804 mRNA. Translation: AAV87182.1.
    EU414264 mRNA. Translation: ACA49544.1.
    AF382949 mRNA. Translation: AAQ02792.1.
    AY907670 mRNA. Translation: AAX86045.1.
    EF061296 mRNA. Translation: ABP97451.1.
    EF061297 mRNA. Translation: ABP97452.1.
    EF061298 mRNA. Translation: ABP97453.1.
    EF061299 mRNA. Translation: ABP97454.1.
    EF061300 mRNA. Translation: ABP97455.1.
    EF061301 mRNA. Translation: ABP97456.1.
    EF061302 mRNA. Translation: ABP97457.1.
    EF061303 mRNA. Translation: ABP97458.1.
    EF061304 mRNA. Translation: ABP97459.1.
    AL163195 Genomic DNA. No translation available.
    BC130311 mRNA. Translation: AAI30312.1.
    BC130313 mRNA. Translation: AAI30314.1.
    CCDSiCCDS32036.1. [P60153-1]
    CCDS53883.1. [P60153-2]
    CCDS55904.1. [P60153-2]
    RefSeqiNP_001001673.2. NM_001001673.3. [P60153-1]
    NP_001103826.1. NM_001110356.1. [P60153-1]
    NP_001103827.1. NM_001110357.1. [P60153-1]
    NP_001103828.1. NM_001110358.1. [P60153-2]
    NP_001103829.1. NM_001110359.1. [P60153-2]
    NP_001103830.1. NM_001110360.1. [P60153-2]
    NP_001103831.1. NM_001110361.1. [P60153-2]
    NP_001276039.1. NM_001289110.1. [P60153-1]
    XP_006720205.1. XM_006720142.1. [P60153-1]
    UniGeneiHs.533972.

    Genome annotation databases

    EnsembliENST00000338904; ENSP00000340162; ENSG00000188655. [P60153-1]
    ENST00000404716; ENSP00000384683; ENSG00000188655. [P60153-2]
    ENST00000429244; ENSP00000409504; ENSG00000188655. [P60153-1]
    ENST00000553541; ENSP00000451285; ENSG00000188655. [P60153-1]
    ENST00000553706; ENSP00000450570; ENSG00000188655. [P60153-2]
    ENST00000554964; ENSP00000450599; ENSG00000188655. [P60153-1]
    ENST00000555230; ENSP00000450800; ENSG00000188655. [P60153-1]
    ENST00000556208; ENSP00000451160; ENSG00000188655. [P60153-2]
    ENST00000557068; ENSP00000451565; ENSG00000188655. [P60153-1]
    ENST00000557209; ENSP00000450987; ENSG00000188655. [P60153-2]
    GeneIDi390443.
    KEGGihsa:390443.
    UCSCiuc001vxq.4. human. [P60153-2]
    uc010aho.3. human. [P60153-1]

    Polymorphism databases

    DMDMi38605140.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY665804 mRNA. Translation: AAV87182.1 .
    EU414264 mRNA. Translation: ACA49544.1 .
    AF382949 mRNA. Translation: AAQ02792.1 .
    AY907670 mRNA. Translation: AAX86045.1 .
    EF061296 mRNA. Translation: ABP97451.1 .
    EF061297 mRNA. Translation: ABP97452.1 .
    EF061298 mRNA. Translation: ABP97453.1 .
    EF061299 mRNA. Translation: ABP97454.1 .
    EF061300 mRNA. Translation: ABP97455.1 .
    EF061301 mRNA. Translation: ABP97456.1 .
    EF061302 mRNA. Translation: ABP97457.1 .
    EF061303 mRNA. Translation: ABP97458.1 .
    EF061304 mRNA. Translation: ABP97459.1 .
    AL163195 Genomic DNA. No translation available.
    BC130311 mRNA. Translation: AAI30312.1 .
    BC130313 mRNA. Translation: AAI30314.1 .
    CCDSi CCDS32036.1. [P60153-1 ]
    CCDS53883.1. [P60153-2 ]
    CCDS55904.1. [P60153-2 ]
    RefSeqi NP_001001673.2. NM_001001673.3. [P60153-1 ]
    NP_001103826.1. NM_001110356.1. [P60153-1 ]
    NP_001103827.1. NM_001110357.1. [P60153-1 ]
    NP_001103828.1. NM_001110358.1. [P60153-2 ]
    NP_001103829.1. NM_001110359.1. [P60153-2 ]
    NP_001103830.1. NM_001110360.1. [P60153-2 ]
    NP_001103831.1. NM_001110361.1. [P60153-2 ]
    NP_001276039.1. NM_001289110.1. [P60153-1 ]
    XP_006720205.1. XM_006720142.1. [P60153-1 ]
    UniGenei Hs.533972.

    3D structure databases

    ProteinModelPortali P60153.
    SMRi P60153. Positions 80-186.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000340162.

    Polymorphism databases

    DMDMi 38605140.

    Proteomic databases

    PaxDbi P60153.
    PRIDEi P60153.

    Protocols and materials databases

    DNASUi 390443.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338904 ; ENSP00000340162 ; ENSG00000188655 . [P60153-1 ]
    ENST00000404716 ; ENSP00000384683 ; ENSG00000188655 . [P60153-2 ]
    ENST00000429244 ; ENSP00000409504 ; ENSG00000188655 . [P60153-1 ]
    ENST00000553541 ; ENSP00000451285 ; ENSG00000188655 . [P60153-1 ]
    ENST00000553706 ; ENSP00000450570 ; ENSG00000188655 . [P60153-2 ]
    ENST00000554964 ; ENSP00000450599 ; ENSG00000188655 . [P60153-1 ]
    ENST00000555230 ; ENSP00000450800 ; ENSG00000188655 . [P60153-1 ]
    ENST00000556208 ; ENSP00000451160 ; ENSG00000188655 . [P60153-2 ]
    ENST00000557068 ; ENSP00000451565 ; ENSG00000188655 . [P60153-1 ]
    ENST00000557209 ; ENSP00000450987 ; ENSG00000188655 . [P60153-2 ]
    GeneIDi 390443.
    KEGGi hsa:390443.
    UCSCi uc001vxq.4. human. [P60153-2 ]
    uc010aho.3. human. [P60153-1 ]

    Organism-specific databases

    CTDi 390443.
    GeneCardsi GC14M021024.
    HGNCi HGNC:20673. RNASE9.
    HPAi HPA003391.
    MIMi 614014. gene.
    neXtProti NX_P60153.
    PharmGKBi PA134887351.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46399.
    HOGENOMi HOG000236243.
    HOVERGENi HBG056874.
    InParanoidi P60153.
    OMAi KNGIRKC.
    OrthoDBi EOG7XDBHR.
    PhylomeDBi P60153.
    TreeFami TF338401.

    Miscellaneous databases

    GenomeRNAii 390443.
    NextBioi 103822.
    PROi P60153.
    SOURCEi Search...

    Gene expression databases

    Bgeei P60153.
    CleanExi HS_RNASE9.
    Genevestigatori P60153.

    Family and domain databases

    Gene3Di 3.10.130.10. 1 hit.
    InterProi IPR001427. RNaseA.
    IPR023412. RNaseA_domain.
    [Graphical view ]
    PANTHERi PTHR11437. PTHR11437. 1 hit.
    Pfami PF00074. RnaseA. 1 hit.
    [Graphical view ]
    ProDomi PD000535. RNaseA. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF54076. SSF54076. 1 hit.
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories."
      Cho S., Beintema J.J., Zhang J.
      Genomics 85:208-220(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cloning, expression and location of RNase9 in human epididymis."
      Liu J., Li J., Wang H., Zhang C., Li N., Lin Y., Liu J., Wang W.
      BMC Res. Notes 1:111-111(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS SER-148 AND PRO-204, FUNCTION, TISSUE SPECIFICITY.
      Tissue: Epididymis.
    3. "Human RNASE9 transcript variants."
      Liu Q., Hamil K.G., Gao B., French F.S., Hall S.H., Zhang Y.-L.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS SER-148 AND PRO-204.
    4. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-148 AND PRO-204.
    6. "Human ribonuclease 9, a member of ribonuclease A superfamily, specifically expressed in epididymis, is a novel sperm-binding protein."
      Cheng G.Z., Li J.Y., Li F., Wang H.Y., Shi G.X.
      Asian J. Androl. 11:240-251(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-36, FUNCTION, TISSUE SPECIFICITY, SIGNAL SEQUENCE CLEAVAGE SITE.

    Entry informationi

    Entry nameiRNAS9_HUMAN
    AccessioniPrimary (citable) accession number: P60153
    Secondary accession number(s): A2RQR8
    , A8QJS1, Q5GAN7, Q6KG53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: November 28, 2003
    Last modified: July 9, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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