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P60090

- ODPA_STAAW

UniProt

P60090 - ODPA_STAAW

Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (28 Nov 2003)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Pyruvate, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciSAUR196620:GJ9Z-1000-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
    Gene namesi
    Name:pdhA
    Ordered Locus Names:MW0976
    OrganismiStaphylococcus aureus (strain MW2)
    Taxonomic identifieri196620 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000418: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 370370Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162210Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.

    Protein-protein interaction databases

    STRINGi196620.MW0976.

    Structurei

    3D structure databases

    ProteinModelPortaliP60090.
    SMRiP60090. Positions 8-370.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1071.
    HOGENOMiHOG000281335.
    KOiK00161.
    OMAiNNGYAIT.
    OrthoDBiEOG6VMTKR.

    Family and domain databases

    Gene3Di3.40.50.970. 1 hit.
    InterProiIPR001017. DH_E1.
    IPR017596. PdhA/BkdA.
    IPR029061. THDP-binding.
    [Graphical view]
    PfamiPF00676. E1_dh. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 1 hit.
    TIGRFAMsiTIGR03181. PDH_E1_alph_x. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P60090-1 [UniParc]FASTAAdd to Basket

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    MAPKLQAQFD AVKVLNDTQS KFEMVQILDE NGNVVNEDLV PDLTDEQLVE    50
    LMERMVWTRI LDQRSISLNR QGRLGFYAPT AGQEASQLAS QYALEKEDYI 100
    LPGYRDVPQI IWHGLPLTEA FLFSRGHFKG NQFPEGVNAL SPQIIIGAQY 150
    IQAAGVAFAL KKRGKNAVAI TYTGDGGSSQ GDFYEGINFA AAYKAPAIFV 200
    IQNNNYAIST PRSKQTAAET LAQKAIAVGI PGIQVDGMDA LAVYQATKEA 250
    RDRAVAGEGP TLIETMTYRY GPHTMAGDDP TRYRTSDEDA EWEKKDPLVR 300
    FRKFLENKGL WNEDKENEVI ERAKADIKAA IKEADNTEKQ TVTSLMEIMY 350
    EDMPQNLAEQ YEIYKEKESK 370
    Length:370
    Mass (Da):41,383
    Last modified:November 28, 2003 - v1
    Checksum:i66BD3BF8A0C9565F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000033 Genomic DNA. Translation: BAB94841.1.
    RefSeqiNP_645793.1. NC_003923.1.

    Genome annotation databases

    EnsemblBacteriaiBAB94841; BAB94841; BAB94841.
    GeneIDi1003088.
    KEGGisam:MW0976.
    PATRICi19568532. VBIStaAur44266_1025.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000033 Genomic DNA. Translation: BAB94841.1 .
    RefSeqi NP_645793.1. NC_003923.1.

    3D structure databases

    ProteinModelPortali P60090.
    SMRi P60090. Positions 8-370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196620.MW0976.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB94841 ; BAB94841 ; BAB94841 .
    GeneIDi 1003088.
    KEGGi sam:MW0976.
    PATRICi 19568532. VBIStaAur44266_1025.

    Phylogenomic databases

    eggNOGi COG1071.
    HOGENOMi HOG000281335.
    KOi K00161.
    OMAi NNGYAIT.
    OrthoDBi EOG6VMTKR.

    Enzyme and pathway databases

    BioCyci SAUR196620:GJ9Z-1000-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 1 hit.
    InterProi IPR001017. DH_E1.
    IPR017596. PdhA/BkdA.
    IPR029061. THDP-binding.
    [Graphical view ]
    Pfami PF00676. E1_dh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 1 hit.
    TIGRFAMsi TIGR03181. PDH_E1_alph_x. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MW2.

    Entry informationi

    Entry nameiODPA_STAAW
    AccessioniPrimary (citable) accession number: P60090
    Secondary accession number(s): Q931U0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: November 28, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3