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P60087

- ARGI_STAAM

UniProt

P60087 - ARGI_STAAM

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Protein

Arginase

Gene

arg

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.

Cofactori

Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi103 – 1031Manganese 1PROSITE-ProRule annotation
Metal bindingi126 – 1261Manganese 1PROSITE-ProRule annotation
Metal bindingi126 – 1261Manganese 2PROSITE-ProRule annotation
Metal bindingi128 – 1281Manganese 2PROSITE-ProRule annotation
Metal bindingi130 – 1301Manganese 1PROSITE-ProRule annotation
Binding sitei180 – 1801SubstrateBy similarity
Metal bindingi229 – 2291Manganese 1PROSITE-ProRule annotation
Metal bindingi229 – 2291Manganese 2PROSITE-ProRule annotation
Metal bindingi231 – 2311Manganese 2PROSITE-ProRule annotation
Binding sitei274 – 2741SubstrateBy similarity

GO - Molecular functioni

  1. arginase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine metabolic process Source: UniProtKB-KW
  2. urea cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2223-MONOMER.
UniPathwayiUPA00158; UER00270.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase (EC:3.5.3.1)
Gene namesi
Name:arg
Ordered Locus Names:SAV2164
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002481: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302ArginasePRO_0000173720Add
BLAST

2D gel databases

World-2DPAGE0002:P60087.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2164.

Structurei

3D structure databases

ProteinModelPortaliP60087.
SMRiP60087. Positions 5-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 1325Substrate bindingBy similarity
Regioni139 – 1413Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000204319.
KOiK01476.
OMAiVYEATHA.
OrthoDBiEOG6BKJ5H.
PhylomeDBiP60087.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60087-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKTKAIDII GAPSTFGQRK LGVDLGPTAI RYAGLISRLK QLDLDVYDKG
60 70 80 90 100
DIKVPAVNIE KFHSEQKGLR NYDEIIDVNQ KLNKEVSASI ENNRFPLVLG
110 120 130 140 150
GDHSIAVGSV SAISKHYNNL GVIWYDAHGD LNIPEESPSG NIHGMPLRIL
160 170 180 190 200
TGEGPKELLE LNSNVIKPEN IVLIGMRDLD KGERQFIKDH NIKTFTMSDI
210 220 230 240 250
DKLGIKEVIE NTIEYLKSRN VDGVHLSLDV DALDPLETPG TGTRVLGGLS
260 270 280 290 300
YRESHFALEL LHQSHLISSM DLVEVNPLID SNNHTAEQAV SLVGTFFGET

LL
Length:302
Mass (Da):33,265
Last modified:November 28, 2003 - v1
Checksum:iDD98335783BAC146
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58326.1.
RefSeqiNP_372688.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58326; BAB58326; SAV2164.
GeneIDi1122180.
KEGGisav:SAV2164.
PATRICi19565204. VBIStaAur52173_2237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58326.1 .
RefSeqi NP_372688.1. NC_002758.2.

3D structure databases

ProteinModelPortali P60087.
SMRi P60087. Positions 5-302.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158878.SAV2164.

2D gel databases

World-2DPAGE 0002:P60087.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB58326 ; BAB58326 ; SAV2164 .
GeneIDi 1122180.
KEGGi sav:SAV2164.
PATRICi 19565204. VBIStaAur52173_2237.

Phylogenomic databases

eggNOGi COG0010.
HOGENOMi HOG000204319.
KOi K01476.
OMAi VYEATHA.
OrthoDBi EOG6BKJ5H.
PhylomeDBi P60087.

Enzyme and pathway databases

UniPathwayi UPA00158 ; UER00270 .
BioCyci SAUR158878:GJJ5-2223-MONOMER.

Family and domain databases

Gene3Di 3.40.800.10. 1 hit.
InterProi IPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view ]
PANTHERi PTHR11358. PTHR11358. 1 hit.
Pfami PF00491. Arginase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036979. Arginase. 1 hit.
PRINTSi PR00116. ARGINASE.
TIGRFAMsi TIGR01229. rocF_arginase. 1 hit.
PROSITEi PS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiARGI_STAAM
AccessioniPrimary (citable) accession number: P60087
Secondary accession number(s): Q9R2U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: November 26, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3