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Protein

Arginase

Gene

arg

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.By similarity

Cofactori

Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase (arg)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi103Manganese 1PROSITE-ProRule annotation1
Metal bindingi126Manganese 1PROSITE-ProRule annotation1
Metal bindingi126Manganese 2PROSITE-ProRule annotation1
Metal bindingi128Manganese 2PROSITE-ProRule annotation1
Metal bindingi130Manganese 1PROSITE-ProRule annotation1
Binding sitei180SubstrateBy similarity1
Metal bindingi229Manganese 1PROSITE-ProRule annotation1
Metal bindingi229Manganese 2PROSITE-ProRule annotation1
Metal bindingi231Manganese 2PROSITE-ProRule annotation1
Binding sitei243SubstrateBy similarity1
Binding sitei274SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processArginine metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00158; UER00270

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase (EC:3.5.3.1By similarity)
Gene namesi
Name:arg
Ordered Locus Names:SAV2164
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001737201 – 302ArginaseAdd BLAST302

Proteomic databases

PaxDbiP60087

2D gel databases

World-2DPAGE0002:P60087

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2164

Structurei

3D structure databases

ProteinModelPortaliP60087
SMRiP60087
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni128 – 132Substrate bindingBy similarity5
Regioni139 – 141Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CYW Bacteria
COG0010 LUCA
HOGENOMiHOG000204319
KOiK01476
OMAiSAVARHC
PhylomeDBiP60087

Family and domain databases

InterProiView protein in InterPro
IPR014033 Arginase
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
PRINTSiPR00116 ARGINASE
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01229 rocF_arginase, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P60087-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTKAIDII GAPSTFGQRK LGVDLGPTAI RYAGLISRLK QLDLDVYDKG
60 70 80 90 100
DIKVPAVNIE KFHSEQKGLR NYDEIIDVNQ KLNKEVSASI ENNRFPLVLG
110 120 130 140 150
GDHSIAVGSV SAISKHYNNL GVIWYDAHGD LNIPEESPSG NIHGMPLRIL
160 170 180 190 200
TGEGPKELLE LNSNVIKPEN IVLIGMRDLD KGERQFIKDH NIKTFTMSDI
210 220 230 240 250
DKLGIKEVIE NTIEYLKSRN VDGVHLSLDV DALDPLETPG TGTRVLGGLS
260 270 280 290 300
YRESHFALEL LHQSHLISSM DLVEVNPLID SNNHTAEQAV SLVGTFFGET

LL
Length:302
Mass (Da):33,265
Last modified:November 28, 2003 - v1
Checksum:iDD98335783BAC146
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB58326.1
RefSeqiWP_000167867.1, NC_002758.2

Genome annotation databases

EnsemblBacteriaiBAB58326; BAB58326; SAV2164
KEGGisav:SAV2164

Similar proteinsi

Entry informationi

Entry nameiARGI_STAAM
AccessioniPrimary (citable) accession number: P60087
Secondary accession number(s): Q9R2U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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