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P60087 (ARGI_STAAM) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginase

EC=3.5.3.1
Gene names
Name:arg
Ordered Locus Names:SAV2164
OrganismStaphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]
Taxonomic identifier158878 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

L-arginine + H2O = L-ornithine + urea.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Pathway

Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.

Sequence similarities

Belongs to the arginase family.

Ontologies

Keywords
   Biological processArginine metabolism
   LigandManganese
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

urea cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionarginase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302Arginase
PRO_0000173720

Regions

Region128 – 1325Substrate binding By similarity
Region139 – 1413Substrate binding By similarity

Sites

Metal binding1031Manganese 1 By similarity
Metal binding1261Manganese 1 By similarity
Metal binding1261Manganese 2 By similarity
Metal binding1281Manganese 2 By similarity
Metal binding1301Manganese 1 By similarity
Metal binding2291Manganese 1 By similarity
Metal binding2291Manganese 2 By similarity
Metal binding2311Manganese 2 By similarity
Binding site1801Substrate By similarity
Binding site2741Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P60087 [UniParc].

Last modified November 28, 2003. Version 1.
Checksum: DD98335783BAC146

FASTA30233,265
        10         20         30         40         50         60 
MTKTKAIDII GAPSTFGQRK LGVDLGPTAI RYAGLISRLK QLDLDVYDKG DIKVPAVNIE 

        70         80         90        100        110        120 
KFHSEQKGLR NYDEIIDVNQ KLNKEVSASI ENNRFPLVLG GDHSIAVGSV SAISKHYNNL 

       130        140        150        160        170        180 
GVIWYDAHGD LNIPEESPSG NIHGMPLRIL TGEGPKELLE LNSNVIKPEN IVLIGMRDLD 

       190        200        210        220        230        240 
KGERQFIKDH NIKTFTMSDI DKLGIKEVIE NTIEYLKSRN VDGVHLSLDV DALDPLETPG 

       250        260        270        280        290        300 
TGTRVLGGLS YRESHFALEL LHQSHLISSM DLVEVNPLID SNNHTAEQAV SLVGTFFGET 


LL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000017 Genomic DNA. Translation: BAB58326.1.
RefSeqNP_372688.1. NC_002758.2.

3D structure databases

ProteinModelPortalP60087.
SMRP60087. Positions 5-302.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING158878.SAV2164.

2D gel databases

World-2DPAGE0002:P60087.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB58326; BAB58326; SAV2164.
GeneID1122180.
KEGGsav:SAV2164.
PATRIC19565204. VBIStaAur52173_2237.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0010.
HOGENOMHOG000204319.
KOK01476.
OMADQDTHLH.
OrthoDBEOG6BKJ5H.
ProtClustDBCLSK885803.

Enzyme and pathway databases

BioCycSAUR158878:GJJ5-2223-MONOMER.
UniPathwayUPA00158; UER00270.

Family and domain databases

Gene3D3.40.800.10. 1 hit.
InterProIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERPTHR11358. PTHR11358. 1 hit.
PTHR11358:SF2. PTHR11358:SF2. 1 hit.
PfamPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFPIRSF036979. Arginase. 1 hit.
PRINTSPR00116. ARGINASE.
TIGRFAMsTIGR01229. rocF_arginase. 1 hit.
PROSITEPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGI_STAAM
AccessionPrimary (citable) accession number: P60087
Secondary accession number(s): Q9R2U3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: November 13, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways