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P60087

- ARGI_STAAM

UniProt

P60087 - ARGI_STAAM

Protein

Arginase

Gene

arg

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (28 Nov 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-arginine + H2O = L-ornithine + urea.

    Cofactori

    Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi103 – 1031Manganese 1PROSITE-ProRule annotation
    Metal bindingi126 – 1261Manganese 1PROSITE-ProRule annotation
    Metal bindingi126 – 1261Manganese 2PROSITE-ProRule annotation
    Metal bindingi128 – 1281Manganese 2PROSITE-ProRule annotation
    Metal bindingi130 – 1301Manganese 1PROSITE-ProRule annotation
    Binding sitei180 – 1801SubstrateBy similarity
    Metal bindingi229 – 2291Manganese 1PROSITE-ProRule annotation
    Metal bindingi229 – 2291Manganese 2PROSITE-ProRule annotation
    Metal bindingi231 – 2311Manganese 2PROSITE-ProRule annotation
    Binding sitei274 – 2741SubstrateBy similarity

    GO - Molecular functioni

    1. arginase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine metabolic process Source: UniProtKB-KW
    2. urea cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Arginine metabolism

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSAUR158878:GJJ5-2223-MONOMER.
    UniPathwayiUPA00158; UER00270.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginase (EC:3.5.3.1)
    Gene namesi
    Name:arg
    Ordered Locus Names:SAV2164
    OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
    Taxonomic identifieri158878 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000002481: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302ArginasePRO_0000173720Add
    BLAST

    2D gel databases

    World-2DPAGE0002:P60087.

    Interactioni

    Protein-protein interaction databases

    STRINGi158878.SAV2164.

    Structurei

    3D structure databases

    ProteinModelPortaliP60087.
    SMRiP60087. Positions 5-302.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni128 – 1325Substrate bindingBy similarity
    Regioni139 – 1413Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the arginase family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0010.
    HOGENOMiHOG000204319.
    KOiK01476.
    OMAiVYEATHA.
    OrthoDBiEOG6BKJ5H.
    PhylomeDBiP60087.

    Family and domain databases

    Gene3Di3.40.800.10. 1 hit.
    InterProiIPR014033. Arginase.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view]
    PANTHERiPTHR11358. PTHR11358. 1 hit.
    PfamiPF00491. Arginase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036979. Arginase. 1 hit.
    PRINTSiPR00116. ARGINASE.
    TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
    PROSITEiPS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60087-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKTKAIDII GAPSTFGQRK LGVDLGPTAI RYAGLISRLK QLDLDVYDKG    50
    DIKVPAVNIE KFHSEQKGLR NYDEIIDVNQ KLNKEVSASI ENNRFPLVLG 100
    GDHSIAVGSV SAISKHYNNL GVIWYDAHGD LNIPEESPSG NIHGMPLRIL 150
    TGEGPKELLE LNSNVIKPEN IVLIGMRDLD KGERQFIKDH NIKTFTMSDI 200
    DKLGIKEVIE NTIEYLKSRN VDGVHLSLDV DALDPLETPG TGTRVLGGLS 250
    YRESHFALEL LHQSHLISSM DLVEVNPLID SNNHTAEQAV SLVGTFFGET 300
    LL 302
    Length:302
    Mass (Da):33,265
    Last modified:November 28, 2003 - v1
    Checksum:iDD98335783BAC146
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB58326.1.
    RefSeqiNP_372688.1. NC_002758.2.

    Genome annotation databases

    EnsemblBacteriaiBAB58326; BAB58326; SAV2164.
    GeneIDi1122180.
    KEGGisav:SAV2164.
    PATRICi19565204. VBIStaAur52173_2237.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB58326.1 .
    RefSeqi NP_372688.1. NC_002758.2.

    3D structure databases

    ProteinModelPortali P60087.
    SMRi P60087. Positions 5-302.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158878.SAV2164.

    2D gel databases

    World-2DPAGE 0002:P60087.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB58326 ; BAB58326 ; SAV2164 .
    GeneIDi 1122180.
    KEGGi sav:SAV2164.
    PATRICi 19565204. VBIStaAur52173_2237.

    Phylogenomic databases

    eggNOGi COG0010.
    HOGENOMi HOG000204319.
    KOi K01476.
    OMAi VYEATHA.
    OrthoDBi EOG6BKJ5H.
    PhylomeDBi P60087.

    Enzyme and pathway databases

    UniPathwayi UPA00158 ; UER00270 .
    BioCyci SAUR158878:GJJ5-2223-MONOMER.

    Family and domain databases

    Gene3Di 3.40.800.10. 1 hit.
    InterProi IPR014033. Arginase.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view ]
    PANTHERi PTHR11358. PTHR11358. 1 hit.
    Pfami PF00491. Arginase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036979. Arginase. 1 hit.
    PRINTSi PR00116. ARGINASE.
    TIGRFAMsi TIGR01229. rocF_arginase. 1 hit.
    PROSITEi PS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mu50 / ATCC 700699.

    Entry informationi

    Entry nameiARGI_STAAM
    AccessioniPrimary (citable) accession number: P60087
    Secondary accession number(s): Q9R2U3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: November 28, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3