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Protein

Anti-sigma-B factor antagonist

Gene

rsbV

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-2236-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-sigma-B factor antagonist
Alternative name(s):
Anti-anti-sigma-B factor
Gene namesi
Name:rsbV
Ordered Locus Names:SAOUHSC_02300
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 108108Anti-sigma-B factor antagonistPRO_0000194194Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei57 – 571PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated by RsbW on a serine residue.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02300.

Structurei

3D structure databases

ProteinModelPortaliP60070.
SMRiP60070. Positions 2-106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 108106STASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105WN5. Bacteria.
COG1366. LUCA.
HOGENOMiHOG000270156.
KOiK04749.
OMAiHLLVNME.
OrthoDBiEOG6J48NK.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR003658. Anti-sigma_ant.
IPR002645. STAS_dom.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
TIGRFAMsiTIGR00377. ant_ant_sig. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLNIETTTQ DKFYEVKVGG ELDVYTVPEL EEVLTPMRQD GTRDIYVNLE
60 70 80 90 100
NVSYMDSTGL GLFVGTLKAL NQNDKELYIL GVSDRIGRLF EITGLKDLMH

VNEGTEVE
Length:108
Mass (Da):12,205
Last modified:November 28, 2003 - v1
Checksum:i461FC096E18D9AEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07645 Genomic DNA. Translation: CAA68930.1.
CP000253 Genomic DNA. Translation: ABD31334.1.
RefSeqiYP_500778.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD31334; ABD31334; SAOUHSC_02300.
GeneIDi3919171.
KEGGisao:SAOUHSC_02300.
PATRICi19581935. VBIStaAur99865_2084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07645 Genomic DNA. Translation: CAA68930.1.
CP000253 Genomic DNA. Translation: ABD31334.1.
RefSeqiYP_500778.1. NC_007795.1.

3D structure databases

ProteinModelPortaliP60070.
SMRiP60070. Positions 2-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02300.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD31334; ABD31334; SAOUHSC_02300.
GeneIDi3919171.
KEGGisao:SAOUHSC_02300.
PATRICi19581935. VBIStaAur99865_2084.

Phylogenomic databases

eggNOGiENOG4105WN5. Bacteria.
COG1366. LUCA.
HOGENOMiHOG000270156.
KOiK04749.
OMAiHLLVNME.
OrthoDBiEOG6J48NK.

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-2236-MONOMER.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR003658. Anti-sigma_ant.
IPR002645. STAS_dom.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
TIGRFAMsiTIGR00377. ant_ant_sig. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The alternative sigma factor sigmaB in Staphylococcus aureus: regulation of the sigB operon in response to growth phase and heat shock."
    Kullik I., Giachino P.
    Arch. Microbiol. 167:151-159(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The Staphylococcus aureus NCTC 8325 genome."
    Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
    (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 8325.

Entry informationi

Entry nameiRSBV_STAA8
AccessioniPrimary (citable) accession number: P60070
Secondary accession number(s): O05343, P95842, Q2FWJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: July 6, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.