Arginine/agmatine antiporter - Escherichia coli (strain K12)

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Reviewed, UniProtKB/Swiss-Prot P60061 (ADIC_ECOLI)

Last modified December 15, 2009. Version 58. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Arginine/agmatine antiporter

Gene names

Name:	adiC
Synonyms:	aniC, yjdD, yjdE
Ordered Locus Names:	b4115, JW4076

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

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Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Exchange of extracellular arginine for intracellular agmatine. Required for arginine-dependent acid resistance. Ref.4 Ref.5
Subcellular location	Cell inner membrane; Multi-pass membrane protein.
Induction	By acidic conditions. Ref.4
Sequence similarities	Belongs to the amino acid-polyamine-organocation (APC) superfamily.

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Ontologies

Keywords
Biological process	Amino-acid transport Antiport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	amino acid transport Inferred from electronic annotation. Source: UniProtKB-KW transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid transmembrane transporter activity Inferred from electronic annotation. Source: InterPro antiporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 445

445

Arginine/agmatine antiporter

PRO_0000054230

Regions

Topological domain

1 – 9

Cytoplasmic Potential

Transmembrane

10 – 30

Potential

Topological domain

31 – 38

Periplasmic Potential

Transmembrane

39 – 59

Potential

Topological domain

60 – 98

Cytoplasmic Potential

Transmembrane

99 – 119

Potential

Topological domain

120 – 122

Periplasmic Potential

Transmembrane

123 – 143

Potential

Topological domain

144 – 152

Cytoplasmic Potential

Transmembrane

153 – 173

Potential

Topological domain

174 – 196

Periplasmic Potential

Transmembrane

197 – 217

Potential

Topological domain

218 – 225

Cytoplasmic Potential

Transmembrane

226 – 246

Potential

Topological domain

247 – 275

Periplasmic Potential

Transmembrane

276 – 296

Potential

Topological domain

297 – 321

Cytoplasmic Potential

Transmembrane

322 – 342

Potential

Topological domain

343 – 355

Periplasmic Potential

Transmembrane

356 – 376

Potential

Topological domain

377 – 385

Cytoplasmic Potential

Transmembrane

386 – 406

Potential

Topological domain

407 – 408

Periplasmic Potential

Transmembrane

409 – 429

Potential

Topological domain

430 – 445

Cytoplasmic Potential

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Sequences

Sequence

Length

Mass (Da)

Tools

P60061-1 [UniParc].

Last modified November 28, 2003. Version 1.
Checksum: 359F70C489A20663
Show »

FASTA

445

46,843

        10         20         30         40         50         60 
MSSDADAHKV GLIPVTLMVS GNIMGSGVFL LPANLASTGG IAIYGWLVTI IGALGLSMVY 

        70         80         90        100        110        120 
AKMSFLDPSP GGSYAYARRC FGPFLGYQTN VLYWLACWIG NIAMVVIGVG YLSYFFPILK 

       130        140        150        160        170        180 
DPLVLTITCV VVLWIFVLLN IVGPKMITRV QAVATVLALI PIVGIAVFGW FWFRGETYMA 

       190        200        210        220        230        240 
AWNVSGLGTF GAIQSTLNVT LWSFIGVESA SVAAGVVKNP KRNVPIATIG GVLIAAVCYV 

       250        260        270        280        290        300 
LSTTAIMGMI PNAALRVSAS PFGDAARMAL GDTAGAIVSF CAAAGCLGSL GGWTLLAGQT 

       310        320        330        340        350        360 
AKAAADDGLF PPIFARVNKA GTPVAGLIIV GILMTIFQLS SISPNATKEF GLVSSVSVIF 

       370        380        390        400        410        420 
TLVPYLYTCA ALLLLGHGHF GKARPAYLAV TTIAFLYCIW AVVGSGAKEV MWSFVTLMVI 

       430        440 
TAMYALNYNR LHKNPYPLDA PISKD

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R. Nucleic Acids Res. 23:2105-2119(1995) [PubMed: 7610040] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"YjdE (AdiC) is the arginine:agmatine antiporter essential for arginine-dependent acid resistance in Escherichia coli." Gong S., Richard H., Foster J.W. J. Bacteriol. 185:4402-4409(2003) [PubMed: 12867448] [Abstract] Cited for: FUNCTION, INDUCTION. Strain: K12.
[5]	"Arginine-agmatine antiporter in extreme acid resistance in Escherichia coli." Iyer R., Williams C., Miller C. J. Bacteriol. 185:6556-6561(2003) [PubMed: 14594828] [Abstract] Cited for: FUNCTION. Strain: K12 / MG1655 / ATCC 47076.
[6]	"Global topology analysis of the Escherichia coli inner membrane proteome." Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G. Science 308:1321-1323(2005) [PubMed: 15919996] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: K12 / MG1655 / ATCC 47076.

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Cross-references

Sequence databases
	U14003 Genomic DNA. Translation: AAA97015.1. Frameshift. U14003 Genomic DNA. Translation: AAA97014.1. Frameshift. U00096 Genomic DNA. Translation: AAC77076.1. AP009048 Genomic DNA. Translation: BAE78117.1.
PIR	B65221. S56343.
RefSeq	AP_004616.1. NP_418539.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P60061.
Protein family/group databases
TCDB	2.A.3.2.5. amino acid-polyamine-organocation (APC) family.
Genome annotation databases
GeneID	948628.
GenomeReviews	Gene locus JW4076 in contig AP009048_GR. Gene locus b4115 in contig U00096_GR.
KEGG	ecj:JW4076. eco:b4115.
Organism-specific databases
EchoBASE	EB2355.
EcoGene	EG12462. adiC.
CMR	Search...
Phylogenomic databases
HOGENOM	HBG586921.
OMA	AITFIAF.
Enzyme and pathway databases
BioCyc	EcoCyc:YJDE-MON. ECOL168927:B4115-MON.
Gene expression databases
Genevestigator	P60061.
Family and domain databases
InterPro	IPR002293. AA/rel_permease1. IPR004841. Permease_region. [Graphical view]
PANTHER	PTHR11785. AA/rel_permease1. 1 hit.
Pfam	PF00324. AA_permease. 1 hit. [Graphical view]
PIRSF	PIRSF006060. AA_transporter. 1 hit.
ProtoNet	Search...

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Entry information

Entry name

ADIC_ECOLI

Accession

Primary (citable) accession number: P60061
Secondary accession number(s): P39268, P39269, Q2M6I9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	November 28, 2003
Last modified:	December 15, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents