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P60059

- SC61G_HUMAN

UniProt

P60059 - SC61G_HUMAN

Protein

Protein transport protein Sec61 subunit gamma

Gene

SEC61G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Necessary for protein translocation in the endoplasmic reticulum.By similarity

    GO - Molecular functioni

    1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro
    2. protein transporter activity Source: UniProtKB

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    3. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    4. cellular protein metabolic process Source: Reactome
    5. gene expression Source: Reactome
    6. protein targeting to ER Source: UniProtKB
    7. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    8. translation Source: Reactome

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_111178. ER-Phagosome pathway.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

    Protein family/group databases

    TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein transport protein Sec61 subunit gamma
    Gene namesi
    Name:SEC61G
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:18277. SEC61G.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: MGI

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134939045.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6868Protein transport protein Sec61 subunit gammaPRO_0000104195Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP60059.
    PaxDbiP60059.
    PRIDEiP60059.

    Expressioni

    Gene expression databases

    BgeeiP60059.
    CleanExiHS_SEC61G.
    GenevestigatoriP60059.

    Organism-specific databases

    HPAiHPA053196.

    Interactioni

    Subunit structurei

    Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.By similarity

    Protein-protein interaction databases

    BioGridi117039. 2 interactions.
    IntActiP60059. 1 interaction.
    MINTiMINT-3021864.
    STRINGi9606.ENSP00000341538.

    Structurei

    3D structure databases

    ProteinModelPortaliP60059.
    SMRiP60059. Positions 1-68.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini62 – 687ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 6129HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SecE/SEC61-gamma family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG302441.
    HOGENOMiHOG000194479.
    HOVERGENiHBG058067.
    InParanoidiP60059.
    KOiK07342.
    OMAiNQFLTRC.
    OrthoDBiEOG74R1TZ.
    PhylomeDBiP60059.
    TreeFamiTF300232.

    Family and domain databases

    Gene3Di1.20.5.820. 1 hit.
    HAMAPiMF_00422. SecE.
    InterProiIPR023391. Prot_translocase_SecE_dom.
    IPR022943. SecE.
    IPR008158. Translocase_Sec61-g.
    IPR001901. Translocase_SecE/Sec61-g.
    [Graphical view]
    PfamiPF00584. SecE. 1 hit.
    [Graphical view]
    SUPFAMiSSF103456. SSF103456. 1 hit.
    TIGRFAMsiTIGR00327. secE_euk_arch. 1 hit.
    PROSITEiPS01067. SECE_SEC61G. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60059-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQVMQFVEP SRQFVKDSIR LVKRCTKPDR KEFQKIAMAT AIGFAIMGFI   50
    GFFVKLIHIP INNIIVGG 68
    Length:68
    Mass (Da):7,741
    Last modified:November 21, 2003 - v1
    Checksum:i14C8279A22548561
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF054184 mRNA. Translation: AAC99401.1.
    CR456979 mRNA. Translation: CAG33260.1.
    AK311845 mRNA. Translation: BAG34787.1.
    CH471201 Genomic DNA. Translation: EAW50960.1.
    BC009480 mRNA. Translation: AAH09480.1.
    BC051840 mRNA. Translation: AAH51840.1.
    CCDSiCCDS5513.1.
    PIRiS42412.
    RefSeqiNP_001012474.1. NM_001012456.1.
    NP_055117.1. NM_014302.3.
    UniGeneiHs.488282.

    Genome annotation databases

    EnsembliENST00000352861; ENSP00000341538; ENSG00000132432.
    ENST00000395535; ENSP00000378906; ENSG00000132432.
    ENST00000415949; ENSP00000388337; ENSG00000132432.
    ENST00000450622; ENSP00000409884; ENSG00000132432.
    GeneIDi23480.
    KEGGihsa:23480.
    UCSCiuc003tqf.3. human.

    Polymorphism databases

    DMDMi38503386.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF054184 mRNA. Translation: AAC99401.1 .
    CR456979 mRNA. Translation: CAG33260.1 .
    AK311845 mRNA. Translation: BAG34787.1 .
    CH471201 Genomic DNA. Translation: EAW50960.1 .
    BC009480 mRNA. Translation: AAH09480.1 .
    BC051840 mRNA. Translation: AAH51840.1 .
    CCDSi CCDS5513.1.
    PIRi S42412.
    RefSeqi NP_001012474.1. NM_001012456.1.
    NP_055117.1. NM_014302.3.
    UniGenei Hs.488282.

    3D structure databases

    ProteinModelPortali P60059.
    SMRi P60059. Positions 1-68.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117039. 2 interactions.
    IntActi P60059. 1 interaction.
    MINTi MINT-3021864.
    STRINGi 9606.ENSP00000341538.

    Protein family/group databases

    TCDBi 3.A.5.9.1. the general secretory pathway (sec) family.

    Polymorphism databases

    DMDMi 38503386.

    Proteomic databases

    MaxQBi P60059.
    PaxDbi P60059.
    PRIDEi P60059.

    Protocols and materials databases

    DNASUi 23480.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000352861 ; ENSP00000341538 ; ENSG00000132432 .
    ENST00000395535 ; ENSP00000378906 ; ENSG00000132432 .
    ENST00000415949 ; ENSP00000388337 ; ENSG00000132432 .
    ENST00000450622 ; ENSP00000409884 ; ENSG00000132432 .
    GeneIDi 23480.
    KEGGi hsa:23480.
    UCSCi uc003tqf.3. human.

    Organism-specific databases

    CTDi 23480.
    GeneCardsi GC07M054787.
    HGNCi HGNC:18277. SEC61G.
    HPAi HPA053196.
    MIMi 609215. gene.
    neXtProti NX_P60059.
    PharmGKBi PA134939045.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302441.
    HOGENOMi HOG000194479.
    HOVERGENi HBG058067.
    InParanoidi P60059.
    KOi K07342.
    OMAi NQFLTRC.
    OrthoDBi EOG74R1TZ.
    PhylomeDBi P60059.
    TreeFami TF300232.

    Enzyme and pathway databases

    Reactomei REACT_111178. ER-Phagosome pathway.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

    Miscellaneous databases

    GeneWikii SEC61G.
    GenomeRNAii 23480.
    NextBioi 45833.
    PROi P60059.
    SOURCEi Search...

    Gene expression databases

    Bgeei P60059.
    CleanExi HS_SEC61G.
    Genevestigatori P60059.

    Family and domain databases

    Gene3Di 1.20.5.820. 1 hit.
    HAMAPi MF_00422. SecE.
    InterProi IPR023391. Prot_translocase_SecE_dom.
    IPR022943. SecE.
    IPR008158. Translocase_Sec61-g.
    IPR001901. Translocase_SecE/Sec61-g.
    [Graphical view ]
    Pfami PF00584. SecE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103456. SSF103456. 1 hit.
    TIGRFAMsi TIGR00327. secE_euk_arch. 1 hit.
    PROSITEi PS01067. SECE_SEC61G. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Skin.
    6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSC61G_HUMAN
    AccessioniPrimary (citable) accession number: P60059
    Secondary accession number(s): B2R4J0, P38384, Q6IB25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 21, 2003
    Last sequence update: November 21, 2003
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3