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Protein

Protein transport protein Sec61 subunit gamma

Gene

SEC61G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for protein translocation in the endoplasmic reticulum.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-381038 XBP1(S) activates chaperone genes

Protein family/group databases

TCDBi3.A.5.9.1 the general secretory pathway (sec) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit gamma
Gene namesi
Name:SEC61G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000132432.13
HGNCiHGNC:18277 SEC61G
MIMi609215 gene
neXtProtiNX_P60059

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 61HelicalSequence analysisAdd BLAST29
Topological domaini62 – 68ExtracellularSequence analysis7

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23480
OpenTargetsiENSG00000132432
PharmGKBiPA134939045

Polymorphism and mutation databases

BioMutaiSEC61G
DMDMi38503386

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001041951 – 68Protein transport protein Sec61 subunit gammaAdd BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei18PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP60059
MaxQBiP60059
PaxDbiP60059
PeptideAtlasiP60059
PRIDEiP60059
TopDownProteomicsiP60059

PTM databases

iPTMnetiP60059
PhosphoSitePlusiP60059
SwissPalmiP60059

Expressioni

Gene expression databases

BgeeiENSG00000132432
CleanExiHS_SEC61G
ExpressionAtlasiP60059 baseline and differential
GenevisibleiP60059 HS

Organism-specific databases

HPAiHPA053196

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SFTPCP116863EBI-4402709,EBI-10197617

Protein-protein interaction databases

BioGridi117039, 5 interactors
IntActiP60059, 4 interactors
MINTiP60059
STRINGi9606.ENSP00000341538

Structurei

3D structure databases

ProteinModelPortaliP60059
SMRiP60059
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecE/SEC61-gamma family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3498 Eukaryota
ENOG4111WJ7 LUCA
GeneTreeiENSGT00390000001319
HOGENOMiHOG000194479
HOVERGENiHBG058067
InParanoidiP60059
KOiK07342
OMAiQFLTRCT
OrthoDBiEOG091G19JS
PhylomeDBiP60059
TreeFamiTF300232

Family and domain databases

Gene3Di1.20.5.820, 1 hit
HAMAPiMF_00422 SecE, 1 hit
InterProiView protein in InterPro
IPR023391 Prot_translocase_SecE_dom_sf
IPR022943 SecE
IPR008158 Translocase_Sec61-g
IPR001901 Translocase_SecE/Sec61-g
PfamiView protein in Pfam
PF00584 SecE, 1 hit
SUPFAMiSSF103456 SSF103456, 1 hit
TIGRFAMsiTIGR00327 secE_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS01067 SECE_SEC61G, 1 hit

Sequencei

Sequence statusi: Complete.

P60059-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQVMQFVEP SRQFVKDSIR LVKRCTKPDR KEFQKIAMAT AIGFAIMGFI
60
GFFVKLIHIP INNIIVGG
Length:68
Mass (Da):7,741
Last modified:November 21, 2003 - v1
Checksum:i14C8279A22548561
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054184 mRNA Translation: AAC99401.1
CR456979 mRNA Translation: CAG33260.1
AK311845 mRNA Translation: BAG34787.1
CH471201 Genomic DNA Translation: EAW50960.1
BC009480 mRNA Translation: AAH09480.1
BC051840 mRNA Translation: AAH51840.1
CCDSiCCDS5513.1
PIRiS42412
RefSeqiNP_001012474.1, NM_001012456.1
NP_055117.1, NM_014302.3
UniGeneiHs.488282

Genome annotation databases

EnsembliENST00000352861; ENSP00000341538; ENSG00000132432
ENST00000395535; ENSP00000378906; ENSG00000132432
ENST00000415949; ENSP00000388337; ENSG00000132432
ENST00000450622; ENSP00000409884; ENSG00000132432
GeneIDi23480
KEGGihsa:23480
UCSCiuc003tqf.4 human

Similar proteinsi

Entry informationi

Entry nameiSC61G_HUMAN
AccessioniPrimary (citable) accession number: P60059
Secondary accession number(s): B2R4J0, P38384, Q6IB25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: February 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health