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Protein

Protein transport protein Sec61 subunit gamma

Gene

SEC61G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for protein translocation in the endoplasmic reticulum.By similarity

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro
  2. protein transporter activity Source: UniProtKB

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  4. cellular protein metabolic process Source: Reactome
  5. gene expression Source: Reactome
  6. protein targeting to ER Source: UniProtKB
  7. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  8. translation Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_111178. ER-Phagosome pathway.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

Protein family/group databases

TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit gamma
Gene namesi
Name:SEC61G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18277. SEC61G.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei33 – 6129HelicalSequence AnalysisAdd
BLAST
Topological domaini62 – 687ExtracellularSequence Analysis

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939045.

Polymorphism and mutation databases

BioMutaiSEC61G.
DMDMi38503386.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6868Protein transport protein Sec61 subunit gammaPRO_0000104195Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP60059.
PaxDbiP60059.
PRIDEiP60059.

Expressioni

Gene expression databases

BgeeiP60059.
CleanExiHS_SEC61G.
ExpressionAtlasiP60059. baseline and differential.
GenevestigatoriP60059.

Organism-specific databases

HPAiHPA053196.

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SFTPCP116863EBI-4402709,EBI-10197617

Protein-protein interaction databases

BioGridi117039. 4 interactions.
IntActiP60059. 2 interactions.
MINTiMINT-3021864.
STRINGi9606.ENSP00000341538.

Structurei

3D structure databases

SMRiP60059. Positions 7-68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecE/SEC61-gamma family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302441.
GeneTreeiENSGT00390000001319.
HOGENOMiHOG000194479.
HOVERGENiHBG058067.
InParanoidiP60059.
KOiK07342.
OMAiRQFAKDS.
OrthoDBiEOG74R1TZ.
PhylomeDBiP60059.
TreeFamiTF300232.

Family and domain databases

Gene3Di1.20.5.820. 1 hit.
HAMAPiMF_00422. SecE.
InterProiIPR023391. Prot_translocase_SecE_dom.
IPR022943. SecE.
IPR008158. Translocase_Sec61-g.
IPR001901. Translocase_SecE/Sec61-g.
[Graphical view]
PfamiPF00584. SecE. 1 hit.
[Graphical view]
SUPFAMiSSF103456. SSF103456. 1 hit.
TIGRFAMsiTIGR00327. secE_euk_arch. 1 hit.
PROSITEiPS01067. SECE_SEC61G. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60059-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQVMQFVEP SRQFVKDSIR LVKRCTKPDR KEFQKIAMAT AIGFAIMGFI
60
GFFVKLIHIP INNIIVGG
Length:68
Mass (Da):7,741
Last modified:November 21, 2003 - v1
Checksum:i14C8279A22548561
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054184 mRNA. Translation: AAC99401.1.
CR456979 mRNA. Translation: CAG33260.1.
AK311845 mRNA. Translation: BAG34787.1.
CH471201 Genomic DNA. Translation: EAW50960.1.
BC009480 mRNA. Translation: AAH09480.1.
BC051840 mRNA. Translation: AAH51840.1.
CCDSiCCDS5513.1.
PIRiS42412.
RefSeqiNP_001012474.1. NM_001012456.1.
NP_055117.1. NM_014302.3.
UniGeneiHs.488282.

Genome annotation databases

EnsembliENST00000352861; ENSP00000341538; ENSG00000132432.
ENST00000395535; ENSP00000378906; ENSG00000132432.
ENST00000415949; ENSP00000388337; ENSG00000132432.
ENST00000450622; ENSP00000409884; ENSG00000132432.
GeneIDi23480.
KEGGihsa:23480.
UCSCiuc003tqf.3. human.

Polymorphism and mutation databases

BioMutaiSEC61G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054184 mRNA. Translation: AAC99401.1.
CR456979 mRNA. Translation: CAG33260.1.
AK311845 mRNA. Translation: BAG34787.1.
CH471201 Genomic DNA. Translation: EAW50960.1.
BC009480 mRNA. Translation: AAH09480.1.
BC051840 mRNA. Translation: AAH51840.1.
CCDSiCCDS5513.1.
PIRiS42412.
RefSeqiNP_001012474.1. NM_001012456.1.
NP_055117.1. NM_014302.3.
UniGeneiHs.488282.

3D structure databases

SMRiP60059. Positions 7-68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117039. 4 interactions.
IntActiP60059. 2 interactions.
MINTiMINT-3021864.
STRINGi9606.ENSP00000341538.

Protein family/group databases

TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

Polymorphism and mutation databases

BioMutaiSEC61G.
DMDMi38503386.

Proteomic databases

MaxQBiP60059.
PaxDbiP60059.
PRIDEiP60059.

Protocols and materials databases

DNASUi23480.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352861; ENSP00000341538; ENSG00000132432.
ENST00000395535; ENSP00000378906; ENSG00000132432.
ENST00000415949; ENSP00000388337; ENSG00000132432.
ENST00000450622; ENSP00000409884; ENSG00000132432.
GeneIDi23480.
KEGGihsa:23480.
UCSCiuc003tqf.3. human.

Organism-specific databases

CTDi23480.
GeneCardsiGC07M054787.
HGNCiHGNC:18277. SEC61G.
HPAiHPA053196.
MIMi609215. gene.
neXtProtiNX_P60059.
PharmGKBiPA134939045.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG302441.
GeneTreeiENSGT00390000001319.
HOGENOMiHOG000194479.
HOVERGENiHBG058067.
InParanoidiP60059.
KOiK07342.
OMAiRQFAKDS.
OrthoDBiEOG74R1TZ.
PhylomeDBiP60059.
TreeFamiTF300232.

Enzyme and pathway databases

ReactomeiREACT_111178. ER-Phagosome pathway.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

Miscellaneous databases

ChiTaRSiSEC61G. human.
GeneWikiiSEC61G.
GenomeRNAii23480.
NextBioi45833.
PROiP60059.
SOURCEiSearch...

Gene expression databases

BgeeiP60059.
CleanExiHS_SEC61G.
ExpressionAtlasiP60059. baseline and differential.
GenevestigatoriP60059.

Family and domain databases

Gene3Di1.20.5.820. 1 hit.
HAMAPiMF_00422. SecE.
InterProiIPR023391. Prot_translocase_SecE_dom.
IPR022943. SecE.
IPR008158. Translocase_Sec61-g.
IPR001901. Translocase_SecE/Sec61-g.
[Graphical view]
PfamiPF00584. SecE. 1 hit.
[Graphical view]
SUPFAMiSSF103456. SSF103456. 1 hit.
TIGRFAMsiTIGR00327. secE_euk_arch. 1 hit.
PROSITEiPS01067. SECE_SEC61G. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Skin.
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSC61G_HUMAN
AccessioniPrimary (citable) accession number: P60059
Secondary accession number(s): B2R4J0, P38384, Q6IB25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: April 29, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.