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P60059

- SC61G_HUMAN

UniProt

P60059 - SC61G_HUMAN

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Protein

Protein transport protein Sec61 subunit gamma

Gene
SEC61G
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Necessary for protein translocation in the endoplasmic reticulum By similarity.UniRule annotation

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro
  2. protein transporter activity Source: UniProtKB

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  4. cellular protein metabolic process Source: Reactome
  5. gene expression Source: Reactome
  6. protein targeting to ER Source: UniProtKB
  7. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  8. translation Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_111178. ER-Phagosome pathway.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

Protein family/group databases

TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit gamma
Gene namesi
Name:SEC61G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:18277. SEC61G.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei33 – 6129Helical; Reviewed predictionAdd
BLAST
Topological domaini62 – 687Extracellular Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939045.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6868Protein transport protein Sec61 subunit gammaUniRule annotationPRO_0000104195Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP60059.
PaxDbiP60059.
PRIDEiP60059.

Expressioni

Gene expression databases

BgeeiP60059.
CleanExiHS_SEC61G.
GenevestigatoriP60059.

Organism-specific databases

HPAiHPA053196.

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma By similarity.

Protein-protein interaction databases

BioGridi117039. 2 interactions.
IntActiP60059. 1 interaction.
MINTiMINT-3021864.
STRINGi9606.ENSP00000341538.

Structurei

3D structure databases

ProteinModelPortaliP60059.
SMRiP60059. Positions 1-68.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecE/SEC61-gamma family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302441.
HOGENOMiHOG000194479.
HOVERGENiHBG058067.
InParanoidiP60059.
KOiK07342.
OMAiNQFLTRC.
OrthoDBiEOG74R1TZ.
PhylomeDBiP60059.
TreeFamiTF300232.

Family and domain databases

Gene3Di1.20.5.820. 1 hit.
HAMAPiMF_00422. SecE.
InterProiIPR023391. Prot_translocase_SecE_dom.
IPR022943. SecE.
IPR008158. Translocase_Sec61-g.
IPR001901. Translocase_SecE/Sec61-g.
[Graphical view]
PfamiPF00584. SecE. 1 hit.
[Graphical view]
SUPFAMiSSF103456. SSF103456. 1 hit.
TIGRFAMsiTIGR00327. secE_euk_arch. 1 hit.
PROSITEiPS01067. SECE_SEC61G. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60059-1 [UniParc]FASTAAdd to Basket

« Hide

MDQVMQFVEP SRQFVKDSIR LVKRCTKPDR KEFQKIAMAT AIGFAIMGFI   50
GFFVKLIHIP INNIIVGG 68
Length:68
Mass (Da):7,741
Last modified:November 21, 2003 - v1
Checksum:i14C8279A22548561
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF054184 mRNA. Translation: AAC99401.1.
CR456979 mRNA. Translation: CAG33260.1.
AK311845 mRNA. Translation: BAG34787.1.
CH471201 Genomic DNA. Translation: EAW50960.1.
BC009480 mRNA. Translation: AAH09480.1.
BC051840 mRNA. Translation: AAH51840.1.
CCDSiCCDS5513.1.
PIRiS42412.
RefSeqiNP_001012474.1. NM_001012456.1.
NP_055117.1. NM_014302.3.
UniGeneiHs.488282.

Genome annotation databases

EnsembliENST00000352861; ENSP00000341538; ENSG00000132432.
ENST00000395535; ENSP00000378906; ENSG00000132432.
ENST00000415949; ENSP00000388337; ENSG00000132432.
ENST00000450622; ENSP00000409884; ENSG00000132432.
GeneIDi23480.
KEGGihsa:23480.
UCSCiuc003tqf.3. human.

Polymorphism databases

DMDMi38503386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF054184 mRNA. Translation: AAC99401.1 .
CR456979 mRNA. Translation: CAG33260.1 .
AK311845 mRNA. Translation: BAG34787.1 .
CH471201 Genomic DNA. Translation: EAW50960.1 .
BC009480 mRNA. Translation: AAH09480.1 .
BC051840 mRNA. Translation: AAH51840.1 .
CCDSi CCDS5513.1.
PIRi S42412.
RefSeqi NP_001012474.1. NM_001012456.1.
NP_055117.1. NM_014302.3.
UniGenei Hs.488282.

3D structure databases

ProteinModelPortali P60059.
SMRi P60059. Positions 1-68.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117039. 2 interactions.
IntActi P60059. 1 interaction.
MINTi MINT-3021864.
STRINGi 9606.ENSP00000341538.

Protein family/group databases

TCDBi 3.A.5.9.1. the general secretory pathway (sec) family.

Polymorphism databases

DMDMi 38503386.

Proteomic databases

MaxQBi P60059.
PaxDbi P60059.
PRIDEi P60059.

Protocols and materials databases

DNASUi 23480.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000352861 ; ENSP00000341538 ; ENSG00000132432 .
ENST00000395535 ; ENSP00000378906 ; ENSG00000132432 .
ENST00000415949 ; ENSP00000388337 ; ENSG00000132432 .
ENST00000450622 ; ENSP00000409884 ; ENSG00000132432 .
GeneIDi 23480.
KEGGi hsa:23480.
UCSCi uc003tqf.3. human.

Organism-specific databases

CTDi 23480.
GeneCardsi GC07M054787.
HGNCi HGNC:18277. SEC61G.
HPAi HPA053196.
MIMi 609215. gene.
neXtProti NX_P60059.
PharmGKBi PA134939045.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302441.
HOGENOMi HOG000194479.
HOVERGENi HBG058067.
InParanoidi P60059.
KOi K07342.
OMAi NQFLTRC.
OrthoDBi EOG74R1TZ.
PhylomeDBi P60059.
TreeFami TF300232.

Enzyme and pathway databases

Reactomei REACT_111178. ER-Phagosome pathway.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

Miscellaneous databases

GeneWikii SEC61G.
GenomeRNAii 23480.
NextBioi 45833.
PROi P60059.
SOURCEi Search...

Gene expression databases

Bgeei P60059.
CleanExi HS_SEC61G.
Genevestigatori P60059.

Family and domain databases

Gene3Di 1.20.5.820. 1 hit.
HAMAPi MF_00422. SecE.
InterProi IPR023391. Prot_translocase_SecE_dom.
IPR022943. SecE.
IPR008158. Translocase_Sec61-g.
IPR001901. Translocase_SecE/Sec61-g.
[Graphical view ]
Pfami PF00584. SecE. 1 hit.
[Graphical view ]
SUPFAMi SSF103456. SSF103456. 1 hit.
TIGRFAMsi TIGR00327. secE_euk_arch. 1 hit.
PROSITEi PS01067. SECE_SEC61G. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Skin.
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSC61G_HUMAN
AccessioniPrimary (citable) accession number: P60059
Secondary accession number(s): B2R4J0, P38384, Q6IB25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: September 3, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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