P60059 (SC61G_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein transport protein Sec61 subunit gamma

Gene names

Name:

SEC61G

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	68 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Necessary for protein translocation in the endoplasmic reticulum By similarity.
Subunit structure	Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the SecE/SEC61-gamma family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Traceable author statement. Source: Reactome translation Traceable author statement. Source: Reactome
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	P-P-bond-hydrolysis-driven protein transmembrane transporter activity Inferred from electronic annotation. Source: InterPro protein transporter activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 68	68	Protein transport protein Sec61 subunit gamma		PRO_0000104195
Regions
	Topological domain	1 – 32	32	Cytoplasmic Potential
	Transmembrane	33 – 61	29	Helical; Potential
	Topological domain	62 – 68	7	Extracellular Potential

Sequences

	Sequence		Length	Mass (Da)
	P60059 [UniParc]. Last modified November 21, 2003. Version 1. Checksum: 14C8279A22548561	FASTA	68	7,741
	10 20 30 40 50 60 MDQVMQFVEP SRQFVKDSIR LVKRCTKPDR KEFQKIAMAT AIGFAIMGFI GFFVKLIHIP INNIIVGG

References

[1]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Skin.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF054184 mRNA. Translation: AAC99401.1. CR456979 mRNA. Translation: CAG33260.1. AK311845 mRNA. Translation: BAG34787.1. CH471201 Genomic DNA. Translation: EAW50960.1. BC009480 mRNA. Translation: AAH09480.1. BC051840 mRNA. Translation: AAH51840.1.
IPI	IPI00006072.
PIR	S42412.
RefSeq	NP_001012474.1. NM_001012456.1. NP_055117.1. NM_014302.3.
UniGene	Hs.488282.
3D structure databases
ProteinModelPortal	P60059.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-3021864.
STRING	9606.ENSP00000341538.
Protein family/group databases
TCDB	3.A.5.9.1. general secretory pathway (Sec) family.
Polymorphism databases
DMDM	38503386.
Proteomic databases
PaxDb	P60059.
PRIDE	P60059.
Protocols and materials databases
DNASU	23480.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000352861; ENSP00000341538; ENSG00000132432. ENST00000395535; ENSP00000378906; ENSG00000132432. ENST00000415949; ENSP00000388337; ENSG00000132432. ENST00000450622; ENSP00000409884; ENSG00000132432.
GeneID	23480.
KEGG	hsa:23480.
UCSC	uc003tqf.3. human.
Organism-specific databases
CTD	23480.
GeneCards	GC07M054787.
HGNC	HGNC:18277. SEC61G.
HPA	HPA053196.
MIM	609215. gene.
neXtProt	NX_P60059.
PharmGKB	PA134939045.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG302441.
HOGENOM	HOG000194479.
HOVERGEN	HBG058067.
InParanoid	P60059.
KO	K07342.
OMA	KQFAKDS.
OrthoDB	EOG40GCSH.
PhylomeDB	P60059.
Enzyme and pathway databases
Reactome	REACT_17015. Metabolism of proteins. REACT_6900. Immune System. REACT_71. Gene Expression.
Gene expression databases
Bgee	P60059.
CleanEx	HS_SEC61G.
Genevestigator	P60059.
GermOnline	ENSG00000132432. Homo sapiens.
Family and domain databases
Gene3D	1.20.5.820. 1 hit.
InterPro	IPR023391. Prot_translocase_SecE_dom. IPR008158. Translocase_Sec61-g. IPR001901. Translocase_SecE/Sec61-g. [Graphical view]
Pfam	PF00584. SecE. 1 hit. [Graphical view]
SUPFAM	SSF103456. SecE_euk_arc. 1 hit.
TIGRFAMs	TIGR00327. secE_euk_arch. 1 hit.
PROSITE	PS01067. SECE_SEC61G. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23480.
NextBio	45833.
SOURCE	Search...

Entry information

Entry name

SC61G_HUMAN

Accession

Primary (citable) accession number: P60059
Secondary accession number(s): B2R4J0, P38384, Q6IB25

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	November 21, 2003
Last modified:	May 29, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.