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Protein

Protein transport protein Sec61 subunit gamma

Gene

SEC61G

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for protein translocation in the endoplasmic reticulum.

GO - Molecular functioni

  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro
  • protein transporter activity Source: UniProtKB

GO - Biological processi

  • protein targeting to ER Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-CFA-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit gamma
Gene namesi
Name:SEC61G
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 18

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 61HelicalSequence analysisAdd BLAST29
Topological domaini62 – 68ExtracellularSequence analysis7

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: Reactome
  • integral component of endoplasmic reticulum membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001041941 – 68Protein transport protein Sec61 subunit gammaAdd BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei18PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP60058.

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000005144.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WWBelectron microscopy6.48B1-68[»]
3JC2electron microscopy3.6027-68[»]
4CG5electron microscopy7.40B1-68[»]
4CG6electron microscopy7.80B1-68[»]
4CG7electron microscopy6.90B1-68[»]
5A6Uelectron microscopy9.00G7-68[»]
DisProtiDP00117.
ProteinModelPortaliP60058.
SMRiP60058.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60058.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecE/SEC61-gamma family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3498. Eukaryota.
ENOG4111WJ7. LUCA.
GeneTreeiENSGT00390000001319.
HOGENOMiHOG000194479.
HOVERGENiHBG058067.
InParanoidiP60058.
KOiK07342.
OMAiHIPLNHA.
OrthoDBiEOG091G19JS.
TreeFamiTF300232.

Family and domain databases

Gene3Di1.20.5.820. 1 hit.
HAMAPiMF_00422. SecE. 1 hit.
InterProiIPR023391. Prot_translocase_SecE_dom.
IPR022943. SecE.
IPR008158. Translocase_Sec61-g.
IPR001901. Translocase_SecE/Sec61-g.
[Graphical view]
PfamiPF00584. SecE. 1 hit.
[Graphical view]
SUPFAMiSSF103456. SSF103456. 1 hit.
TIGRFAMsiTIGR00327. secE_euk_arch. 1 hit.
PROSITEiPS01067. SECE_SEC61G. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQVMQFVEP SRQFVKDSIR LVKRCTKPDR KEFQKIAMAT AIGFAIMGFI
60
GFFVKLIHIP INNIIVGG
Length:68
Mass (Da):7,741
Last modified:November 21, 2003 - v1
Checksum:i14C8279A22548561
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25086 mRNA. Translation: AAA19705.1.
RefSeqiNP_001003325.1. NM_001003325.1.
UniGeneiCfa.40294.

Genome annotation databases

EnsembliENSCAFT00000005555; ENSCAFP00000005144; ENSCAFG00000003459.
GeneIDi404017.
KEGGicfa:404017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25086 mRNA. Translation: AAA19705.1.
RefSeqiNP_001003325.1. NM_001003325.1.
UniGeneiCfa.40294.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WWBelectron microscopy6.48B1-68[»]
3JC2electron microscopy3.6027-68[»]
4CG5electron microscopy7.40B1-68[»]
4CG6electron microscopy7.80B1-68[»]
4CG7electron microscopy6.90B1-68[»]
5A6Uelectron microscopy9.00G7-68[»]
DisProtiDP00117.
ProteinModelPortaliP60058.
SMRiP60058.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000005144.

Proteomic databases

PaxDbiP60058.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000005555; ENSCAFP00000005144; ENSCAFG00000003459.
GeneIDi404017.
KEGGicfa:404017.

Organism-specific databases

CTDi23480.

Phylogenomic databases

eggNOGiKOG3498. Eukaryota.
ENOG4111WJ7. LUCA.
GeneTreeiENSGT00390000001319.
HOGENOMiHOG000194479.
HOVERGENiHBG058067.
InParanoidiP60058.
KOiK07342.
OMAiHIPLNHA.
OrthoDBiEOG091G19JS.
TreeFamiTF300232.

Enzyme and pathway databases

ReactomeiR-CFA-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

EvolutionaryTraceiP60058.

Family and domain databases

Gene3Di1.20.5.820. 1 hit.
HAMAPiMF_00422. SecE. 1 hit.
InterProiIPR023391. Prot_translocase_SecE_dom.
IPR022943. SecE.
IPR008158. Translocase_Sec61-g.
IPR001901. Translocase_SecE/Sec61-g.
[Graphical view]
PfamiPF00584. SecE. 1 hit.
[Graphical view]
SUPFAMiSSF103456. SSF103456. 1 hit.
TIGRFAMsiTIGR00327. secE_euk_arch. 1 hit.
PROSITEiPS01067. SECE_SEC61G. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC61G_CANLF
AccessioniPrimary (citable) accession number: P60058
Secondary accession number(s): P38384
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.