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Protein

Fructose-bisphosphate aldolase class 1

Gene

fda

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (pfk)
  4. Fructose-bisphosphate aldolase class 1 (fda)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei176Proton acceptorUniRule annotation1
Active sitei211Schiff-base intermediate with dihydroxyacetone-PUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1UniRule annotation (EC:4.1.2.13UniRule annotation)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolaseUniRule annotation
Gene namesi
Name:fdaUniRule annotation
Synonyms:fbaB
Ordered Locus Names:PG_1755
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000000588 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002169021 – 293Fructose-bisphosphate aldolase class 1Add BLAST293

Interactioni

Protein-protein interaction databases

STRINGi242619.PG1755.

Structurei

Secondary structure

1293
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 11Combined sources11
Beta strandi14 – 19Combined sources6
Helixi23 – 25Combined sources3
Helixi26 – 32Combined sources7
Helixi37 – 39Combined sources3
Helixi43 – 59Combined sources17
Helixi61 – 64Combined sources4
Beta strandi65 – 73Combined sources9
Helixi75 – 78Combined sources4
Beta strandi80 – 82Combined sources3
Helixi87 – 95Combined sources9
Beta strandi98 – 102Combined sources5
Helixi123 – 132Combined sources10
Beta strandi137 – 144Combined sources8
Helixi149 – 167Combined sources19
Turni168 – 170Combined sources3
Beta strandi172 – 179Combined sources8
Helixi186 – 203Combined sources18
Beta strandi208 – 213Combined sources6
Turni218 – 221Combined sources4
Helixi222 – 225Combined sources4
Beta strandi230 – 236Combined sources7
Helixi242 – 249Combined sources8
Beta strandi256 – 260Combined sources5
Helixi261 – 264Combined sources4
Helixi273 – 292Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IQTX-ray2.46A1-293[»]
ProteinModelPortaliP60053.
SMRiP60053.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60053.

Family & Domainsi

Sequence similaritiesi

Belongs to the class I fructose-bisphosphate aldolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105WYW. Bacteria.
COG3588. LUCA.
KOiK01623.
OMAiEPEVDIH.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00729. FBP_aldolase_1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
IPR023014. FBA_I_Gram+-type.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKEQLQQMR QAPGFVGALD QSGGSTPKAL KAYGIQPDAY QSEEEMFDLI
60 70 80 90 100
HQMRTRMITS PAFATGKIIG VILFERTMRG KIEGMPTADF LWEKRHIVPF
110 120 130 140 150
LKVDKGLQDE ANGVQLMKPF PELGKLCEEA VGYHVFGTKM RSVIKQANEQ
160 170 180 190 200
GIRDIVEQQF QWGKEILSHG LVPILEPEVD IHCPEKAKAE EILKRELLAQ
210 220 230 240 250
LDKMTEPVML KITIPTVDNF YKEIIEHPMM LRVVALSGGY SREQANELLS
260 270 280 290
RNHGVIASFS RALVEGLSAR QTDAEFNAML EASIEDVYQA SIK
Length:293
Mass (Da):32,987
Last modified:November 21, 2003 - v1
Checksum:i8BF85BFF649DCE93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015924 Genomic DNA. Translation: AAQ66757.1.
RefSeqiWP_005875392.1. NC_002950.2.

Genome annotation databases

EnsemblBacteriaiAAQ66757; AAQ66757; PG_1755.
GeneIDi2552379.
KEGGipgi:PG_1755.
PATRICi22980496. VBIPorGin134034_1622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015924 Genomic DNA. Translation: AAQ66757.1.
RefSeqiWP_005875392.1. NC_002950.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IQTX-ray2.46A1-293[»]
ProteinModelPortaliP60053.
SMRiP60053.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi242619.PG1755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAQ66757; AAQ66757; PG_1755.
GeneIDi2552379.
KEGGipgi:PG_1755.
PATRICi22980496. VBIPorGin134034_1622.

Phylogenomic databases

eggNOGiENOG4105WYW. Bacteria.
COG3588. LUCA.
KOiK01623.
OMAiEPEVDIH.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Miscellaneous databases

EvolutionaryTraceiP60053.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00729. FBP_aldolase_1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
IPR023014. FBA_I_Gram+-type.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALF1_PORGI
AccessioniPrimary (citable) accession number: P60053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.