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P60052

- SODC_PANTR

UniProt

P60052 - SODC_PANTR

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Protein
Superoxide dismutase [Cu-Zn]
Gene
SOD1
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Binds 1 copper ion per subunit By similarity.
Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Copper; catalytic By similarity
Metal bindingi49 – 491Copper; catalytic By similarity
Metal bindingi64 – 641Copper; catalytic By similarity
Metal bindingi64 – 641Zinc; structural By similarity
Metal bindingi72 – 721Zinc; structural By similarity
Metal bindingi81 – 811Zinc; structural By similarity
Metal bindingi84 – 841Zinc; structural By similarity
Metal bindingi121 – 1211Copper; catalytic By similarity

GO - Molecular functioni

  1. chaperone binding Source: UniProtKB
  2. copper ion binding Source: UniProtKB
  3. protein phosphatase 2B binding Source: UniProtKB
  4. superoxide dismutase activity Source: UniProtKB
  5. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. activation of MAPK activity Source: UniProtKB
  2. anterograde axon cargo transport Source: Ensembl
  3. apoptotic DNA fragmentation Source: UniProtKB
  4. auditory receptor cell stereocilium organization Source: UniProtKB
  5. cell aging Source: UniProtKB
  6. cellular iron ion homeostasis Source: UniProtKB
  7. double-strand break repair Source: UniProtKB
  8. embryo implantation Source: UniProtKB
  9. glutathione metabolic process Source: UniProtKB
  10. heart contraction Source: UniProtKB
  11. hydrogen peroxide biosynthetic process Source: UniProtKB
  12. locomotory behavior Source: UniProtKB
  13. muscle cell cellular homeostasis Source: UniProtKB
  14. myeloid cell homeostasis Source: UniProtKB
  15. negative regulation of cholesterol biosynthetic process Source: UniProtKB
  16. negative regulation of neuron apoptotic process Source: UniProtKB
  17. neurofilament cytoskeleton organization Source: UniProtKB
  18. ovarian follicle development Source: UniProtKB
  19. peripheral nervous system myelin maintenance Source: UniProtKB
  20. positive regulation of catalytic activity Source: UniProtKB
  21. positive regulation of cytokine production Source: UniProtKB
  22. positive regulation of intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
  23. positive regulation of superoxide anion generation Source: Ensembl
  24. reactive oxygen species metabolic process Source: UniProtKB
  25. regulation of Rac GTPase activity Source: Ensembl
  26. regulation of blood pressure Source: UniProtKB
  27. regulation of mitochondrial membrane potential Source: UniProtKB
  28. regulation of multicellular organism growth Source: UniProtKB
  29. regulation of protein kinase activity Source: UniProtKB
  30. relaxation of vascular smooth muscle Source: UniProtKB
  31. removal of superoxide radicals Source: UniProtKB
  32. response to axon injury Source: UniProtKB
  33. response to drug Source: UniProtKB
  34. response to ethanol Source: UniProtKB
  35. response to heat Source: UniProtKB
  36. response to hydrogen peroxide Source: UniProtKB
  37. response to organic substance Source: UniProtKB
  38. response to superoxide Source: UniProtKB
  39. retina homeostasis Source: UniProtKB
  40. retrograde axon cargo transport Source: Ensembl
  41. sensory perception of sound Source: UniProtKB
  42. spermatogenesis Source: UniProtKB
  43. superoxide anion generation Source: Ensembl
  44. superoxide metabolic process Source: UniProtKB
  45. transmission of nerve impulse Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Gene namesi
Name:SOD1
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 21

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoplasmic vesicle Source: UniProtKB
  3. cytosol Source: UniProtKB
  4. dendrite cytoplasm Source: UniProtKB
  5. extracellular matrix Source: UniProtKB
  6. extracellular space Source: UniProtKB
  7. mitochondrion Source: UniProtKB
  8. neuronal cell body Source: UniProtKB
  9. nucleus Source: UniProtKB
  10. plasma membrane Source: Ensembl
  11. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 154153Superoxide dismutase [Cu-Zn]
PRO_0000164063Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei4 – 41N6-succinyllysine By similarity
Lipidationi7 – 71S-palmitoyl cysteine By similarity
Modified residuei10 – 101N6-succinyllysine By similarity
Disulfide bondi58 ↔ 147 By similarity
Modified residuei92 – 921N6-succinyllysine By similarity
Modified residuei99 – 991Phosphoserine By similarity
Modified residuei123 – 1231N6-acetyllysine; alternate By similarity
Modified residuei123 – 1231N6-succinyllysine; alternate By similarity
Modified residuei137 – 1371N6-acetyllysine; alternate By similarity
Modified residuei137 – 1371N6-succinyllysine; alternate By similarity

Post-translational modificationi

Palmitoylation helps nuclear targeting and decreases catalytic activity By similarity.
Succinylation, adjacent to copper catalytic site probably inhibit activity. Desuccinylated by SIRT5, enhancing activity By similarity.

Keywords - PTMi

Acetylation, Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiP60052.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000056696.

Structurei

3D structure databases

ProteinModelPortaliP60052.
SMRiP60052. Positions 2-154.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2032.
GeneTreeiENSGT00530000063226.
HOGENOMiHOG000263447.
HOVERGENiHBG000062.
KOiK04565.
OMAiEIEVKLH.
OrthoDBiEOG776SR4.
TreeFamiTF105131.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60052-1 [UniParc]FASTAAdd to Basket

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MATKAVCVLK GDGPVQGIIN FEQKESNGPV KVWGSIKGLT EGLHGFHVHE    50
FGDNTAGCTS AGPHFNPLSR KHGGPKDEER HVGDLGNVTA DKDGVADVSI 100
EDSVISLSGD HCIIGRTLVV HEKADDLGKG GNEESTKTGN AGSRLACGVI 150
GIAQ 154
Length:154
Mass (Da):15,936
Last modified:January 23, 2007 - v2
Checksum:i25CA38DA8D564483
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB087266 mRNA. Translation: BAC20345.1.
RefSeqiNP_001009025.1. NM_001009025.1.
UniGeneiPtr.428.

Genome annotation databases

EnsembliENSPTRT00000025826; ENSPTRP00000023837; ENSPTRG00000013847.
GeneIDi449637.
KEGGiptr:449637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB087266 mRNA. Translation: BAC20345.1 .
RefSeqi NP_001009025.1. NM_001009025.1.
UniGenei Ptr.428.

3D structure databases

ProteinModelPortali P60052.
SMRi P60052. Positions 2-154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9598.ENSPTRP00000056696.

Chemistry

BindingDBi P60052.

Proteomic databases

PRIDEi P60052.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000025826 ; ENSPTRP00000023837 ; ENSPTRG00000013847 .
GeneIDi 449637.
KEGGi ptr:449637.

Organism-specific databases

CTDi 6647.

Phylogenomic databases

eggNOGi COG2032.
GeneTreei ENSGT00530000063226.
HOGENOMi HOG000263447.
HOVERGENi HBG000062.
KOi K04565.
OMAi EIEVKLH.
OrthoDBi EOG776SR4.
TreeFami TF105131.

Miscellaneous databases

NextBioi 20832742.

Family and domain databases

Gene3Di 2.60.40.200. 1 hit.
InterProi IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
PRINTSi PR00068. CUZNDISMTASE.
SUPFAMi SSF49329. SSF49329. 1 hit.
PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure, molecular evolution, and gene expression of primate superoxide dismutases."
    Fukuhara R., Tezuka T., Kageyama T.
    Gene 296:99-109(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSODC_PANTR
AccessioniPrimary (citable) accession number: P60052
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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