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P60052

- SODC_PANTR

UniProt

P60052 - SODC_PANTR

Protein

Superoxide dismutase [Cu-Zn]

Gene

SOD1

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Binds 1 copper ion per subunit.By similarity
    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi47 – 471Copper; catalyticBy similarity
    Metal bindingi49 – 491Copper; catalyticBy similarity
    Metal bindingi64 – 641Copper; catalyticBy similarity
    Metal bindingi64 – 641Zinc; structuralBy similarity
    Metal bindingi72 – 721Zinc; structuralBy similarity
    Metal bindingi81 – 811Zinc; structuralBy similarity
    Metal bindingi84 – 841Zinc; structuralBy similarity
    Metal bindingi121 – 1211Copper; catalyticBy similarity

    GO - Molecular functioni

    1. chaperone binding Source: UniProtKB
    2. copper ion binding Source: UniProtKB
    3. protein phosphatase 2B binding Source: UniProtKB
    4. superoxide dismutase activity Source: UniProtKB
    5. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. activation of MAPK activity Source: UniProtKB
    2. anterograde axon cargo transport Source: Ensembl
    3. apoptotic DNA fragmentation Source: UniProtKB
    4. auditory receptor cell stereocilium organization Source: UniProtKB
    5. cell aging Source: UniProtKB
    6. cellular iron ion homeostasis Source: UniProtKB
    7. double-strand break repair Source: UniProtKB
    8. embryo implantation Source: UniProtKB
    9. glutathione metabolic process Source: UniProtKB
    10. heart contraction Source: UniProtKB
    11. hydrogen peroxide biosynthetic process Source: UniProtKB
    12. locomotory behavior Source: UniProtKB
    13. muscle cell cellular homeostasis Source: UniProtKB
    14. myeloid cell homeostasis Source: UniProtKB
    15. negative regulation of cholesterol biosynthetic process Source: UniProtKB
    16. negative regulation of neuron apoptotic process Source: UniProtKB
    17. neurofilament cytoskeleton organization Source: UniProtKB
    18. ovarian follicle development Source: UniProtKB
    19. peripheral nervous system myelin maintenance Source: UniProtKB
    20. positive regulation of catalytic activity Source: UniProtKB
    21. positive regulation of cytokine production Source: UniProtKB
    22. positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
    23. positive regulation of superoxide anion generation Source: Ensembl
    24. reactive oxygen species metabolic process Source: UniProtKB
    25. regulation of blood pressure Source: UniProtKB
    26. regulation of mitochondrial membrane potential Source: UniProtKB
    27. regulation of multicellular organism growth Source: UniProtKB
    28. regulation of protein kinase activity Source: UniProtKB
    29. regulation of Rac GTPase activity Source: Ensembl
    30. relaxation of vascular smooth muscle Source: UniProtKB
    31. removal of superoxide radicals Source: UniProtKB
    32. response to axon injury Source: UniProtKB
    33. response to drug Source: UniProtKB
    34. response to ethanol Source: UniProtKB
    35. response to heat Source: UniProtKB
    36. response to hydrogen peroxide Source: UniProtKB
    37. response to organic substance Source: UniProtKB
    38. response to superoxide Source: UniProtKB
    39. retina homeostasis Source: UniProtKB
    40. retrograde axon cargo transport Source: Ensembl
    41. sensory perception of sound Source: UniProtKB
    42. spermatogenesis Source: UniProtKB
    43. superoxide anion generation Source: Ensembl
    44. superoxide metabolic process Source: UniProtKB
    45. transmission of nerve impulse Source: UniProtKB

    Keywords - Molecular functioni

    Antioxidant, Oxidoreductase

    Keywords - Ligandi

    Copper, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
    Gene namesi
    Name:SOD1
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Chromosome 21

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytoplasmic vesicle Source: UniProtKB
    3. cytosol Source: UniProtKB
    4. dendrite cytoplasm Source: UniProtKB
    5. extracellular matrix Source: UniProtKB
    6. extracellular space Source: UniProtKB
    7. mitochondrion Source: UniProtKB
    8. neuronal cell body Source: UniProtKB
    9. nucleus Source: UniProtKB
    10. plasma membrane Source: Ensembl
    11. protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 154153Superoxide dismutase [Cu-Zn]PRO_0000164063Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei4 – 41N6-succinyllysineBy similarity
    Lipidationi7 – 71S-palmitoyl cysteineBy similarity
    Modified residuei10 – 101N6-succinyllysineBy similarity
    Disulfide bondi58 ↔ 147By similarity
    Modified residuei92 – 921N6-succinyllysineBy similarity
    Modified residuei99 – 991PhosphoserineBy similarity
    Modified residuei123 – 1231N6-acetyllysine; alternateBy similarity
    Modified residuei123 – 1231N6-succinyllysine; alternateBy similarity
    Modified residuei137 – 1371N6-acetyllysine; alternateBy similarity
    Modified residuei137 – 1371N6-succinyllysine; alternateBy similarity

    Post-translational modificationi

    Palmitoylation helps nuclear targeting and decreases catalytic activity.By similarity
    Succinylation, adjacent to copper catalytic site probably inhibit activity. Desuccinylated by SIRT5, enhancing activity By similarity.By similarity

    Keywords - PTMi

    Acetylation, Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PRIDEiP60052.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9598.ENSPTRP00000056696.

    Structurei

    3D structure databases

    ProteinModelPortaliP60052.
    SMRiP60052. Positions 2-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Cu-Zn superoxide dismutase family.Curated

    Phylogenomic databases

    eggNOGiCOG2032.
    GeneTreeiENSGT00530000063226.
    HOGENOMiHOG000263447.
    HOVERGENiHBG000062.
    KOiK04565.
    OMAiEIEVKLH.
    OrthoDBiEOG776SR4.
    TreeFamiTF105131.

    Family and domain databases

    Gene3Di2.60.40.200. 1 hit.
    InterProiIPR018152. SOD_Cu/Zn_BS.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view]
    PfamiPF00080. Sod_Cu. 1 hit.
    [Graphical view]
    PRINTSiPR00068. CUZNDISMTASE.
    SUPFAMiSSF49329. SSF49329. 1 hit.
    PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P60052-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATKAVCVLK GDGPVQGIIN FEQKESNGPV KVWGSIKGLT EGLHGFHVHE    50
    FGDNTAGCTS AGPHFNPLSR KHGGPKDEER HVGDLGNVTA DKDGVADVSI 100
    EDSVISLSGD HCIIGRTLVV HEKADDLGKG GNEESTKTGN AGSRLACGVI 150
    GIAQ 154
    Length:154
    Mass (Da):15,936
    Last modified:January 23, 2007 - v2
    Checksum:i25CA38DA8D564483
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB087266 mRNA. Translation: BAC20345.1.
    RefSeqiNP_001009025.1. NM_001009025.1.
    UniGeneiPtr.428.

    Genome annotation databases

    EnsembliENSPTRT00000025826; ENSPTRP00000023837; ENSPTRG00000013847.
    GeneIDi449637.
    KEGGiptr:449637.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB087266 mRNA. Translation: BAC20345.1 .
    RefSeqi NP_001009025.1. NM_001009025.1.
    UniGenei Ptr.428.

    3D structure databases

    ProteinModelPortali P60052.
    SMRi P60052. Positions 2-154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9598.ENSPTRP00000056696.

    Chemistry

    BindingDBi P60052.

    Proteomic databases

    PRIDEi P60052.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPTRT00000025826 ; ENSPTRP00000023837 ; ENSPTRG00000013847 .
    GeneIDi 449637.
    KEGGi ptr:449637.

    Organism-specific databases

    CTDi 6647.

    Phylogenomic databases

    eggNOGi COG2032.
    GeneTreei ENSGT00530000063226.
    HOGENOMi HOG000263447.
    HOVERGENi HBG000062.
    KOi K04565.
    OMAi EIEVKLH.
    OrthoDBi EOG776SR4.
    TreeFami TF105131.

    Miscellaneous databases

    NextBioi 20832742.

    Family and domain databases

    Gene3Di 2.60.40.200. 1 hit.
    InterProi IPR018152. SOD_Cu/Zn_BS.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view ]
    Pfami PF00080. Sod_Cu. 1 hit.
    [Graphical view ]
    PRINTSi PR00068. CUZNDISMTASE.
    SUPFAMi SSF49329. SSF49329. 1 hit.
    PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure, molecular evolution, and gene expression of primate superoxide dismutases."
      Fukuhara R., Tezuka T., Kageyama T.
      Gene 296:99-109(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiSODC_PANTR
    AccessioniPrimary (citable) accession number: P60052
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 21, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3