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P60051

- UBP14_PANTR

UniProt

P60051 - UBP14_PANTR

Protein

Ubiquitin carboxyl-terminal hydrolase 14

Gene

USP14

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei114 – 1141NucleophilePROSITE-ProRule annotation
    Active sitei435 – 4351Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. endopeptidase inhibitor activity Source: Ensembl
    3. ubiquitin thiolesterase activity Source: Ensembl

    GO - Biological processi

    1. regulation of chemotaxis Source: Ensembl
    2. regulation of proteasomal protein catabolic process Source: Ensembl
    3. synaptic transmission Source: Ensembl
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.015.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 14 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 14
    Ubiquitin thioesterase 14
    Ubiquitin-specific-processing protease 14
    Gene namesi
    Name:USP14
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Chromosome 18

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. cytoplasmic membrane-bounded vesicle Source: Ensembl
    3. plasma membrane Source: UniProtKB-SubCell
    4. proteasome complex Source: UniProtKB-KW
    5. synapse Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493Ubiquitin carboxyl-terminal hydrolase 14PRO_0000080638Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei143 – 1431PhosphoserineBy similarity
    Modified residuei235 – 2351PhosphothreonineBy similarity
    Modified residuei449 – 4491N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiP60051.

    Interactioni

    Subunit structurei

    Homodimer Potential. Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1 By similarity.By similarityCurated

    Protein-protein interaction databases

    STRINGi9598.ENSPTRP00000016705.

    Structurei

    3D structure databases

    ProteinModelPortaliP60051.
    SMRiP60051. Positions 6-86, 98-483.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 8077Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini105 – 483379USPAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiNOG286607.
    GeneTreeiENSGT00390000009615.
    HOGENOMiHOG000202292.
    HOVERGENiHBG054185.
    InParanoidiP60051.
    KOiK11843.
    OMAiDWGNLKI.
    OrthoDBiEOG7F7W8H.
    TreeFamiTF314494.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR019954. Ubiquitin_CS.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    SMARTiSM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS00299. UBIQUITIN_1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60051-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG    50
    GTLKDDDWGN IKIKNGMTLL MMGSADALPE EPSAKTVFVE DMTEEQLASA 100
    MELPCGLTNL GNTCYMNATV QCIRSVPELK DALKRYAGAL RASGEMASAQ 150
    YITAALRDLF DSMDKTSSSI PPIILLQFLH MAFPQFAEKG EQGQYLQQDA 200
    NECWIQMMRV LQQKLEAIED DSVKETDSSS ASAATPSKKK SLIDQFFGVE 250
    FETTMKCTES EEEEVTKGKE NQLQLSCFIN QEVKYLFTGL KLRLQEEITK 300
    QSPTLQRNAL YIKSSKISRL PAYLTIQMVR FFYKEKESVN AKVLKDVKFP 350
    LMLDMYELCT PELQEKMVSF RSKFKDLEDK KVNQQPNTSD KKSSPQKEVK 400
    YEPFSFADDI GSNNCGYYDL QAVLTHQGRS SSSGHYVSWV KRKQDEWIKF 450
    DDDKVSIVTP EDILRLSGGG DWHIAYVLLY GPRRVEIMEE ESE 493
    Length:493
    Mass (Da):55,941
    Last modified:January 23, 2007 - v2
    Checksum:iF4679A86E9DF00FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY191612 Genomic DNA. Translation: AAP23261.1.
    RefSeqiNP_001038961.1. NM_001045496.1.
    UniGeneiPtr.5420.

    Genome annotation databases

    EnsembliENSPTRT00000009757; ENSPTRP00000055013; ENSPTRG00000009815.
    GeneIDi455325.
    KEGGiptr:455325.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY191612 Genomic DNA. Translation: AAP23261.1 .
    RefSeqi NP_001038961.1. NM_001045496.1.
    UniGenei Ptr.5420.

    3D structure databases

    ProteinModelPortali P60051.
    SMRi P60051. Positions 6-86, 98-483.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9598.ENSPTRP00000016705.

    Protein family/group databases

    MEROPSi C19.015.

    Proteomic databases

    PRIDEi P60051.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPTRT00000009757 ; ENSPTRP00000055013 ; ENSPTRG00000009815 .
    GeneIDi 455325.
    KEGGi ptr:455325.

    Organism-specific databases

    CTDi 9097.

    Phylogenomic databases

    eggNOGi NOG286607.
    GeneTreei ENSGT00390000009615.
    HOGENOMi HOG000202292.
    HOVERGENi HBG054185.
    InParanoidi P60051.
    KOi K11843.
    OMAi DWGNLKI.
    OrthoDBi EOG7F7W8H.
    TreeFami TF314494.

    Miscellaneous databases

    NextBioi 20836735.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR019954. Ubiquitin_CS.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    SMARTi SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS00299. UBIQUITIN_1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution."
      Dennehey B.K., Gutches D.G., McConkey E.H., Krauter K.S.
      Genomics 83:493-501(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiUBP14_PANTR
    AccessioniPrimary (citable) accession number: P60051
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 21, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3