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Protein

Somatostatin

Gene

Sst

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Somatostatin inhibits the release of somatotropin.

GO - Molecular functioni

  • hormone activity Source: RGD

GO - Biological processi

  • cell-cell signaling Source: GO_Central
  • cell surface receptor signaling pathway Source: GO_Central
  • hyperosmotic response Source: RGD
  • regulation of cell migration Source: GO_Central
  • response to acidic pH Source: RGD
  • response to amino acid Source: RGD
  • response to drug Source: RGD
  • response to heat Source: RGD
  • response to organonitrogen compound Source: RGD
  • response to steroid hormone Source: RGD

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin
Cleaved into the following 3 chains:
Gene namesi
Name:Sst
Synonyms:Smst
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi3761. Sst.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
PeptideiPRO_000003309925 – 34Antrin10
PropeptideiPRO_000003310035 – 88Add BLAST54
PeptideiPRO_000003310189 – 116Somatostatin-28Add BLAST28
PeptideiPRO_0000033102103 – 116Somatostatin-14Add BLAST14

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi105 ↔ 116

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP60042.
PRIDEiP60042.

PTM databases

iPTMnetiP60042.
PhosphoSitePlusiP60042.

Miscellaneous databases

PMAP-CutDBiP60042.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001837.
GenevisibleiP60042. RN.

Interactioni

GO - Molecular functioni

  • hormone activity Source: RGD

Protein-protein interaction databases

ELMiP60042.
STRINGi10116.ENSRNOP00000002519.

Chemistry databases

BindingDBiP60042.

Structurei

3D structure databases

ProteinModelPortaliP60042.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQ5. Eukaryota.
ENOG4111WUI. LUCA.
GeneTreeiENSGT00510000047914.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP60042.
KOiK05237.
OMAiGEPEDIR.
OrthoDBiEOG091G157X.
PhylomeDBiP60042.
TreeFamiTF333185.

Family and domain databases

InterProiView protein in InterPro
IPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiView protein in Pfam
PF03002. Somatostatin. 1 hit.
PIRSFiPIRSF001814. Somatostatin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSCRLQCAL AALCIVLALG GVTGAPSDPR LRQFLQKSLA AATGKQELAK
60 70 80 90 100
YFLAELLSEP NQTENDALEP EDLPQAAEQD EMRLELQRSA NSNPAMAPRE
110
RKAGCKNFFW KTFTSC
Length:116
Mass (Da):12,746
Last modified:July 21, 1986 - v1
Checksum:iD48B5454C4490375
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43T → Y (PubMed:6145156).Curated1
Sequence conflicti79Q → H in AAA42162 (PubMed:6120163).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02248 Genomic DNA. Translation: AAA42161.1.
V01271 mRNA. Translation: CAA24579.1.
J00787 Genomic DNA. Translation: AAA42164.1.
M25890 mRNA. Translation: AAA42167.1.
J00788 mRNA. Translation: AAA42162.1.
PIRiA20983. RIRTS1.
RefSeqiNP_036791.1. NM_012659.2.
UniGeneiRn.34418.

Genome annotation databases

EnsembliENSRNOT00000002519; ENSRNOP00000002519; ENSRNOG00000001837.
GeneIDi24797.
KEGGirno:24797.
UCSCiRGD:3761. rat.

Similar proteinsi

Entry informationi

Entry nameiSMS_RAT
AccessioniPrimary (citable) accession number: P60042
Secondary accession number(s): P01167
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: August 30, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families