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Protein

Somatostatin

Gene

Sst

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Somatostatin inhibits the release of somatotropin.

GO - Molecular functioni

  • hormone activity Source: RGD

GO - Biological processi

  • cell-cell signaling Source: GO_Central
  • cell surface receptor signaling pathway Source: GO_Central
  • hyperosmotic response Source: RGD
  • regulation of cell migration Source: GO_Central
  • response to acidic pH Source: RGD
  • response to amino acid Source: RGD
  • response to drug Source: RGD
  • response to heat Source: RGD
  • response to organonitrogen compound Source: RGD
  • response to steroid hormone Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin
Cleaved into the following 3 chains:
Gene namesi
Name:Sst
Synonyms:Smst
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi3761. Sst.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Peptidei25 – 3410AntrinPRO_0000033099
Propeptidei35 – 8854PRO_0000033100Add
BLAST
Peptidei89 – 11628Somatostatin-28PRO_0000033101Add
BLAST
Peptidei103 – 11614Somatostatin-14PRO_0000033102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi105 ↔ 116

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP60042.

PTM databases

iPTMnetiP60042.

Miscellaneous databases

PMAP-CutDBP60042.

Expressioni

Gene expression databases

GenevisibleiP60042. RN.

Interactioni

GO - Molecular functioni

  • hormone activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002519.

Chemistry

BindingDBiP60042.

Structurei

3D structure databases

ProteinModelPortaliP60042.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQ5. Eukaryota.
ENOG4111WUI. LUCA.
GeneTreeiENSGT00510000047914.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP60042.
KOiK05237.
OMAiAEQDDMR.
OrthoDBiEOG7H4DXK.
PhylomeDBiP60042.
TreeFamiTF333185.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSCRLQCAL AALCIVLALG GVTGAPSDPR LRQFLQKSLA AATGKQELAK
60 70 80 90 100
YFLAELLSEP NQTENDALEP EDLPQAAEQD EMRLELQRSA NSNPAMAPRE
110
RKAGCKNFFW KTFTSC
Length:116
Mass (Da):12,746
Last modified:July 21, 1986 - v1
Checksum:iD48B5454C4490375
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431T → Y (PubMed:6145156).Curated
Sequence conflicti79 – 791Q → H in AAA42162 (PubMed:6120163).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02248 Genomic DNA. Translation: AAA42161.1.
V01271 mRNA. Translation: CAA24579.1.
J00787 Genomic DNA. Translation: AAA42164.1.
M25890 mRNA. Translation: AAA42167.1.
J00788 mRNA. Translation: AAA42162.1.
PIRiA20983. RIRTS1.
RefSeqiNP_036791.1. NM_012659.2.
UniGeneiRn.34418.

Genome annotation databases

EnsembliENSRNOT00000002519; ENSRNOP00000002519; ENSRNOG00000001837.
GeneIDi24797.
KEGGirno:24797.
UCSCiRGD:3761. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02248 Genomic DNA. Translation: AAA42161.1.
V01271 mRNA. Translation: CAA24579.1.
J00787 Genomic DNA. Translation: AAA42164.1.
M25890 mRNA. Translation: AAA42167.1.
J00788 mRNA. Translation: AAA42162.1.
PIRiA20983. RIRTS1.
RefSeqiNP_036791.1. NM_012659.2.
UniGeneiRn.34418.

3D structure databases

ProteinModelPortaliP60042.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002519.

Chemistry

BindingDBiP60042.

PTM databases

iPTMnetiP60042.

Proteomic databases

PaxDbiP60042.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002519; ENSRNOP00000002519; ENSRNOG00000001837.
GeneIDi24797.
KEGGirno:24797.
UCSCiRGD:3761. rat.

Organism-specific databases

CTDi6750.
RGDi3761. Sst.

Phylogenomic databases

eggNOGiENOG410IXQ5. Eukaryota.
ENOG4111WUI. LUCA.
GeneTreeiENSGT00510000047914.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP60042.
KOiK05237.
OMAiAEQDDMR.
OrthoDBiEOG7H4DXK.
PhylomeDBiP60042.
TreeFamiTF333185.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PMAP-CutDBP60042.
PROiP60042.

Gene expression databases

GenevisibleiP60042. RN.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Isolation, characterization, and DNA sequence of the rat somatostatin gene."
    Tavianini M.A., Hayes T.E., Magazin M.D., Minth C.D., Dixon J.E.
    J. Biol. Chem. 259:11798-11803(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide and amino acid sequence comparisons of preprosomatostatins."
    Argos P., Taylor W.L., Minth C.D., Dixon J.E.
    J. Biol. Chem. 258:8788-8793(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Rat pre-prosomatostatin. Structure and processing by microsomal membranes."
    Goodman R.H., Aron D.C., Roos B.A.
    J. Biol. Chem. 258:5570-5573(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Biosynthesis of rat preprosomatostatin."
    Goodman R.H., Montminy M.R., Low M.J., Habener J.F.
    Adv. Exp. Med. Biol. 188:31-47(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Somatostatin-28 encoded in a cloned cDNA obtained from a rat medullary thyroid carcinoma."
    Goodman R.H., Jacobs J.W., Dee P.C., Habener J.F.
    J. Biol. Chem. 257:1156-1159(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 38-116.
  7. "A new prosomatostatin-derived peptide reveals a pattern for prohormone cleavage at monobasic sites."
    Benoit R., Ling N., Esch F.
    Science 238:1126-1129(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-34.
    Strain: Sprague-Dawley.
    Tissue: Stomach.

Entry informationi

Entry nameiSMS_RAT
AccessioniPrimary (citable) accession number: P60042
Secondary accession number(s): P01167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 6, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.