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P60041

- SMS_MOUSE

UniProt

P60041 - SMS_MOUSE

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Protein

Somatostatin

Gene

Sst

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Somatostatin inhibits the release of somatotropin.

GO - Biological processi

  1. hyperosmotic response Source: Ensembl
  2. regulation of cell migration Source: MGI
  3. response to amino acid Source: Ensembl
  4. response to drug Source: Ensembl
  5. response to heat Source: Ensembl
  6. response to steroid hormone Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin
Cleaved into the following 3 chains:
Gene namesi
Name:Sst
Synonyms:Smst
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:98326. Sst.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Peptidei25 – 3410AntrinPRO_0000033092
Propeptidei35 – 8854By similarityPRO_0000033093Add
BLAST
Peptidei89 – 11628Somatostatin-28PRO_0000033094Add
BLAST
Peptidei103 – 11614Somatostatin-14PRO_0000033095Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi105 ↔ 116By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP60041.
PRIDEiP60041.

Expressioni

Gene expression databases

BgeeiP60041.
CleanExiMM_SST.
ExpressionAtlasiP60041. baseline and differential.
GenevestigatoriP60041.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004480.

Structurei

3D structure databases

ProteinModelPortaliP60041.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44503.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP60041.
KOiK05237.
OMAiTNSNPAM.
OrthoDBiEOG7H4DXK.
PhylomeDBiP60041.
TreeFamiTF333185.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60041-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSCRLQCAL AALCIVLALG GVTGAPSDPR LRQFLQKSLA AATGKQELAK
60 70 80 90 100
YFLAELLSEP NQTENDALEP EDLPQAAEQD EMRLELQRSA NSNPAMAPRE
110
RKAGCKNFFW KTFTSC
Length:116
Mass (Da):12,746
Last modified:July 21, 1986 - v1
Checksum:iD48B5454C4490375
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51468 Genomic DNA. Translation: CAA35831.1.
BC010770 mRNA. Translation: AAH10770.1.
CCDSiCCDS28080.1.
PIRiS08416. RIMSS1.
RefSeqiNP_033241.1. NM_009215.1.
UniGeneiMm.2453.

Genome annotation databases

EnsembliENSMUST00000004480; ENSMUSP00000004480; ENSMUSG00000004366.
GeneIDi20604.
KEGGimmu:20604.
UCSCiuc007ytx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51468 Genomic DNA. Translation: CAA35831.1 .
BC010770 mRNA. Translation: AAH10770.1 .
CCDSi CCDS28080.1.
PIRi S08416. RIMSS1.
RefSeqi NP_033241.1. NM_009215.1.
UniGenei Mm.2453.

3D structure databases

ProteinModelPortali P60041.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000004480.

Chemistry

BindingDBi P60041.

Proteomic databases

PaxDbi P60041.
PRIDEi P60041.

Protocols and materials databases

DNASUi 20604.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004480 ; ENSMUSP00000004480 ; ENSMUSG00000004366 .
GeneIDi 20604.
KEGGi mmu:20604.
UCSCi uc007ytx.1. mouse.

Organism-specific databases

CTDi 6750.
MGIi MGI:98326. Sst.

Phylogenomic databases

eggNOGi NOG44503.
HOGENOMi HOG000036630.
HOVERGENi HBG017816.
InParanoidi P60041.
KOi K05237.
OMAi TNSNPAM.
OrthoDBi EOG7H4DXK.
PhylomeDBi P60041.
TreeFami TF333185.

Miscellaneous databases

NextBioi 298941.
PROi P60041.
SOURCEi Search...

Gene expression databases

Bgeei P60041.
CleanExi MM_SST.
ExpressionAtlasi P60041. baseline and differential.
Genevestigatori P60041.

Family and domain databases

InterProi IPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view ]
PANTHERi PTHR10558. PTHR10558. 1 hit.
Pfami PF03002. Somatostatin. 1 hit.
[Graphical view ]
PIRSFi PIRSF001814. Somatostatin. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the mouse preprosomatostatin gene."
    Fuhrmann G., Heilig R., Kempf J., Ebel A.
    Nucleic Acids Res. 18:1287-1287(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiSMS_MOUSE
AccessioniPrimary (citable) accession number: P60041
Secondary accession number(s): P01167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3