Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P60041 (SMS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Somatostatin

Cleaved into the following 3 chains:

  1. Antrin
  2. Somatostatin-28
  3. Somatostatin-14
Gene names
Name:Sst
Synonyms:Smst
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length116 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Somatostatin inhibits the release of somatotropin.

Subcellular location

Secreted.

Sequence similarities

Belongs to the somatostatin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 By similarity
Peptide25 – 3410Antrin
PRO_0000033092
Propeptide35 – 8854 By similarity
PRO_0000033093
Peptide89 – 11628Somatostatin-28
PRO_0000033094
Peptide103 – 11614Somatostatin-14
PRO_0000033095

Amino acid modifications

Disulfide bond105 ↔ 116 By similarity

Sequences

Sequence LengthMass (Da)Tools
P60041 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: D48B5454C4490375

FASTA11612,746
        10         20         30         40         50         60 
MLSCRLQCAL AALCIVLALG GVTGAPSDPR LRQFLQKSLA AATGKQELAK YFLAELLSEP 

        70         80         90        100        110 
NQTENDALEP EDLPQAAEQD EMRLELQRSA NSNPAMAPRE RKAGCKNFFW KTFTSC 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the mouse preprosomatostatin gene."
Fuhrmann G., Heilig R., Kempf J., Ebel A.
Nucleic Acids Res. 18:1287-1287(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X51468 Genomic DNA. Translation: CAA35831.1.
BC010770 mRNA. Translation: AAH10770.1.
CCDSCCDS28080.1.
PIRRIMSS1. S08416.
RefSeqNP_033241.1. NM_009215.1.
UniGeneMm.2453.

3D structure databases

ProteinModelPortalP60041.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000004480.

Chemistry

BindingDBP60041.

Proteomic databases

PaxDbP60041.
PRIDEP60041.

Protocols and materials databases

DNASU20604.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000004480; ENSMUSP00000004480; ENSMUSG00000004366.
GeneID20604.
KEGGmmu:20604.
UCSCuc007ytx.1. mouse.

Organism-specific databases

CTD6750.
MGIMGI:98326. Sst.

Phylogenomic databases

eggNOGNOG44503.
HOGENOMHOG000036630.
HOVERGENHBG017816.
InParanoidP60041.
KOK05237.
OMATNSNPAM.
OrthoDBEOG7H4DXK.
PhylomeDBP60041.
TreeFamTF333185.

Gene expression databases

BgeeP60041.
CleanExMM_SST.
GenevestigatorP60041.

Family and domain databases

InterProIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERPTHR10558. PTHR10558. 1 hit.
PfamPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFPIRSF001814. Somatostatin. 1 hit.
ProtoNetSearch...

Other

NextBio298941.
PROP60041.
SOURCESearch...

Entry information

Entry nameSMS_MOUSE
AccessionPrimary (citable) accession number: P60041
Secondary accession number(s): P01167
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot