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Protein

Somatostatin

Gene

Sst

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Somatostatin inhibits the release of somatotropin.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin
Cleaved into the following 3 chains:
Gene namesi
Name:Sst
Synonyms:Smst
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:98326. Sst.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Peptidei25 – 3410AntrinPRO_0000033092
Propeptidei35 – 8854By similarityPRO_0000033093Add
BLAST
Peptidei89 – 11628Somatostatin-28PRO_0000033094Add
BLAST
Peptidei103 – 11614Somatostatin-14PRO_0000033095Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi105 ↔ 116By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP60041.
PRIDEiP60041.

Expressioni

Gene expression databases

BgeeiP60041.
CleanExiMM_SST.
ExpressionAtlasiP60041. baseline and differential.
GenevisibleiP60041. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004480.

Structurei

3D structure databases

ProteinModelPortaliP60041.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44503.
GeneTreeiENSGT00510000047914.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP60041.
KOiK05237.
OMAiRMELQRS.
OrthoDBiEOG7H4DXK.
PhylomeDBiP60041.
TreeFamiTF333185.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSCRLQCAL AALCIVLALG GVTGAPSDPR LRQFLQKSLA AATGKQELAK
60 70 80 90 100
YFLAELLSEP NQTENDALEP EDLPQAAEQD EMRLELQRSA NSNPAMAPRE
110
RKAGCKNFFW KTFTSC
Length:116
Mass (Da):12,746
Last modified:July 21, 1986 - v1
Checksum:iD48B5454C4490375
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51468 Genomic DNA. Translation: CAA35831.1.
BC010770 mRNA. Translation: AAH10770.1.
CCDSiCCDS28080.1.
PIRiS08416. RIMSS1.
RefSeqiNP_033241.1. NM_009215.1.
UniGeneiMm.2453.

Genome annotation databases

EnsembliENSMUST00000004480; ENSMUSP00000004480; ENSMUSG00000004366.
GeneIDi20604.
KEGGimmu:20604.
UCSCiuc007ytx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51468 Genomic DNA. Translation: CAA35831.1.
BC010770 mRNA. Translation: AAH10770.1.
CCDSiCCDS28080.1.
PIRiS08416. RIMSS1.
RefSeqiNP_033241.1. NM_009215.1.
UniGeneiMm.2453.

3D structure databases

ProteinModelPortaliP60041.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004480.

Chemistry

BindingDBiP60041.

Proteomic databases

PaxDbiP60041.
PRIDEiP60041.

Protocols and materials databases

DNASUi20604.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004480; ENSMUSP00000004480; ENSMUSG00000004366.
GeneIDi20604.
KEGGimmu:20604.
UCSCiuc007ytx.1. mouse.

Organism-specific databases

CTDi6750.
MGIiMGI:98326. Sst.

Phylogenomic databases

eggNOGiNOG44503.
GeneTreeiENSGT00510000047914.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP60041.
KOiK05237.
OMAiRMELQRS.
OrthoDBiEOG7H4DXK.
PhylomeDBiP60041.
TreeFamiTF333185.

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

NextBioi298941.
PROiP60041.
SOURCEiSearch...

Gene expression databases

BgeeiP60041.
CleanExiMM_SST.
ExpressionAtlasiP60041. baseline and differential.
GenevisibleiP60041. MM.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the mouse preprosomatostatin gene."
    Fuhrmann G., Heilig R., Kempf J., Ebel A.
    Nucleic Acids Res. 18:1287-1287(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiSMS_MOUSE
AccessioniPrimary (citable) accession number: P60041
Secondary accession number(s): P01167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 22, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.