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P60041

- SMS_MOUSE

UniProt

P60041 - SMS_MOUSE

Protein

Somatostatin

Gene

Sst

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Somatostatin inhibits the release of somatotropin.

    GO - Biological processi

    1. hyperosmotic response Source: Ensembl
    2. regulation of cell migration Source: MGI
    3. response to amino acid Source: Ensembl
    4. response to drug Source: Ensembl
    5. response to heat Source: Ensembl
    6. response to steroid hormone Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Somatostatin
    Cleaved into the following 3 chains:
    Gene namesi
    Name:Sst
    Synonyms:Smst
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:98326. Sst.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Peptidei25 – 3410AntrinPRO_0000033092
    Propeptidei35 – 8854By similarityPRO_0000033093Add
    BLAST
    Peptidei89 – 11628Somatostatin-28PRO_0000033094Add
    BLAST
    Peptidei103 – 11614Somatostatin-14PRO_0000033095Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi105 ↔ 116By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PaxDbiP60041.
    PRIDEiP60041.

    Expressioni

    Gene expression databases

    BgeeiP60041.
    CleanExiMM_SST.
    GenevestigatoriP60041.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000004480.

    Structurei

    3D structure databases

    ProteinModelPortaliP60041.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the somatostatin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44503.
    HOGENOMiHOG000036630.
    HOVERGENiHBG017816.
    InParanoidiP60041.
    KOiK05237.
    OMAiTNSNPAM.
    OrthoDBiEOG7H4DXK.
    PhylomeDBiP60041.
    TreeFamiTF333185.

    Family and domain databases

    InterProiIPR004250. Somatostatin.
    IPR018142. Somatostatin/Cortistatin_C.
    [Graphical view]
    PANTHERiPTHR10558. PTHR10558. 1 hit.
    PfamiPF03002. Somatostatin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001814. Somatostatin. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P60041-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSCRLQCAL AALCIVLALG GVTGAPSDPR LRQFLQKSLA AATGKQELAK    50
    YFLAELLSEP NQTENDALEP EDLPQAAEQD EMRLELQRSA NSNPAMAPRE 100
    RKAGCKNFFW KTFTSC 116
    Length:116
    Mass (Da):12,746
    Last modified:July 21, 1986 - v1
    Checksum:iD48B5454C4490375
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51468 Genomic DNA. Translation: CAA35831.1.
    BC010770 mRNA. Translation: AAH10770.1.
    CCDSiCCDS28080.1.
    PIRiS08416. RIMSS1.
    RefSeqiNP_033241.1. NM_009215.1.
    UniGeneiMm.2453.

    Genome annotation databases

    EnsembliENSMUST00000004480; ENSMUSP00000004480; ENSMUSG00000004366.
    GeneIDi20604.
    KEGGimmu:20604.
    UCSCiuc007ytx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51468 Genomic DNA. Translation: CAA35831.1 .
    BC010770 mRNA. Translation: AAH10770.1 .
    CCDSi CCDS28080.1.
    PIRi S08416. RIMSS1.
    RefSeqi NP_033241.1. NM_009215.1.
    UniGenei Mm.2453.

    3D structure databases

    ProteinModelPortali P60041.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000004480.

    Chemistry

    BindingDBi P60041.

    Proteomic databases

    PaxDbi P60041.
    PRIDEi P60041.

    Protocols and materials databases

    DNASUi 20604.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004480 ; ENSMUSP00000004480 ; ENSMUSG00000004366 .
    GeneIDi 20604.
    KEGGi mmu:20604.
    UCSCi uc007ytx.1. mouse.

    Organism-specific databases

    CTDi 6750.
    MGIi MGI:98326. Sst.

    Phylogenomic databases

    eggNOGi NOG44503.
    HOGENOMi HOG000036630.
    HOVERGENi HBG017816.
    InParanoidi P60041.
    KOi K05237.
    OMAi TNSNPAM.
    OrthoDBi EOG7H4DXK.
    PhylomeDBi P60041.
    TreeFami TF333185.

    Miscellaneous databases

    NextBioi 298941.
    PROi P60041.
    SOURCEi Search...

    Gene expression databases

    Bgeei P60041.
    CleanExi MM_SST.
    Genevestigatori P60041.

    Family and domain databases

    InterProi IPR004250. Somatostatin.
    IPR018142. Somatostatin/Cortistatin_C.
    [Graphical view ]
    PANTHERi PTHR10558. PTHR10558. 1 hit.
    Pfami PF03002. Somatostatin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001814. Somatostatin. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the mouse preprosomatostatin gene."
      Fuhrmann G., Heilig R., Kempf J., Ebel A.
      Nucleic Acids Res. 18:1287-1287(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiSMS_MOUSE
    AccessioniPrimary (citable) accession number: P60041
    Secondary accession number(s): P01167
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3